207,559 results match your criteria month studies

Potential for optimizing management of obesity in the secondary prevention of coronary heart disease.

Eur Heart J Qual Care Clin Outcomes 2021 Jul 27. Epub 2021 Jul 27.

Department of Medicine, Solna, Karolinska Institutet, FoU - Tema Hjärta och Kärl, S1:02, Karolinska Universitetssjukhuset/Solna, SE-171 76, Stockholm, Sweden.

Aims: Prevention guidelines have identified the management of obese patients as an important priority to reduce the burden of incident and recurrent cardiovascular disease. Still, studies have demonstrated that over 80% of patients with coronary heart disease (CHD) fail to achieve their weight target. Here, we describe advice received and actions reported by overweight CHD patients since being discharged from hospital and how weight changes relate to their risk profile. Read More

View Article and Full-Text PDF

Tracking Pandemic Severity Using Data on the Age Structure of Mortality: Lessons From the 1918 Influenza Pandemic in Michigan.

Am J Public Health 2021 Jul;111(S2):S149-S155

Siddharth Chandra is with the Asian Studies Center and James Madison College at Michigan State University, East Lansing, with a courtesy appointment in the Department of Epidemiology and Biostatistics. Julia Christensen is with James Madison College at Michigan State University, East Lansing.

To test whether distortions in the age structure of mortality during the 1918 influenza pandemic in Michigan tracked the severity of the pandemic. We calculated monthly excess deaths during the period of 1918 to 1920 by using monthly data on all-cause deaths for the period of 1912 to 1920 in Michigan. Next, we measured distortions in the age distribution of deaths by using the Kuiper goodness-of-fit test statistic comparing the monthly distribution of deaths by age in 1918 to 1920 with the baseline distribution for the corresponding month for 1912 to 1917. Read More

View Article and Full-Text PDF

Percutaneous cryoablation of chondroblastoma and osteoblastoma in pediatric patients.

Insights Imaging 2021 Jul 27;12(1):106. Epub 2021 Jul 27.

Department of Interventional Radiology, Hospital Clínic Barcelona, Barcelona, Spain.

Background: To review the safety and efficacy of percutaneous cryoablation for the treatment of chondroblastoma and osteoblastoma in the pediatric and adolescent population.

Materials And Methods: A retrospective review from 2016 to 2020 was performed to evaluate clinical and imaging response to percutaneous cryoablation in 11 symptomatic patients with diagnosis of chondroblastoma and osteoblastoma treated from two pediatric hospitals with at least 12-month follow-up. Technical success (correct needle placement and potential full coverage of the tumor with the planned ablation zone) and clinical success (relief of the symptoms) were evaluated. Read More

View Article and Full-Text PDF

Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population.

Elife 2021 Jul 27;10. Epub 2021 Jul 27.

Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.

Until COVID-19 drugs specifically developed to treat COVID-19 become more widely accessible, it is crucial to identify whether existing medications have a protective effect against severe disease. Towards this objective, we conducted a large population study in Clalit Health Services (CHS), the largest healthcare provider in Israel, insuring over 4.7 million members. Read More

View Article and Full-Text PDF

Systematic Review and Meta-analysis of Outcome after Mild Traumatic Brain Injury in Older People.

J Int Neuropsychol Soc 2021 Jul 27:1-20. Epub 2021 Jul 27.

Department of Psychology, Caulfield Hospital, Caulfield, Australia.

Objective: Older age is often identified as a risk factor for poor outcome from traumatic brain injury (TBI). However, this relates predominantly to mortality following moderate-severe TBI. It remains unclear whether increasing age exerts risk on the expected recovery from mild TBI (mTBI). Read More

View Article and Full-Text PDF

A systematic review and meta-analyses of food preference modifications after bariatric surgery.

Obes Rev 2021 Jul 26. Epub 2021 Jul 26.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec, Quebec, Canada.

This systematic review and meta-analyses aimed to synthesize evidence of the link between bariatric surgery and changes in food preferences, considering the method of assessment. MEDLINE, Cochrane Library, Web of Science, Cinahl, PsychINFO, ProQuest, and Open grey were searched incorporating two blocks of terms ("Intervention" and "Food Preferences"). Interventional or observational studies involving patients (BMI ≥ 35 kg m ) with sleeve gastrectomy (SG) or Roux-en-Y Gastric Bypass (RYGB) and a control group were included. Read More

View Article and Full-Text PDF

Minimally invasive robotic cervicothoracic fusion: a case report and review of literature.

AME Case Rep 2021 25;5:24. Epub 2021 Jul 25.

Department of Neurosurgery, University of California San Diego School of Medicine, San Diego, CA, USA.

Minimally invasive surgery (MIS) of the posterior cervical spine with robotic assistance has recently emerged to treat degenerative disc disease. Robotic arms and 3D neuronavigation with preoperatively planned placement are used to achieve real-time intraoperative guidance, reducing screw malposition through increased accuracy and stability. This results in decreased blood loss, postoperative pain, and quicker recovery time compared to other techniques. Read More

View Article and Full-Text PDF

Portable Acquisition of Auditory ERPs: A Pilot Study of Premature Infants.

Pediatr Neurol 2021 Jun 12. Epub 2021 Jun 12.

Department of Paediatrics, University of Colombo, Colombo, Sri Lanka.

Background: Prior work suggests that event-related potential (ERP) studies in infancy may help predict developmental outcome.

Methods: As part of a longitudinal study of early child development, we used the auditory oddball stimulus paradigm with a portable electroencephalography system to obtain ERP data from two-month-old infants (32 term, six preterm) in Sri Lanka. The mismatch negativity was calculated between 200 and 350 milliseconds after stimulus presentation. Read More

View Article and Full-Text PDF

Comparison of fatigue and fatigability correlates in Korean breast cancer survivors and differences in associations with anxiety, depression, sleep disturbance, and endocrine symptoms: a randomized controlled trial.

BMC Cancer 2021 Jul 26;21(1):855. Epub 2021 Jul 26.

College of Nursing, Mo-Im Kim Nursing Research Institute, Yonsei University, Seoul, Korea, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Background: Fatigue is one of the most common and burdensome symptoms experienced by cancer patients. In interventions intended to reduce fatigue in such patients, fatigability, or perception of fatigue contextualized to activities of fixed intensity and duration, may also be measured. This study investigated the effects of a 15-month intervention on fatigue and fatigability in breast cancer survivors (BCS); explored the fatigue-fatigability relationship; and evaluated the impacts of fatigue and fatigability on anxiety, depression, sleep disturbance, and endocrine symptoms. Read More

View Article and Full-Text PDF

Real-world migraine-related healthcare resource utilization and costs associated with improved vs. worsened/stable migraine: a panel-based chart review in France, Germany, Italy, and Spain.

J Med Econ 2021 Jul 27. Epub 2021 Jul 27.

Novartis Pharma AG, Basel, Switzerland.

Objective: To estimate the migraine-related healthcare resource utilization (HRU) and costs among patients with improved vs. worsened/stable migraine.

Methods: This was a follow-up to a retrospective, panel-based chart review conducted in France, Germany, Italy, and Spain among a panel of physicians (neurologists, headache specialists, and pain specialists) who agreed to participate in patient studies and had treated ≥10 migraine patients in 2017. Read More

View Article and Full-Text PDF

Boosting the input: 9-month-olds' sensitivity to low-frequency phonotactic patterns in novel wordforms.

Infancy 2021 Jul 23. Epub 2021 Jul 23.

Department of Psychology, University of Calgary, Calgary, Alberta, Canada.

To learn their first words, infants must attend to a variety of cues that signal word boundaries. One such cue infants might use is the language-specific phonotactics to track legal combinations and positions of segments within a word. Studies have demonstrated that, when tested across statistically high and low phonotactics, infants repeatedly reject the low-frequency wordforms. Read More

View Article and Full-Text PDF

Declining energy predicts incident mobility disability and mortality risk in healthy older adults.

J Am Geriatr Soc 2021 Jul 23. Epub 2021 Jul 23.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Background: The purpose was to examine whether longitudinal changes in self-reported energy predict incident mobility disability and mortality. We further explored whether changes in energy-related behaviors (physical activity, appetite, or sleep quality) would explain these associations.

Methods: N = 2021 participants from the Health, Aging and Body Composition Study free from mobility disability and with at least three energy assessments from years 2 to 10. Read More

View Article and Full-Text PDF

Adipose tissue-derived stromal vascular fraction for treating hands of patients with systemic sclerosis: a multicentre randomized trial.

Rheumatology (Oxford) 2021 Jul 23. Epub 2021 Jul 23.

Vascular Research Center Marseille, INSERM, INRA, Aix-Marseille University, MARSEILLE, FRANCE.

Objective: To assess the superiority of adipose tissue-derived stromal vascular fraction (AD-SVF) injection into the fingers vs placebo in reducing hand disability in systemic sclerosis (SSc) patients.

Methods: We performed a double-blind, multicentre, phase II trial from October 2015 to January 2018 in France. SSc patients with a Cochin Hand Function Scale (CHFS) ≥20/90 were randomized 1:1 to receive injection of AD-SVF or placebo. Read More

View Article and Full-Text PDF

Distinguishing repeated polymerase chain reaction positivity from re-infections in COVID-19.

Influenza Other Respir Viruses 2021 Jul 23. Epub 2021 Jul 23.

Liver Transplantation Research Center, Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Background: Possibility of reinfection with SARS-CoV-2 changes our view on herd immunity and vaccination and can impact worldwide quarantine policies. We performed real-time polymerase chain reaction (RT-PCR) follow-up studies on recovered patients to assess possible development of reinfections and re-positivity.

Methods: During a 6-month period, 202 PCR-confirmed recovering COVID-19 patients entered this study. Read More

View Article and Full-Text PDF

Does Hyperlipasemia Predict Worse Clinical Outcomes in COVID-19? A Multicenter Retrospective Cohort Study.

J Clin Gastroenterol 2021 Jul 22. Epub 2021 Jul 22.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Indiana University School of Medicine, Fort Wayne, IN University Hospital Southampton, NHS Foundation Trust, Southampton, UK Icahn School of Medicine at Mount Sinai, New York, NY.

Goal: We aim to perform a multicenter retrospective cohort study to determine if elevated serum lipase determines clinical outcomes in patients with coronavirus disease 2019 (COVID-19).

Background: Several cases of acute pancreatitis (AP) have recently been reported in association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Most of the evidence is based on elevated serum lipase values without objective demonstration of pancreatic inflammation or necrosis. Read More

View Article and Full-Text PDF

Minimally invasive permanent pacemaker implantation immediately after birth: from delivery room to heart surgery.

Cardiol Young 2021 Jul 23:1-3. Epub 2021 Jul 23.

Department of Pediatric Cardiology, Dr. Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Introduction: Congenital atrioventricular block is diagnosed in uterine life, at birth, or early in life. Atrioventricular blocks can be life threatening immediately at birth so urgent pacemaker implantation techniques are requested. Reasons can be cardiac or non-cardiac, but regardless of the reason, operations are challenging. Read More

View Article and Full-Text PDF

Wernicke encephalopathy in a lung cancer patient receiving home medical care.

Palliat Support Care 2021 Jul 23:1-3. Epub 2021 Jul 23.

Department of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Objective: Cancer patients often want to spend their final days at home, and it is essential that general practitioners have knowledge of and technical skills related to cancer medicine and symptom relief. Recent clinical studies have revealed that Wernicke encephalopathy (WE) is quite common in cancer patients. However, there have been no reports to date on WE in cancer patients undergoing home medical care. Read More

View Article and Full-Text PDF

Formation of the upper digestive tract by the ileum - right colon for patient with concurrent cancers of the esophagus and the stomach: A case report.

Int J Surg Case Rep 2021 Jul 21;85:106232. Epub 2021 Jul 21.

Bach Mai Hospital, Hanoi, Viet Nam; Hanoi University of Public Health, Hanoi, Viet Nam.

Introduction And Importance: A very rare case with presence of both esophageal and gastric cancers raised questions on how to perform optimal surgery for such cases. To date, reports on experimental surgery strategies for these rare cases remained sparse in the literatures.

Case Presentation: A 61-year-old male patient having epigastric abdominal pain and swallowing difficulties for a month prior to the hospital. Read More

View Article and Full-Text PDF

LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification.

Hear Res 2021 Jul 15;409:108311. Epub 2021 Jul 15.

GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, C.H.U. B36, B-4000 Liège, Belgium. Electronic address:

There is now growing evidence that hypercholesterolemia and high serum levels of low-density lipoproteins (LDL) predispose to sensorineural hearing loss. Circulating LDL-cholesterol is delivered to peripheral tissues via LDL receptor (LDLR) -mediated endocytosis. Recently, it has been shown that LDLR gene polymorphisms are associated with higher susceptibility to sudden deafness. Read More

View Article and Full-Text PDF

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy.

Epilepsy Behav 2021 Jul 23;122:108205. Epub 2021 Jul 23.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA.

Recent approval of Epidiolex® (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy. However, a large number of patients with epilepsy elect to use alternative artisanal CBD products due to cost or access constraints. Despite widespread availability and variety of these artisanal CBD products, studies evaluating their safety or efficacy are rare, making conclusions about clinical utility uncertain. Read More

View Article and Full-Text PDF

Physical touch during father-infant interactions is associated with paternal oxytocin levels.

Infant Behav Dev 2021 Jul 23;64:101613. Epub 2021 Jul 23.

University of Southern California, Los Angeles, CA, United States.

Introduction: Physical connection, particularly parent-to-infant touch, is critical for the well-being of infants and may support the development of the parent-infant bond. Physical touch has also been found to stimulate oxytocin levels. This study tested whether fathers' micro-coded touch behaviors during parent-child interaction predicted their subsequent oxytocin levels. Read More

View Article and Full-Text PDF

Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects.

Reprod Toxicol 2021 Jul 23. Epub 2021 Jul 23.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:

Accumulating studies have been focused on the independent effects of air pollutants and ambient heat exposure on congenital heart defects (CHDs) but with inconsistent results, and their interactive effect remains unclear. A case-control study including 921 cases and 9210 controls was conducted in Changsha, China in warm season in 2015-2018. The gravidas were assigned monthly averages of daily air pollutants and daily maximum temperature using the nearest monitoring station method and city-wide average method, respectively, during the first trimester of pregnancy. Read More

View Article and Full-Text PDF

Pricing through health apps generated data-Digital dividend as a game changer: Discrete choice experiment.

PLoS One 2021 26;16(7):e0254786. Epub 2021 Jul 26.

WHU -Otto Beisheim School of Management, Chair of Digital Marketing, Vallendar, GER.

Objectives: The objective of this paper is to study under which circumstances wearable and health app users would accept a compensation payment, namely a digital dividend, to share their self-tracked health data.

Methods: We conducted a discrete choice experiment alternative, a separated adaptive dual response. We chose this approach to reduce extreme response behavior, considering the emotionally-charged topic of health data sales, and to measure willingness to accept. Read More

View Article and Full-Text PDF

Feasibility and impact of near-point-of-care integrated TB/HIV testing in Malawi and Zimbabwe.

AIDS 2021 Jul 22. Epub 2021 Jul 22.

Clinton Health Access Initiative, Boston, USA Clinton Health Access Initiative, Harare, Zimbabwe Clinton Health Access Initiative, Lilongwe, Malawi Ministry of Health and Child Care, Harare, Zimbabwe Ministry of Health and Population, Lilongwe, Malawi. Authors contributed equally.

Objectives: Near-point-of-care (POC) testing for early infant diagnosis (EID) and viral load (VL) expedites clinical action and improves outcomes, but requires capital investment. We assessed whether excess capacity on existing near-POC devices used for TB diagnosis could be leveraged to increase near-POC HIV molecular testing, termed integrated testing, without compromising TB services.

Design: Pre/post implementation studies in 10 health facilities in Malawi and 8 in Zimbabwe. Read More

View Article and Full-Text PDF

Enhancing the Stabilization Potential of Lyophilization for Extracellular Vesicles.

Adv Healthc Mater 2021 Jul 26:e2100538. Epub 2021 Jul 26.

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universitaet Muenchen, Munich, 81377, Germany.

Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs are usually stored at -80 °C which limits potential clinical applicability. Freeze-drying of EVs striving for long-term stable formulations is therefore studied. Read More

View Article and Full-Text PDF

Factors Influencing Early Serum Uric Acid Fluctuation After Bariatric Surgery in Patients with Hyperuricemia.

Obes Surg 2021 Jul 26. Epub 2021 Jul 26.

The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, No. 82 Qinglong Road, Chengdu, 610031, Sichuan Province, China.

Purpose: In the short-term after bariatric surgery, the incidence of gout flare was increased. Patients with hyperuricemia are among the high-risk group of postoperative gout attacks. The drastic fluctuation of uric acid is a risk factor for gout flare. Read More

View Article and Full-Text PDF

Investigating the potential of bioremediation in aged oil-polluted hypersaline soils in the south oilfields of Iran.

Environ Monit Assess 2021 Jul 26;193(8):517. Epub 2021 Jul 26.

Department of Soil Science, College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran.

To date, studies for bioremediation of oil-polluted hypersaline soils have been neglected or limited to specific spots. Hence, in this study, ten samples of oil field soils in the Khuzestan province of Iran were collected to evaluate bioremediation's feasibility. These samples were analyzed for their physicochemical properties as well as the most probable number of total and hydrocarbon-degrading bacteria. Read More

View Article and Full-Text PDF

One Decade of Online Patient Feedback: Longitudinal Analysis of Data From a German Physician Rating Website.

J Med Internet Res 2021 Jul 26;23(7):e24229. Epub 2021 Jul 26.

Institute of History and Ethics in Medicine, Technical University of Munich, Munich, Germany.

Background: Feedback from patients is an essential element of a patient-oriented health care system. Physician rating websites (PRWs) are a key way patients can provide feedback online. This study analyzes an entire decade of online ratings for all medical specialties on a German PRW. Read More

View Article and Full-Text PDF

Feasibility, Efficacy, and Efficiency of eHealth-Supported Pediatric Asthma Care: Six-Month Quasi-Experimental Single-Arm Pretest-Posttest Study.

JMIR Form Res 2021 Jul 26;5(7):e24634. Epub 2021 Jul 26.

Biomedical Signals and Systems, University of Twente, Enschede, Netherlands.

Background: Early detection of loss of asthma control can effectively reduce the burden of the disease. However, broad implementation in clinical practice has not been accomplished so far. We are in need of research investigating the operationalization of eHealth pediatric asthma care in practice, which can provide the most potential benefits in terms of adoption, efficiency, and effectiveness. Read More

View Article and Full-Text PDF

Fetal exposure to tofacitinib during the first trimester: A healthy newborn case report.

Birth Defects Res 2021 Jul 26. Epub 2021 Jul 26.

Pharmacy Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Introduction: Preclinical studies with tofacitinib demonstrated teratogenic effects. Data about effects on human fetuses are limited and current recommendations are to immediately discontinue the treatment. Our purpose is to report a case of exposure to tofacitinib during the first trimester of pregnancy. Read More

View Article and Full-Text PDF