Gastroenterology 2021 Apr 2. Epub 2021 Apr 2.
Intestinal Stem Cell Biology Lab, Wellcome Centre Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK. Electronic address:
Background And Aims: In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimental pathway inactivation. Intestinal regeneration is underpinned by dedifferentiation and cell plasticity, but the signalling pathways that regulate this adaptive reprogramming are not well understood. Read More