20,319 results match your criteria mortality end-stage

A comparison of COVID-19 inpatients by HIV status.

Int J STD AIDS 2021 Jun 22:9564624211023015. Epub 2021 Jun 22.

Division of Infectious Diseases, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.

COVID-19 in-hospital morbidity and mortality in people living with HIV (PLWH) were compared to HIV-negative COVID-19 patients within a New York City metropolitan health system, the hardest hit region in the United States early in the pandemic. A total of 10,202 inpatients were diagnosed with COVID-19, of which 99 were PLWH. PLWH were younger (58. Read More

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Natural history of NASH.

Liver Int 2021 06;41 Suppl 1:78-82

Department of Medical Sciences, Division of Gastroenterology and Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Non-alcoholic fatty liver disease (NAFLD) is the fastest growing cause of chronic liver disease worldwide. Although only a small proportion of NAFLD patients will progress to end-stage liver disease and death, the clinical burden of NAFLD is substantial due the sheer number of individuals affected worldwide. In fact, recent estimates suggest that 25% of the world have NAFLD, which is now one of the leading causes of cirrhosis and indications for liver transplantation. Read More

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End-stage liver disease: Management of hepatorenal syndrome.

Liver Int 2021 06;41 Suppl 1:119-127

Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Hepatorenal syndrome (HRS) is a serious complication of cirrhosis with high morbidity and mortality rates. Recently, the definition of HRS type 1 has been updated and is now called HRS-AKI. This new definition reduces the risk of delaying HRS treatment and eliminates the need to establish a minimum creatinine cut-off for the diagnosis of HRS-AKI. Read More

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Drug-induced liver injury at a tertiary care centre in Germany: Model for End-stage Liver Disease is the best predictor of outcome.

Liver Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background & Aims: Agents most frequently inducing idiosyncratic drug-induced liver injury (DILI) differ between countries worldwide. Besides, there is no consistent data on the best model predicting mortality or the need for liver transplantation in DILI. We here analysed the DILI cohort of our centre with regard to causative drugs and clinical outcome. Read More

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National Trends for Peripheral Artery Disease and End Stage Renal Disease From the National Inpatient Sample Database.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211025625

Northshore University Health Systems Cardiovascular Institute, Evanston, IL, USA.

Peripheral artery disease (PAD), and subsequent chronic limb-threatening ischemia (CLTI), are frequently encountered among patients with end-stage renal disease (ESRD). Their coexistence is less favorable in comparison to patients with ESRD alone. We sought to investigate trends, comorbidities, determinants for cost, and prognostic outcomes in patients with concomitant ESRD and PAD. Read More

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Sodium-Glucose Co-transporter-2 Inhibitors and Nephroprotection in Diabetic Patients: More Than a Challenge.

Front Med (Lausanne) 2021 4;8:654557. Epub 2021 Jun 4.

Unit of Internal Medicine, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.

Diabetic nephropathy is the most common cause of end-stage renal disease worldwide. Control of blood glucose and blood pressure (BP) reduces the risk of developing this complication, but once diabetic nephropathy is established, it is then only possible to slow its progression. Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a novel class of oral hypoglycemic agents that increase urinary glucose excretion by suppressing glucose reabsorption at the renal proximal tubule. Read More

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Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study.

Front Immunol 2021 2;12:624821. Epub 2021 Jun 2.

Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, United States.

Kidney disease affects 10% of the world population and is associated with increased mortality. Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage kidney disease in children, often failing standard immunosuppression. Here, we report the results of a prospective study to investigate the immunological impact and safety of a gluten-free and dairy-free (GF/DF) diet in children with SRNS. Read More

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Hyponatremia and Liver Transplantation: A Narrative Review.

J Cardiothorac Vasc Anesth 2021 May 23. Epub 2021 May 23.

Department of Anesthesiology and Perioperative Medicine, Penn State Health, Milton S. Hershey Medical Center/Penn State College of Medicine, Hershey, PA.

Hyponatremia is a common electrolyte disorder in patients with end-stage liver disease (ESLD) and is associated with increased mortality on the liver transplantation (LT) waiting list. The impact of hyponatremia on outcomes after LT is unclear. Ninety-day and one-year mortality may be increased, but the data are conflicting. Read More

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Association between physical activity and mortality in end-stage kidney disease: a systematic review of observational studies.

BMC Nephrol 2021 Jun 18;22(1):227. Epub 2021 Jun 18.

Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Maia, Portugal.

Background: End-stage Kidney Disease patients have a high mortality and hospitalization risk. The association of these outcomes with physical activity is described in the general population and in other chronic diseases. However, few studies examining this association have been completed in end-stage Kidney Disease patients, raising the need to systematically review the evidence on the association of physical activity with mortality and hospitalization in this population. Read More

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Cardiac changes following arteriovenous fistula creation in a mouse model.

J Vasc Access 2021 Jun 18:11297298211026083. Epub 2021 Jun 18.

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL, USA.

Background: Arteriovenous fistula (AVF) creation may negatively affect cardiac structure and function and impact cardiovascular mortality. The objective of this study was to develop and characterize the cardiac changes following AVF creation in a murine AVF model.

Methods: AVFs were constructed using the carotid artery and jugular vein in C57BL/6 mice. Read More

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Reducing the burden of cardiovascular disease in children with chronic kidney disease: prevention vs. damage limitation.

Rukshana Shroff

Pediatr Nephrol 2021 Jun 18. Epub 2021 Jun 18.

UCL Great Ormond Street Hospital for Children and Institute of Child Health, London, WC1N 3JH, UK.

Cardiovascular disease (CVD) is a life-limiting condition in patients with chronic kidney disease (CKD) and is rapidly progressive, especially in those with stage 5 CKD and on dialysis. Cardiovascular mortality, although reducing, remains at least 30 times higher than in the general pediatric population. The American Heart Association guidelines for cardiovascular risk reduction in high-risk pediatric patients has stratified pediatric CKD patients in the "high risk" category for the development of CVD, with associated pathological and/or clinical evidence for manifest coronary disease before 30 years of age. Read More

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Linoleic Acid-Derived Oxylipins Differentiate Early Stage Alcoholic Hepatitis From Mild Alcohol-Associated Liver Injury.

Hepatol Commun 2021 Jun 9;5(6):947-960. Epub 2021 Feb 9.

Division of Gastroenterology, Hepatology, and Nutrition Department of Medicine University of Louisville Louisville KY USA.

Alcohol-associated liver disease (ALD) is a spectrum of liver disorders ranging from steatosis to steatohepatitis, fibrosis, and cirrhosis. Alcohol-associated hepatitis (AH) is an acute and often severe form of ALD with substantial morbidity and mortality. The mechanisms and mediators of ALD progression and severity are not well understood, and effective therapeutic options are limited. Read More

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Assessment of the Frail Patient With End-Stage Liver Disease: A Practical Overview of Sarcopenia, Physical Function, and Disability.

Hepatol Commun 2021 Jun 26;5(6):923-937. Epub 2021 Feb 26.

Liver Transplant Unit Queen Elizabeth University Hospital Birmingham Birmingham United Kingdom.

Frailty has emerged as a powerful predictor of clinical outcomes (e.g., decompensation, hospitalization, mortality) in patients with end-stage liver disease (ESLD). Read More

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Glucose Homeostasis, Hypoglycemia, and the Burnt-Out Diabetes Phenomenon in Kidney Disease.

Semin Nephrol 2021 Mar;41(2):96-103

Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, Orange, CA; Nephrology Section, Tibor Rubin Veterans Affairs Long Beach Healthcare System, Long Beach CA.

Chronic kidney disease (CKD) is among the most prevalent and dire complications of diabetes mellitus in adults across the world. Diabetes substantially contributes to the burden of kidney disease, such that one third to one half of CKD in the United States and many other countries is attributable to diabetic kidney disease (DKD). As DKD progresses to end-stage renal disease (ESRD), patients are at heightened risk for atypical glycemic complications, including the development of burnt-out diabetes, manifested by hypoglycemic bouts and poor outcomes. Read More

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The Role of Growth Hormone in Chronic Kidney Disease.

Semin Nephrol 2021 Mar;41(2):144-155

Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, La Jolla, CA. Electronic address:

Growth hormone (GH) has become a critical therapy for treating growth delay and failure in pediatric chronic kidney disease. Recombinant human GH treatment is safe and significantly improves height and height velocity in these growing patients and improved growth outcomes are associated with decreased morbidity and mortality as well as improved quality of life. However, the utility of recombinant human GH in adults with chronic kidney disease and end-stage renal disease for optimization of body habitus and reducing frailty remains uncertain. Read More

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Baseline Frailty as a Predictor of Survival after Critical Care: a Retrospective Cohort Study of Older Adults Receiving Home Care in Ontario, Canada.

Chest 2021 Jun 14. Epub 2021 Jun 14.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Background: The extent by which the degree of baseline frailty, as measured using standardized multidimensional health assessments before admission to hospital, predicts survival among older adults following admission to an intensive care unit (ICU) remains unclear.

Research Question: Is baseline frailty an independent predictor of survival among older adults receiving care in an ICU?

Study Design And Methods: Retrospective cohort study of community-dwelling older adults (age ≥65 years) receiving public home services that were admitted to any ICU in Ontario, Canada between April 1st, 2009 and March 31st, 2015. All individuals had an interRAI-Home Care (RAI-HC) assessment completed within 180 days of ICU admission; these assessments were linked to hospital discharge abstract records. Read More

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Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Type 1 Cardiorenal Syndrome.

J Cardiovasc Pharmacol Ther 2021 Jun 17:10742484211022625. Epub 2021 Jun 17.

Department of Pharmacy Services, 25213SSM Health Saint Louis University Hospital, St. Louis, MO, USA.

Introduction: Angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blocker (ARB) discontinuation during acute heart failure (AHF) is associated with increased mortality following hospitalization. Although the etiology of acute kidney injury (AKI) in type 1 cardiorenal syndrome (CRS) has been linked to renal venous congestion, ACE-I/ARB withdrawal (AW) theoretically promotes renal function recovery. ACE-I/ARBs are dose-reduced or withheld in approximately half of patients with CRS, but the subsequent impact on renal function remains largely uninvestigated. Read More

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Hepatorenal dysfunction predicts operative mortality after triple valve surgery: Utility of MELD-Na.

J Card Surg 2021 Jun 16. Epub 2021 Jun 16.

Division of Cardiothoracic Surgery, Prince of Wales Hospital, Hong Kong.

Background: Despite significant advancements in operative techniques and myocardial protection, triple valve surgery (TVS) remains a formidable operation with a relatively high in-hospital mortality. We evaluated the prognostic value of Model for End-stage Liver Disease score including sodium (MELD-Na) for mortality after TVS and its predictive value when incorporated in the EuroSCORE risk model.

Methods: We performed a retrospective cohort study of 61 consecutive patients who underwent TVS from November 2005 to June 2016. Read More

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Operationalizing Ethical Guidance for Ventilator Allocation in Minnesota: Saving the Most Lives or Exacerbating Health Disparities?

Crit Care Explor 2021 Jun 11;3(6):e0455. Epub 2021 Jun 11.

All authors: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, MN.

A statewide working group in Minnesota created a ventilator allocation scoring system in anticipation of functioning under a Crisis Standards of Care declaration. The scoring system was intended for patients with and without coronavirus disease 2019. There was disagreement about whether the scoring system might exacerbate health disparities and about whether the score should include age. Read More

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Coronary Artery Calcification as a Marker for Coronary Artery Stenosis: Comparing Kidney Failure to the General Population.

Kidney Med 2021 May-Jun;3(3):386-394.e1. Epub 2021 Apr 20.

Department of Nephrology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Amsterdam.

Rationale & Objective: The presence of calcified plaques in the coronary arteries is associated with cardiovascular mortality and is a hallmark of chronic kidney failure, but it is unclear whether this is associated with the same degree of coronary artery stenosis as in patients without kidney disease. We compared the relationship of coronary artery calcification (CAC) and stenosis between dialysis patients and patients without chronic kidney disease (CKD).

Study Design: Observational cohort study. Read More

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The Production, Efficacy, and Safety of Machine-Generated Bicarbonate Solution for Continuous Venovenous Hemodialysis (CVVHD): The Cleveland Clinic Method.

Kidney Med 2021 May-Jun;3(3):353-359.e1. Epub 2021 Mar 10.

Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH.

Rationale & Objective: Since 1994, the Nephrology and Hypertension Department at the Cleveland Clinic has prepared and used bicarbonate-based solution for continuous venovenous hemodialysis (CVVHD) using a standard volumetric hemodialysis machine rather than purchasing from a commercial vendor. This report describes the process of producing Cleveland Clinic UltraPure Solution (CCUPS), quality and safety monitoring, economic costs, and clinical outcomes.

Study Design: Retrospective study. Read More

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Circulating Osteoprotegerin in Chronic Kidney Disease and All-Cause Mortality.

Int J Gen Med 2021 9;14:2413-2420. Epub 2021 Jun 9.

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

Background: Chronic kidney disease (CKD) is associated with cardiovascular disease (CKD), mineral and bone disorder (CKD-MBD) and high mortality. Bone-related factors such as osteopontin (OPN), osteocalcin (OC), osteoprotegerin (OPG) and fibroblast growth factor 23 (FGF23) were linked to cardiovascular complications of CKD and are expected to have predictive value in CKD patients.

Purpose: The aim of this study was to assess the relationship of OPN, OC, OPG and FGF23 to clinical characteristics and to evaluate their ability to predict mortality in patients with different CKD stages. Read More

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Diminished Non-Classical Monocytes in the Blood Associate with Disease Severity in Alcoholic Hepatitis.

Clin Exp Gastroenterol 2021 9;14:259-267. Epub 2021 Jun 9.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Objective: Alcoholic hepatitis (AH) holds a high mortality, and vast macrophage infiltration of the liver is involved in the progressive liver injury. No efficient medical treatment exists, and macrophages may be a future treatment target. Here, we examine associations between non-classical monocyte subsets and cell surface markers of migration with disease activity in patients with severe AH. Read More

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Prognostic Factors Related to the Mortality Rate of Acute-on-Chronic Liver Failure Patients.

Diabetes Metab Syndr Obes 2021 9;14:2573-2580. Epub 2021 Jun 9.

Difficult & Complicated Liver diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Critical illness-related corticosteroid insufficiency (CIRCI) is known to be a common complication in patients with acute-on-chronic liver failure (ACLF). However, factors that predict the survival rate of ACLF patients remain unclear. The present study aims to determine the prognostic factors that impinge on the survival rate of ACLF patients. Read More

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Chronic anticoagulation is not associated with a reduced risk of acute kidney injury in hospitalised Covid-19 patients.

BMC Nephrol 2021 06 16;22(1):224. Epub 2021 Jun 16.

Manchester Institute of Nephrology and Transplantation, Manchester University NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK.

Background: Coronavirus-19 (COVID-19) has been declared a global pandemic by the World Health Organisation. Severe disease typically presents with respiratory failure but Acute Kidney Injury (AKI) and a hypercoagulable state can also occur. Early reports suggest that thrombosis may be linked with AKI. Read More

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Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis.

PLoS Negl Trop Dis 2021 Jun 15;15(6):e0009156. Epub 2021 Jun 15.

Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with different pre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was a lack of systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients with various RRT.

Methodology/principal Findings: We searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. Read More

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Impact of polypharmacy on all-cause mortality and hospitalization in incident hemodialysis patients: a cohort study.

Clin Exp Nephrol 2021 Jun 15. Epub 2021 Jun 15.

Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki city, Miyazaki, 889-1692, Japan.

Background: Polypharmacy (PP) is common in end-stage chronic renal disease patients largely due to the presence of multiple comorbid conditions. Although PP is potentially harmful, its relationship with mortality and morbidity in hemodialysis patients currently remains unclear.

Methods: Study design: cohort study. Read More

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Black Patients With Cirrhosis Have Higher Mortality and Lower Transplant Rates: Results From a Metropolitan Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Chicago, IL.

Background And Aims: Estimates of racial disparity in cirrhosis have been limited by lack of large-scale, longitudinal data, which track patients from diagnosis to death and/or transplant.

Approach And Results: We analyzed a large, metropolitan, population-based electronic health record data set from seven large health systems linked to the state death registry and the national transplant database. Multivariate competing risk analyses, adjusted for sex, age, insurance status, Elixhauser score, etiology of cirrhosis, HCC, portal hypertensive complication, and Model for End-Stage Liver Disease-Sodium (MELD-Na), examined the relationship between race, transplant, and cause of death as defined by blinded death certificate review. Read More

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Assessing predicted heart mass size matching in obese heart transplant recipients.

J Heart Lung Transplant 2021 May 12. Epub 2021 May 12.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Predicted heart mass (PHM) is currently the most reliable metric for donor-recipient size matching in heart transplantation. Undersizing PHM donor-recipient match more than 20% independently predicts reduced survival. However, it is unclear if this is the case in obese recipients, in whom size matching can be challenging. Read More

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Do we have to rely on metric-based quality improvement strategies for the management of ESKD?

Nephrol Dial Transplant 2021 Jun 14. Epub 2021 Jun 14.

Clinical Research Branch, Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Italy.

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