8,559 results match your criteria mor


The properties of particleboard composites made from three sorghum (Sorghum bicolor) accessions using maleic acid adhesive.

Chemosphere 2021 Dec 3:133163. Epub 2021 Dec 3.

Forest Products Department, Faculty of Forestry and Environment, IPB University, Bogor, Indonesia. Electronic address:

It is very important to develop green composite materials owing to increasing global environmental issues. One of the alternative raw materials for the production of green composites is biomass. Bagasse sorghum is a promising alternative raw material for the manufacturing of particleboard composites. Read More

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December 2021

Effectiveness of BNT162b2 mRNA COVID-19 vaccine against SARS-CoV-2 variant Beta (B.1.351) among persons identified through contact tracing in Israel: A prospective cohort study.

EClinicalMedicine 2021 Dec 29;42:101190. Epub 2021 Nov 29.

Public Health Services, Israel Ministry of Health, Jerusalem, Israel.

Background: SARS-CoV-2 variant Beta (B.1.351) was designated as a Variant of Concern (VoC) after becoming the dominant strain in South Africa and spreading internationally. Read More

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December 2021

Detraining Slows and Maintenance Training Over 6 Years Halts Parkinsonian Symptoms-Progression.

Front Neurol 2021 19;12:737726. Epub 2021 Nov 19.

Somogy County Kaposi Mór Teaching Hospital, Kaposvár, Hungary.

There are scant data to demonstrate that the long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose in Parkinson's disease (PD). After randomization, the Exercise-only (E, = 19) group completed an initial 3-week-long, 15-session supervised, high-intensity sensorimotor agility exercise program designed to improve the postural stability. The Exercise + Maintenance (E + M, = 22) group completed the 3-week program and continued the same program three times per week for 6 years. Read More

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November 2021

Behavioral changes and neurochemical responses in Chinese rare minnow exposed to four psychoactive substances.

Sci Total Environ 2021 Dec 1:152100. Epub 2021 Dec 1.

Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, 310058 Hangzhou, China. Electronic address:

With the increase use of psychoactive pharmaceuticals, these substances and their metabolites are frequently detected in aquatic environment. However, there is still a knowledge gap in the neurotoxicity of these pollutants on aquatic organisms as well as related behavioral effects. In this study, the effects of four psychoactive substances alprazolam (ALPZ), lorazepam (LORZ), codeine (COD) and morphine (MOR) were investigated on 23 neurochemicals and 5 behaviors in Chinese rare minnow (Gobiocypris rarus). Read More

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December 2021

Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.

Parasit Vectors 2021 Dec 4;14(1):597. Epub 2021 Dec 4.

Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.

Background: Cyathostomins are the most important and common parasitic nematodes of horses, with > 50 species known to occur worldwide. The frequent and indiscriminate use of anthelmintics has resulted in the development of anthelmintic resistance (AR) in horse nematodes. In this study we assessed the efficacy of commonly used anthelmintics against cyathostomins in Australian thoroughbred horses. Read More

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December 2021

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn.

J Neuroinflammation 2021 Dec 2;18(1):279. Epub 2021 Dec 2.

Laboratory of Pain Research, Institute of Physiology, The Czech Academy of Sciences, Videnska 1083, 142 20, Praha 4, Czech Republic.

Background: Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at nociceptive synapses in the spinal cord dorsal horn. It was suggested that increased release of different chemokines under pathological conditions may play a role in this process. Read More

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December 2021

Assessing the Catalytic Behavior of Platinum Group Metal-Based Ultrathin Nanowires Using X-ray Absorption Spectroscopy.

ACS Appl Mater Interfaces 2021 Dec 1. Epub 2021 Dec 1.

Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, United States.

Ultrathin metal-based nanowires have excelled as electrocatalysts in small-molecule reactions, such as the oxygen reduction reaction (ORR), the methanol oxidation reaction (MOR), and the ethanol oxidation reaction (EOR), and have consistently outperformed analogous Pt/C standards. As such, a detailed understanding of the structural and electronic properties of ultrathin nanowires is essential in terms of understanding structure-property correlations, which are crucial in the rational design of ever more sophisticated electrocatalysts. X-ray absorption spectroscopy (XAS) represents an important and promising characterization technique with which to acquire unique insights into the electronic structure and the local atomic structure of nanomaterials. Read More

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December 2021

Medical and Social Factors Associated with Referral for Elder Abuse Services in a National Healthcare System.

J Gerontol A Biol Sci Med Sci 2021 Nov 25. Epub 2021 Nov 25.

VA Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA.

Background: Elder abuse (EA) is common and has devastating health consequences yet is not systematically assessed or documented in most health systems, limiting efforts to target healthcare-based interventions. Our objective was to examine sociodemographic and medical characteristics associated with documented referrals for EA assessment or services in a national US healthcare system.

Methods: We conducted a national case-control study in US Veterans Health Administration facilities of primary care (PC)-engaged Veterans age ≥60 years who were evaluated by social work (SW) for EA-related concerns between 2010-18. Read More

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November 2021

A newly intervention strategy in preeclampsia: Targeting PD-1/Tim-3 signaling pathways to modulate the polarization of decidual macrophages.

FASEB J 2022 Jan;36(1):e22073

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) are important immune checkpoint receptors that prevent an overreacted maternal immune response to fetal antigens during pregnancy. Disruption of complex immune regulation mechanisms is associated with adverse pregnancy outcomes, including preeclampsia (PE). Our recent study showed that the Tim-3 pathway was involved in the regulation of decidual macrophage polarization. Read More

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January 2022

Seasonal variations in carbonaceous species of PM aerosols at an urban location situated in Indo-Gangetic Plain and its relationship with transport pathways, including the potential sources.

J Environ Manage 2021 Nov 25:114049. Epub 2021 Nov 25.

Department of Environment Studies, Panjab University, Chandigarh, 160014, India. Electronic address:

The study examines the variation in organic carbon (OC) and elemental carbon (EC) in PM concentration at an urban location of Indo-Gangetic Plains (IGP) to understand the impact of seasonality and regional crop residue burning activities. Seasonal cluster analysis of backward air masses and concentration-weighted trajectory (CWT) analysis was performed to identify seasonal transport pathways and potential source regions of carbonaceous aerosols. The mean PM level during the study period was 57 ± 41. Read More

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November 2021

Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?

Viruses 2021 Nov 22;13(11). Epub 2021 Nov 22.

Central Virology Laboratory, Ministry of Health, Public Health Services, The Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan 52620, Israel.

Background: Hepatitis E (HEV) is an emerging cause of viral hepatitis worldwide. Swine carrying hepatitis E genotype 3 (HEV-3) are responsible for the majority of chronic viral hepatitis cases in developed countries. Recently, genotype 7 (HEV-7), isolated from a dromedary camel in the United Arab Emirates, was also associated with chronic viral hepatitis in a transplant recipient. Read More

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November 2021

Deciphering Reserve Mobilization, Antioxidant Potential, and Expression Analysis of Starch Synthesis in Sorghum Seedlings under Salt Stress.

Plants (Basel) 2021 Nov 15;10(11). Epub 2021 Nov 15.

Department of Food Sciences, University Centre Reaseheath, Reaseheath College, Nantwich CW5 6DF, UK.

Salt stress is one of the major constraints affecting plant growth and agricultural productivity worldwide. Sorghum is a valuable food source and a potential model for studying and better understanding the salt stress mechanics in the cereals and obtaining a more comprehensive knowledge of their cellular responses. Herein, we examined the effects of salinity on reserve mobilization, antioxidant potential, and expression analysis of starch synthesis genes. Read More

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November 2021

Mechanistic Studies of Antibiotic Adjuvants Reducing Kidney's Bacterial Loads upon Systemic Monotherapy.

Pharmaceutics 2021 Nov 17;13(11). Epub 2021 Nov 17.

Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.

We describe the design and attributes of a linear pentapeptide-like derivative (COOcO) screened for its ability to elicit bactericidal competences of plasma constituents against Gram-negative bacteria (GNB). In simpler culture media, the lipopeptide revealed high aptitudes to sensitize resilient GNB to hydrophobic and/or efflux-substrate antibiotics, whereas in their absence, COOcO only briefly delayed bacterial proliferation. Instead, at low micromolar concentrations, the lipopeptide has rapidly lowered bacterial proton and ATP levels, although significantly less than upon treatment with its bactericidal analog. Read More

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November 2021

Characterization of the Synergistic Effect between Ligands of Opioid and Free Fatty Acid Receptors in the Mouse Model of Colitis.

Molecules 2021 Nov 11;26(22). Epub 2021 Nov 11.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland.

Background: Recent studies suggest that lipids, including free fatty acids (FFAs), are necessary for proper μ opioid receptor (MOR) binding and that activation of opioid receptors (ORs) improves intestinal inflammation. The objective of the study was to investigate a possible interaction between the ORs and FFA receptors (FFARs) ligands in the colitis.

Methods: The potential synergistic effect of ORs and FFARs ligands was evaluated using mouse model of acute colitis induced by dextran sulfate sodium (DSS, 4%). Read More

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November 2021

Long-Term Results of Kidney Transplantation in the Elderly: Comparison between Different Donor Settings.

J Clin Med 2021 Nov 15;10(22). Epub 2021 Nov 15.

Institute of Nephrology, Beilinson Medical Center, Petach-Tikva 49100, Israel.

With scarce organ supply, a selection of suitable elderly candidates for transplant is needed, as well as auditing the long-term outcomes after transplant. We conducted an observational cohort study among our patient cohort >60 years old with a long follow up. (1). Read More

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November 2021

The Heat Shock Protein 60 and Pap1 Participate in the -Host Interaction.

J Fungi (Basel) 2021 Nov 12;7(11). Epub 2021 Nov 12.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P., Guanajuato 36050, Gto., Mexico.

is one of the etiological agents of sporotrichosis, a worldwide-distributed subcutaneous mycosis. Its cell wall contains a glycoconjugate composed of rhamnose, mannose, glucuronic acid, and proteins, named peptidorhamnomannan, which harbors important -specific immunogenic epitopes. Although the peptidorhamnomannan carbohydrate moiety has been extensively studied, thus far, little is known about the protein core. Read More

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November 2021

Taphonomic and Diagenetic Pathways to Protein Preservation, Part I: The Case of Specimen MOR 1125.

Biology (Basel) 2021 Nov 17;10(11). Epub 2021 Nov 17.

Museum of the Rockies, Montana State University, Bozeman, MT 59717, USA.

Many recent reports have demonstrated remarkable preservation of proteins in fossil bones dating back to the Permian. However, preservation mechanisms that foster the long-term stability of biomolecules and the taphonomic circumstances facilitating them remain largely unexplored. To address this, we examined the taphonomic and geochemical history of specimen Museum of the Rockies (MOR) 1125, whose right femur and tibiae were previously shown to retain still-soft tissues and endogenous proteins. Read More

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November 2021

Strategies towards safer opioid analgesics - a review of old and upcoming targets.

Br J Pharmacol 2021 Nov 26. Epub 2021 Nov 26.

Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA.

Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target the mu opioid receptor (MOR) whose activation results in adverse effects like respiratory depression, addiction, and abuse liability. Various approaches have been used by the field to separate receptor mediated analgesic actions from its adverse effects. Read More

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November 2021

Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.

Cancer Cell Int 2021 Nov 25;21(1):622. Epub 2021 Nov 25.

Department of Anesthesiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230036, China.

Background: Morphine, a µ-opioid receptor (MOR) agonist, has been shown to be related to the activity of cancer cells, and a higher morphine dosage reduces the survival time of patients with lung cancer. However, the effect of morphine on the malignant behavior of lung cancer cells remains unclear. The aim of this study was to investigate the specific molecular mechanism by which morphine regulates the malignant biological behavior of non-small cell lung cancer. Read More

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November 2021

Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, .

J Biomol Struct Dyn 2021 Nov 25:1-12. Epub 2021 Nov 25.

Faculty of Health, Department of Nursing, Muş Alparslan University, Muş, Turkey.

The present ethnobotanical study unravelled the phenolic reservoir (UHPLC-MS/TQ-MS) and pharmacological activity (antioxidant and enzyme inhibitory activities) of an endemic plant, Hub.-Mor. (Asteraceae). Read More

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November 2021

COVID-19 pandemic and sudden rise in crop residue burning in India: issues and prospects for sustainable crop residue management.

Environ Sci Pollut Res Int 2021 Nov 25. Epub 2021 Nov 25.

Department of Environment Studies, Panjab University, Chandigarh, 160014, India.

The seasonal burning of crop residue significantly affects the environment, leading to poor air quality over Indo-Gangetic Plain (IGP) in India. Hence, there have been significant efforts to minimize crop residue burning through policy, innovations, and awareness measures. However, an abrupt increase in paddy residue burning was observed over IGP during 2020. Read More

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November 2021

G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists.

Proc Natl Acad Sci U S A 2021 Nov;118(48)

Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458

The ability of a ligand to preferentially promote engagement of one signaling pathway over another downstream of GPCR activation has been referred to as signaling bias, functional selectivity, and biased agonism. The presentation of ligand bias reflects selectivity between active states of the receptor, which may result in the display of preferential engagement with one signaling pathway over another. In this study, we provide evidence that the G protein-biased mu opioid receptor (MOR) agonists SR-17018 and SR-14968 stabilize the MOR in a wash-resistant yet antagonist-reversible G protein-signaling state. Read More

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November 2021

Influence of meteorological parameters and air pollutants on the airborne pollen of city Chandigarh, India.

Sci Total Environ 2021 Nov 20:151829. Epub 2021 Nov 20.

Department of Environment Studies, Panjab University, Chandigarh 160014, India.

Pollen, climatic variables and air pollutants coexist in nature with the potential to interact with one another and play a crucial role in increasing allergic diseases. The current study evaluates the influence of meteorological parameters and air pollutants on the airborne pollen in an urban city, Chandigarh, situated in the Indo-Gangetic Plains. Airborne pollen monitoring was done following Spanish Aerobiological Network guidelines and dynamics of daily total pollen and six most abundant taxa were studied from June 2018 to June 2020. Read More

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November 2021

μ-opioid receptor availability is associated with sex drive in human males.

Cogn Affect Behav Neurosci 2021 Nov 22. Epub 2021 Nov 22.

Turku Pet Centre and Turku University Hospital, FI-20520, Turku, Finland.

The endogenous mu-opioid receptor (MOR) system modulates a multitude of social and reward-related functions, and exogenous opiates also influence sex drive in humans and animals. Sex drive shows substantial variation across humans, and it is possible that individual differences in MOR availability underlie interindividual of variation in human sex drive. We measured healthy male subjects' (n = 52) brain's MOR availability with positron emission tomography (PET) using an agonist radioligand, [C]carfentanil, that has high affinity for MORs. Read More

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November 2021

Opioid receptors modulate parallel fiber-Purkinje cell synaptic transmission in mouse cerebellum.

Neurosci Lett 2021 Nov 20:136356. Epub 2021 Nov 20.

Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City, Jilin Province 133002, China. Electronic address:

Opioid receptors play important roles in, among others, learning and memory, emotional responses, addiction, and pain. In recent years, the cerebellum has received increasing attention for its role in non-motor functions. The Purkinje cell (PC) is the only efferent neuron in the cerebellar cortex, and receives glutamatergic synaptic inputs from the parallel fibers (PF) formed by the axons of granule cells. Read More

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November 2021

Prevalence of Newcastle Disease Virus in Commercial and Backyard Poultry in Haryana, India.

Front Vet Sci 2021 4;8:725232. Epub 2021 Nov 4.

Department of Veterinary Population Medicine and Veterinary Diagnostic Laboratory, University of Minnesota, St. Paul, MN, United States.

Newcastle disease virus (NDV) causes Newcastle disease (ND) in poultry. The ND is a highly contagious disease, which is endemic in several countries despite regular vaccination with live or killed vaccines. Studies on NDV in India are mostly targeted toward its detection and characterization from disease outbreaks. Read More

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November 2021

A Case of Steroid-Associated Expressive Aphasia.

Cureus 2021 Oct 18;13(10):e18863. Epub 2021 Oct 18.

Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, USA.

Expressive aphasia (non-fluent aphasia) is characterized by the inability to produce words or sentences. The most common cause of expressive aphasia is stroke, usually due to thrombus or emboli in the middle cerebellar artery or internal carotid artery affecting Broca's area. We present an important, reversible, and previously undescribed cause of a purely expressive aphasia secondary to steroid use. Read More

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October 2021

MeCP2 Epigenetic Silencing of Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions.

Front Neurosci 2021 5;15:743207. Epub 2021 Nov 5.

Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Opioids are the last option for the pharmacological treatment of neuropathic pain, but their antinociceptive effects are limited. Decreased mu opioid receptor (MOR) expression in the peripheral nervous system may contribute to this. Here, we showed that nerve injury induced hypermethylation of the gene promoter and an increased expression of methyl-CpG binding protein 2 (MeCP2) in injured dorsal root ganglion (DRG). Read More

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November 2021

Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias.

Eur J Med Chem 2021 Nov 12:113986. Epub 2021 Nov 12.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China. Electronic address:

Biased agonism refers to the ability of compounds to drive preferred signaling pathways and avoid adverse signaling pathways in a ligand-dependent manner for some G-protein-coupled receptors. It is thought that the separation of therapeutic efficacy (e.g. Read More

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November 2021