Talanta 2021 Apr 10;225:121993. Epub 2020 Dec 10.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China. Electronic address:
Organic-inorganic hybrid monolithic columns, due to the comprehensive advantages, have been applied as promising solid-phase separation matrices for pretreatment of complex samples in biomedical and environmental analyses, however, a tremendous time and efforts are cost to optimize the preparation methods of hybrid monolithic columns with different functional groups for various target analytes. Herein, we proposed a strategy to develop basic hybrid monolithic column materials for flexible and facile post-functionalization. Three kinds of single-functionalized (amine, thiol, and carboxyl) and two kinds of bi-functionalized (amine and thiol, and amine and carboxyl) hybrid monolithic columns were immobilized with gold nanoparticles (GNPs) as intermediary bridge to construct the universal substrates. Read More