157,879 results match your criteria mood disorders


Subthreshold psychiatric symptoms as potential predictors of postpartum depression.

Health Care Women Int 2021 Oct 15:1-13. Epub 2021 Oct 15.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.

The authors' purpose in the present study is to examine the role of subthreshold mental disorders as predictors of Postpartum Depression (PPD). 110 pregnancy women were evaluated as follow: the General 5-Spectrum Measure at 26 weeks of gestation; the Edinburgh Postnatal Depression Scale at 3/6 months after delivery. Only 4. Read More

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October 2021

The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder.

Front Neurol 2021 28;12:721126. Epub 2021 Sep 28.

Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.

Major depressive disorder (MDD) is a prominent cause of disability worldwide. Current antidepressant drugs produce full remission in only about one-third of MDD patients and there are no biomarkers to guide physicians in selecting the best treatment for individuals. There is an urgency to learn more about the etiology of MDD and to identify new targets that will lead to improved therapy and hopefully aid in predicting and preventing MDD. Read More

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September 2021

Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives.

Front Aging Neurosci 2021 28;13:742632. Epub 2021 Sep 28.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Mild traumatic brain injury (mTBI) can lead to long-term neurological dysfunction and increase one's risk of neurodegenerative disease. Several repercussions of mTBI have been identified and well-studied, including neuroinflammation, gliosis, microgliosis, excitotoxicity, and proteinopathy - however the pathophysiological mechanisms activating these pathways after mTBI remains controversial and unclear. Emerging research suggests DNA damage-induced cellular senescence as a possible driver of mTBI-related sequalae. Read More

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September 2021

Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?

Mol Psychiatry 2021 Oct 14. Epub 2021 Oct 14.

Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Recent studies have suggested that mitochondrial dysfunction and dysregulated neuroinflammatory pathways are involved in the pathophysiology of major depressive disorder (MDD). Here, we aimed to assess the differences in markers of mitochondrial dynamics, mitophagy, general autophagy, and apoptosis in peripheral blood mononuclear cells (PBMCs) of MDD patients (n = 77) and healthy controls (HCs, n = 24). Moreover, we studied inflammation engagement as a moderator of mitochondria dysfunctions on the severity of depressive symptoms. Read More

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October 2021

Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens.

Transl Psychiatry 2021 10 14;11(1):530. Epub 2021 Oct 14.

Molecular Neurophysiology Laboratory, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Ketamine elicits rapid and durable antidepressant actions in treatment-resistant patients with mood disorders such as major depressive disorder and bipolar depression. The mechanisms might involve the induction of metaplasticity in brain regions associated with reward-related behaviors, mood, and hedonic drive, particularly the ventral tegmental area (VTA) and the nucleus accumbens (NAc). We have examined if ketamine alters the insertion of the GluA2 subunit of AMPA receptors (AMPAR), which determines calcium permeability of the channel, at glutamatergic synapses onto dopamine (DA) neurons in the VTA and spiny projection neurons (SPNs) in the Core region of the NAc. Read More

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October 2021

Efficacy of a Low-threshold, Culturally-Sensitive Group Psychoeducation Programme for Asylum Seekers (LoPe): study protocol for a multicentre randomised controlled trial.

BMJ Open 2021 Oct 14;11(10):e047385. Epub 2021 Oct 14.

Faculty of Psychology, Outpatient Unit for Research, Teaching and Practice, University of Vienna, Vienna, Austria.

Introduction: Despite high levels of mental distress, accessing psychological treatment is difficult for asylum seekers in Western host countries due to a lack of knowledge about mental disorders, and the health system, as well as due to cultural and language barriers. This study aims to investigate whether brief culturally sensitive and transdiagnostic psychoeducation is effective in increasing mental health literacy.

Methods And Analysis: The study is a parallel two-group randomised controlled trial with 1:1 individual allocation to either culturally sensitive, low-threshold psychoeducation ('Tea Garden' (TG)) or a waitlist (WL) control group. Read More

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October 2021

Menopausal symptoms in epithelial ovarian cancer survivors: a GINECO VIVROVAIRE2 study.

Gynecol Oncol 2021 Oct 11. Epub 2021 Oct 11.

Clinical Research Department, Centre François Baclesse, av general Harris, Caen, France; INSERM, U1086, Caen, France; University of Caen Normandy, UMR-S1077, Caen, France; Department of Oncology, CHU de Caen, Caen, France.

Objective: We have previously shown that epithelial ovarian cancer (EOC) and its treatments have negative effects on long-term quality of life (QoL) and fatigue. The present multicenter study investigated the main menopausal symptoms and gynecological management of EOC survivors (EOCS).

Methods: 166 patients with relapse-free ≥3 years after the end of treatment attended a consultation with a gynecologist, including a questionnaire related to vasomotor symptoms (VMS) and sexuality, a clinical examination, a blood sample and an osteodensitometry. Read More

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October 2021

Scoping review of health outcomes for people with disabilities in user-led organisations.

Aust J Prim Health 2021 Oct 15. Epub 2021 Oct 15.

A user-led organisation (ULO) may be defined as an organisation that is run and controlled by the people who use the services provided by that organisation. ULOs provide services to their members, such as information, advice, support, treatment and training. ULOs may also be involved in advocacy, influencing local service provision, government policy and public perceptions of disability. Read More

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October 2021

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19.

Curr Psychiatry Rep 2021 10 1;23(10):68. Epub 2021 Oct 1.

Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD, USA.

Purpose Of Review: We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology.

Recent Findings: Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Read More

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October 2021

Associations of Maternal Diabetes During Pregnancy With Psychiatric Disorders in Offspring During the First 4 Decades of Life in a Population-Based Danish Birth Cohort.

JAMA Netw Open 2021 Oct 1;4(10):e2128005. Epub 2021 Oct 1.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Maternal diabetes has been suggested as a risk factor for attention-deficit/hyperactivity disorder and autism in offspring, but evidence on its association with the full spectrum of psychiatric disorders remains lacking.

Objective: To investigate the associations between maternal diabetes diagnosed before or during pregnancy and 10 types of psychiatric disorders in offspring during the first 4 decades of life.

Design, Setting, And Participants: This population-based cohort study used data from several Danish nationwide medical and administrative registries in Denmark on all 2 413 335 live births from 1978 to 2016. Read More

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October 2021

Stress symptoms and Coronavirus disease 2019 (COVID-19): a comparative study between Attention Deficit Hyperactivity Disorder and typically developing children and adolescents.

Minerva Pediatr (Torino) 2021 Oct 14. Epub 2021 Oct 14.

Department of Developmental and Social Psychology, Sapienza University, Rome, Italy.

Background: Coronavirus disease 2019 (COVID-19) related confinement severely impacted people wellbeing. Many studies focused on general population, although it is reasonable to expect that patients with neurodevelopmental disorders might have been at higher risk. Children/adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) might be potentially more vulnerable, due to their intolerance to forced restrictions that limit stimulating experiences, to obligation to follow instructions and to acceptation of imposed rules We aimed to compare stress-related behavioral changes of the first COVD-19 related confinement among 6-18 years old ADHD and typically developing subjects. Read More

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October 2021

The Outstanding Beneficial Roles of Irisin in Depressive Disorders.

Endokrynol Pol 2021 Oct 14. Epub 2021 Oct 14.

Kastamonu University, Faculty of Medicine, Department of Physiology, Kastamonu University, Faculty of Medicine, Department of Physiology, 37100 Kastamonu, Turkey.

Objective: Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that associated with fluctation in appetite, body weight, and energy situations in addition to serious mood problems. The aim of this review is concentrated to investigate possible link between energy regulatory hormones of irisin and depressive disorders. Read More

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October 2021

[Electroconvulsive therapy in the treatment of depression in anorexia nervosa].

Tijdschr Psychiatr 2021 ;63(9):673-678

Background: Often anorexia nervosa occurs with other psychiatric comorbidities of which mood disorders are the most frequent. Depressive feelings hamper the chance of a favourable outcome of this persistent disorder. In addition, the underweight makes antidepressants work suboptimal. Read More

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October 2021

[Pramipexole in bipolar depression: a literature review and clinical recommendations].

Authors:
V Dionys P Sienaert

Tijdschr Psychiatr 2021 ;63(9):658-664

Background: Bipolar depression is a common clinical problem and forms a major challenge in clinical practice as there is a paucity of treatment options.

Aim: To review the evidence for pramipexole as a treatment option in treatment-resistant bipolar depression.

Method: A PubMed search was performed using the search terms bipolar disorder or mood disorder or depressive disorder, treatment resistant and pramipexole or dopamine agonist. Read More

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October 2021

[Use of depot antipsychotics in Belgium between 1997 and 2016].

Tijdschr Psychiatr 2021 ;63(9):630-637

Background: Antipsychotics are considered the cornerstone for the treatment of schizophrenia and are increasingly used in the treatment of mood disorders. A lack of drug adherence is a frequently occurring problem. Depot antipsychotics have been co-developed in order to deal with this problem. Read More

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October 2021

Measuring anxiety in Lewy Body Disease - Which scale to choose?

Clin Park Relat Disord 2021 28;5:100110. Epub 2021 Sep 28.

Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, New South Wales, Australia.

Background: Anxiety is among the most prevalent mood disorders in Lewy Body Disease (LBD) (i.e., Parkinson's disease (PD), Dementia with Lewy bodies DLB), and those at-risk for developing LBD (e. Read More

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September 2021

Epidemiology of undiagnosed depression in people with diabetes mellitus: a comparative analysis of Ireland, England and the USA.

BMJ Open 2021 Oct 13;11(10):e049155. Epub 2021 Oct 13.

School of Public Health, University College Cork-National University of Ireland, Cork, Ireland.

Objectives: Improving detection of depression in people with diabetes is recommended. However, little is known about how different health systems compare in depression detection. We estimated and compared the (1) prevalence of depression detection in people with and without diabetes, and (2) association between diabetes and undiagnosed depression across three health systems. Read More

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October 2021

Effect of specialised versus generalised outpatient treatment for bipolar disorder: the CAG Bipolar trial - study protocol for a randomised controlled trial.

BMJ Open 2021 Oct 13;11(10):e048821. Epub 2021 Oct 13.

Psychiatric Center Copenhagen, Copenhagen, Denmark.

Introduction: Despite current available treatment patients with bipolar disorder often experience relapses and decreased overall functioning. Furthermore, patients with bipolar disorder are often not treated medically or psychologically according to guidelines and recommendations. A Clinical Academic Group is a new treatment initiative bringing together clinical services, research, education and training to offer care and treatment that is based on reliable evidence backed up by research. Read More

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October 2021

Intravenous ketamine for rapid treatment of major depressive disorder in the general medical hospital.

BMJ Case Rep 2021 Oct 13;14(10). Epub 2021 Oct 13.

Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.

Major depressive disorder (MDD) is common in general medical settings, and can usually be treated with conventional oral antidepressants. For some patients, however, oral treatment is refused or not possible, and the untreated symptoms can have a significant impact on the treatment of the acute medical problem. Use of intravenous ketamine has been widely reported in mental health settings for the treatment of MDD. Read More

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October 2021

[Sleep-related breathing disorders in children and teenagers: diagnosis, consequences and comorbidities].

Orthod Fr 2019 Dec;90(3-4):273-287

Unité de sommeil pédiatrique, ESEFNP, HFME, Hospices Civils de Lyon & U1028, CRNL, Université Lyon 1, 59 boulevard Pinel, 69500 Lyon, France, U1028, CNRL, Université de Lyon 1, 59 boulevard Pinel, 69500 Lyon, France.

Obstructive sleep apnoea syndrome (OSAS) is a frequent sleep-related breathing disorder in children with a prevalence of approximately 3% between the ages of 3 and 8. Its origin is multifactorial (hypertrophy of pharyngeal soft tissues, narrowing of the bone airways, damage to the neuromuscular tone). The symptoms and clinical signs to look for during the day and at night are directly related to upper airway (UA) obstruction or poor sleep quality. Read More

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December 2019

Wolfram-like syndrome - another face of a rare disease in children.

J Pediatr Endocrinol Metab 2021 Oct 13. Epub 2021 Oct 13.

Department of Clinical Genetics, Medical University of Lodz, Lodz, Poland.

Objectives: The presence of two pathogenic variants in the gene leads to the occurrence of a rare genetic disease in children - Wolfram syndrome (WFS), which includes insulin-dependent diabetes mellitus (DM), optic atrophy (OA), diabetes insipidus (DI), and deafness (D). However, the presence of a single mutation in the gene results in a number of other autosomal dominant inherited diseases, including Wolfram-like syndrome (WFS-like).

Case Presentation: A 10-year-old boy was referred to the Genetic Outpatient Clinic with suspected WFS based on the coexistence of D, type 1 DM, short stature, and abnormalities in ophthalmologic examination (astigmatism and OA due to the optical coherence tomography result). Read More

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October 2021

Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet.

Geroscience 2021 Oct 13. Epub 2021 Oct 13.

Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR, 97006, USA.

Obesity, the cessation of ovarian steroids with menopause, and age are risk factors for mood disorders, dementia, and Alzheimer's disease (AD). However, immediate hormone therapy (HT) after menopause may have beneficial effects in different brain regions involved in memory and cognition. To more closely replicate the age, endocrine, and metabolic environment of obese postmenopausal women, either on or off HT, middle-aged female rhesus macaques were ovariectomized/hysterectomized (OvH) and maintained on a high-fat, high-sugar, obesogenic Western-style diet (WSD) for 30 months; half of the animals received HT immediately after OvH and half served as placebo controls. Read More

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October 2021

Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life.

J Neurogastroenterol Motil 2021 Oct;27(4):602-611

Division of Gastroenterology, Aichi Medical University School of Medicine, Yazakokarimata, Nagakute, Aichi, Japan.

Background/aims: Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.

Methods: This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Read More

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October 2021

Dysphoria and Irritability-Diagnostic Pitfalls in the Assessment of Interictal Dysphoric Disorder in Epilepsy.

J Clin Med 2021 Oct 8;10(19). Epub 2021 Oct 8.

Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 80-952 Gdansk, Poland.

This article aims to review the concept of epilepsy-specific psychiatric disturbance, Interictal Dysphoric Disorder (IDD), focusing on issues related to its core symptoms and methodological pitfalls. In the psychiatric literature, an epilepsy-specific pleomorphic mood disorder has been long recognized and described as IDD, a condition characterized by eight symptoms, which are grouped into four labile depressive symptoms, two labile affective symptoms, and two specific symptoms. The existence of IDD is still a matter of debate because of several methodological issues. Read More

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October 2021

Sleep Quality and Eating Disorder-Related Psychopathologies in Patients with Night Eating Syndrome and Binge Eating Disorders.

J Clin Med 2021 Oct 8;10(19). Epub 2021 Oct 8.

Eating Disorders Institution, Psychiatric Division, Rambam Health Care Campus, Haifa 31096, Israel.

Night eating syndrome (NES) is an eating disorder (ED) characterized by nocturnal ingestion (NI), evening hyperphagia, morning anorexia, as well as mood and sleep disturbances. This study compared subjective and objective sleep quality and ED-related psychopathologies in patients seeking treatment for ED. Method: The sample was composed of 170 women, aged 18-68, who were referred for an ED assessment from 2011 to 2020. Read More

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October 2021

Circadian Characteristics in Patients under Treatment for Substance Use Disorders and Severe Mental Illness (Schizophrenia, Major Depression and Bipolar Disorder).

J Clin Med 2021 Sep 25;10(19). Epub 2021 Sep 25.

Department of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Passeig de la Vall d'Hebrón 171, 08035 Barcelona, Spain.

Dual disorders (substance use and mental illness comorbidity) are a condition that has been strongly associated with severe symptomatology and clinical complications. The study of circadian characteristics in patients with Severe Mental Illness or Substance Use Disorder (SUD) has shown that such variables are related with mood symptoms and worse recovery. In absence of studies about circadian characteristics in patients with dual disorders we examined a sample of 114 male participants with SUD and comorbid Schizophrenia (SZ+; = 38), Bipolar Disorder (BD+; = 36) and Major Depressive Disorder (MDD+; = 40). Read More

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September 2021

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family.

Int J Environ Res Public Health 2021 Sep 22;18(19). Epub 2021 Sep 22.

Service de Pédiatrie, Unité d'Endocrinologie-Gynécologie Pédiatrique, CHU Montpellier, University Montpellier, 34090 Montpellier, France.

Background: Psychiatric disorders in children exposed in utero to diethylstilbestrol (DES) are still debated. We report here the impact of DES prescribed to suppress lactation on the children born after such treatment and their progeny, focusing particularly on psychiatric disorders.

Case Presentation: We report here an informative family in which one or more psychiatric problems (e. Read More

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September 2021

Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis.

Int J Mol Sci 2021 Sep 28;22(19). Epub 2021 Sep 28.

INSERM, Stem Cell and Brain Research Institute U1208, Univ Lyon, Université Claude Bernard Lyon 1, 69500 Bron, France.

For a yet unknown reason, a substantial share of patients suffering from COVID-19 develop long-lasting neuropsychiatric symptoms ranging from cognitive deficits to mood disorders and/or an extreme fatigue. We previously reported that in non-neural cells, angiotensin-1 converting enzyme 2 (), the gene coding for the SARS-CoV2 host receptor, harbors tight co-expression links with dopa-decarboxylase (), an enzyme involved in the metabolism of dopamine. Here, we mined and integrated data from distinct human expression atlases and found that, among a wide range of tissues and cells, enterocytes of the small intestine express the highest expression levels of , and several key genes supporting the metabolism of neurotransmitters. Read More

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September 2021

Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases.

Int J Mol Sci 2021 Sep 23;22(19). Epub 2021 Sep 23.

Department of Pharmacology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Inwardly rectifying Kir4.1 channels in astrocytes mediate spatial potassium (K) buffering, a clearance mechanism for excessive extracellular K, in tripartite synapses. In addition to K homeostasis, astrocytic Kir4. Read More

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September 2021