5,961 results match your criteria molecularly imprinted


Biodegradable magnesium ion-doped silica-based molecularly imprinted nanoparticles for targeting tumor cells to drugs controlled release and recognition mechanism research.

Colloids Surf B Biointerfaces 2022 Jun 27;217:112665. Epub 2022 Jun 27.

College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China.

Herein, we designed and constructed a novel biodegradable molecularly imprinted nanoparticles (Mg-SMSNs/DOX-Ce6 @MIPs) using a new degradable functional monomer prepared by glycerol and lactide, on magnesium ion-doped stellated mesoporous silica nanoparticles (Mg-SMSNs). These nanoparticles loaded with the anticancer drug doxorubicin (DOX) and chlorin e6 (Ce6) were used to target sialic acid (SA) overexpressed on the surface of tumor cells and release drugs in response to the tumor microenvironment. The molecularly imprinted layer avoided premature drug leakage, meanwhile, the large number of ester bonds contained in the functional monomers in the layer degraded by protonation in the tumor microenvironment to expose the drugs. Read More

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Surface Characteristics and Formation of Polyserotonin Thin Films for Bioelectrical and Biocompatible Interfaces.

Langmuir 2022 Jul 1. Epub 2022 Jul 1.

Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

In this study, we examined the fundamental surface characteristics of a polyserotonin (pST) film, which is attractive as a bioelectrical and biocompatible interface of biosensors. The pST film can easily be modified on electrode materials such as Au by self-polymerization and electropolymerization. By a simple cytotoxicity test using nonadhesive living cells, we found that the pST film is biocompatible for culturing cells on it. Read More

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Molecularly-imprinted polymer-base bulk optode for the determination of ivabradine hydrochloride in Procoralan®.

RSC Adv 2022 Jun 15;12(27):17645-17654. Epub 2022 Jun 15.

Department of Chemistry, Faculty of Women, Ain Shams University Cairo Egypt.

IVH may be administered orally twice per day for treating heart failure, sinus rhythm, heart-related chest pain and angina pectoris, and its overdose may cause problems such as blurred vision, uncontrolled blood pressure, prolonged bradycardia, and others. A molecularly imprinted polymer-based bulk optode, miptode, was constructed for the determination of ivabradine hydrochloride (IVH) in its pharmaceutical preparation Procoralan®. The molecularly-imprinted polymers (MIPs) were prepared in different ratios, and MIP3 had the highest imprinting factor (1. Read More

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Molecular imprinting as a tool for determining molecular markers: a lung cancer case.

RSC Adv 2022 Jun 15;12(28):17747-17754. Epub 2022 Jun 15.

School of Chemistry, College of Science and Engineering, University of Leicester Leicester UK +44-(0)116-0294-4666.

Determining which cancer patients will be sensitive to a given therapy is essential for personalised medicine. Thus, it is important to develop new tools that will allow us to stratify patients according to their predicted response to treatment. The aim of work presented here was to use molecular imprinting for determining the sensitivity of lung cancer cell lines to ionising radiation based on cell surface proteomic differences. Read More

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Portable and on-site electrochemical sensor based on surface molecularly imprinted magnetic covalent organic framework for the rapid detection of tetracycline in food.

Food Chem 2022 Jun 20;395:133532. Epub 2022 Jun 20.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:

In this study, for the first time, surface molecularly imprinted magnetic covalent organic frameworks ([email protected]@MIPs) were combined with disposable screen-printed electrode (SPE) to construct a portable and on-site electrochemical sensor for the rapid detection of tetracycline (TC). The [email protected]@MIPs, which was prepared by layer-by-layer modification method, had good magnetism and excellent adsorption ability. With the help of disposable SPE, equipped with a magnet, the electrode modification process was simplified and the detection efficiency was improved. Read More

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Recent Advances in the Application of Covalent Organic Frameworks in Extraction: A Review.

Crit Rev Anal Chem 2022 Jun 26:1-34. Epub 2022 Jun 26.

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu Province, China.

Covalent organic frameworks (COFs) are a class of emerging materials that are synthesized based on the covalent bonds between different building blocks. COFs possess unique attributes in terms of high porosity, tunable structure, ordered channels, easy modification, large surface area, and great physical and chemical stability. Due to these features, COFs have been extensively applied as adsorbents in various extraction modes. Read More

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An insight into polyscopoletin electrosynthesis by a quality-by-design approach.

J Mater Sci 2022 Jun 22:1-15. Epub 2022 Jun 22.

Laboratorio di Chimica Analitica, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali (Di.S.Te.B.A.), Università del Salento, 73100 Lecce, Italy.

Scopoletin (SP) as a functional monomer for electropolymerization has recently been investigated in the context of molecularly imprinted polymers for biosensing applications. Herein we describe an in-depth analysis of the mechanisms involved in the electropolymerization of SP toward the optimization of the experimental conditions for applications in sensor studies. PolySP films have been in situ synthesized on a standard glassy carbon electrodes by varying three independent experimental parameters, and the output of the analysis has been evaluated in terms of the resulting electroactive area and surface coverage. Read More

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Highly selective molecularly imprinted-electrochemiluminescence sensor based on perovskite/Ru(bpy) for simazine detection in aquatic products.

Sci Total Environ 2022 Jun 24;843:156925. Epub 2022 Jun 24.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China. Electronic address:

A novel molecularly imprinted electrochemiluminescence (MIECL) sensor based on the luminescence of molecularly imprinted polymer-perovskite (MIP-CsPbBr) layer and Ru(bpy) was fabricated for simazine detection. MIP-CsPbBr layers were immobilized onto the surface of glassy carbon electrode as the capture and signal amplification probe, and Ru(bpy) and co-reactant tripropylamine exhibited stronger electrochemiluminescence (ECL) emission. Under optimal conditions, the ECL signal of the MIECL sensor was linearly quenched, with the logarithm of simazine concentration ranging from 0. Read More

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A molecularly-imprinted SERS sensor based on a [email protected] substrate for the selective capture and sensitive detection of tryptamine in foods.

Food Chem 2022 Jun 21;394:133536. Epub 2022 Jun 21.

Key Laboratory of Food Processing Technology and Quality Control in Shandong Province, College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271018, People's Republic of China. Electronic address:

Herein, a molecularly imprinted surface-enhanced Raman spectroscopy (SERS) sensor was developed for the selective capture and sensitive detection of tryptamine in foods. The SERS sensor exploited silver nanoparticle-decorated TiO ([email protected]) substrates for Raman signal enhancement via synergistic effect of electromagnetic enhancement and photoinduced charge-transfer, whilst surface functionalization with the molecularly imprinted polymer ensured selective tryptamine capture. The SERS spectrum of tryptamine on the sensor closely matched that predicted by density functional simulations. Read More

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Recent development in the design of artificial enzymes through molecular imprinting technology.

J Mater Chem B 2022 Jun 24. Epub 2022 Jun 24.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China.

Enzymes, a class of proteins or RNA with high catalytic efficiency and specificity, have inspired generations of scientists to develop enzyme mimics with similar capabilities. Many enzyme mimics have been developed in the past few decades based on small molecules, DNA, and nanomaterials. These artificial enzymes are of great interest because of their low cost and high stability. Read More

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Biosensors for with Molecularly Imprinted Polymer (MIP) Technique.

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. ( is the most common cause of nosocomial infections in hospitals. can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. Read More

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Preparation and Recognition Properties of Molecularly Imprinted Nanofiber Membrane of Chrysin.

Polymers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.

The separation and extraction of chrysin from active ingredients of natural products are of great significance, but the existing separation and extraction methods have certain drawbacks. Here, chrysin molecularly imprinted nanofiber membranes (MINMs) were prepared by means of electrospinning using chrysin as a template and polyvinyl alcohol and natural renewable resource rosin ester as membrane materials, which were used for the separation of active components in the natural product. The MINM was examined using Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Read More

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Integration of Adenylate Kinase 1 with Its Peptide Conformational Imprint.

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Department of Chemistry, National Dong Hwa University, Hualien 97403, Taiwan.

In the present study, molecularly imprinted polymers (MIPs) were used as a tool to grasp a targeted α-helix or β-sheet of protein. During the fabrication of the hinge-mediated MIPs, elegant cavities took shape in a special solvent on quartz crystal microbalance (QCM) chips. The cavities, which were complementary to the protein secondary structure, acted as a peptide conformational imprint (PCI) for adenylate kinase 1 (AK1). Read More

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Technology for Rapid Detection of Cyromazine Residues in Fruits and Vegetables: Molecularly Imprinted Electrochemical Sensors.

Biosensors (Basel) 2022 Jun 14;12(6). Epub 2022 Jun 14.

Key Laboratory of Germplasm Resources Biology of Tropical Special Ornamental Plants of Hainan Province, College of Forestry, Hainan University, Haikou 570228, China.

Cyromazine is an insect growth regulator insecticide with high selectivity and is widely used in the production and cultivation of fruits and vegetables. In recent years, incidents of excessive cyromazine residues in food have occurred frequently, and it is urgent to establish an accurate, fast, and convenient method for the detection of cyromazine residues to ensure the safety of edible agricultural products. To achieve rapid detection of cyromazine residues, we prepared a molecularly imprinted electrochemical sensor for the detection of cyromazine residues in agricultural products. Read More

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Towards Development of Molecularly Imprinted Electrochemical Sensors for Food and Drug Safety: Progress and Trends.

Biosensors (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Key Laboratory of Fermentation Engineering (Ministry of Education), College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, China.

Due to their advantages of good flexibility, low cost, simple operations, and small equipment size, electrochemical sensors have been commonly employed in food safety. However, when they are applied to detect various food or drug samples, their stability and specificity can be greatly influenced by the complex matrix. By combining electrochemical sensors with molecular imprinting techniques (MIT), they will be endowed with new functions of specific recognition and separation, which make them powerful tools in analytical fields. Read More

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Greenificated Molecularly Imprinted Materials for Advanced Applications.

Adv Mater 2022 Jun 23:e2203154. Epub 2022 Jun 23.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Shandong Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China.

Molecular imprinting technology (MIT) produces artificial binding sites with precise complementarity to substrates and thereby is capable of exquisite molecular recognition. Over five decades of evolution, it was predicted that the resulting host imprinted materials would overtake natural receptors for research and application purposes, but in practice, this has not yet been realized due to the unsustainability of their life cycles (i.e. Read More

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Application of a needle trap device packed with a [email protected] nano-composite for efficient sampling and determination of airborne diazinon pesticide.

RSC Adv 2022 May 31;12(25):16267-16276. Epub 2022 May 31.

School of Medicine, Shahrekord University of Medical Sciences Shahrekord Iran.

In this research, a novel, selective, and efficient porous adsorbent nano-composite comprising a molecularly imprinted polymer and a metal-organic framework ([email protected]) was employed for sampling, extraction and analysis of diazinon from the air by a needle trap device (NTD), for the first time. The synthesized [email protected] sorbent was characterized by the FT-IR, XRD, FE-SEM, TEM, and EDS techniques. Then, the effective parameters of the sampling (temperature and humidity) and desorption (time and temperature) process were optimized by response surface methodology (RSM). Read More

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Fully Inkjet-Printed Chemiresistive Sensor Array Based on Molecularly Imprinted Sol-Gel Active Materials.

ACS Sens 2022 Jun 22. Epub 2022 Jun 22.

Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 819-0395, Japan.

The fabrication of chemiresistive sensors by inkjet printing is recognized as a breakthrough in gas-sensing applications. One challenge of this technology, however, is how to enhance the cross-selectivity of the sensor array. Herein, we present a ketjen black (KB) ink and molecularly imprinted sol-gel (MISG) inks to support the fabrication of a fully inkjet-printed chemiresistive sensor array, enabling the highly accurate recognition of volatile organic acids (VOAs) on the molecular level. Read More

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Quartz crystal microbalance-based biosensing of hepatitis B antigen using a molecularly imprinted polydopamine film.

Talanta 2022 Jun 7;249:123659. Epub 2022 Jun 7.

Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia; Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia; Tropical Medicine and Biology Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address:

Quartz crystal microbalance (QCM)-based biosensors are highly attractive as rapid diagnostic devices for detecting infectious diseases. However, the fabrication of QCM-based biosensors often involves tedious processes due to the poor stability of the biological recognition elements. In this work, the simple self-polymerisation of dopamine was used to functionalise the QCM crystal surface with a molecularly imprinted polydopamine (MIPDA) sensing film for detecting the hepatitis B core antigen (HBcAg), a serological biomarker of hepatitis B. Read More

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An up-conversion test paper based on "switch-off" of fluorescence is constructed to sensitively and selectively detect cancer-causing dye Sudan III in lipstick.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 16;280:121515. Epub 2022 Jun 16.

State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address:

Cancer-causing dye Sudan III is banned adding to cosmetics, so a method for detecting trace Sudan III in cosmetics is established. A single dispersed up-conversion molecularly imprinted fluorescent nanoprobe is constructed and coated on the filter paper. The mechanism for detecting Sudan III by this composite fluorescent nanoprobes-paper is systematically analyzed. Read More

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Polydopamine-based molecularly imprinted electrochemical sensor for the highly selective determination of ecstasy components.

Analyst 2022 Jun 21. Epub 2022 Jun 21.

Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced Analytical Science, School of Chemistry and Chemical Engineering, c/o School of Civil Engineering, Guangzhou University, Guangzhou 510006, PR China.

3,4-Methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) are the main components of illicit stimulant drugs, also known as "ecstasy", which belong to psychoactive medicine and tend to be increasingly abused among drug addicts worldwide. Herein, an electrochemical sensor based on molecularly imprinted polydopamine ([email protected]) was developed to detect MDA and MDMA using differential pulse voltammetry (DPV). An MIP film on a Au electrode was synthesized electrochemical polymerization with the safe chemical DA as the polymerization monomer and the uncontrolled pharmaceutical intermediate 3,4-methylenedioxyphenethylamine (MDPEA) as the template molecule, which can provide a great quantity of specific binding sites and expand the practical application of the sensor. Read More

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Construction of ratiometric fluorescence sensor and test strip with smartphone based on molecularly imprinted dual-emission quantum dots for the selective and sensitive detection of domoic acid.

Chemosphere 2022 Oct 17;304:135405. Epub 2022 Jun 17.

Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, PR China; Cell and Biomolecule Recognition Research Center, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, PR China. Electronic address:

Domoic acid (DA), a highly neurotoxic metabolite produced by phytoplankton, contaminates seafood products and threats humankind. Herein, we have proposed a molecular imprinting fluorescence sensor with internal standard ratiometric mode for sensing of DA in seafood and seawater. In this study, the silicon-coated blue luminous carbon dots ([email protected]) and CdTe acted as reference probe (430 nm) and response probe (610 nm), respectively. Read More

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October 2022

Ag nanoparticles/PbTiO with in-situ photocatalytic process and its application in an ultra-sensitive molecularly imprinted hemoglobin detection.

Colloids Surf B Biointerfaces 2022 Jun 14;217:112641. Epub 2022 Jun 14.

College of Chemistry, Qishan Campus, Fuzhou University, Fuzhou, Fujian 350108, PR China; National & Local Joint Biomeidical Engineering Research Center on Phototodynamics Technology, Fuzhou, Fujian 350108, PR China; Fujian Key Lab of Medical Instrument and Pharmaceutical Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China; Fujian Key Lab of Eco-Industrial Green Technology (Wuyi University), Wuyi University, Wuyishan, Fujian 354300, PR China. Electronic address:

An electrochemical sensor based on loading molecularly imprinted polymers (MIP) on the material surface can improve the specificity towards the object. In this work, a T-shaped PbTiO with a high active-exposed (110) facet was prepared by a hydrothermal process. Then, Ag nanoparticles (Ag NPs) modified T-shaped PbTiO was obtained by in-situ photocatalytic reduced method under UV irradiation, where a hetero-junction was formed with a well lattice matching between the (111) facet of Ag and the (110) facet of PbTiO. Read More

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A sensitive and selective electrochemical sensor based on molecularly imprinted polymer for the assay of teriflunomide.

Talanta 2022 Jun 14;249:123689. Epub 2022 Jun 14.

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey. Electronic address:

In this work, pyrrole-histidine has been designed, synthesized and, used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The molecularly imprinted thin film of electrochemical sensor was constructed by directly electropolymerization of co-polymer of pyrrole-histidine (PyHis) with pyrrole in the presence of a template, TER, on a glassy carbon electrode (GCE). After electropolymerization, the structure and morphology of the fabricated MIP sensor were characterized by Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) and its electrochemical parameters such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS). Read More

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Isoform-specific recognition of phosphopeptides by molecular imprinting nanoparticles with double-binding mode.

Anal Chim Acta 2022 Aug 6;1219:340034. Epub 2022 Jun 6.

Center for Supramolecular Chemical Biology, State Key Laboratory of Supramolecular Structure and Materials, School of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address:

Phosphorylation is one of the most important post-translational modifications of proteins, but due to the low abundance of phosphopeptides, enrichment is an essential step before mass spectrometric analysis. Although there are a number of enrichment methods developed targeting different forms of proteins phosphorylations, there are few reports on specific recognition and capture of single phosphopeptide. Herein, based on the advantages of dual affinity of TiO and urea to a phosphate group and molecular imprinting towards the peptide sequence, the precise recognition of intact phosphorylated peptides was successfully achieved. Read More

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Water-compatible Janus molecularly imprinted particles with mouth-like opening: Rapid removal of pharmaceuticals from hospital effluents.

Chemosphere 2022 Oct 14;304:135350. Epub 2022 Jun 14.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:

Pharmaceuticals in hospital effluents, often discharged into the public sewage network without sufficient treatment, have shown negative impacts to the human health and aquatic environment. However, the conventional adsorbents used to remove these micropollutants had several deficiencies, including slow uptake kinetics and poor selectivity. To overcome these challenges, water-compatible Janus MIP particles (J-MIPs) with mouth-like openings were synthesized using seeded interfacial polymerization in this work. Read More

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October 2022

Selective detection of carbendazim using a upconversion fluorescence sensor modified by biomimetic molecularly imprinted polymers.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 9:121457. Epub 2022 Jun 9.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China. Electronic address:

The persistence of carbendazim residues in the food chain poses a potential risk to human health. Therefore, an eco-friendly selective and sensitive fluorescence nanosensor was established for carbendazim determination based on molecularly imprinted polymer (MIP) modified upconversion nanoparticles (UCNPs). The molecularly imprinted coating with methacrylamide as a functional monomer and carbendazim as a template molecule grafted on the UCNPs ([email protected]) constituted fluorescent recognition elements. Read More

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Specific recognition of a target protein, cytochrome , using molecularly imprinted hydrogels.

J Mater Chem B 2022 Jun 16. Epub 2022 Jun 16.

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.

Protein imprinted hydrogel, which is one form of protein imprinted molecularly imprinted polymer (MIP), is an important material for enzyme-linked immunosorbent assay, drug delivery materials, sensors, separation materials, To obtain a high protein recognition performance, it is essential to optimize the involved compositions. This work studies a (poly(ethylene glycol) diacrylate/poly(ethylene glycol) acrylate), in short (PEGDA/PEGA), based MIP hydrogel targeting cytochrome recognition. The presented MIP hydrogel employs water-soluble PEGDA as the crosslinker, PEGA as the side chain, and sodium allylsulfonate as the functional monomer. Read More

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A flower-like ionic molecularly imprinted membrane for the deglycosylation of rutin.

Anal Sci 2022 Jun 15. Epub 2022 Jun 15.

School of Chemical Biology and Materials Engineering, Suzhou University of Science and Technology, Suzhou, 215009, Jiangsu, China.

A kind of molecularly imprinted polymer based on ionic liquids (MIPIL) with flower-like shape was developed for the adsorption of rutin and its deglycosylated product. The MIPIL film was characterized by scanning electron microscope (SEM) and X-ray photo-electron spectroscopy (XPS). The adsorption capacity of quercetin on the proposed imprinted cavity of rutin in the presence of glucose and rhamnose was 3. Read More

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Molecularly imprinted polymers for selective extraction/microextraction of cancer biomarkers: A review.

Mikrochim Acta 2022 06 13;189(7):255. Epub 2022 Jun 13.

Functional Materials Division, Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden.

Over recent years, great efforts have been extensively documented in top scientific journals on the development of methods for early diagnosis, treatment, and monitoring of cancers which are prevalent critical diseases with a high mortality rate among men and women. The determination of cancer biomarkers using different optimum methodologies is one of the finest options for achieving these goals with more precision, speed, and at a lower cost than traditional clinical procedures. In this regard, while focusing on specific biomarkers, molecularly imprinted technology has enabled novel diagnostic techniques for a variety of diseases. Read More

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