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Hematologic safety of palbociclib in combination with endocrine therapy in patients with benign ethnic neutropenia and advanced breast cancer.

Cancer 2021 Jun 22. Epub 2021 Jun 22.

Georgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, District of Columbia.

Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, including palbociclib, are approved to treat hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) and are associated with hematologic toxicity. African American women, who are underrepresented in CDK4/6 inhibitor clinical trials, may experience worse neutropenia because of benign ethnic neutropenia. The authors specifically investigated the hematologic safety of palbociclib in African American women with HR-positive/HER2-negative ABC. Read More

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The importance of social zeitgeber in paediatric type 1 narcolepsy: What we can learn from the COVID-19 restrictions adopted in Italy?

J Sleep Res 2021 Jun 22:e13423. Epub 2021 Jun 22.

IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

The lockdown due to the new coronavirus pandemic (COVID-19) has led to unparalleled changes in several aspects of human behaviour. During the lockdown, the general population delayed sleep timing and spent more time in bed; however, little is known on the effects of COVID-19 restriction on children and adolescents suffering type 1 narcolepsy. In the last months of 2019, we performed follow-up actigraphy in 18 type 1 narcolepsy children and adolescents under stable pharmacological treatment with sodium oxybate. Read More

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[The influence of the capsular defect as a risk factor for recurrence in pleomorphic adenoma].

Laryngorhinootologie 2021 Jun 22. Epub 2021 Jun 22.

Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Objective:  Aim of this study was to enlighten various aspects of the capsular defect of a pleomorphic adenoma and to analyze its influence on recurrence rate with the help of our data and the relevant literature.

Material And Methods:  The clinical records and histopathological findings of all patients who underwent parotidectomy for pleomorphic adenoma between 2006 and 2020 were evaluated retrospectively. The histological slides of all tumours were critically re-evaluated for this study by an experienced head and neck pathologist. Read More

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Topical treatment of multiple erosive, ulcerative skin lesions in an Indian rhinoceros (Rhinoceros unicornis).

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Jun 22;49(3):210-214. Epub 2021 Jun 22.

Centre for Clinical Veterinary Medicine, Ludwig Maximilian University.

A 30-year-old, intact female Indian rhinoceros () was presented with ongoing erosive, ulcerative skin lesions over a 4-year-period. The lesions appeared to be non-pruritic and non-seasonal. A systemic antibiotic therapy had been unsuccessful. Read More

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[Surgery site healing disorder following laparotomy in cattle: a retrospective study].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Jun 22;49(3):157-166. Epub 2021 Jun 22.

Universitätsklinik für Wiederkäuer, Department für Nutztiere und öffentliches Gesundheitswesen in der Veterinärmedizin, Veterinärmedizinische Universität Wien.

Objectives: Wound healing processes in consequence to bovine abdominal surgery performed from 2007 to 2016 at the University of Veterinary Medicine in Vienna were retrospectively assessed. The aim of this study was to evaluate the occurrence of wound healing complications following abdominal surgery in cattle during this 10-year-period as well as to identify possible risk factors such as elevated temperatures.

Material And Methods: Surgical procedures finding inclusion comprised ileus, left and right abomasal displacement, caecal dilation or displacement (right flank laparotomies), foreign body syndrome (left flank laparotomy), and umbilical surgery. Read More

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Hyperbaric oxygen treatment for toxic epidermal necrolysis: A case report.

Diving Hyperb Med 2021 Jun;51(2):216-219

University of Health Sciences, Kartal Dr Lütfi Kirdar City Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

Toxic epidermal necrolysis (TEN) is a potentially life-threatening muco-cutaneous disease, largely caused by an idiosyncratic reaction to medication or infectious disease, and is characterised by acute necrosis of the epidermis. No definitive consensus regarding the treatment of TEN has been agreed. A 60-year-old woman, diagnosed with multiple myeloma three months prior, was admitted with signs of TEN to the intensive care burns unit. Read More

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Statin associated lower cancer risk and related mortality in patients with heart failure.

Eur Heart J 2021 Jun 22. Epub 2021 Jun 22.

Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, No. 1 Haiyuan 1st Rd, Futian district, Shenzhen city, Guangdong province, 518009, China.

Aims: Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association of statin use with cancer risk and cancer-related mortality among patients with HF are sparse.

Methods And Results: Using a previously validated territory-wide clinical information registry, statin use was ascertained among all eligible patients with HF (n = 87 102) from 2003 to 2015. Read More

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Serum cortisol as a predictor for posttraumatic stress disorder symptoms in post-myocardial infarction patients.

J Affect Disord 2021 Jun 5;292:687-694. Epub 2021 Jun 5.

Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

Background: After an acute myocardial infarction (MI), patients may develop posttraumatic stress disorder (PTSD). There is evidence for alterations in the hypothalamic-pituitary-adrenal axis in PTSD. An association between patients` cortisol level after experiencing an MI and subsequent PTSD symptoms has not been investigated yet. Read More

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Deep learning-based automated detection of pulmonary embolism on CT pulmonary angiograms: No significant effects on report communication times and patient turnaround in the emergency department nine months after technical implementation.

Eur J Radiol 2021 Jun 11;141:109816. Epub 2021 Jun 11.

Department of Radiology, University Hospital Basel, University of Basel, Switzerland. Electronic address:

Objectives: Rapid communication of CT exams positive for pulmonary embolism (PE) is crucial for timely initiation of anticoagulation and patient outcome. It is unknown if deep learning automated detection of PE on CT Pulmonary Angiograms (CTPA) in combination with worklist prioritization and an electronic notification system (ENS) can improve communication times and patient turnaround in the Emergency Department (ED).

Methods: In 01/2019, an ENS allowing direct communication between radiology and ED was installed. Read More

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Oxaliplatin/capecitabine or carboplatin/paclitaxel-based preoperative chemoradiation for resectable oesophageal adenocarcinoma (NeoSCOPE): Long-term results of a randomised controlled trial.

Eur J Cancer 2021 Jun 19;153:153-161. Epub 2021 Jun 19.

Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, CF14 2TL, UK.

Aim: This is the first randomised study to evaluate toxicity and survival outcomes of two neoadjuvant chemoradiotherapy (CRT) regimens for patients with localised oesophageal adenocarcinoma (OAC) or gastro-oesophageal junction (GOJ) adenocarcinoma. The initial results showed comparable toxicity between regimens and pathological complete response (pCR) rate favouring CarPacRT. Herein, we report survival, progression patterns, and long-term toxicity after a median follow-up of 40. Read More

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Phase 1 dose-escalation and pharmacokinetic study of regorafenib in paediatric patients with recurrent or refractory solid malignancies.

Eur J Cancer 2021 Jun 19;153:142-152. Epub 2021 Jun 19.

Children & Young People's Unit, Paediatric and Adolescent Oncology Drug Development Team, The Royal Marsden NHS Foundation Trust and Division of Clinical Studies, Institute of Cancer Research, Sutton, UK.

Background: This phase 1 study evaluated safety, pharmacokinetics (PK), maximum tolerated dose (MTD), and antitumour activity of regorafenib in paediatric patients with solid tumours.

Patients And Methods: Patients (aged 6 months to <18 years) with recurrent/refractory solid tumours received oral regorafenib once daily for 3 weeks on/1 week off. The starting dose (60 mg/m) was derived from an adult physiology-based PK model and scaled to children; dose escalation was followed by safety expansion of the MTD cohort. Read More

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Methotrexate treatment in hand osteoarthritis refractory to usual treatments: A randomised, double-blind, placebo-controlled trial.

Semin Arthritis Rheum 2021 May 6;51(4):831-838. Epub 2021 May 6.

Department of Rheumatology, Pasteur Hospital, Nice University Hospital, Cote d'Azur University, Nice F-06000, France; Department of Rheumatology, University of Cote d'Azur, Nice Hospital, Laboratory LAMHESS, EA6312, IBV CNRS IMR 7277 INSERM U1091 UNS, France.

Objective: To examine the effect of methotrexate (MTX) on pain and structural progression in symptomatic erosive hand osteoarthritis (HOA).

Methods: This 1-year prospective, single-centre, randomised, double-blind, placebo-controlled study (www.ClinicalTrial. Read More

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IL-38 as an early predictor of the ischemic stroke prognosis.

Cytokine 2021 Jun 19;146:155626. Epub 2021 Jun 19.

School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Ischemic stroke is caused by a sudden neurological defect following a vascular occlusion and elicits a local and systemic inflammation in brain tissue. Interleukin-38 is an anti-inflammatory cytokine associated with ischemic and inflammatory diseases. This study was designed to analyze the effect of tPA therapy on interleukin-38 serum level changes and the serum level of IL-38 in the prognosis of ischemic stroke patients in the next three months. Read More

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Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience.

Leuk Res 2021 Jun 11;109:106642. Epub 2021 Jun 11.

Haematology and Bone Marrow Transplant Unit, IRCSS San Raffaele Scientific Institute, Italy. Electronic address:

Background: Chronic Graft versus Host Disease (GvHD) is a serious complication of allogeneic hematopoietic stem cell transplant that severely impacts quality of life and long-term survival. About 50-to-60 % of patients treated with steroids require a further line of therapy due to lack of sustained response. Ruxolitinib, a JAK1/2 inhibitor, has recently been approved for the treatment of acute GvHD. Read More

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Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study.

EBioMedicine 2021 Jun 19;69:103442. Epub 2021 Jun 19.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology, Beijing 100191, China. Electronic address:

Background: Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics.

Methods: We retrospectively sampled 235 patients receiving nCRT with the minimum 36 months' postoperative follow-up from three hospitals. Read More

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Hypofractionated Intensity Modulated Radiation Therapy With Concurrent Chemotherapy in Locally Advanced Non-Small Cell Lung Cancer: A Phase II Prospective Clinical Trial (GASTO1011).

Pract Radiat Oncol 2021 Jun 19. Epub 2021 Jun 19.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou; Lung Cancer Institute of Sun Yat-sen University, Guangzhou.; Guangdong Association Study of Thoracic Oncology, Guangzhou. Electronic address:

Purpose: We aimed to explore the efficacy and toxicity of split-course hypofractionated radiotherapy with concurrent chemotherapy (HRT-CHT) in patients with locally advanced non-small cell lung cancer (LANSCLC) in this single-arm, phase II study.

Methods: LANSCLC patients were considered eligible if their forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC%) and carbon monoxide diffusing capacity (DLCO%) were ≥40% and ≥45%, respectively. HRT-CHT using the IMRT technique was administered with 51 Gy in 17 fractions as the first course followed by a break. Read More

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Pharyngeal airway space changes and stability following an extended LeFort-I osteotomy advancement in cleft lip and palate and non-cleft lip and palate patients: a long term comparison study.

J Stomatol Oral Maxillofac Surg 2021 Jun 19. Epub 2021 Jun 19.

Division of Oral and Maxillofacial Surgery, Mayo Clinic, Rochester, MN, USA.

Purpose: The aim of this study was to evaluate effects of extended maxillary advancement osteotomy on pharyngeal airway space (PAS) in mid-facial deficient cleft lip and palate (CLP) patients and mid-facial deficient non-CLP patients.

Methods: Pharyngeal airway space (PAS) of 10 CLP and 10 non-CLP patients with the mean age of 19 years 10 months was measured on digitized lateral cephalograms taken shortly before maxillary advancement operation with Quadrangular Le Fort I osteotomy (QLF-I) (T0), early post-operative, (T1) and long term post-operative (T2). Two way repeated analysis of variance, independent samples t-test and correlations tests were used for statistical analysis of airway and skeletal changes. Read More

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Successful termination of ventricular tachycardia with intrinsic anti-tachycardia pacing.

Indian Pacing Electrophysiol J 2021 Jun 19. Epub 2021 Jun 19.

Department of Clinical Engineering, Ogaki Municipal Hospital, Ogaki, Japan.

Intrinsic anti-tachycardia pacing (iATP) is a novel automated ATP algorithm that employs post-pacing interval (PPI) to design the next ATP sequence based on an analysis of the prior failed ATP sequence. A patient with hypertrophic cardiomyopathy received an implantable cardioverter-defibrillator (ICD) (Cobalt™ XT DR, Medtronic, Minneapolis, MN, USA) following an episode of syncope due to macro-reentrant ventricular tachycardia (VT) (right bundle branch block configuration, cycle length [CL] 280 ms). The VF zone was set to VTCL <300 ms and iATP therapy was prescribed before and during capacitor charging. Read More

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Cancer-elicited inflammation attenuates response and outcome in tyrosine kinase inhibitor naive patients with advanced NSCLC.

Pharmacol Res 2021 Jun 19:105734. Epub 2021 Jun 19.

Biological Resource Center, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China. Electronic address:

Objective: Cancer elicited inflammation is the main environmental cause leading to carcinogenesis and metastasis of non-small cell lung cancer (NSCLC). Roles of the inflammatory biomarker in predicting the clinical efficacy of tyrosine kinase inhibitor (TKI) and prognosis of naive patients with advanced NSCLC need to be determined, and the best inflammatory predicted biomarker remains unknown.

Methods: A total of 178 eligible advanced NSCLC patients (124 and 54 cases within discovery and validation cohorts, respectively) who received first-line EGFR-TKI between July of 2014 and October of 2020 were enrolled in the present study. Read More

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Clinical Significance of Global Wasted Work in patients with Heart Failure receiving Cardiac Resynchronization Therapy.

J Am Soc Echocardiogr 2021 Jun 19. Epub 2021 Jun 19.

Université Lille Nord de France, GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Laboratoire d'échocardiographie, service de cardiologie Nord, Centre des Valvulopathies, Faculté de Médecine et de Maïeutique, Université Catholique de Lille, Lille, France; Centre Hospitalier Universitaire d'Amiens, Amiens, France. Electronic address:

Background: The relationship between myocardial work assessment using pressure-strain loops by echocardiography prior to cardiac resynchronization therapy (CRT) and response to CRT has been recently revealed. Among myocardial work parameters, the impact of left ventricular (LV) myocardial global wasted work (GWW) on response to CRT and outcome following CRT has been seldom studied. Hence, we evaluated here the relationship between preprocedural GWW and outcome in a large prospective cohort of patients with heart failure and reduced ejection fraction (HFrEF) receiving CRT. Read More

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Safety of Contemporary Heart Failure Therapy in Patients with Continuous-Flow Left Ventricular Assist Devices.

J Card Fail 2021 Jun 19. Epub 2021 Jun 19.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany. Electronic address:

Background: There are limited data available concerning the safety, optimal administration and benefits of contemporary heart failure therapy in patients after left ventricular assist device (LVAD) implantation.

Methods: Between 2015 and 2019, 257 patients underwent LVAD implantation and were included in this observational study. Oral heart failure therapy was initiated and up-titrated during the further course. Read More

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J Pediatr Adolesc Gynecol 2021 Jun 19. Epub 2021 Jun 19.

Pediatric Urology Unit, Santobono-PausiliponChildren's Hospital, Naples, Italy.

Background: Yolk sac tumour (YST) is a malignant entity that often occurs in girls less than 3 years of age and is the most frequent type of primary extragonadal germ cell tumours.

Case: We describe the case of an 11-month-old girl who was referred to our centre for vaginal bleeding with evidence of a uterine mass on ultrasonography. Preoperative investigations confirmed YST of the uterine cervix without metastasis. Read More

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Spinal and cranio-cervical mycetoma: a difficult surgery, with poor prognosis.

Neurochirurgie 2021 Jun 19. Epub 2021 Jun 19.

Department of Neurosurgery, Hôpital de Bretonneau, Tours, France.

Background: Few central nervous systems (CNS) cases of actinomycetoma have been recorded in the literature, and most were reported in tropical and subtropical regions. The management of this invasive infection is difficult, especially when it affects the spine and the cranio-cervical regions.

Case: We report an unusual case of a cranio-cervical junction actinomycetoma, in a patient presenting a cerebellar syndrome from brainstem compression. Read More

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Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis.

Am J Obstet Gynecol 2021 Jun 19. Epub 2021 Jun 19.


Background: Treatment outcomes after pelvic organ prolapse (POP) surgery are often presented as dichotomous 'success or failure' based upon anatomic and symptom criteria. However, clinical experience suggests some women with outcome 'failures' are asymptomatic and perceive their surgery to be successful, while others have anatomic resolution, but continue to report symptoms. Characterizing failure types could be a useful step to refine definitions of success, understand mechanisms of failure, and identify individuals who may benefit from specific therapies. Read More

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How are central foveal and choroidal thickness affected in patients with mild COVID-19 infection?

Bosn J Basic Med Sci 2021 May 21. Epub 2021 May 21.

Department of Ophthalmology, Elazığ City Hospital, Elazığ, Turkey.

The aim of this study was to evaluate the effects of  COVID-19 on central foveal and choroidal thicknesses. Thirty-two patients with a positive SARS-CoV-2 PCR test who received outpatient treatment within the previous two months and 32 healthy controls were included in the study. Patients requiring hospitalization due to COVID-19 as well as the patients who received either intensive care support and/or antiplatelet therapy, smokers, or patients with systemic or ocular diseases were excluded from the study. Read More

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Aortic arch uncrossing using a tracheal resection procedure.

Halkawt Nuri

Multimed Man Cardiothorac Surg 2021 Jun 22;2021. Epub 2021 Jun 22.

Cardiac Surgery Division, Gaslini Children's Hospitals, Genova, Italy.

One category of vascular rings is the right aortic arch associated with the diverticulum of Kommerell from which the left subclavian artery usually originates. In some cases, the right aortic arch crosses behind the trachea and the esophagus from right to left. The trachea and esophagus are compressed by the right aortic arch, the left ligamentum, and the posterior crossing aorta, which causes the typical symptoms of noisy breathing, dyspnea on exertion, dysphagia, and frequent upper respiratory tract infections. Read More

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Natural history of small asymptomatic kidney and residual stones over a long-term follow-up: Systematic review over 25 years.

BJU Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Urology, University Hospital Southampton, Tremona Road, Southampton, UK.

Introduction: Incidental identification of small, asymptomatic renal calculi has risen with increasing high-resolution imaging. The natural history of such stones and small residual fragments remains unclear, however kidney stone disease (KSD) demands growing healthcare resource utilisation with wide-ranging costs of treatment and varying management recommendations.

Materials And Methods: We systematically reviewed the natural history of small asymptomatic kidney and residual stones using the Cochrane and PRISMA methodology. Read More

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Long-term Outcomes after Seton Placement for Perianal Fistulae with and without Crohn's Disease.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Colorectal Surgery Division, Department of Surgery, St. Paul's Hospital, Vancouver, BC, USA.

Aim: Perianal sepsis in Crohn's fistulae is managed with antibiotics and surgical drainage; a non-cutting seton is used for an identified trans-sphincteric fistula tract. Optimal management following seton placement for initial control of perianal sepsis remains to be determined. Our main objective was to assess success rates of curative surgery, seton removal, or long-term indwelling seton in patients with and without Crohn's. Read More

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Appendiceal pseudomyxoma peritonei: predictors of recurrence and iterative surgery.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Aim: Appendiceal pseudomyxoma peritonei (PMP) is a rare entity, with recurrence rates up to 26% despite optimal cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Evidence specific to PMP originating from non-infiltrative appendiceal mucinous neoplasms (Low grade - LAMN and high grade - HAMN) is lacking. The aim of this study was to identify patterns of recurrence and predictive factors for patients appropriate for iterative surgery. Read More

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Colonic Disease Recurrence following Proctectomy with End Colostomy for Anorectal Crohn's Disease.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Department of Surgery, Mount Sinai Hospital, University of Toronto, Canada.

Aim: In patients with anorectal Crohn's disease, it remains uncertain whether a total proctocolectomy with end ileostomy or proctectomy with end colostomy should be recommended due to the unknown rate of disease recurrence in the remaining colon.

Methods: A retrospective review of all patients with a known diagnosis of Crohn's disease who underwent a proctectomy with end colostomy for distal Crohn's disease between January 1, 2010 and January 1, 2019 at two IBD referral centers was conducted. Data collected included patient demographics, surgical variables at the time of proctectomy, and postoperative clinical, endoscopic and surgical recurrence rates. Read More

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