1,362,402 results match your criteria mortality]

Outcomes after Acute Peritoneal Dialysis for Critical Cardiorenal Syndrome Type 1.

Cardiorenal Med 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhonratchasima, Thailand.

Introduction: The aim of the study was to demonstrate the outcomes of peritoneal dialysis (PD) in critically ill cardiorenal syndrome type 1 (CRS1).

Methods: A cohort of 147 patients with CRS1 who received PD from 2011 to 2019 in a referral hospital in Thailand was analyzed. The primary outcome was 30-day in-hospital mortality. Read More

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The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran.

Kidney Blood Press Res 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Nephrology Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kidney involvement, ranging from mild hematuria and proteinuria to acute kidney injury (AKI) in patients with coronavirus disease-2019 (COVID-19), is a recent finding with various incidence rates reported among hospitalized patients with COVID-19. Given the various AKI rates and their associated risk factors, lack of AKI recovery in the majority of patients hospitalized with COVID-19, and limited data regarding AKI in patients with COVID-19 in Iran, we aim to investigate the potential risk factors for AKI development and its incidence in patients hospitalized with COVID-19.

Methods: In this retrospective cohort study, we enrolled adult patients referred to the Sina Hospital, Iran, from February 20 to May 14, 2020, with either a positive PCR test or a highly susceptible chest computed tomography features consistent with COVID-19 diagnosis. Read More

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Efficacy of Chininum Sulphuricum 30C against Malaria: An in vitro and in vivo Study.

Complement Med Res 2021 Jul 27:1-10. Epub 2021 Jul 27.

Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, India.

Background: New effective, economical and safe antimalarial drugs are urgently needed due to the development of multi-drug-resistant strains of the parasite. Homeopathy uses ultra-diluted doses of various substances to stimulate autoregulatory and self-healing processes to cure various ailments. The aim of the study was to evaluate the in vitro and in vivo antimalarial efficacy of a homeopathic drug, Chininum sulphuricum 30C. Read More

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Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis.

Gerontology 2021 Jul 27:1-16. Epub 2021 Jul 27.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Background: Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis.

Objective: This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. Read More

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Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury.

Kidney Blood Press Res 2021 Jul 27:1-10. Epub 2021 Jul 27.

Nephrology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Based on the pathophysiology of acute kidney injury (AKI), it is plausible that certain early interventions by the nephrologist could influence its trajectory. In this study, we investigated the impact of 5 early nephrology interventions on starting kidney replacement therapy (KRT), AKI progression, and death.

Methods: In a prospective cohort at the Hospital Civil of Guadalajara, we followed up for 10 days AKI patients in whom a nephrology consultation was requested. Read More

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Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study.

Gerontology 2021 Jul 27:1-8. Epub 2021 Jul 27.

Department of Anesthesia, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Perioperative neurocognitive disorders (PNDs) refer to cognitive decline identified in the preoperative or postoperative period. It has been reported that the incidence of postoperative neurocognitive impairment after noncardiac surgery in patients older than 65 at 1 week was 25.8∼41. Read More

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IgM-enriched immunoglobulin in COVID-19: Case series of 15 severely ill SARS-CoV-2-infected patients.

Int Immunopharmacol 2021 Jul 23;99:107998. Epub 2021 Jul 23.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

The healthcare system in Iran, like most around the world, is managing thousands of patients hospitalised with COVID-19. In Iran, in-hospital mortality is in the region of 25%, rising to 50-60% in patients admitted to intensive care. Hyperinflammation, characterised by cytokine storm, appears to be a hallmark of severe COVID-19 and to date only the anti-inflammatory drug dexamethasone has been shown to reduce mortality in those hospitalised with the disease. Read More

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Role of hematopoietic cells in Mycobacterium tuberculosis infection.

Tuberculosis (Edinb) 2021 Jul 21;130:102109. Epub 2021 Jul 21.

Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), Italy; Department of Biomedicine, Neurosciences and Advanced Diagnostic (Bi.N.D.); University of Palermo, Palermo 90127, Italy. Electronic address:

Tuberculosis remains one of the most significant causes of mortality worldwide and the current situation shows a re-emergence of TB due to the emergence of new antibiotic-resistant strains and the widespread of disease caused by immunodeficiencies. For these reasons, a big effort is made to improve the therapeutic strategies against Mycobacterium tuberculosis and to perform new therapeutic and diagnostic strategies. This review analyzes the various hematopoietic populations, their role and the different changes they undergo during Mycobacterium tuberculosis infection or disease. Read More

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INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression.

Adv Med Sci 2021 Jul 21;66(2):372-380. Epub 2021 Jul 21.

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia. Electronic address:

Objectives: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. Read More

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A disproportionate epidemic: COVID-19 cases and deaths among essential workers in Toronto, Canada.

Ann Epidemiol 2021 Jul 24. Epub 2021 Jul 24.

St. Michael's Hospital, University of Toronto, Toronto, Canada; Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Shelter-in-place mandates and closure of non-essential businesses have been central to COVID19 response strategies including in Toronto, Canada. Approximately half of the working population in Canada are employed in occupations that do not allow for remote work suggesting potentially limited impact of some of the strategies proposed to mitigate COVID-19 acquisition and onward transmission risks and associated morbidity and mortality. We compared per-capita rates of COVID-19 cases and deaths from January 23, 2020 to January 24, 2021, across neighborhoods in Toronto by proportion of the population working in essential services. Read More

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EVAR Conversion is an Increasingly Common Indication for Open AAA Repair.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville.

Objective: Although EVAR re-intervention is common, conversion to open repair(EVAR-c) occurs less frequently but can be associated with significant technical complexity and perioperative risk. There is a paucity of data highlighting the evolution of peri-procedural results surrounding EVAR-c and change in practice patterns, especially for referral centers that increasingly manage EVAR failures. The purpose of this analysis was to perform a temporal analysis of our EVAR-c experience and describe changes in patient selection, operative details and outcomes. Read More

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HCV Positive Allograft Use in Heart Transplant is Associated With Increased Access to Overdose Donors and Reduced Waitlist Mortality Without Compromising Outcomes.

J Card Fail 2021 Jul 24. Epub 2021 Jul 24.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address:

Background: Despite ongoing donor shortages in heart transplant, donor candidates arising from drug overdose (OD) are increasingly prevalent. These donors carry a high preponderance of now curable Hepatitis C virus (HCV). This study investigates temporal trends and regional variability in HCV+ allograft use in heart transplant, assessing the relation of HCV+ graft use on OD donor usage as well as waitlist and post-transplant outcomes. Read More

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Perioperative Outcomes and Survival after Preoperative Immunotherapy for Non-small-cell Lung Cancer.

Ann Thorac Surg 2021 Jul 24. Epub 2021 Jul 24.

Massachusetts General Hospital, Boston MA. Electronic address:

Background: Although preoperative immunotherapy (IT) is increasingly utilized for non-small-cell lung cancer (NSCLC), there remains a paucity of robust clinical data on its safety and long-term survival. Our objective was to evaluate the perioperative outcomes and survival associated with IT followed by surgery for patients with NSCLC.

Methods: Outcomes of patients with NSCLC who underwent lung resection after preoperative chemotherapy (PC)±radiation or IT (with or without chemotherapy or chemoradiation) in the National Cancer Data Base (2010-2017) were evaluated using Kaplan Meier analysis, multivariable logistic regression, multivariable Cox proportional hazards analysis, and propensity score-matched analysis. Read More

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Performance of Predictive Models for 30-day Hospitalization and Mortality after COVID-19 Infection.

Ann Am Thorac Soc 2021 Jul 27. Epub 2021 Jul 27.

Kaiser Permanente Northern California, 214681, Division of Research, Oakland, California, United States.

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Diagnostic accuracy of C-reactive protein, procalcitonin and neutrophils for the early detection of anastomotic leakage after colorectal resection. A multicentric, prospective study.

Colorectal Dis 2021 Jul 27. Epub 2021 Jul 27.

Hospital Universitario y Politecnico la Fe, Colorectal Surgery Unit, Valencia, Spain.

Aim: To determine the accuracy of C-reactive protein, procalcitonin and neutrophils in the early detection (fourth postoperative day) of anastomotic leak (AL) after colorectal surgery.

Methods: We conducted a multicentre, prospective study that included a consecutive series of patients who underwent colorectal resection with anastomosis without ostomy (September 2015 to December 2017). CRP, procalcitonin and neutrophils values on the fourth postoperative day after colorectal resection along with the postoperative outcome (60-day anastomotic leak, morbidity and mortality) were prospectively included in an online, anonymous database. Read More

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Global and Swedish review of rotavirus vaccines showed considerable reductions in morbidity and mortality.

Acta Paediatr 2021 Jul 27. Epub 2021 Jul 27.

¹Public Health Agency, Sweden.

Rotavirus infections cause severe gastroenteritis in small children, with both high morbidity and mortality. The rotavirus vaccine has been recommended by the World Health Organization since 2009 and was being used by 108 countries by 2019. It joined Sweden's national immunisation programme that year, after five years of selective regional use. Read More

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The Galleria mellonella-Enteropathogenic Escherichia coli Model System: Characterization of Pathogen Virulence and Insect Immune Responses.

J Insect Sci 2021 Jul;21(4)

Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.

The use of Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae), an economical insect model, for the study of enteropathogenic Escherichia coli (Migula) (EPEC), a diarrheagenic human pathogen, has been demonstrated previously but remains poorly understood. The present study characterizes the Galleria-EPEC system extensively for future studies using this system. We found that EPEC causes disease in G. Read More

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A co-designed integrated kidney and diabetes model of care improves mortality, glycaemic control and self-care.

Nephrol Dial Transplant 2021 Jul 26. Epub 2021 Jul 26.

School of Public Health and Preventive Medicine, Monash University, VIC, Australia.

Background: Current health-care models are ill-equipped for managing people with diabetes and chronic kidney disease (CKD). We evaluated the impact of a new diabetes and kidney disease service (DKS) on hospitalisation, mortality, clinical and patient relevant outcomes.

Methods: Longitudinal analyses of adult patients with diabetes and CKD (stages 3a to 5) were performed using outpatient and hospitalisation data from January 2015 to October 2018. Read More

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The role of interleukin-6 as a prognostic biomarker for predicting acute exacerbation in interstitial lung diseases.

PLoS One 2021 27;16(7):e0255365. Epub 2021 Jul 27.

Division of Pulmonology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Background: Interstitial lung diseases (ILDs) are chronic, parenchymal lung diseases with a variable clinical course and a poor prognosis. Within various clinical courses, acute exacerbation (AE) is a devastating condition with significant morbidity and high mortality. The aim of this study was to investigate the role of interleukin-6 (IL-6) to predict AE and prognosis in patients with ILD. Read More

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The Mean Unfulfilled Lifespan (MUL): A new indicator of the impact of mortality shocks on the individual lifespan, with application to mortality reversals induced by COVID-19.

PLoS One 2021 27;16(7):e0254925. Epub 2021 Jul 27.

California Center for Population Research (CCPR), University of California, Los Angeles (UCLA), Los Angeles, CA, United States of America.

Declines in period life expectancy at birth (PLEB) provide seemingly intuitive indicators of the impact of a cause of death on the individual lifespan. Derived under the assumption that future mortality conditions will remain indefinitely those observed during a reference period, however, their intuitive interpretation becomes problematic when period conditions reflect a temporary mortality "shock", resulting from a natural disaster or the diffusion of a new epidemic in the population for instance. Rather than to make assumptions about future mortality, I propose measuring the difference between a period average age at death and the average expected age at death of the same individuals (death cohort): the Mean Unfulfilled Lifespan (MUL). Read More

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COVID-19 severity and mortality in multiple sclerosis are not associated with immunotherapy: Insights from a nation-wide Austrian registry.

PLoS One 2021 27;16(7):e0255316. Epub 2021 Jul 27.

Department of Neurology, Medical University of Vienna, Vienna, Austria.

Background: The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by SARS-CoV-2 and in guiding disease-modifying treatment (DMT).

Objective: To characterize the prevalence and outcome of COVID-19 in pwMS specifically associated with different DMT in a nationwide population-based study.

Methods: We included patients aged ≥18 years with a confirmed diagnosis of MS and a diagnosis of COVID-19 established between January 1, 2020 and December 31, 2020. Read More

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The burden of scrub typhus in India: A systematic review.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009619. Epub 2021 Jul 27.

Department of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Scrub typhus, a vector-borne zoonotic infection caused by the bacteria Orientia tsutsugamushi, is one of the most common and clinically important rickettsial infections worldwide. An estimated one million cases occur annually with a high case fatality rate. Although scrub typhus is a major public health threat in India, the burden and distribution remains unclear. Read More

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Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009559. Epub 2021 Jul 27.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. Read More

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Clinical Presentations, Management and Outcomes of Rhino-Orbital-Cerebral Mucormycosis (ROCM) Following COVID-19: A Multi-Centric Study.

Ophthalmic Plast Reconstr Surg 2021 Jul 27. Epub 2021 Jul 27.

Ophthalmic Plastic Surgery Service, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad; Aditya Jyot Eye Hospital; Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai; Kempegowda Institute of Medical Sciences, Bangalore, India; Manipal Hospital, Bangalore; P D Hinduja National Hospital and Medical Research Centre, Sir H N Reliance Foundation Hospital, Mumbai; Eye Hub Vision Care, Faridabad; and I-Plast Eye and Plastic Surgery Centre, Amritsar, India.

Purpose: To report clinical presentations and factors affecting outcomes in rhino-orbital-cerebral mucormycosis following COVID-19.

Methods: Retrospective multi-centric interventional case series of 58 eyes with rhino-orbital-cerebral mucormycosis. Demography, clinical parameters and management outcomes were noted. Read More

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Efficacy and Safety of Thalidomide in Patients with Complicated Central Nervous System Tuberculosis: A Systematic Review and Meta-Analysis.

Am J Trop Med Hyg 2021 Jul 27. Epub 2021 Jul 27.

Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India.

Thalidomide, an anti-inflammatory and immunomodulatory agent, has a potential role in cases with central nervous system tuberculosis (CNS-TB) with paradoxical reactions. Although several articles have described the use of thalidomide in CNS-TB, no systematic review has been performed in this regard. Different electronic databases were searched for articles describing the use of thalidomide in patients with CNS-TB. Read More

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Efficacy of Etanercept in the Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Cutis 2021 Jun;107(6):E22-E28

Drs. Dreyer, Torres, and Leavitt are from the Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles. Dr. Stoddard is from the Department of Dermatology, University of Michigan, Ann Arbor. Dr. Sutton is from the Department of Dermatology, University of Nebraska, Lincoln. Dr. Aleshin is from the Department of Dermatology, Stanford University, California. Drs. Crew and Worswick are from the Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles.

It has been suggested that the use of etanercept for treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) might provide improved mortality benefit and decreased skin healing times. This retrospective study compared the use of single-dose subcutaneous etanercept to intravenous immunoglobulin (IVIG) and supportive care alone. Thirteen patients were treated with a single dose (50 mg) of subcutaneous etanercept. Read More

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Device Profile of the Zephyr Endobronchial Valve in Heterogenous Emphysema: Overview of its Safety and Efficacy.

Expert Rev Med Devices 2021 Jul 27. Epub 2021 Jul 27.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Introduction: Emphysema affects millions of people in the United States; the underlying pathophysiology is destruction of lung parenchyma resulting in hyperinflation. To date mainstay of treatment is medical care however currently there are 2 surgical treatment strategies approved by the FDA to reduce lung hyperinflation. First being lung volume reduction surgery (LVRS) which carries significant higher risk of mortality within 90 days of the procedure versus bronchoscopic lung volume reduction surgery (BLVR). Read More

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Thyroid hormone levels during hospital admission inform disease severity and mortality in COVID-19 patients.

Thyroid 2021 Jul 27. Epub 2021 Jul 27.

Federal University of Bahia, 28111, Department of Bioregulation, Health and Science Institute, Salvador, BA, Brazil.

Introduction: Illness severity in patients infected with COVID-19 is variable.

Methods: Here we conducted an observational, longitudinal, and prospective cohort study to investigate serum thyroid hormone levels (TH) in adult COVID-19 patients, admitted between June and August 2020, and to determine whether they reflect the severity or mortality associated with the disease.

Results: 245 patients [median age: 62 (49-75) years] were stratified in non-critical (181) and critically ill (64). Read More

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The Frequency of Atypical and Extreme Values for Pharyngeal Phase Swallowing Measures in Mild Parkinson Disease Compared to Healthy Aging.

J Speech Lang Hear Res 2021 Jul 27:1-19. Epub 2021 Jul 27.

Swallowing Rehabilitation Research Laboratory, KITE Research Institute - University Health Network, Toronto, Ontario, Canada.

Purpose Dysphagia is thought to be prevalent and a leading cause of morbidity and mortality in people with Parkinson disease (PwPD). The aim of this study was to compare the frequencies of atypical and extreme values for measures of swallowing physiology in PwPD and in an age- and sex-matched cohort of healthy adults. Atypical and extreme values were defined, respectively, as values falling in the 25% and 5% tails of the reference distribution for healthy adults under age 60 years. Read More

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