17,795 results match your criteria molecules greater


Plasmon-Driven Interfacial Catalytic Reactions in Plasmonic MOF Nanoparticles.

Anal Chem 2021 Sep 21. Epub 2021 Sep 21.

National-municipal Joint Engineering Laboratory for Chemical Process, Intensification and Reaction, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, PR China.

Benefiting from the noble metal nanoparticle core and organic porous nanoshell, plasmonic metal-organic frameworks (MOFs) become a nanostructure with great enhancement of the electromagnetic field and a high density of reaction sites, which has fantastic optical properties in surface plasmon-related fields. In this work, the plasmon-driven interfacial catalytic reactions involving -aminothiophenol to 4,4'-dimercaptoazobenzene (-DMAB) in both the liquid and gaseous phases are studied in plasmonic MOF nanoparticles, which consist of a Ag nanoparticle core and an organic shell (ZIF-8). The surface-enhanced Raman spectroscopy (SERS) spectra recorded at the plasmonic MOF in an aqueous environment demonstrate that the reversible plasmon-driven interfacial catalytic reactions could be modulated by a reductant (NaBH) or oxidant (HO). Read More

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September 2021

A prion accelerates proliferation at the expense of lifespan.

Elife 2021 09 15;10. Epub 2021 Sep 15.

Department of Chemical & Systems Biology, Stanford University School of Medicine, Stanford, United States.

In fluctuating environments, switching between different growth strategies, such as those affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise, however. Mechanisms that aberrantly increase cell size or proliferation-such as mutations or chemicals that interfere with growth regulatory pathways-can also shorten lifespan. Read More

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September 2021

Memory specific to temporal features of sound is formed by cue-selective enhancements in temporal coding enabled by inhibition of an epigenetic regulator.

J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Dept. of Psychology, Rutgers- The State University of New Jersey, Piscataway, NJ 08854.

Recent investigation of memory-related functions in the auditory system have capitalized on the use of memory-modulating molecules to probe the relationship between memory and its substrates in auditory system coding. For example, epigenetic mechanisms, which regulate gene expression necessary for memory consolidation, are powerful modulators of learning-induced neuroplasticity and long-term memory formation (LTM). Inhibition of the epigenetic regulator histone deacetylase 3 (HDAC3) promotes LTM that is highly specific for features of sound. Read More

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September 2021

Hematopoietic and non-hematopoietic p66Shc differentially regulates stem cell traffic and vascular response to ischemia in diabetes.

Antioxid Redox Signal 2021 Sep 20. Epub 2021 Sep 20.

University of Padova, Department of Medicine, Via Giustiniani 2, Padova, Italy, 35128;

Aims: Peripheral artery disease (PAD) is a severe complication of diabetes, characterized by defective traffic of hematopoietic stem/progenitor cells (HSPCs). We examined the hematopoietic versus non-hematopoietic role of p66Shc in regulating HSPC traffic and blood flow recovery after ischemia in diabetic mice.

Results: Using streptozotocin-induced diabetes, chimeric mice with GFP+ bone marrow (BM), and the hind-limb ischemia model, we found that the physiologic mobilization and homing of HSPCs was abolished by diabetes, along with impaired vascular recovery. Read More

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September 2021

Responses of steroid estrogen biodegradation to cyanobacterial organic matter biodegradability in the water column of a eutrophic lake.

Sci Total Environ 2021 Sep 2;805:150058. Epub 2021 Sep 2.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

The co-occurrence of cyanobacterial harmful algal blooms and contaminants is an increasing environmental concern in freshwater worldwide. Our field investigations coupled with laboratory incubations demonstrated that the microbial degradation potential of 17β-estradiol (E2) with estrone as the intermediate was primarily driven by increased dissolved organic matter (DOM) in the water column of a cyanobacterial bloom. To explain the intrinsic contribution of cyanobacterial-derived DOM (C-DOM) to estrogen biodegradation, a combination of methods including bioassay, ultrahigh-resolution mass spectrometry, and microbial ecology were applied. Read More

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September 2021

A TbPO-based capturer for environmental extracellular antibiotic genes by interrogating lanthanide phosphates nanoneedles.

J Hazard Mater 2021 Sep 10;423(Pt B):127139. Epub 2021 Sep 10.

School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China. Electronic address:

Accurate determination of antibiotic resistance genes (ARGs) in environmental DNA molecules (eDNA) is challenging owing to its low abundance in the aquatic environment. Here we report a facile and cost-efficient approach to extract trace amount of eDNAs in the aquatic environment using LnPO nanomaterials. Among the nanomaterials, less crystalline TbPO nanoneedles was identified as the most prominent candidate for long stranded DNA and short stranded DNA with adsorption efficiency above 97%. Read More

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September 2021

Determination of lipid profiles of Dezhou donkey meat using an LC-MS-based lipidomics method.

J Food Sci 2021 Sep 17. Epub 2021 Sep 17.

College of Agronomy, Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, China.

Intramuscular fat (IMF) is an important factor affecting meat quality, but lipid and metabolic profiles of donkey meat remain unclear. The present study was conducted to investigate lipid characteristics in different parts of Dezhou donkey using lipidomics. The results show that IMF was more abundant in longissimus dorsi muscle (LDM) than rump muscle (RM) and hamstring muscle (HM), and mainly composed of triglycerides (TGs) rich in saturated fatty acid (SFAs) and monounsaturated fatty acid (MUFAs). Read More

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September 2021

Local delivery strategies to restore immune homeostasis in the context of inflammation.

Adv Drug Deliv Rev 2021 Sep 13:113971. Epub 2021 Sep 13.

Department of Bioengineering, University of Pittsburgh, 302 Benedum Hall, 3700 O'Hara Street, Pittsburgh PA 15260; Department of Chemical Engineering, University of Pittsburgh, 940 Benedum Hall, 3700 O'Hara Street, Pittsburgh PA, 15213; Department of Clinical and Translational Science, University of Pittsburgh, Forbes Tower, Suite 7057, Pittsburgh PA, 15213; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh PA 15219; Department of Immunology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh PA 15213; Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Terrace Street, Pittsburgh PA, 15213; Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh PA, 15213. Electronic address:

Immune homeostasis is maintained by a precise balance between effector immune cells and regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater ratio of effector to regulatory cues, can promote the development and propagation of inflammatory diseases/conditions (i.e. Read More

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September 2021

Operating regimes of cavity solitons by virtue of a graphene flake saturable absorber.

Phys Rev E 2021 Aug;104(2-1):024209

School of Physics and Materials Science, Thapar Institute of Engineering and Technology, Patiala - 147004, Punjab, India.

Exploiting the. broadband operating frequency regimes of a graphene flake saturable absorber (GFSA), a cavity soliton (CS) is excited in heretofore unexplored ultraviolet and visible regions. A broad-area device, namely, a vertical cavity surface emitting laser (VCSEL) is taken as a host of CSs; a two-dimensional (2D) transverse soliton, which is quite different from the conventional propagating one. Read More

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Ultrafast energy transfer between lipid-linked chromophores and plant light-harvesting complex II.

Phys Chem Chem Phys 2021 Sep 15;23(35):19511-19524. Epub 2021 Sep 15.

School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK.

Light-Harvesting Complex II (LHCII) is a membrane protein found in plant chloroplasts that has the crucial role of absorbing solar energy and subsequently performing excitation energy transfer to the reaction centre subunits of Photosystem II. LHCII provides strong absorption of blue and red light, however, it has minimal absorption in the green spectral region where solar irradiance is maximal. In a recent proof-of-principle study, we enhanced the absorption in this spectral range by developing a biohybrid system where LHCII proteins together with lipid-linked Texas Red (TR) chromophores were assembled into lipid membrane vesicles. Read More

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September 2021

Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell-Derived Cells Suppresses Rhinovirus-Induced Neutrophilic Airway Inflammation by Regulating Th1- and Th17-Type Responses.

Immune Netw 2021 Aug 17;21(4):e26. Epub 2021 Aug 17.

College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University, Iksan 54596, Korea.

Asthma exacerbations are a major cause of intractable morbidity, increases in health care costs, and a greater progressive loss of lung function. Asthma exacerbations are most commonly triggered by respiratory viral infections, particularly with human rhinovirus (hRV). Respiratory viral infections are believed to affect the expression of indoleamine 2,3-dioxygenase (IDO), a limiting enzyme in tryptophan catabolism, which is presumed to alter asthmatic airway inflammation. Read More

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WAKsing plant immunity, waning diseases.

J Exp Bot 2021 Sep 14. Epub 2021 Sep 14.

Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, United Kingdom.

With the requirement to breed more productive crop plants to feed a growing global population, compounded by increasingly wide-spread resistance to pesticides exhibited by pathogens, plant immunity is becoming an increasingly important area of research. Of the genes that contribute to disease resistance, the wall-associated receptor-like kinases (WAKs) are increasingly shown to play a major role, in addition to their contribution to plant growth and development or tolerance to abiotic stresses. Being transmembrane proteins, WAKs form a central pillar of a plant cells ability to monitor and interact with their extracellular environments. Read More

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September 2021

Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds.

J Pharm Pharm Sci 2021 ;24:475-483

College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Purpose: Organic anion transporting polypeptide (OATP) 1B3 transports many clinically important drugs, including statins, from blood into the liver. It exclusively expresses in human liver under normal physiological conditions. There is no rodent ortholog of human OATP1B3. Read More

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January 2021

Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution.

J Food Biochem 2021 Sep 12:e13917. Epub 2021 Sep 12.

Division of Human Ecology, Korea National Open University, Seoul, Korea.

A continuous high-fat/high-fructose diet induces inflammation and lowers vascular endothelial function in the body. This research examined the effects of black raspberry (BR) powder consumption on the inflammatory response and endothelial dysfunction in rats fed with a high-fat diet and fructose solution. Wistar rats were randomly divided into two groups as control (AIN-93G diet + distilled water) and HFF (high-fat diet + 20% fructose solution) groups, for 16 weeks. Read More

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September 2021

Systems analysis of miRNA biomarkers to inform drug safety.

Arch Toxicol 2021 Sep 12. Epub 2021 Sep 12.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool, L69 3GE, UK.

microRNAs (miRNAs or miRs) are short non-coding RNA molecules which have been shown to be dysregulated and released into the extracellular milieu as a result of many drug and non-drug-induced pathologies in different organ systems. Consequently, circulating miRs have been proposed as useful biomarkers of many disease states, including drug-induced tissue injury. miRs have shown potential to support or even replace the existing traditional biomarkers of drug-induced toxicity in terms of sensitivity and specificity, and there is some evidence for their improved diagnostic and prognostic value. Read More

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September 2021

Is the Antibacterial Activity of Multi-Walled Carbon Nanotubes (MWCNTs) Related to Antibiotic Resistance? An Assessment in Clinical Isolates.

Int J Environ Res Public Health 2021 Sep 3;18(17). Epub 2021 Sep 3.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.

Antimicrobial resistance has spread globally, compromising the treatment of common infections. This feature is particularly harmful for nosocomial pathogens that can survive on hospital surfaces. Research studies have been conducted to evaluate new materials that are able to counteract the microbial growth and the colonization of the hospital environment. Read More

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September 2021

Validation of an Analytical Method for the Simultaneous Determination of Hyaluronic Acid Concentration and Molecular Weight by Size-Exclusion Chromatography.

Molecules 2021 Sep 3;26(17). Epub 2021 Sep 3.

Tecnología Alimentaria, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Normalistas 800, Guadalajara C.P. 44270, Jalisco, Mexico.

The hyaluronic acid (HA) global market growth can be attributed to its use in medical, cosmetic, and pharmaceutical applications; thus, it is important to have validated, analytical methods to ensure confidence and security of its use (and to save time and resources). In this work, a size-exclusion chromatography method (HPLC-SEC) was validated to determine the concentration and molecular distribution of HA simultaneously. Analytical curves were developed for concentration and molecular weight in the ranges of 100-1000 mg/L and 0. Read More

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September 2021

Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32.

Molecules 2021 Sep 1;26(17). Epub 2021 Sep 1.

Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.

Imidazo[1,2-]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity. Two of these substituted 3-nitro-6-amino-imidazo[1,2-]pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC 40-50 nM), which we have previously reported. In this study, we wanted to test the biological efficacy of these compounds. Read More

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September 2021

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics.

Molecules 2021 Sep 1;26(17). Epub 2021 Sep 1.

Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul 04763, Korea.

Amongst the countless marine organisms, seaweeds are considered as one of the richest sources of biologically active ingredients having powerful biological activities. Seaweeds or marine macroalgae are macroscopic multicellular eukaryotic photosynthetic organisms and have the potential to produce a large number of valuable compounds, such as proteins, carbohydrates, fatty acids, amino acids, phenolic compounds, pigments, etc. Since it is a prominent source of bioactive constituents, it finds diversified industrial applications viz food and dairy, pharmaceuticals, medicinal, cosmeceutical, nutraceutical, etc. Read More

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September 2021

Evaluation of Chemical Compositions, Antioxidant Capacity and Intracellular Antioxidant Action in Fish Bone Fermented with .

Molecules 2021 Aug 31;26(17). Epub 2021 Aug 31.

Department of Chemical and Materials Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 80778, Taiwan.

Fish bones (FBs) are aquatic by-products that are sources of antioxidant-active peptides, calcium dietary supplements, and biomedical materials. Usually, fermentation of these by-products via microorganisms brings desirable changes, enhancing their value. This study investigates the value addition of FB when fermented with (MP) for different time intervals, such as 3 days (F3) and 6 days (F6). Read More

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Dynamic Behavior of Rotation Transmission Nano-System in Helium Environment: A Molecular Dynamics Study.

Molecules 2021 Aug 27;26(17). Epub 2021 Aug 27.

School of Material Science and Engineering, Nanchang Hangkong University, Nanchang 330063, China.

The molecular dynamics (MD) method is used to investigate the influence of the shielding gas on the dynamic behavior of the heterogeneous rotation transmission nano-system (RTS) built on carbon nanotubes (CNTs) and boron nitride nanotube (BNNT) in a helium environment. In the heterogeneous RTS, the inner CNT acts as a rotor, the middle BNNT serves as a motor, and the outer CNT functions as a stator. The rotor will be actuated to rotate by the motor due to the interlayer van der Waals effects and the end effects. Read More

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Analysis of Processing Effects on Glucosinolate Profiles in Red Cabbage by LC-MS/MS in Multiple Reaction Monitoring Mode.

Molecules 2021 Aug 26;26(17). Epub 2021 Aug 26.

Food Science Institute, Zhejiang Academy of Agricultural Sciences, Hangzhou 311300, China.

Red cabbage ( L. var. ) continues to receive increasing attention on its health-promoting properties because of its high glucosinolate content. Read More

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Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

Bioorg Med Chem 2021 Aug 5;46:116349. Epub 2021 Aug 5.

Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States. Electronic address:

Human epithelial 15-lipoxygenase-2 (h15-LOX-2, ALOX15B) is expressed in many tissues and has been implicated in atherosclerosis, cystic fibrosis and ferroptosis. However, there are few reported potent/selective inhibitors that are active ex vivo. In the current work, we report newly discovered molecules that are more potent and structurally distinct from our previous inhibitors, MLS000545091 and MLS000536924 (Jameson et al, PLoS One, 2014, 9, e104094), in that they contain a central imidazole ring, which is substituted at the 1-position with a phenyl moiety and with a benzylthio moiety at the 2-position. Read More

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Insights into the Factors Controlling the Origin of Activation Barriers in Group 13 Analogues of the Four-Membered N-Heterocyclic Carbenes.

ACS Omega 2021 Aug 20;6(34):22272-22283. Epub 2021 Aug 20.

Department of Applied Chemistry, National Chiayi University, Chiayi 60004, Taiwan.

The mechanisms of C-H bond insertion and alkene cycloaddition were investigated theoretically using five model systems: group 13 analogues of the four-membered nucleophilic -heterocyclic carbenes (NHCs) (; E = group 13 element). The theoretical findings indicate that, except for with HC=CH, these four-membered NHCs undergo insertion and [1 + 2] cycloaddition reactions with difficulty because their activation barriers are quite high (31 kcal/mol). The theoretically confirmed chemical inertness of the four-membered NHCs and might explain why they have been experimentally detected at room temperature. Read More

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Application of Oleogel and Conventional Fats for Ultrasound-assisted Obtaining of Vegan Creams.

J Oleo Sci 2021 Sep 8. Epub 2021 Sep 8.

Department of Physicochemistry and Material Technology, Kazimierz Pulaski University of Technologies and Humanities.

The purpose of this study was to determine the impact of the fat system type (milk fat - MF, palm oil - PO or oleogel - OG, i.e. RO-LO - rapeseed oil and linseed oil mixture structured by candelilla wax) on the properties of soy creams, in comparison with dairy cream. Read More

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September 2021

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye.

Cutan Ocul Toxicol 2021 Sep 8:1-9. Epub 2021 Sep 8.

Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.

Purpose: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).

Methods: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0. Read More

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September 2021

Improving identification of low abundance and hydrophobic proteins using fluoroalcohol mediated supramolecular biphasic systems with quaternary ammonium salts.

J Chromatogr A 2021 Aug 18;1655:462483. Epub 2021 Aug 18.

Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA. Electronic address:

In this study, a newly discovered Supramolecular Biphasic System (S-BPS) was used in bottom-up proteomics of the Saccharomyces cerevisiae strain of yeast. We took advantage of S-BPS in bottom-up proteomics of this strain of yeast as the protein sample, while the results were compared to routinely used solubilizing reagents, such as urea, and sodium dodecyl sulfate (SDS). With the S-BPS, we identified 3043 proteins as compared to 2653 proteins that were identified in the control system. Read More

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Ultrasonication enhanced the multi-scale structural characteristics of rice starch following short-chain fatty acids acylation.

Int J Biol Macromol 2021 Sep 4;190:333-342. Epub 2021 Sep 4.

College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China; ARC Functional Grains Centre, Charles Sturt University, Wagga Wagga, NSW 2678, Australia. Electronic address:

Considering the variation of the diffusion character of the three anhydrides, ultrasonication was applied for investigating its impact on the reaction efficiency of the rice starch acylation from three short-chain fatty acids (SCFAs). The current data indicated that the signal peak of the FTIR spectrum at 1720 cm and additional resonances in the NMR confirmed the occurrence of the acylation reaction onto the starch molecules. More interestingly, this is the first study to reveal that a lower power density ultrasonication improved the reaction efficiencies of acetylation (19%), while a higher power density could lead to a reduced acylation reactivity of propionylation compared to the control one. Read More

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September 2021

Simple lattice model of self-assembling metal-organic layers of pyridyl-substituted porphyrins and copper on Au(111) surface.

Phys Chem Chem Phys 2021 Sep 22;23(36):20365-20378. Epub 2021 Sep 22.

Omsk State Technical University, 11 Mira, Omsk, 644050, Russian Federation.

A simple lattice model of metal-organic adsorption layers self-assembling on a Au(111) surface and based on pyridyl-substituted porphyrins differing in the number of functional groups and their position has been proposed. The model has been parameterized using DFT methods. The ground state analysis of the considered model demonstrates the variety of surface-confined metal-organic networks (SMONs) containing square, linear, and discrete elements appearing in the adsorption layer depending on the partial pressure of the components. Read More

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September 2021

Systematic Review and Recommendations to Combine Newer Therapies With Conventional Therapy in Psoriatic Disease.

Front Med (Lausanne) 2021 19;8:696597. Epub 2021 Aug 19.

Consultant Dermatologist, Mehektagul Dermaclinic, New Delhi, India.

Psoriasis continues to have unmet needs in its management despite introduction of newer molecules. Monotherapy with these newer agents may not achieve therapeutic goals in all cases, hence necessitating their combinations with other molecules. Improved understanding of newer as well as conventional treatment modalities and experiences in their combinations hence necessitates therapeutic guidelines for their use in psoriasis. Read More

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