183,169 results match your criteria molecular transport


Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers.

Biosensors (Basel) 2021 Sep 3;11(9). Epub 2021 Sep 3.

NMI Natural and Medical Sciences Institute, University of Tübingen, Markwiesenstraße 55, 72770 Reutlingen, Germany.

Endothelial and epithelial cellular barriers play a vital role in the selective transport of solutes and other molecules. The properties and function of these barriers are often affected in case of inflammation and disease. Modelling cellular barriers in vitro can greatly facilitate studies of inflammation, disease mechanisms and progression, and in addition, can be exploited for drug screening and discovery. Read More

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September 2021

A Solid Supported Membrane Electrophysiology Assay for Efficient Characterization of Ion-Coupled Transport.

J Biol Chem 2021 Sep 22:101220. Epub 2021 Sep 22.

Department of Biochemistry, University of Wisconsin-Madison. Electronic address:

Transport stoichiometry determination can provide great insight into the mechanism and function of ion-coupled transporters. Traditional reversal potential assays are a reliable, general method for determining the transport stoichiometry of ion-coupled transporters, but the time and material costs of this technique hinder investigations of transporter behavior under multiple experimental conditions. Solid supported membrane electrophysiology (SSME) allows multiple recordings of liposomal or membrane samples adsorbed onto a sensor, and is sensitive enough to detect transport currents from moderate-flux transporters that are inaccessible to traditional electrophysiology techniques. Read More

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September 2021

Molecularly Engineered Black Phosphorus Heterostructures with Improved Ambient Stability and Enhanced Charge Carrier Mobility.

Adv Mater 2021 Sep 24:e2105694. Epub 2021 Sep 24.

Center for Advancing Electronics Dresden (cfaed) and Department of Chemistry and Food Chemistry, Technische Universität Dresden, Mommsenstrasse 4, Dresden, 01069, Germany.

Overcoming the intrinsic instability and preserving unique electronic properties are key challenges for the practical applications of black phosphorus (BP) under ambient conditions. Here, it is demonstrated that molecular heterostructures of BP and hexaazatriphenylene derivatives (BP/HATs) enable improved environmental stability and charge transport properties. The strong interfacial coupling and charge transfer between the HATs and the BP lattice decrease the surface electron density and protect BP sheets from oxidation, resulting in an excellent ambient lifetime of up to 21 d. Read More

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September 2021

A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis.

Cell Res 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Membrane Biology, Beijing, China.

Under stress, the endomembrane system undergoes reorganization to support autophagosome biogenesis, which is a central step in autophagy. How the endomembrane system remodels has been poorly understood. Here we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment (ERGIC) and the ER-exit site (ERES) in the ER-Golgi system, which is essential for promoting autophagosome biogenesis induced by different stress stimuli. Read More

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September 2021

Polycyclic aromatic hydrocarbons in the snow cover of the northern city agglomeration.

Sci Rep 2021 Sep 24;11(1):19074. Epub 2021 Sep 24.

Laboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", Northern (Arctic) Federal University, Arkhangelsk, Russia.

Sixteen priority polycyclic aromatic hydrocarbons (PAHs) were qualitatively and quantitatively assessed by high-performance liquid chromatography with fluorescence detection in snow samples collected at 46 sites of Arkhangelsk as a world's largest city above 64 degrees north latitude. The average, maximum and minimum PAH concentrations in snow were 168, 665, and 16 ng/kg, respectively. The average toxic equivalent value in benzo(a)pyrene units was 3. Read More

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September 2021

Molecular characteristics of biochar-derived organic matter sub-fractions extracted by ultrasonication.

Sci Total Environ 2021 Sep 9;806(Pt 1):150190. Epub 2021 Sep 9.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Biochar-derived organic matter is key to carbon dynamics and pollutant transport in soils remediated by biochar. A limited understanding of the molecular composition of biochar-derived organic matter limits the ability to accurately predict the chemical cycle within soil and how biochar-derived organic matter will interact with contaminants. To describe the relatively comprehensive structure information of soybean straw biochar-extractable organic matter (BEOM) at the molecular level, we used solvents of different polarities, namely, petroleum ether (PE), carbon disulfide (CS), methanol (CHOH) and acetone (CHCOCH), to extract organic samples from soybean straw biochar and used Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) for analysis. Read More

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September 2021

Supplementation of oleic acid, stearic acid, palmitic acid and β-hydroxybutyrate increase H3K9me3 in endometrial epithelial cells of cattle cultured in vitro.

Anim Reprod Sci 2021 Sep 11;233:106851. Epub 2021 Sep 11.

Department of Animal Science, McGill University, Saint-Anne-de-Bellevue, QC, Canada. Electronic address:

There is growing evidence that greater than homeostatic blood concentrations of nonesterified fatty acids (NEFAs) and β-hydroxybutyrate (BHBA) have negative consequences on dairy cow's fertility, but effects on cell homeostasis in the reproductive system is not completely understood. In this study, lipids accumulation, reactive oxygen species (ROS) concentrations, abundance of gene transcripts, and immunofluorescence signal of H3K4me3 and H3K9me3 were evaluated in endometrial epithelial cells of cattle cultured with NEFAs (Oleic (OA), Stearic (SA) and Palmitic (PA) acids), BHBA, NEFAs + BHBA or each of the three NEFAs alone. The cellular lipids were in greater concentrations as a result of NEFAs + BHBA, NEFAs, SA or OA supplementation, but not by BHBA or PA. Read More

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September 2021

Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana.

Plant J 2021 Sep 24. Epub 2021 Sep 24.

Department of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA.

Zinc (Zn) is essential for normal plant growth and development. The ZIP (ZRT, IRT-like Protein) family members are involved in Zn transport and cellular Zn homeostasis throughout the domains of life. In this study, we have characterized four ZIP transporters from Arabidopsis thaliana (IRT3, ZIP4, ZIP6 and ZIP9) to better understand their functional roles. Read More

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September 2021

Myosin XI-B is involved in the transport of vesicles and organelles in pollen tubes of Arabidopsis thaliana.

Plant J 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

The movement of organelles and vesicles in pollen tubes depends on F-actin. However, the molecular mechanism through which plant myosin XI drives the movement of organelles is still controversial, and the relationship between myosin XI and vesicle movement in pollen tubes is also unclear. In this study, we found that the siliques of the myosin xi-b/e mutant were obviously shorter than those of the wild-type (WT) and that the seed set of the mutant was severely deficient. Read More

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September 2021

Differential barcoding of opioid receptors trafficking.

J Neurosci Res 2021 Sep 24. Epub 2021 Sep 24.

Département de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.

Over the past several years, studies have highlighted the δ-opioid receptor (DOPr) as a promising therapeutic target for chronic pain management. While exhibiting milder undesired effects than most currently prescribed opioids, its specific agonists elicit effective analgesic responses in numerous animal models of chronic pain, including inflammatory, neuropathic, diabetic, and cancer-related pain. However, as compared with the extensively studied μ-opioid receptor, the molecular mechanisms governing its trafficking remain elusive. Read More

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September 2021

ZmCTLP1 is required for the maintenance of lipid homeostasis and the basal endosperm transfer layer in maize kernels.

New Phytol 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Plant Physiology and Biochemistry and National Maize Improvement Center, Department of Plant Genetics and Breeding, China Agricultural University, Beijing, 100193, P. R. China.

Maize kernel weight is influenced by the unloading of nutrients from the maternal placenta and their passage through the transfer tissue of the basal endosperm transfer layer (BETL) and the basal intermediate zone (BIZ) to the upper part of the endosperm. Here, we show that Small kernel 10 (Smk10) encodes a choline transporter-like protein 1 (ZmCTLP1) that facilitates choline uptake and is located in the trans-Golgi network (TGN). Its loss-of-function results in reduced choline content, leading to smaller kernels with a lower starch content. Read More

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September 2021

Cation-chloride cotransport mediated by an ion pair transporter.

Org Biomol Chem 2021 Sep 24. Epub 2021 Sep 24.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Ion transport mediated by an ion pair receptor 1 bearing both cation and anion binding sites is presented. The ion pair binding property was revealed by means of H NMR titrations in organic solutions and X-ray analysis in the solid state. Single crystal structures demonstrated that 1 and CaI formed a solvent-separated ion-pair complex with two iodides each interacting with a triazine ring through anion-π interactions, whereas the calcium ion is bound by a pentaethylene glycol moiety. Read More

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September 2021

Management of phosphorus nutrient amidst climate change for sustainable agriculture.

J Environ Qual 2021 Sep 24. Epub 2021 Sep 24.

Xavier Research Foundation, St. Xavier's College, Palayamkottai, Tamil Nadu, 620002, India.

Nutrients are essential for plant growth and development; they influence the overall agricultural production. Phosphorus (P) is a major nutrient required for many physiological and biochemical functions of the plant. Phosphate rock is the major source of phosphate fertilizer which is becoming increasingly limited in both developing and developed countries. Read More

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September 2021

Mimicking human riboflavin responsive neuromuscular disorders by silencing flad-1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission.

IUBMB Life 2021 Sep 24. Epub 2021 Sep 24.

Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.

Riboflavin (Rf), or vitamin B2, is the precursor of FMN and FAD, redox cofactors of several dehydrogenases involved in energy metabolism, redox balance and other cell regulatory processes. FAD synthase, coded by FLAD1 gene in humans, is the last enzyme in the pathway converting Rf into FAD. Mutations in FLAD1 gene are responsible for neuromuscular disorders, in some cases treatable with Rf. Read More

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September 2021

Outstanding Questions on the Beneficial Role of Silicon in Crop Plants.

Plant Cell Physiol 2021 Sep 24. Epub 2021 Sep 24.

National Agri-Food Biotechnology Institute (NABI), Mohali, 140308India.

Silicon (Si) is widely accepted as a beneficial element for plants. Despite the substantial progress made in understanding Si transport mechanisms and modes of action in plants, several questions remain unanswered. In this review, we discuss such outstanding questions and issues commonly encountered by biologists studying the role of Si in plants in relation to Si bioavailability. Read More

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September 2021

Multifarious colloidal structures: new insight into ternary and quadripartite ordered assemblies.

Nanoscale 2021 Sep 24. Epub 2021 Sep 24.

Department of Mechanical and Manufacturing Engineering, Miami University, Oxford, OH, USA.

DNA-mediated assembly of colloidal particles can be utilized to produce a variety of structures which may have desirable phononic, photonic, or electronic transport properties. Recent developments in linker-mediated assembly processes allow for interactions to be coordinated between many different types of colloidal particles more easily and with fewer unique sequences than direct hybridization. However, the dynamics of colloidal self-assembly becomes increasingly more complex when coordinating interactions between three or more distinct interacting elements. Read More

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September 2021

Highly efficient T-shaped deep-red thermally activated delayed fluorescence emitters: substitution position effect.

Phys Chem Chem Phys 2021 Sep 24. Epub 2021 Sep 24.

Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, Shandong Normal University, 250014 Jinan, China.

Modulating the relationship between molecular structures and luminescence properties as well as charge transfer properties of deep-red thermally activated delayed fluorescence (TADF) emitters has always been a great challenge, especially in the solid state. In this work, the light-emitting properties of a T-shaped molecule (TPA-DPPZ) with donors at the -position are theoretically investigated in the solid state with the combined quantum mechanics/molecular mechanics (QM/MM) method and the thermal vibration correlation function (TVCF) theory. In comparison with a Y-shaped molecule (TPA-DPPZ with donors at the -position), TPA-DPPZ acquires a reduced HOMO-LUMO energy gap and red-shifted emission. Read More

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September 2021

Impact of Nanoscale Morphology on Charge Carrier Delocalization and Mobility in an Organic Semiconductor.

Adv Mater 2021 Sep 23:e2104852. Epub 2021 Sep 23.

Department of Physics and Astronomy and Thomas Young Centre London, University College London, Gower Street, London, WC1E 6BT, UK.

A central challenge of organic semiconductor research is to make cheap, disordered materials that exhibit high electrical conductivity. Unfortunately, this endeavor is hampered by the poor fundamental understanding of the relationship between molecular packing structure and charge carrier mobility. Here a novel computational methodology is presented that fills this gap. Read More

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September 2021

Tuning Conjugated Polymer Chain Packing for Stretchable Semiconductors.

Adv Mater 2021 Sep 24:e2104747. Epub 2021 Sep 24.

Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.

In order to apply polymer semiconductors to stretchable electronics, they need to be easily deformed under strain without being damaged. A small number of conjugated polymers, typically with semicrystalline packing structures, have been reported to exhibit mechanical stretchability. Herein, a method is reported to modify polymer semiconductor packing-structure using a molecular additive, dioctyl phthalate (DOP), which is found to act as a molecular spacer, to be inserted between the amorphous chain networks and disrupt the crystalline packing. Read More

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September 2021

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling.

J Cell Sci 2021 Sep 24. Epub 2021 Sep 24.

Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany.

Sortilin is a neuronal receptor for apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with apoE3 but is lost with apoE4, the main risk factor for Alzheimer's disease (AD). Read More

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September 2021

Subtle Side Chain Triggers Unexpected Two-Channel Charge Transport Property Enabling 80% Fill Factors and Efficient Thick-Film Organic Photovoltaics.

Innovation (N Y) 2021 Feb 5;2(1):100090. Epub 2021 Feb 5.

CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.

To clearly show how important the impact of side chains on organic solar cells (OSCs) is, we designed three acceptors IDIC-CPh ( = 4, 5, or 6) via subtle side-chain regulation. Despite this small change, significant distinctions were detected. IDIC-C4Ph devices achieve an optimal efficiency of 13. Read More

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February 2021

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

Front Cell Dev Biol 2021 7;9:720656. Epub 2021 Sep 7.

Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin. Mitochondria are responsible for cellular respiration via the function of the electron oxidative phosphorylation system (OXPHOS), located in the mitochondrial inner membrane and composed of the four electron transport chain (ETC) enzymes (complexes I-IV), and the ATP synthase (complex V). Even though the mtDNA encodes essential OXPHOS components, the large majority of the structural subunits and additional biogenetical factors (more than seventy proteins) are encoded in the nucleus and translated in the cytoplasm. Read More

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September 2021

A Rare Case of Ewing's-like Adamantinoma of Tibia Managed by Limb Salvage Surgery Using Long Segment Ilizarov Bone Transport: A Case Report and Review of Literature.

J Orthop Case Rep 2021 May;11(5):61-67

Department of Plastic Surgery, Government Medical College, Kozhikode Kerala, India.

Introduction: Adamantinoma is a rare low-grade malignant tumor in young adults. Recent advances in molecular techniques have shown different variants with discordance between genotype and phenotype. This poses a challenge in diagnosis and management. Read More

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Early Leukocyte Responses in Models of Healing and Non-Healing Human Infections.

Front Cell Infect Microbiol 2021 7;11:687607. Epub 2021 Sep 7.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, United States.

Early host-pathogen interactions drive the host response and shape the outcome of natural infections caused by intracellular microorganisms. These interactions involve a number of immune and non-immune cells and tissues, along with an assortment of host and pathogen-derived molecules. Our current knowledge has been predominantly derived from research on the relationships between the pathogens and the invaded host cell(s), limiting our understanding of how microbes elicit and modulate immunological responses at the organismal level. Read More

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September 2021

The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma.

PeerJ 2021 1;9:e12123. Epub 2021 Sep 1.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.

Methods: Several bioinformatics tools and experiments were used to identify the immune-related profiles and prognostic values of AlkB family in HCC. Read More

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September 2021

Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy.

Oxid Med Cell Longev 2021 13;2021:6347792. Epub 2021 Sep 13.

Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea.

Autophagy is an essential cellular process that involves the transport of cytoplasmic content in double-membraned vesicles to lysosomes for degradation. Neurons do not undergo cytokinesis, and thus, the cell division process cannot reduce levels of unnecessary proteins. The primary cause of neurodegenerative disorders (NDs) is the abnormal deposition of proteins inside neuronal cells, and this could be averted by autophagic degradation. Read More

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September 2021

Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H symporter STP10.

Nat Plants 2021 Sep 23. Epub 2021 Sep 23.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

Sugars are essential sources of energy and carbon and also function as key signalling molecules in plants. Sugar transport proteins (STP) are proton-coupled symporters responsible for uptake of glucose from the apoplast into plant cells. They are integral to organ development in symplastically isolated tissues such as seed, pollen and fruit. Read More

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September 2021

Molecular interpretation of the carbon nitride performance as a template for the transport of anti-cancer drug into the biological membrane.

Sci Rep 2021 Sep 23;11(1):18981. Epub 2021 Sep 23.

Department of Chemistry, University of Birjand, Birjand, Iran.

Evaluation of interaction mechanism between 2-dimensional (2D) nanomaterials and cell membranes is a critical issue in providing guidelines for biomedical applications. Recent progress in computer-aided molecular design tools, especially molecular dynamics (MD) simulation, afford a cost-effective approach to achieving this goal. In this work, based on this hypothesis, by utilizing theoretical methods including MD simulation and free energy calculations, a process is evaluated in which the Doxorubicin (DOX)-loaded onto carbon nitride (CN) nanosheet faced with bilayer membrane. Read More

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September 2021

Hollow zeolitic imidazolate framework-7 coated stainless steel fiber for solid phase microextraction of volatile biomarkers in headspace gas of breast cancer cell lines.

Anal Chim Acta 2021 Oct 2;1181:338901. Epub 2021 Aug 2.

Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China. Electronic address:

In this work, we reported the preparation of the hollow zeolitic imidazolate framework-7 (ZIF-7) via etching ZIF-7 with tannic acid, and further fabricated the hollow ZIF-7 coated fiber for the solid phase microextraction (SPME) of the five volatile biomarkers (acetone, isopropanol, hexanal, hexanol and decanal) generated from breast cancer cell lines. The hollow structure not only endowed higher extraction performance for the SPME of analytes, but also improved the diffusion rate of the analytes inside the hollow ZIF-7. Under the optimal conditions, the hollow ZIF-7 coated fiber offered high extraction capacity (25-153 mg g) and enhancement factors (EFs, 2023-11250) for the five biomarkers, good linearity (R > 0. Read More

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October 2021

High-Voltage and Wide-Temperature Lithium Metal Batteries Enabled by Ultrathin MOF-Derived Solid Polymer Electrolytes with Modulated Ion Transport.

ACS Appl Mater Interfaces 2021 Sep 23. Epub 2021 Sep 23.

Beijing Key Laboratory of Ionic Liquids Clean Process, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Solid polymer electrolytes (SPEs) of superior ionic conductivity, long-term cycling stability, and good interface compatibility are regarded as promising candidates to enable the practical applications of solid lithium metal batteries (SLMBs). Here, a mixed-matrix SPE (MMSE) with incorporated metal-organic frameworks (MOFs) and ionic liquid is prepared. The dissociation of Li salt in MMSE can be promoted effectively due to the introduction of MOF the Fourier-transform infrared spectroscopy (FT-IR) analysis, density functional theory calculation, and molecular dynamics simulation. Read More

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September 2021