248,090 results match your criteria morbidity mortality

Breast cancer patients treated with intrathecal therapy for leptomeningeal metastases in a large real-life database.

ESMO Open 2021 May 10;6(3):100150. Epub 2021 May 10.

Department of Medical Oncology, Institut Curie, Saint-Cloud and Paris, France. Electronic address:

Background: Leptomeningeal metastasis (LM) is a rare complication of metastatic breast cancer (MBC), with high morbidity/mortality rates. Our study aimed to describe the largest-to-date real-life population of MBC patients treated with intrathecal (IT) therapy and to evaluate prognostic models.

Methods: The Epidemiological Strategy and Medical Economics (ESME) MBC database (NCT03275311) includes all consecutive patients who have initiated treatment for MBC since 2008. Read More

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Osteoporosis medication is associated with mortality risk reduction among adults with epilepsy: An observational study.

Daniel G Whitney

Bone 2021 May 10:116003. Epub 2021 May 10.

Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background: Adults with epilepsy have an increased risk of fragility fractures, which contributes to an accelerated rate of premature morbidity and mortality. In the general population, osteoporosis treatment has shown improvements in health and survival, possibly through improving skeletal robustness; however, the effect of osteoporosis medication on survival among adults with epilepsy has not been investigated. The purpose of this propensity score-matched, observational cohort study was to determine if osteoporosis medication was associated with mortality risk among adults with epilepsy. Read More

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Long-term survival following transvenous lead extraction. Importance of indication and comorbidities.

Heart Rhythm 2021 May 10. Epub 2021 May 10.

Cardiology Department, Guy's and St Thomas' NHS Foundation Trust, London, UK; School of Biomedical Engineering and Imaging Sciences, King's College London, UK.

Background: Long-term outcomes are poorly understood, and data is lacking in patients undergoing transvenous lead extraction (TLE).

Objective: The purpose of this study was to evaluate factors influencing survival in patients undergoing TLE depending on extraction indication.

Methods: Clinical data from consecutive patients undergoing TLE in the reference centre between 2000 and 2019 were prospectively collected. Read More

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Leveraging Artificial Intelligence in Ischemic Stroke Imaging.

J Neuroradiol 2021 May 10. Epub 2021 May 10.

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Artificial intelligence (AI) is having a disruptive and transformative effect on clinical medicine. Prompt clinical diagnosis and imaging are critical for minimizing the morbidity and mortality associated with ischemic strokes. Clinicians must understand the current strengths and limitations of AI to provide optimal patient care. Read More

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Beclin-1, an autophagy-related protein, is associated with the disease severity of COVID-19.

Life Sci 2021 May 10:119596. Epub 2021 May 10.

Hatay Mustafa Kemal University, Faculty of Medicine, Department of Infection Disease and Clinical Microbiology, Hatay, Turkey.

Aims: Coronavirus disease 2019 (COVID-19), which is a highly contagious disease, is an ongoing outbreak worldwide with high morbidity and mortality. The approaches targeting the autophagy processes might have promising diagnostic and therapeutic values against Coronavirus infection. Here, we aimed to investigate the relationship of Beclin-1 (BECN1), an autophagy-related protein, with blood parameters and the clinical severity in patients with COVID-19. Read More

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Days Alive Out of Hospital in Heart Failure: Insights from the PARADIGM-HF and CHARM Trials.

Am Heart J 2021 May 10. Epub 2021 May 10.

Director, Division of Cardiology and Nephrology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration.

Background: An endpoint that has received some attention in recent cardiovascular trials is 'days alive and out of hospital' (DAOH). Percent DAOH is a natural extension of DAOH that adjusts for differences in length of follow-up. This endpoint measure incorporates mortality and morbidity together in a way that has the potential to give more insight regarding treatment effects compared to conventional time-to-event endpoints. Read More

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An investment case for the prevention and management of rheumatic heart disease in the African Union 2021-30: a modelling study.

Lancet Glob Health 2021 May 10. Epub 2021 May 10.

Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA; Program in Global Noncommunicable Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Partners In Health, Boston, MA, USA. Electronic address:

Background: Despite declines in deaths from rheumatic heart disease (RHD) in Africa over the past 30 years, it remains a major cause of cardiovascular morbidity and mortality on the continent. We present an investment case for interventions to prevent and manage RHD in the African Union (AU).

Methods: We created a cohort state-transition model to estimate key outcomes in the disease process, including cases of pharyngitis from group A streptococcus, episodes of acute rheumatic fever (ARF), cases of RHD, heart failure, and deaths. Read More

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Prevalence of Mycoplasma spp. in the Respiratory Tract of Healthy North American Bison (Bison bison) and Comparison with Serum Antibody Status.

J Wildl Dis 2021 May 13. Epub 2021 May 13.

Wildlife Livestock Disease Investigations Team, USDA:APHIS:Veterinary Services, 4101 LaPorte Ave., Fort Collins, Colorado 80521, USA.

Mycoplasma bovis is a primary cause of respiratory and reproductive diseases in North American bison (Bison bison), with significant morbidity and mortality. The epidemiology of M. bovis in bison is poorly understood, hindering efforts to develop effective control measures. Read More

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A Novel Report on the Compassionate Use of Baricitinib in Treating a Pediatric Patient With Severe Symptoms of COVID-19 Infection.

J Med Cases 2021 Mar 19;12(3):94-98. Epub 2021 Jan 19.

Richmond University Medical Center, Staten Island, NY, USA.

Since the outbreak of the pandemic coronavirus disease 2019 (COVID-19), there has been an increasing need for treatment to decrease morbidity and mortality of patients presenting with severe disease symptoms. There has been increasing evidence to suggest that the pathophysiological basis is a severe inflammatory response that resembles the cytokine release syndrome. Current strategies to counteract this involve modifiers of the immune response such as interleukin (IL)-6 receptor blockers and Janus kinase (JAK) inhibitors. Read More

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Teenage pregnancy as a risk factor for placental abruption: Findings from the prospective Japan environment and children's study.

PLoS One 2021 13;16(5):e0251428. Epub 2021 May 13.

Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.

Objective: Placental abruption is a significant obstetric complication that affects both maternal and neonatal mortality and morbidity. The present study examined the effect of maternal age on the incidence of placental abruption.

Methods: We used data of singleton pregnancies from the Japan Environment and Children's Study, which was a prospective birth cohort study conducted between January 2011 and March 2014 across 15 regional centers in Japan. Read More

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Modeling non-Gaussian data analysis on determinants of underweight among under five children in rural Ethiopia: Ethiopian demographic and health survey 2016 evidences.

PLoS One 2021 13;16(5):e0251239. Epub 2021 May 13.

Statistics Department, Under Natural and Computational Science College, University of Gondar, Gondar, Ethiopia.

Background: Childhood under-nutrition is a major global health problem. Although the rate of under-nutrition in Ethiopia has declined in the last decade, but it still remains being the major causes of morbidity and mortality of children under-five years. The problem is even worse in rural areas. Read More

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Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis.

PLoS One 2021 13;16(5):e0246600. Epub 2021 May 13.

Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America.

Atherosclerotic vascular disease resulting from unstable plaques is the leading cause of morbidity and mortality in subjects with type 2 diabetes (T2D), and thus a major therapeutic goal is to discover T2D drugs that can also promote atherosclerotic plaque stability. Genetic or pharmacologic inhibition of mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2 or MK2) in obese mice improves glucose homeostasis and enhances insulin sensitivity. We developed two novel orally active small-molecule inhibitors of MK2, TBX-1 and TBX-2, and tested their effects on metabolism and atherosclerosis in high-fat Western diet (WD)-fed Ldlr-/- mice. Read More

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Rickettsial infections: A blind spot in our view of neglected tropical diseases.

PLoS Negl Trop Dis 2021 May 13;15(5):e0009353. Epub 2021 May 13.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Rickettsial diseases are a group of vector-borne bacterial infections that cause acute febrile illness with potentially severe or fatal complications. These vector-borne diseases are prevalent in tropical and subtropical regions worldwide and disproportionately affect poorer communities but are scientifically underrecognized. Despite this, they are not included in the World Health Organization's list of neglected tropical diseases nor were they mentioned in Peter Hotez's recent reflections on "What constitutes a neglected tropical disease?" in PLOS Neglected Tropical Diseases [1]. Read More

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Demographic and Social Factors Associated with COVID-19 Vaccination Initiation Among Adults Aged ≥65 Years - United States, December 14, 2020-April 10, 2021.

MMWR Morb Mortal Wkly Rep 2021 May 14;70(19):725-730. Epub 2021 May 14.

Compared with other age groups, older adults (defined here as persons aged ≥65 years) are at higher risk for COVID-19-associated morbidity and mortality and have therefore been prioritized for COVID-19 vaccination (1,2). Ensuring access to vaccines for older adults has been a focus of federal, state, and local response efforts, and CDC has been monitoring vaccination coverage to identify and address disparities among subpopulations of older adults (2). Vaccine administration data submitted to CDC were analyzed to determine the prevalence of COVID-19 vaccination initiation among adults aged ≥65 years by demographic characteristics and overall. Read More

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Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.

Circ Res 2021 May 13;128(10):1468-1486. Epub 2021 May 13.

Division of Cardiology, School of Medicine, University of California San Francisco (J.N.N., J.R.T.), San Francisco, CA.

Acute decompensated heart failure (ADHF) is one of the leading admission diagnoses worldwide, yet it is an entity with incompletely understood pathophysiology and limited therapeutic options. Patients admitted for ADHF have high in-hospital morbidity and mortality, as well as frequent rehospitalizations and subsequent cardiovascular death. This devastating clinical course is partly due to suboptimal medical management of ADHF with persistent congestion upon hospital discharge and inadequate predischarge initiation of life-saving guideline-directed therapies. Read More

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Delirium in adult patients in intensive care: nursing interventions.

Br J Nurs 2021 May;30(9):534-538

Assistent Professor, Universidade Católica Portuguesa, Lisbon, Portugal.

Background: Delirium is a neuropsychiatric syndrome of high incidence in the critically ill patient. It is characterised by changes in acute attention and cognition, has a multifactorial aetiology and has a negative impact on the patient's clinical situation and future quality of life. Prevention of delirium and early identification can reduce associated morbidity and mortality. Read More

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Echocardiographic parameters associated with in-hospital adverse outcomes in patients with Takotsubo syndrome.

Echocardiography 2021 May 13. Epub 2021 May 13.

Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Introduction: Takotsubo syndrome (TTS) is an acute heart failure syndrome that leads to significant morbidity and mortality. We sought to evaluate the association of cardiac mechanics on presentation with in-hospital adverse outcomes in patients with apical TTS.

Methods: We retrospectively identified 468 patients with TTS based on ICD-9/10 codes between 2006 and 2017. Read More

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Safety and Efficacy of Neoadjuvant Immune Checkpoint Inhibitor Therapy in Patients with Resectable Non-small-Cell Lung Cancer: A Systematic Review.

Target Oncol 2021 May 13. Epub 2021 May 13.

Thoracic Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan Nanli No 17, Beijing, 100021, People's Republic of China.

Background: Non-small-cell lung cancer (NSCLC) accounts for most new diagnoses of lung cancer, with high morbidity and mortality worldwide. Immune checkpoint inhibitor (ICI) therapy has transformed the treatment of metastatic and advanced NSCLC. For resectable NSCLC, while surgery is the cornerstone of standard treatment, a number of clinical trials of neoadjuvant immunotherapy have been conducted. Read More

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COVID and Cardiovascular Disease: What We Know in 2021.

Curr Atheroscler Rep 2021 May 13;23(7):37. Epub 2021 May 13.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose Of Review: Coronavirus disease 2019 (COVID-19) has been the cause of significant global morbidity and mortality. Here, we review the literature to date of the short-term and long-term consequences of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the heart.

Recent Findings: Early case reports described a spectrum of cardiovascular manifestations of COVID-19, including myocarditis, stress cardiomyopathy, myocardial infarction, and arrhythmia. Read More

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Progress in the Management of Smoldering Multiple Myeloma.

Curr Hematol Malig Rep 2021 May 13. Epub 2021 May 13.

University of Wisconsin Carbone Cancer Center, 600 Highland Ave, Madison, WI, 3792, USA.

Purpose Of Review: Smoldering multiple myeloma (SMM) is defined as an asymptomatic clonal proliferation of pre-malignant plasma cells and an increased risk of progression to multiple myeloma (MM) relative to monoclonal gammopathy of undetermined significance. Whether patients with SMM should be treated prior to development of symptomatic disease is fiercely debated and is a highly active area of research.

Recent Findings: The ECOG E3A06 study demonstrated that early treatment with lenalidomide significantly reduced the risk of progression to MM compared to observation in patients with high risk SMM. Read More

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Minimally invasive surgery rib fracture fixation based on location and anatomical landmarks.

Eur J Trauma Emerg Surg 2021 May 13. Epub 2021 May 13.

Department of Cardiothoracic Surgery, Shijiazhuang Third Hospital, No. 15 Tiyu South Street, Shijiazhuang, 050011, Hebei, China.

Background: Rib fracture is closely related to thoracic injury with high morbidity and mortality. This study aimed to investigate the clinical effect of Zhang ZhiFei (ZZF) zoning method on the selection of incision and approach in minimally invasive surgery for rib fracture.

Methods: A total of 110 patients with rib fractures from July 2017 to July 2019 were enrolled in the study. Read More

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Right-side colectomy with complete mesocolic excision vs conventional right-side colectomy in the treatment of colon cancer: a systematic review and meta-analysis.

Int J Colorectal Dis 2021 May 13. Epub 2021 May 13.

Division of General Surgery, Sanchinarro Hospital, San Pablo University, Calle Oña 10, 28050, Madrid, Spain.

Background: This meta-analysis aims to investigate the role of complete mesocolic excision (CME) in the treatment of right-side colon cancer when compared with standard right-side hemicolectomy, focusing on oncological outcomes, mortality and morbidity rates.

Materials And Methods: A systematic literature search was performed on MEDLINE and EMBASE archives, including studies on CME in right-side colon cancer. Primary outcomes were five-year disease-free survival and five-year overall survival. Read More

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Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women.

JAMA 2021 May 13. Epub 2021 May 13.

Harvard Medical School, Boston, Massachusetts.

Importance: Pregnant women are at increased risk of morbidity and mortality from COVID-19 but have been excluded from the phase 3 COVID-19 vaccine trials. Data on vaccine safety and immunogenicity in these populations are therefore limited.

Objective: To evaluate the immunogenicity of COVID-19 messenger RNA (mRNA) vaccines in pregnant and lactating women, including against emerging SARS-CoV-2 variants of concern. Read More

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The impact of exogenous nitric oxide during cardiopulmonary bypass for cardiac surgery.

Perfusion 2021 May 13:2676591211014821. Epub 2021 May 13.

Department of Cardiothoracic Surgery, Cork University Hospital, Cork, Ireland.

Objectives: Cardiac surgery using cardiopulmonary bypass frequently provokes a systemic inflammatory response syndrome. This can lead to the development of low cardiac output syndrome (LCOS). Both of these can affect morbidity and mortality. Read More

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Encephalitis as Neurological Complication of COVID-19: A Systematic Review and Meta Analysis of Incidence, Outcomes and Predictors.

Eur J Neurol 2021 May 13. Epub 2021 May 13.

Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

Introduction: Although COVID-19 predominantly affects the respiratory system, recent studies have reported the occurrence of neurological disorders such as stroke, in relation to COVID-19 infection. Encephalitis is an inflammatory condition of the brain that has been described as a severe neurological complication of COVID-19. Despite a growing number of reported cases, encephalitis related to COVID-19 infection has not been adequately characterized. Read More

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Long non‑coding RNA‑DUXAP8 regulates TOP2A in the growth and metastasis of osteosarcoma via microRNA‑635.

Mol Med Rep 2021 Jul 13;24(1). Epub 2021 May 13.

The Second Department of Orthopedics, The Affiliated Hospital of Beihua University, Jilin, Jilin 132011, P.R. China.

Osteosarcoma (OS) is a malignant disease with high morbidity and mortality rates in children and adolescents. Evidence has indicated that long non‑coding RNAs (lncRNAs) may serve important roles in human cancer progression, including OS. In the present study, the role of lnc‑double homeobox A pseudogene 8 (DUXAP8) in the development of OS was identified. Read More

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Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways.

Aging (Albany NY) 2021 May 12;13. Epub 2021 May 12.

Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.

Aging is a universal biological process characterized by a progressive deterioration in functional capacity and an increased risk of morbidity and mortality over time. In the lungs, there are considerable changes in lung structure and function with advancing age; however, research on the transcriptomic profile implicated in this process is scanty. In this study, we addressed the lung transcriptome changes during aging, through a global gene expression analysis of normal lungs of mice aged 4- and 18-months old. Read More

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The anti-osteoporosis effects of Vitamin K in postmenopausal women.

Curr Stem Cell Res Ther 2021 May 11. Epub 2021 May 11.

Honghui Hospital Affiliated to Xi Spine surgery, China.

As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Read More

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Type A aortic syndromes in COVID-19 positive patients: Case series from a UK multicentre study.

J Card Surg 2021 May 12. Epub 2021 May 12.

Departments of Cardiothoracic Surgery, University Hospital Southampton, Southampton, UK.

Objective: The coronavirus disease (COVID-19) increases the respiratory complications and carries a higher mortality in the immediate postoperative period. The aim of this study was to analyze the outcomes of patients with type A acute aortic syndromes (AAS) diagnosed with COVID-19 in the perioperative period.

Methods: Retrospective analysis of prospectively collected data between March and August 2020 from 20 participating cardiac surgery centers in the United Kingdom. Read More

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The role of imaging in acute pancreatitis.

Radiol Med 2021 May 12. Epub 2021 May 12.

Dipartimento di diagnostica per immagini, Radioterapia, Oncologia ed Ematologia, Fondazione Universitaria "A. Gemelli", IRCCS - Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy.

Acute pancreatitis is one of the most commonly encountered etiologies in the emergency setting, with a broad spectrum of findings that varies in severity from mild interstitial pancreas to severe forms with significant local and systemic complications that are associated with a substantial degree of morbidity and mortality. In this article the radiological aspect of the terminology and classification of acute pancreatitis are reviewed. The roles of ultrasound, computed tomography, and magnetic resonance imaging in the diagnosis and evaluation of acute pancreatitis and its complications are discussed. Read More

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