733 results match your criteria months post-implantation

Predictive value of frontal QRS-T angle after cardiac resynchronization therapy.

J Electrocardiol 2021 Jul 3;68:24-29. Epub 2021 Jul 3.

Department of Cardiology, Sancaktepe Sehit Profesor Ilhan Varank Education and Research Hospital, Istanbul, Turkey. Electronic address:

Objective: It is practical and useful to detect patients who benefit from cardiac resynchronization therapy (CRT) by electrocardiographic (ECG) methods. In this study, the predictive role of the frontal QRS-T angle and other ECG parameters was evaluated in CRT responder patients.

Method: Seventy-seven consecutive patients with left ventricular ejection fraction (LVEF) ≤ 35%, New York Heart Association (NYHA) classes II-III, ambulatory class IV and normal sinus rhythm, who had complete left bundle branch block and were treated with CRT were included in this study. Read More

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A review of the outcomes of children with designated additional needs receiving cochlear implantation for severe to profound hearing loss.

Cochlear Implants Int 2021 Jul 5:1-7. Epub 2021 Jul 5.

Yorkshire Auditory Implant Service, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK.

Objective: To evaluate one year outcomes of children with additional needs receiving cochlear implantation at the Yorkshire Auditory Implant Service (YAIS) over a ten-year period.

Methods: Retrospective chart review yielded 270 children who received cochlear implants (CIs) at YAIS between 2007 and 2017; 49 children were classified as having additional needs. Audiological performance scales (Meaningful Auditory Information Scale (MAIS), Meaningful Use of Speech Scale (MUSS), Listening in Progress (LIP), Categories of Auditory Performance (CAP), and Speech Intelligibility Rating Scale (SIR)) were analysed pre- and 12 months post-implantation. Read More

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A study on the association of functional hearing behaviors with semantics, morphology and syntax in cochlear-implanted preschool children.

Int J Pediatr Otorhinolaryngol 2021 Jun 29;148:110814. Epub 2021 Jun 29.

Hacettepe University Faculty of Health Sciences, Department of Audiology, Ankara, Turkey. Electronic address:

Objectives: Monitoring children's development of auditory perception, speech and language after implant programming is critical to post-implantation success. Most of the time, it is not possible to perform an evaluation in clinical conditions, and the tests administered may not provide adequate data on children's everyday functional hearing skills. Therefore, administration of functional hearing measures alongside clinical tests will present supplementary data as to both language development and functional hearing performance of children. Read More

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A Retrospective Clinical Audit of Outcomes of Cochlear Implantation in Children with Multiple Disabilities in Comparison with Normal Implantees: A South Indian Experience.

Indian J Otolaryngol Head Neck Surg 2021 Jun 13;73(2):140-146. Epub 2020 Apr 13.

Madras ENT Research Foundation (MERF), No.1, 1st cross street, off. 2nd main road, Raja Annamalaipuram, Chennai, Tamil Nadu 6000028 India.

Aims: Cochlear implantation (CI) is established as a standard remedy for children with congenital bilateral profound hearing loss to attain hearing perception and thereby develop speech and language. A subgroup includes children with multiple disabilities in whom the implant helps to improve their quality of life and also of their families via enhanced communication skills. Cochlear implants today form an integral part of their multi-handicap rehabilitation process. Read More

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Interstitial multi-catheter breast brachytherapy: Technical aspects and experience feedback in a comprehensive cancer center.

Cancer Radiother 2021 Jun 16. Epub 2021 Jun 16.

Department of radiotherapy, institut de cancérologie de Lorraine, 54519 Vandœuvre-lès-Nancy, France.

Purpose: To focus on technical aspects of the implementation of interstitial high dose rate brachytherapy, with a step-by-step approach.

Materials And Methods: Patients were selected during multidisciplinary tumor boards, according to inclusion criteria adapted from GEC-ESTRO guidelines. A CT scan was performed a few days before implantation. Read More

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Evaluation of the histological and biomechanical properties of poly-4-hydroxybutyrate scaffold for pelvic organ prolapse, compared with polypropylene mesh in a rabbit model.

Int Urogynecol J 2021 Jun 14. Epub 2021 Jun 14.

Division of Female Pelvic Medicine and Reconstructive Surgery, Donald and Barbara Zucker School of Medicine at Northwell Health, Long Island, NY, USA.

Introduction And Hypothesis: Poly-4-hydroxybutyrate (P4HB) is a biopolymer produced by Escherichia coli K12 bacteria. P4HB is fully resorbed in vivo by 18-24 months post-implantation. The aim of this study is to evaluate P4HB in the rabbit abdomen and vagina to determine that the biomechanical and histological properties are similar to the standard polypropylene mesh. Read More

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Meta-analysis comparing valve-in-valve TAVR and redo-SAVR in patients with degenerated bioprosthetic aortic valve.

Catheter Cardiovasc Interv 2021 Jun 10. Epub 2021 Jun 10.

Cardiovascular Medicine, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA.

Introduction: The comparative efficacy and safety of valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) and redo-surgical AVR (redo-SAVR) in patients with degenerated bioprosthetic aortic valves remain unknown.

Method: Digital databases were searched to identify relevant articles. Unadjusted odds ratios for dichotomous outcomes were calculated using a random effect model. Read More

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Initial immune response to a FRET-based MMP sensor-immobilized silk fibroin hydrogel in vivo.

Acta Biomater 2021 Jun 1. Epub 2021 Jun 1.

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center (NCVC) Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.

To investigate the initial immune response to biodegradable silk fibroin (SF) hydrogels in vivo, a Förster/fluorescence resonance energy transfer (FRET)-based sensor was developed to detect matrix metalloproteinase (MMP) activity (FRET-MMPS) and immobilized to SF hydrogel. FRET-MMPS immobilized to SF hydrogel in vitro displayed intra-molecular FRET more than inter-molecular FRET, and MMP activity was detected through a decrease in FRET signal intensity. Then, the SF hydrogel modified with FRET-MMPS was implanted into mice subcutaneously, and it was observed that the FRET signal intensity decreased significantly soon (< 3 h) after implantation. Read More

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Exploring gender differences in trajectories of clinical markers and symptoms after left ventricular assist device implantation.

Eur J Cardiovasc Nurs 2021 Jun 3. Epub 2021 Jun 3.

William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA.

Aims: Despite well-known gender differences in heart failure, it is unknown if clinical markers and symptoms differ between women and men after left ventricular assist device (LVAD) implantation. Our aim was to examine gender differences in trajectories of clinical markers (echocardiographic markers and plasma biomarkers) and symptoms from pre- to post-LVAD implantation.

Methods And Results: This was a secondary analysis of data collected from a study of patients from pre- to 1, 3, and 6 months post-LVAD implantation. Read More

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White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation.

Brain Sci 2021 May 8;11(5). Epub 2021 May 8.

Department of Otorhinolaryngology, Head and Neck Surgery, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

The presented prospective study investigated whether structural brain damage, measured with the Fazekas score, could predict hearing rehabilitation outcomes with cochlear implantation (CI). With a follow-up period of 24 months, this study included 49 bilaterally, postlingually hearing impaired CI candidates for unilateral CI (67.3 ± 8. Read More

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Comparative Safety of the TFN-ADVANCED Proximal Femoral Nailing System: Findings from a U.S. Health-Care Database.

J Bone Joint Surg Am 2021 May 20. Epub 2021 May 20.

Epidemiology & Real-World Data Sciences, Medical Devices, Johnson & Johnson, New Brunswick, New Jersey.

Background: Proximal femoral fractures are often treated with cephalomedullary nails. Although nail breakages following fracture repair are infrequent, a recent implant retrieval study suggested that the TFN-ADVANCED (TFNA) Proximal Femoral Nailing System (DePuy Synthes) was susceptible to post-implant breakage. It is unclear whether the risk of breakage among patients who receive the TFNA implant is higher than patients who receive other comparable cephalomedullary nails. Read More

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Antibiotic Prophylaxis and Treatment in Early Cardiac Implantable Electronic Devices Infection.

Med Arch 2021 Feb;75(1):56-60

Department of Cardiology, Queen Alia Heart Institute, Royal Medical Services, Amman, Jordan.

Background: Cardiac implantable electronic devices - PM, ICD, and CRTs- are well-proven life-sustaining and the ultimate destination for many heart conditions. Based on scientific evidence, there is a worldwide incremental increase in CIED implantations numbers.

Objective: Early infection of cardiac implantable electronic devices (CIED)- pacemaker (PM), implantable cardioverter-defibrillator (ICD), and cardiac resynchronization therapy (CRT)- is a growing health challenge. Read More

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February 2021

Long-Term, Multicenter Results With the First Transcutaneous Bone Conduction Implant.

Otol Neurotol 2021 07;42(6):858-866

Department of Otolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Bielefeld, Germany.

Objective: Investigation of long-term safety and performance of an active, transcutaneous bone conduction implant in adults and children up to 36 months post-implantation.

Study Design: Prospective, single-subject repeated-measures design.

Setting: Otolaryngology departments of eight German and Austrian hospitals. Read More

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Development of zoledronic acid containing biomaterials for enhanced guided bone regeneration.

J Pharm Sci 2021 May 11. Epub 2021 May 11.

Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey.

In recent years, biomaterial-based treatments, also called guided bone regeneration (GBR), which aim to establish a bone regeneration site and prevent the migration of gingival connective tissue and / or peripheral epithelium through the defective area during periodontal surgical procedures have come to the fore. In this report, we have developed a nanoparticle bearing thermosensitive in situ gel formulation of Pluronic F127 and poly(D,L-lactic acid) based membrane to reveal their utilization at GBR by in-vivo applications. In addition, the encouragement of the bone formation in defect area via inhibition of osteoclastic activity is intended by fabrication these biodegradable biomaterials at a lowered Zoledronic Acid (ZA) dose. Read More

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Can a Peritoneal Conduit Become an Artery?

EJVES Vasc Forum 2020 13;49:23-29. Epub 2020 Oct 13.

Institute for Circulation and Imaging (ISB) at the Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Objective: Current vascular grafts all have limitations. This study examined peritoneum as a potential graft material and the transfer of peritoneum into a functional artery like conduit after end to end anastomosis into the common carotid artery of sheep. The aim was to investigate whether implantation of a peritoneal tube into the arterial tree results in a structure with function, histological findings, and gene expression like an artery, and whether such arterialisation occurs through a conversion of the phenotype of peritoneal cells or from host cell migration into the implant. Read More

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October 2020

Effectiveness and Safety of the Clareon Monofocal Intraocular Lens: Outcomes from a 12-Month Single-Arm Clinical Study in a Large Sample.

Clin Ophthalmol 2021 20;15:1647-1657. Epub 2021 Apr 20.

Carolina Eye Associates, PA, Southern Pines, NC, USA.

Purpose: This study assessed effectiveness and safety of the novel Clareon intraocular lens (IOL; model SY60CL; Alcon Vision LLC).

Patients And Methods: This was a prospective, single-arm, unmasked clinical trial at 16 investigative clinical sites in the United States. Included were adults ≥22 years who required cataract extraction by phacoemulsification. Read More

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Multimodal Analysis of the Tissue Response to a Bone-Anchored Hearing Implant: Presentation of a Two-Year Case Report of a Patient With Recurrent Pain, Inflammation, and Infection, Including a Systematic Literature Review.

Front Cell Infect Microbiol 2021 30;11:640899. Epub 2021 Mar 30.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Osseointegration is a well-established concept used in applications including the percutaneous Bone-Anchored Hearing System (BAHS) and auricular rehabilitation. To date, few retrieved implants have been described. A systematic review including cases where percutaneous bone-anchored implants inserted in the temporal bone were retrieved and analyzed was performed. Read More

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Biofunctionalized Structure and Ingredient Mimicking Scaffolds Achieving Recruitment and Chondrogenesis for Staged Cartilage Regeneration.

Front Cell Dev Biol 2021 25;9:655440. Epub 2021 Mar 25.

Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, China.

It remains scientifically challenging to regenerate injured cartilage in orthopedics. Recently, an endogenous cell recruitment strategy based on a combination of acellular scaffolds and chemoattractants to specifically and effectively recruit host cells and promote chondrogenic differentiation has brought new hope for articular cartilage regeneration. In this study, a transforming growth factor-β3 (TGF-β3)-loaded biomimetic natural scaffold based on demineralized cancellous bone (DCB) and acellular cartilage extracellular matrix (ECM) was developed and found to improve chondral repair by enhancing cell migration and chondrogenesis. Read More

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Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration.

Biomaterials 2021 05 27;272:120767. Epub 2021 Mar 27.

College of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education), State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. Electronic address:

Mechanistic understanding of the topological cues delivered by biomaterials in promotion of oriented tissue regeneration (e.g., peripheral nerve regrowth) remains largely elusive. Read More

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M-TRAP: Safety and performance of metastatic tumor cell trap device in advanced ovarian cancer patients.

Gynecol Oncol 2021 Jun 29;161(3):681-686. Epub 2021 Mar 29.

Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), CIBERONC, Santiago de Compostela, Spain. Electronic address:

Objective: Despite radical surgery and chemotherapy, most patients with ovarian cancer die due to disease progression. M-Trap is an implantable medical device designed to capture peritoneal disseminated tumor cells with the aim to focalize the disease. This trial analyzed the safety and performance of the device. Read More

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Longitudinal Effects of Left Ventricular Assist Device Implantation on Global and Domain-Specific Cognitive Function.

J Cardiovasc Nurs 2020 Jun 22. Epub 2020 Jun 22.

Kenneth M. Faulkner, PhD, RN, ANP Postdoctoral Research Fellow, Boston College Connell School of Nursing, Chestnut Hill, Massachusetts; and Clinical Assistant Professor, Stony Brook University School of Nursing, New York. Christopher V. Chien, MD, FACC Clinical Assistant Professor of Medicine, University of North Carolina, Chapel Hill. Quin E. Denfeld, PhD, RN Assistant Professor, Oregon Health & Science University School of Nursing, Portland. Jill M. Gelow, MD, MPH Advanced Heart Failure and Transplant Cardiologist, Providence Health Institute, Portland, Oregon. Karen S. Lyons, PhD, FGSA Associate Professor, Boston College Connell School of Nursing, Chestnut Hill, Massachusetts. Kathleen L. Grady, PhD, MS, RN, FAHA, FHFSA, FAAN Professor of Cardiothoracic Surgery and Cardiac Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. James O. Mudd, MD Advanced Heart Disease and Transplant Cardiologist, Providence Spokane Heart Institute, Spokane, Washington. Christopher S. Lee, PhD, FAHA, FHFSA, FAAN Professor and Associate Dean for Research, Boston College Connell School of Nursing, Chestnut Hill, Massachusetts.

Background: Left ventricular assist devices (LVADs) are a common treatment of advanced heart failure, but cognitive dysfunction, which is common in heart failure, could limit the ability to perform postimplantation LVAD care. Implantation of an LVAD has been associated with improved cerebral perfusion and may improve cognitive function post implantation.

Objective: The aim of this study was to quantify longitudinal change in cognitive function after LVAD implantation. Read More

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A Novel Restorative Pulmonary Valve Conduit: Early Outcomes of Two Clinical Trials.

Front Cardiovasc Med 2020 4;7:583360. Epub 2021 Mar 4.

Cardiovascular Core Laboratories, MedStar Health Research Institute, Washington, DC, United States.

We report the first use of a biorestorative valved conduit (Xeltis pulmonary valve-XPV) in children. Based on early follow-up data the valve design was modified; we report on the comparative performance of the two designs at 12 months post-implantation. Twelve children (six male) median age 5 (2 to 12) years and weight 17 (10 to 43) kg, had implantation of the first XPV valve design (XPV-1, group 1; 16 mm ( = 5), and 18 mm ( = 7). Read More

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A Novel Sirolimus-eluting Biodegradable Magnesium-based Alloy Scaffold: Six-month Results In Porcine Peripheral Arteries.

Clin Invest Med 2021 03 21;44(1):E28-37. Epub 2021 Mar 21.

Vascular Surgery Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Magnesium-based alloy scaffold is a promising biodegradable stent due to its intrinsic mechanical performance and biocompatibility. Based on our preliminary experiments, we designed a novel sirolimus-eluting magnesium-based alloy scaffold. This work aimed to assess its safety and degradation performance in vivo. Read More

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Electronic retinal prosthesis for severe loss of vision in geographic atrophy in age-related macular degeneration: First-in-human use.

Eur J Ophthalmol 2021 Mar 18:11206721211000680. Epub 2021 Mar 18.

Second Sight Medical Products, Inc, Sylmar, CA, USA.

Background: To date there are yet no available approved therapies for Geographic Atrophy (GA) secondary to age-related macular degeneration (AMD).

Methods: Single site, non-randomized safety and efficacy study presenting the preliminary results in a cohort of five late stage AMD (GA) patients successfully implanted with the Argus II Retinal Prosthesis System (Second Sight Medical Products Inc., Sylmar, CA, USA). Read More

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Effect of embedded metal fragments on urinary metal levels and kidney biomarkers in the Sprague-Dawley rat.

Toxicol Rep 2021 1;8:463-480. Epub 2021 Mar 1.

Internal Contamination and Metal Toxicity Program, Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD, USA.

Background: Wounds with embedded metal fragments are an unfortunate consequence of armed conflicts. In many cases the exact identity of the metal(s) and their long-term health effects, especially on the kidney, are not known.

Aim Of Study: The aim of this study was to quantitate the urinary levels of metals solubilized from surgically implanted metal pellets and to assess the effect of these metals on the kidney using a battery of biomarker assays. Read More

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Characterization of Inflammatory and Fibrotic Aspects of Tissue Remodeling of Acellular Dermal Matrix in a Nonhuman Primate Model.

Plast Reconstr Surg Glob Open 2021 Feb 16;9(2):e3420. Epub 2021 Feb 16.

Aziyo Biologics, Inc., Silver Spring, Md.

Human acellular dermal matrices (hADMs) are applied in various soft tissue reconstructive surgeries as scaffolds to support tissue remodeling and regeneration. To evaluate the clinical efficacy of hADM implants, it is integral that the hADM does not induce a host chronic inflammatory response leading to fibrotic encapsulation of the implant. In this study, we characterized the inflammatory and fibrosis-related tissue remodeling response of 2 commercial hADM products (SimpliDerm and AlloDerm RTU) in a nonhuman primate model using histology and gene expression profiling. Read More

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February 2021

Incomplete neo-endothelialization of left atrial appendage closure devices is frequent after 6 months: a pilot imaging study.

Int J Cardiovasc Imaging 2021 Jul 5;37(7):2291-2298. Epub 2021 Mar 5.

First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: To bridge neo-endothelialization (NE) of implanted left atrial appendage closure (LAA/LAAC) devices, dual antiplatelet therapy is prescribed. Cardiac computed tomography angiography (cCTA) has been proposed for the evaluation of interventional LAAC. This prospective longitudinal observational study applied a standardized imaging protocol to detect progression of NE of LAAC devices 6 months after implantation. Read More

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Vagus nerve stimulation as a potential modulator of periictal psychotic episodes: A report of four cases.

Epilepsy Behav Rep 2021 11;15:100434. Epub 2021 Feb 11.

Epilepsy Unit, Neurology Department, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.

Drug resistant epilepsy (DRE) has been associated with a high incidence of psychotic disorders. Patients can develop psychosis after starting a new antiseizure medication, after undergoing resective surgery, or after implantation of a vagus nerve stimulation (VNS) system. The aim of this study was to investigate the modulation effect of VNS on psychotic episodes in DRE patients with a pre-existing history of periictal psychotic episodes (PPE). Read More

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February 2021

Comparison of Clinician Versus Parental Perspectives of Outcomes in Cochlear Implantees: A South Indian Experience.

Indian J Otolaryngol Head Neck Surg 2021 Mar 13;73(1):41-44. Epub 2020 Jul 13.

Madras ENT Research Foundation (P) Ltd Chennai, Chennai, India.

Outcomes of cochlear implantation (CI) are generically assessed using standard validated measures like CAP, SIR, MAIS and MUSS scales. Although this reflects the improvement in auditory verbal skills among the implantees with habilitation over one year, the overall perception of their skill development may vary between the parents of these children and the clinicians who provide the habilitation. This study aimed to compare the CAP and SIR scores sequentially over habilitation and further analyzes the correlation between clinician assessment (with CAP/SIR scores) and parental perspective (with MAIS/MUSS scores), at the end of one year of habilitation. Read More

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Cochlear implantation for patients with tinnitus - A systematic review.

Prog Brain Res 2021 14;260:27-50. Epub 2020 Oct 14.

Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Clinical and Experimental Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.

Background: Cochlear implantation (CI) is used in patients with severe-to-profound hearing loss when hearing aids provide limited or no benefit for speech perception. Studies on this topic reported tinnitus reduction as a common side effect of the electrical activation after cochlear implantation. So far, it is unclear what the effect is when patients do receive their implant primarily because of tinnitus complaints. Read More

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October 2020