J Control Release 2021 Jun 26;336:443-456. Epub 2021 Jun 26.
Ann Romney Center for Neurologic Diseases in the Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address:
Pyroglutamate-3 amyloid-β (pGlu3 Aβ) is an N-terminally modified, pathogenic form of amyloid-β that is present in cerebral amyloid plaques and vascular deposits. Here, we used focused ultrasound (FUS) with microbubbles to enhance the intravenous delivery of an Fc-competent anti-pGlu3 Aβ monoclonal antibody, 07/2a mAb, across the blood brain barrier (BBB) in an attempt to improve Aβ removal and memory in aged APP/PS1dE9 mice, an Alzheimer's disease (AD)-like model of amyloidogenesis. First, we demonstrated that bilateral hippocampal FUS-BBB disruption (FUS-BBBD) led to a 5. Read More