2,534 results match your criteria monocentric cohort


Type O blood group associates with higher anti-JC polyomavirus antibody levels.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Background: Patients with multiple sclerosis (MS) and high anti-JC polyomavirus (JCPyV) antibodies in blood have an increased risk for the development of progressive multifocal leukoencephalopathy (PML) when treated for MS. To test the hypothesis that type O blood group associates with anti-JCPyV antibody levels and the risk of developing PML, we characterized ABO blood group antigen on blood samples of 62 patients with PML, and 64 MS controls without PML.

Methods: Monocentric retrospective cohort study. Read More

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A Cluster of Infections in Belgian Military Personnel after Deployment in Kindu, Democratic Republic of Congo: A Retrospective Study.

Trop Med Infect Dis 2021 Jul 8;6(3). Epub 2021 Jul 8.

Center for Infectious Diseases, Queen Astrid Military Hospital, 1120 Brussels, Belgium.

malaria is often neglected due to its less severe course compared to . In 2011-2012, Belgian Armed Forces identified a cluster of cases among military personnel after deployment in the Democratic Republic of Congo (DRC). In this retrospective, monocentric, observational study, clinical and biological features of soldiers diagnosed with after deployment in DRC were reviewed. Read More

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Association of serum vitamin D levels with disease severity, systemic inflammation, prior lung function loss and exacerbations in a cohort of patients with chronic obstructive pulmonary disease (COPD).

J Thorac Dis 2021 Jun;13(6):3597-3609

Department of Pneumology, University Hospital and Medical Faculty, Health Campus Immunology, Infectiology, and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Vitamin D deficiency has been associated with chronic disorders including chronic obstructive pulmonary disease (COPD) but the relationships with inflammation, exacerbations and disease progression remain unclear.

Methods: In this monocentric cross-sectional observational study we analyzed the disease status, systemic inflammation, prior exacerbation frequency and loss in lung function in relation to serum 25-hydroxyvitamin D (25-OHD) levels in a cohort of 94 patients with COPD. Serum 25-OHD, C-reactive protein, interleukin-6 and tumor necrosis factor-α were quantified. Read More

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Long-term clinical follow up of patients suffering from moderate to severe COVID-19 infection: A monocentric prospective observational cohort study.

Int J Infect Dis 2021 Jul 14. Epub 2021 Jul 14.

Department of Pneumology, University hospital of Liège, Liège, Belgium.

Objectives: Various symptoms and considerable organ dysfunction persist following SARS-CoV-2 infection. Uncertainty remains about the potential mid- and long-term health sequelae. We prospectively studied patients hospitalized for COVID-19 in Liège University Hospital, Belgium, to determine the persistent consequences of Coronavirus disease 2019 (COVID-19). Read More

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[Neurogenic bladder and continent cystostomy: Results of a monocentric cohort in a French university hospital].

Prog Urol 2021 Jul 10. Epub 2021 Jul 10.

Service d'urologie et andrologie, centre hospitalier universitaire François-Mitterrand Dijon, centre hospitalier Robert-Morlevat Semur-en-Auxois, 14, rue Paul-Gaffarel, 21000 Dijon, France.

Objective: The main objective was to evaluate the complications of continuous urinary shunts in a French university hospital according to surgical technique and functional results especially on continence. The secondary objective was to evaluate the management of complications.

Methods: A retrospective study was conducted between January 2008 and August 2017. Read More

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The role of musculoskeletal ultrasound in predicting the response to JAK inhibitors: results from a monocentric cohort.

Clin Exp Rheumatol 2021 Jun 26. Epub 2021 Jun 26.

Arthritis Center, Reumatologia, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Italy.

Objectives: In this longitudinal study, we assessed the role of musculoskeletal ultrasound (US) in predicting the efficacy of JAK inhibitors (JAKi) in rheumatoid arthritis (RA) patients.

Methods: We enrolled RA patients starting baricitinib or tofacitinib. All patients were evaluated at baseline and after 4, 12, 24, 48 weeks. Read More

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Effect of Anemia on the Prognosis of Patients with Ventricular Tachyarrhythmias.

Am J Cardiol 2021 Jul 8. Epub 2021 Jul 8.

First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Germany. Electronic address:

This study evaluates the prognostic impact of anemia in patients presenting with ventricular tachyarrhythmias. The present longitudinal, observational, registry-based, monocentric cohort study included retrospectively all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Anemic patients (hemoglobin levels <12. Read More

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Osteoporosis Caused by Systemic Mastocytosis: Prevalence in a Cohort of 8392 Patients with Osteoporosis.

Calcif Tissue Int 2021 Jul 5. Epub 2021 Jul 5.

Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

Indolent systemic mastocytosis (ISM) is a group of heterogenous diseases characterized by abnormal accumulation of mast cells in at least one organ. ISM can be a cause of osteoporosis. The aim of this study is to determine the prevalence, and the prognosis of ISM in a cohort of patients with osteoporosis. Read More

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Tobacco consumption is associated with slow-growing day-6 blastocysts.

F S Rep 2020 Jun 30;1(1):30-36. Epub 2020 Jun 30.

Service de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.

Objective: To investigate if there are any obvious clinical factors associated with delayed blastulation at day 6 (D6) compared with day 5 (D5).

Design: Monocentric observational cohort study from November 2012 to December 2018.

Setting: Tertiary-care academic medical center. Read More

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Long-term quality of life in necrotizing soft-tissue infection survivors: a monocentric prospective cohort study.

Ann Intensive Care 2021 Jul 2;11(1):102. Epub 2021 Jul 2.

Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France.

Background: Compared to other life-threatening infection survivors, long-term health-related quality of life (QOL) of patients surviving necrotizing soft-tissue infections (NSTI) and its determinants are little known. In this monocentric prospective cohort including NSTI survivors admitted between 2014 and 2017, QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36), the Hospital Anxiety and Depression (HAD), the activity of daily living (ADL), instrumental ADL (IADL) scales and the Impact of Event Scale-Revised (IES-R). The primary outcome measure was the SF-36 physical component summary (PCS). Read More

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High Basal Maximal Standardized Uptake Value (SUV) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse.

Cancers (Basel) 2021 Jun 9;13(12). Epub 2021 Jun 9.

Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Via Benevento 6, 00161 Rome, Italy.

Background: Despite that the unfavorable prognostic role of a high Total Metabolic Tumor Volume (TMTV) in Follicular Lymphoma has been demonstrated, the role of SUV alone at baseline PET/CT could have a different prognostic role.

Patients And Methods: We performed a retrospective observational monocentric cohort study. All patients affected by FL who underwent a basal PET/CT were included. Read More

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HPV and Cytology Testing in Women Undergoing 9-Valent HPV Opportunistic Vaccination: A Single-Cohort Follow Up Study.

Vaccines (Basel) 2021 Jun 12;9(6). Epub 2021 Jun 12.

Dipartimento di Scienze Umane, Sociali e della Salute, Università di Cassino e del Lazio Meridionale, 03043 Cassino, Italy.

: This study evaluates the possible effect of 9-valent (9vHPV) vaccination on the results of HPV and cytological tests in a cohort of adult women. : This study is a retrospective, single-cohort, monocentric study. Sexually active women aged 14-70 years, who underwent 9vHPV vaccination, were enrolled. Read More

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The Dilemma of Falls in Older Persons: Never Forget to Investigate the Syncope.

Medicina (Kaunas) 2021 Jun 15;57(6). Epub 2021 Jun 15.

IRCCS Istituti Clinici Scientifici Maugeri, 20138 Milan, Italy.

: Falls represent a major cause of morbidity, hospitalizations, and mortality in older persons. The identification of risk conditions for falling is crucial. This study investigated the presence of syncope as a possible cause of falls in older persons admitted to a Sub-Acute Care Unit (SACU) with a diagnosis of accidental fall after initial management in an emergency department and acute hospitalization. Read More

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Visual Function and Ophthalmological Findings in CHARGE Syndrome: Revision of Literature, Definition of a New Clinical Spectrum and Genotype Phenotype Correlation.

Genes (Basel) 2021 Jun 25;12(7). Epub 2021 Jun 25.

Rare Diseases Unit, Fondazione Policlinico Universitario Gemelli-IRCCS, 00168 Rome, Italy.

CHARGE syndrome (CS) is a rare genetic disease causing multiple anatomical defects and sensory impairment. Visual function is usually reported by caregivers and has never been described with a structured behavioral assessment. Our primary objective was to describe ocular abnormalities, visual function and genotype-ocular-phenotype correlation in CS. Read More

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Reproductive Outcomes after Laparoscopic Myomectomy: Conventional versus Barbed Suture.

J Minim Invasive Gynecol 2021 Jun 25. Epub 2021 Jun 25.

Centre for Advanced Endoscopy & Infertility, Paul's Hospital, Kochi, India (all authors).

Study Objective: To study the reproductive outcomes after laparoscopic myomectomy comparing conventional (nonbarbed) suture with barbed suture used for myometrial defect closure.

Design: Monocentric retrospective cohort study with prospective follow-up survey for reproductive outcomes conducted in April and May 2020.

Setting: Tertiary care center (center for advanced gynecologic laparoscopy and infertility). Read More

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Surgical treatment of rhinophyma: Retrospective monocentric study and literature review.

Ann Dermatol Venereol 2021 Jun 24. Epub 2021 Jun 24.

Dermatology Department, Dermatological Procedures Unit, Bordeaux University Hospital, Hôpital Saint-André, 1, rue Jean Burguet, 33000 Bordeaux, France. Electronic address:

Background: Treatment of rhinophyma consists primarily of destructive procedures. There is currently no consensus regarding treatment. In this study, we propose an algorithm based on a cohort of 25 patients and a literature review. Read More

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Impact of early nutrition route in patients receiving extracorporeal membrane oxygenation: A retrospective cohort study.

JPEN J Parenter Enteral Nutr 2021 Jun 24. Epub 2021 Jun 24.

Intensive Care Unit of Cardiothoracic Surgery, Anesthesia and Critical Care Department, Hôpital Nord Laennec, CHU Nantes, Nantes, France.

Background: Early nutrition management in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. Despite its potentially beneficial effect, enteral nutrition (EN) could be associated with gastrointestinal (GI) complications. Total daily energy requirements remain difficult to achieve with ECMO support. Read More

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Impact of the type of endometrial oestrogen preparation for frozen-thawed embryo (vaginal or transdermal) on perinatal outcomes in an artificial cycle.

J Gynecol Obstet Hum Reprod 2021 Jun 19;50(9):102187. Epub 2021 Jun 19.

Department of Obstetrics and Gynecology, Angers University Hospital, Angers, France. Electronic address:

Introduction: Serum oestradiol concentration at the time of frozen embryo transfer (FET) in artificial cycle are lower when using transdermal administration of oestrogen for endometrial preparation compared to the vaginal route. This difference could have consequences for placentation and establishment of maternal-foetal circulation. The aim of our study was to compare the birth weight of newborns and the perinatal issues after FET in an artificial cycle with regard to the route of administration of oestrogens. Read More

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Operative variations in temporal lobe epilepsy surgery and seizure and memory outcome in 226 patients suffering from hippocampal sclerosis.

Neurol Res 2021 Jun 22:1-10. Epub 2021 Jun 22.

Department of Neurosurgery, Medical University Vienna, Vienna, Austria.

: The aim of this retrospective cohort study was to assess seizure and memory outcomes following temporal lobe surgery in patients suffering from medically refractory temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS).: A retrospective monocentric data analysis was performed in consecutive patients who were operated on during 2002-2018. In the first decennium, standard temporal lobe resections (TLR) were predominately performed, and later, antero-temporal lobe resections (ATLR) were mainly performed. Read More

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The effect of a 24-week training focused on activities of daily living, muscle strengthening, and stability in idiopathic inflammatory myopathies: a monocentric controlled study with follow-up.

Arthritis Res Ther 2021 06 21;23(1):173. Epub 2021 Jun 21.

Institute of Rheumatology, Na Slupi 4, 128 00, Prague 2, Czech Republic.

Background: The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to assess the effect of a 24-week program combining a supervised training of activities of daily living (ADL), resistance, and stability with home exercise for improving muscle function, compared to a daily home-based exercise representing the regular outpatient care.

Methods: Fifty-seven patients with IIM were consecutively and non-selectively enrolled in an intervention (IG, n = 30) or control (CG, n = 27) group. Read More

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General health of patients with diabetic macular edema-The LIPSIA study.

PLoS One 2021 11;16(6):e0252321. Epub 2021 Jun 11.

Department of Ophthalmology, University Hospital Leipzig, Leipzig, Germany.

Purpose: Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.

Methods: Prospective, monocentric observational study. Read More

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[Local spinal profile following operative treatment of thoracolumbar and lumbar fractures : Impact of reduction technique and bone quality].

Unfallchirurg 2021 Jun 10. Epub 2021 Jun 10.

Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Background: The goal of surgery for spinal injuries is fracture reduction, fixation and stable healing in a physiological position. Several open and minimally invasive surgical techniques are available.

Objective: The extent of open reduction and the fixation potential achieved by the AOSpine (AT) and Kluger (KT) techniques were compared. Read More

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Prevalence of carotid web in a French cohort of cryptogenic stroke.

J Neurol Sci 2021 May 28;427:117513. Epub 2021 May 28.

Unité Neurovasculaire, Département de Neurologie, Hôpital Gui de Chauliac, Montpellier, France. Electronic address:

Background And Purpose: Carotid webs (CaW) may be an under-recognized cause of anterior circulation cryptogenic ischemic stroke (ACIS). Prevalence is still unknown in European patients with ACIS.

Objective: To evaluate the prevalence of CaW in ACIS and describe patients with CaW phenotype in a cohort of patients from a French stroke center. Read More

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Preoperative nTMS and Intraoperative Neurophysiology - A Comparative Analysis in Patients With Motor-Eloquent Glioma.

Front Oncol 2021 21;11:676626. Epub 2021 May 21.

Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Background: The resection of a motor-eloquent glioma should be guided by intraoperative neurophysiological monitoring (IOM) but its interpretation is often difficult and may (unnecessarily) lead to subtotal resection. Navigated transcranial magnetic stimulation (nTMS) combined with diffusion-tensor-imaging (DTI) is able to stratify patients with motor-eloquent lesion preoperatively into high- and low-risk cases with respect to a new motor deficit.

Objective: To analyze to what extent preoperative nTMS motor risk stratification can improve the interpretation of IOM phenomena. Read More

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Targeted Next Generation Sequencing and Diagnosis of Congenital Hemolytic Anemias: A Three Years Experience Monocentric Study.

Front Physiol 2021 21;12:684569. Epub 2021 May 21.

UOS Fisiopatologia delle Anemie, UOC Ematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Congenital hemolytic anemias (CHAs) are heterogeneous and rare disorders caused by alterations in structure, membrane transport, metabolism, or red blood cell production. The pathophysiology of these diseases, in particular the rarest, is often poorly understood, and easy-to-apply tools for diagnosis, clinical management, and patient stratification are still lacking. We report the 3-years monocentric experience with a 43 genes targeted Next Generation Sequencing (t-NGS) panel in diagnosis of CHAs; 122 patients from 105 unrelated families were investigated and the results compared with conventional laboratory pathway. Read More

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Skin diseases in hospitalized geriatrics: a 9-year analysis from a University Dermatology Center in Germany.

Arch Dermatol Res 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology and Venereology, Medical Center, Faculty of Medicine, University of Freiburg, Hauptstraße 7, 79104, Freiburg, Germany.

The demographic trend of an ageing society is mirrored in the rising number of hospitalized geriatric patients in Germany. However, there is still a wide gap of knowledge regarding the dermatological diseases, comorbidities and performed procedures within this growingly important group of patients. The study was conducted as a retrospective monocentric data analysis of all patients 65 years or older from the Department of Dermatology, Medical Center-University of Freiburg, Germany. Read More

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Free flap for soft palate reconstruction: long-term functional evaluation of a new technique.

Eur Arch Otorhinolaryngol 2021 Jun 2. Epub 2021 Jun 2.

Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, Service d'ORL, BH 10 CHUV, Avenue du Bugnon, 46-1011, Lausanne, Switzerland.

Purpose: The soft palate (SP) has a complex anatomy and physiology. Reconstruction after tumour resection is a challenge, and procedures that only restore bulk don't give good results. We aim to present a new technique for the in-setting and the functional outcomes. Read More

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Correlation between oncological family history and clinical outcome in a large monocentric cohort of pediatric patients with rhabdomyosarcoma.

Int J Clin Oncol 2021 Aug 1;26(8):1561-1568. Epub 2021 Jun 1.

Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: Rhabdomyosarcoma (RMS), an aggressive soft tissue sarcoma of the skeletal muscle generally affecting children and adolescents, shows extensive heterogeneity in histology, site and age of onset, clinical course, and prognosis. Tumorigenesis of RMS is multifactorial and genetic predisposition together with the family history of cancer may provide critical information to enhance the current knowledge and foster genetic counseling and testing.

Methods: In our study, we evaluated the possible correlation of oncological family history with clinical outcomes in a cohort of RMS 512 patients and treated at the Pediatric Oncology Unit of our Institute. Read More

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