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Views about Primary Care health checks for autistic adults: UK survey findings.

BJGP Open 2022 May 26. Epub 2022 May 26.

Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Morpeth, UK.

Background: Compared to the general population, autistic adults experience higher rates of physical and mental health conditions, premature morbidity and mortality, and barriers to healthcare. A health check for autistic people may improve their health outcomes.

Aim: To establish the views of autistic people toward a primary care health check for autistic people. Read More

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Emerging Concepts in Managing Malignancy in Kidney Transplant Patients.

Semin Nephrol 2022 Jan;42(1):63-75

Transplant Research Center, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Cancer remains a significant cause of morbidity and mortality in kidney transplant recipients, due to long-term immunosuppression. Salient issues to consider in decreasing the burden of malignancy among kidney transplant recipients include pretransplant recipient evaluation, post-transplant screening and monitoring, and optimal treatment strategies for the kidney transplant recipients with cancer. In this review, we address cancer incidence and outcomes, approaches to cancer screening and monitoring pretransplant and post-transplant, as well as treatment strategies, immunosuppressive management, and multidisciplinary approaches in the kidney transplant recipients with cancer. Read More

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January 2022

Gender Differences in Takotsubo Syndrome.

J Am Coll Cardiol 2022 May;79(21):2085-2093

University of Foggia, Department of Medical and Surgical Sciences, Foggia, Italy.

Background: Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized.

Objectives: The aim of the present study is to describe TTS sex differences.

Methods: TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were analyzed. Read More

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Cardiovascular Outcomes in Aortopathy: GenTAC Registry of Genetically Triggered Aortic Aneurysms and Related Conditions.

J Am Coll Cardiol 2022 May;79(21):2069-2081

Division of Cardiology, Weill Cornell Medicine, New York, New York, USA.

Background: The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions) Registry enrolled patients with genetic aortopathies between 2007 and 2016.

Objectives: The purpose of this study was to compare age distribution and probability of elective surgery for proximal aortic aneurysm, any dissection surgery, and cardiovascular mortality among aortopathy etiologies.

Methods: The GenTAC study had a retrospective/prospective design. Read More

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The unintended consequences of COVID-19 vaccine policy: why mandates, passports and restrictions may cause more harm than good.

BMJ Glob Health 2022 May;7(5)

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Vaccination policies have shifted dramatically during COVID-19 with the rapid emergence of population-wide vaccine mandates, domestic vaccine passports and differential restrictions based on vaccination status. While these policies have prompted ethical, scientific, practical, legal and political debate, there has been limited evaluation of their potential unintended consequences. Here, we outline a comprehensive set of hypotheses for why these policies may ultimately be counterproductive and harmful. Read More

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PREVALENCE AND IMPACT OF COMORBIDITIES IN INDIVIDUALS WITH COPD: A SYSTEMATIC REVIEW.

Tuberc Respir Dis (Seoul) 2022 May 27. Epub 2022 May 27.

State University of Bahia (UNEB), Brazil.

Objectives: To describe the frequency of comorbidities associated with COPD and their relation with relevant outcomes.

Methods: A systematic review based on the PRISMA methodology was performed. The systematic search was carried until July 2021, using the MEDLINE, Lilacs and Scielo databases to identify studies related to COPD and its comorbidities. Read More

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Vorinostat combined with Busulfan, Fludarabine, and Clofarabine Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Leukemia: Long-term Study Outcomes.

Transplant Cell Ther 2022 May 23. Epub 2022 May 23.

Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Conditioning regimens play a major role in determining disease outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The use of intravenous (IV) busulfan (Bu) as part of the conditioning chemotherapy has been shown to be effective in controlling disease relapse. However, disease relapse remains a major cause of death following allo-HSCT. Read More

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Effects of the Clostridium butyricum on growth performance, antioxidant capacity, immunity and disease resistance of Litopenaeus Vannamei fed with cottonseed protein concentrate (CPC) replacement of fishmeal in diet.

Fish Shellfish Immunol 2022 May 23. Epub 2022 May 23.

Guangdong Evergreen Feed Industry Co.Ltd, Zhanjiang, 524088, PR China.

Clostridium butyricum (CB) is a gram-positive bacterium that secretes short-chain fatty acids such as butyric acid and so on. An 8-week feeding trial was conducted to investigate the effects of CB on the growth performance, antioxidant capacity, immunity and resistance to Vibrio parahaemolyticus in Litopenaeus Vannamei fed with cottonseed protein concentrate (CPC) replacement of fishmeal. Six iso-nitrogenous (40%) and iso-lipidic (6%) diets were formulated including a positive control group (PC, 25% fishmeal), a negative control group (NC, CPC replaced 30% of fishmeal protein), and 0. Read More

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Helicobacter pylori acquisition rates and the associated risk factors amongst newlywed couples; a prospective cohort study in Tehran, Iran.

Microbes Infect 2022 May 23:104974. Epub 2022 May 23.

Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran; Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The rates and routes of Helicobacter pylori transmission, in a high prevalent country like Iran, with gastric cancer as the leading cause of male cancer mortality is of essence. Here, we have studied the H. pylori-associated risk factors and the likelihood of interspousal transmission. Read More

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Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci.

J Infect 2022 May 23. Epub 2022 May 23.

Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. Electronic address:

Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis.

Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n=8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. Read More

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Exposure to greenspace and cancer incidence, prevalence, and mortality: A systematic review and meta-analyses.

Sci Total Environ 2022 May 23:156180. Epub 2022 May 23.

Univ Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

We conducted a systematic review and meta-analysis of the available literature on the association between greenspace exposure and all-sites and site-specific cancer incidence, prevalence, and mortality in adults. We searched PubMed, Scopus, and Web of Science for original articles published, without language restriction until September 2021. We assessed the risk of bias in each study and the overall quality of evidence for exposure-outcome pairs that were reported in two or more studies. Read More

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Deep sternal wound infection and mortality in cardiac surgery: A meta-analysis.

Ann Thorac Surg 2022 May 23. Epub 2022 May 23.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, NY, USA.

Background: Deep sternal wound infection (DSWI) is a rare but severe complication after cardiac surgery and has been associated with increased early morbidity and mortality. Studies reporting long-term outcomes in patients with DSWI have shown contradictory results. We performed a study-level meta-analysis evaluating the impact of DSWI on short- and long-term clinical outcomes. Read More

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Re-Sternotomy Coronary Artery Bypass 1999-2018: Insights from the STS Adult Cardiac Surgery Database.

Ann Thorac Surg 2022 May 23. Epub 2022 May 23.

Dept. of Cardiothoracic Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Background: We sought to quantify the risk trend of re-sternotomy coronary artery bypass grafting (CABG)over the past two decades.

Methods: We compared the outcomes of 194,804 consecutive re-sternotomy CABG cases and 1,445,894 randomly-selected first-time CABG cases (50% of total) reported to the STS Adult Cardiac Surgery Database between 1999-2018. Primary outcomes were in-hospital mortality and overall morbidity. Read More

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Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments.

Biochem Pharmacol 2022 May 23:115104. Epub 2022 May 23.

Department of Biological Sciences, Al al-bayt University, Al-Mafraq, Jordan.

Cardiac diseases are the leading cause of mortality and morbidity worldwide. Mounting evidence suggests that transglutaminases (TGs), tissue TG (TG2) in particular, are involved in numerous molecular responses underlying the pathogenesis of cardiac diseases. The TG family has several intra- and extracellular functions in the human body, including collagen cross-linking, angiogenesis, cell growth, differentiation, migration, adhesion as well as survival. Read More

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Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid.

Lancet Glob Health 2022 May 23. Epub 2022 May 23.

Department of Epidemiology, Center for Spina Bifida Prevention, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

July 20, 2021 marked the 30th anniversary of the publication of the landmark trial by the British Medical Research Council showing unequivocally that maternal intake of folic acid (vitamin B) starting before pregnancy prevents most cases of infant spina bifida and anencephaly-two major neural tube defects that are severe, disabling, and often fatal. Mandatory food fortification with folic acid is a safe, cost-effective, and sustainable intervention to prevent spina bifida and anencephaly. Yet few countries implement fortification with folic acid; only a quarter of all preventable spina bifida and anencephaly cases worldwide are currently avoided by food fortification. Read More

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Predicting major adverse cardiovascular events in acute coronary syndrome: A scoping review of machine learning approaches.

Appl Clin Inform 2022 May 26. Epub 2022 May 26.

School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of).

Background: Acute coronary syndrome is the topmost cause of death worldwide; therefore, it is necessary to predict major adverse cardiovascular events and cardiovascular deaths in patients with acute coronary syndrome to make correct and timely clinical decisions.

Objective: The current review aimed to highlight algorithms and important predictor variables through examining those studies which used machine learning algorithms for predicting major adverse cardiovascular events in patients with acute coronary syndrome.

Methods: In order to predict major adverse cardiovascular events in patients with acute coronary syndrome, the preferred reporting items for scoping reviews guidelines were used. Read More

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A drug-responsive multicellular human spheroid model to recapitulate drug-induced pulmonary fibrosis.

Biomed Mater 2022 May 26. Epub 2022 May 26.

Department of Bioengineering / EgeSAM-Ege University Translational Pulmonary Research Center, Ege University, Bornova, Izmir, 35040, TURKEY.

Associated with a high mortality rate, pulmonary fibrosis (PF) is the end stage of several interstitial lung diseases. Although many factors are linked to PF progression, initiation of the fibrotic process remains to be studied. Current research focused on generating new strategies to gain a better understanding of the underlying disease mechanism as the animal models remain insufficient to reflect human physiology. Read More

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Melatonin enhances the antioxidant capacity to rescue the honey bee Apis mellifera from the ecotoxicological effects caused by environmental imidacloprid.

Ecotoxicol Environ Saf 2022 May 23;239:113622. Epub 2022 May 23.

College of Life Sciences, Chongqing Normal University, Chongqing, China; Chongqing Key Laboratory of Microsporidia Infection and Control, China; The State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.

Imidacloprid severely poisons the nontarget insect honey bee Apis mellifera. Few treatments are available to mitigate the adverse effects of imidacloprid. The primary concern is that the molecular understanding of imidacloprid toxicity is not comprehensive enough. Read More

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Characteristics and outcomes of sepsis patients with and without COVID-19.

J Infect Public Health 2022 May 16;15(6):670-676. Epub 2022 May 16.

Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany. Electronic address:

Background: The aim of this study was to describe and compare clinical characteristics and outcomes in critically ill septic patients with and without COVID-19.

Methods: From February 2020 to March 2021, patients from surgical and medical ICUs at the University Hospital Dresden were screened for sepsis. Patient characteristics and outcomes were assessed descriptively. Read More

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Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis.

J Infect Public Health 2022 May 16;15(6):654-661. Epub 2022 May 16.

ICAP at Columbia University, Harare, Zimbabwe.

Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality.

Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. Read More

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Adequacy of physician clinical rounds and nursing care elements for non-COVID-19 infected patients admitted during the COVID-19 pandemic.

J Infect Public Health 2022 Apr 28;15(6):648-653. Epub 2022 Apr 28.

Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address:

Background: The COVID-19 pandemic created many challenges for healthcare systems. Frontline workers and especially healthcare professionals were the most severely affected through increased working hours, burnout and major psychological distress.

Objectives: To evaluate the changes in standard care elements which occurred during the COVID-19 pandemic, specifically the physician clinical rounds and nursing care provided to non-COVID-19 infected patients. Read More

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The impact of childhood epilepsy on academic performance: A population-based matched cohort study.

Seizure 2022 May 18;99:91-98. Epub 2022 May 18.

Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.

Objectives: To compare academic performance and high school completion of young people admitted to hospital with epilepsy and matched peers from the general population not admitted to hospital with epilepsy during the study period.

Methods: A population-based matched case-comparison cohort study of young people aged ≤18 years hospitalised with epilepsy during 2005-2018 in New South Wales, Australia, using linked birth, health, education, and mortality records. The comparison cohort was matched on age, sex, and residential postcode. Read More

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A magnetoimpedance biosensor microfluidic platform for detection of glial fibrillary acidic protein in blood for acute stroke classification.

Biosens Bioelectron 2022 May 20;211:114410. Epub 2022 May 20.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia; Department of Medicine, The University of Melbourne, The Royal Melbourne Hospital, Melbourne, VIC, 3050, Australia; Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, VIC, 3010, Australia; Department of Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, VIC, 3010, Australia. Electronic address:

Acute stroke is the third leading cause of mortality and disability worldwide. Administration of appropriate therapy for acute stroke is critically dependent on timely classification into either ischemic or hemorrhagic subtypes, which have divergent treatment pathways. The current classification method is based on neuroimaging, which generally requires the transport of the patient to a hospital-based facility unless a mobile stroke unit is available. Read More

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Increased risk of death immediately after discharge from compulsory care for substance abuse.

Drug Alcohol Depend 2022 May 10;236:109492. Epub 2022 May 10.

Department of Public Health Sciences, Stockholm University, SE-106 91 Stockholm, Sweden.

Background: In Sweden, approximately 1000 persons per year are committed to compulsory care for substance abuse for a maximum duration of six months. People admitted to compulsory care are known to suffer high mortality risks, but whether the risk of dying is further heightened immediately after discharge is not known.

Methods: Individual data from Swedish national registers were used to follow all persons discharged from a six months compulsory care episode in the period 2000-2017 (N = 7, 929). Read More

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Association between cognitive social capital and all-cause mortality in Great East Japan Earthquake survivors: a prospective cohort study.

Public Health 2022 May 23;207:108-112. Epub 2022 May 23.

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.

Objectives: Cognitive social capital (SC), such as attitude, trust, or norms, may help improve resilience among survivors, thus improving their health. However, the association between cognitive SC and the risk of all-cause mortality among survivors after the natural disaster has never been investigated. The purpose of the present study is to investigate the association between cognitive SC and the risk of all-cause mortality among survivors of the Great East Japan Earthquake (GEJE). Read More

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Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes.

J Trace Elem Med Biol 2022 May 20;73:127004. Epub 2022 May 20.

Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address:

Background: Silver nanoparticles (AgNP) are one of the most commercialized types of nanomaterials, with a wide range of applications owing to their antimicrobial activity. They are particularly important in hospitals and other healthcare settings, where they are used to maintain sterility of surfaces, textiles, catheters, medical implants, and more. However, AgNP can not only harm bacteria, but also damage mammalian cells and tissue. Read More

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Impact of moderate-to-severe obstructive sleep apnea on aggressive clinicopathological features of papillary thyroid carcinoma.

Sleep Med 2022 May 5;96:99-104. Epub 2022 May 5.

Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address:

Objective: Obstructive sleep apnea (OSA) may to be strongly associated with cancer mortality. The risk hazards of OSA regarding aggressive features of papillary thyroid carcinoma (PTC) remain unclear. The main objective of this study was to explore the relationship between OSA and aggressive features of PTC. Read More

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Hand-Assisted Laparoscopic Splenectomy with Temporary Splenic Artery Occlusion in Pediatric Patients: The Experience in a Chinese Tertiary Children's Hospital.

J Laparoendosc Adv Surg Tech A 2022 May 26. Epub 2022 May 26.

Department of Pediatric General Surgery, Children's Hospital, Chongqing Medical University, Chongqing, P.R. China.

The hand-assisted laparoscopic splenectomy (HALS) approach overcomes the difficulties experienced with conventional laparoscopic splenectomy (LS) with added advantages. In this study, we compared the HALS technique with standard LS based on the feasibility and intermediate postoperative outcomes in pediatric patients. We retrospectively investigated pediatric patients who underwent HALS or LS from October 2013 to May 2021 at the Children's Hospital, Chongqing Medical University. Read More

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Lessons Learned in Implementing a Chronic Opioid Therapy Management System.

J Patient Saf 2022 May 25. Epub 2022 May 25.

Healthcare Systems Engineering Institute, Northeastern University, Boston, Massachusetts.

Objectives: Opioid misuse has resulted in significant morbidity and mortality in the United States, and safer opioid use represents an important challenge in the primary care setting. This article describes a research collaborative of health service researchers, systems engineers, and clinicians seeking to improve processes for safer chronic opioid therapy management in an academic primary care center. We present implementation results and lessons learned along with an intervention toolkit that others may consider using within their organization. Read More

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