Hepatol Commun 2021 Oct 18. Epub 2021 Oct 18.
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Liver injury, characterized predominantly by elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT), is a common feature of coronavirus disease-2019 (COVID-19) symptom caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2). Additionally, SARS-CoV2 infection is associated with acute-on-chronic liver failure in patients with cirrhosis, and has a notably elevated mortality in patients with alcohol-related liver disease compared to other etiologies. Direct viral infection of the liver with SARS-CoV2 remains controversial, and alternative pathophysiologic explanations for its hepatic effects are an area of active investigation. Read More