49,349 results match your criteria module


The miR156b-GmSPL9d module modulates nodulation by targeting multiple core nodulation genes in soybean.

New Phytol 2021 Dec 4. Epub 2021 Dec 4.

National Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

Symbiotic nodulation is initiated in the roots of legumes in response to low nitrogen and rhizobial signal molecules and is dynamically regulated by a complex regulatory network that coordinates rhizobial infection and nodule organogenesis. It has been shown that the miR156-SPL module mediates nodulation in legumes; however, conclusive evidence of how this module exerts its function during nodulation remains elusive. Here, we report that the miR156b-GmSPL9d module regulates symbiotic nodulation by targeting multiple key regulatory genes in the nodulation signalling pathway of soybean. Read More

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December 2021

An undergraduate laboratory experiment with real-world applications: Utilizing templateless polymerase chain reaction and real-time polymerase chain reaction to test for SARS-CoV-2 RNA.

Biochem Mol Biol Educ 2021 Dec 4. Epub 2021 Dec 4.

College of Health and Natural Sciences, Franklin Pierce University, Rindge, New Hampshire, USA.

We present a course-embedded undergraduate research module that involves real-time polymerase chain reaction testing for the presence of SARS-CoV-2 in environmental samples. A positive control RNA was constructed and two RNA extraction methods were compared and a range of primers were available to compare. Using a combination of published protocols, we assembled a successful project that illustrated a topical exercise similar to real-world assay development. Read More

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December 2021

[Six Cases of Philips Ingenuity CT Maintenance].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Nov;45(6):702-705

Rugao Boai Hospital, Rugao, 226599.

The article describes the failure phenomenon, analysis and processing process of the high-voltage generator module, FRC unit, rack tilt circuit and slip ring system in the daily use of Philips Ingenuity CT, so as to sum up the experience, discuss with the medical staff, and further Deepen the understanding of Philips Ingenuity CT's structure and working principle, and jointly improve the maintenance skills of CT and other large equipments. Read More

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November 2021

[Design and Implementation of Software Platform for AI-ECG Algorithm Research].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Nov;45(6):616-621

Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200433.

A software platform for AI-ECG algorithm research is designed and implemented to better serve the research of ECG artificial intelligence classification algorithm and to solve the problem of subjects data information management. Matlab R2019b and MySQL Sever 8.0 are used to design the software platform. Read More

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November 2021

Find and cut-and-transfer (FiCAT) mammalian genome engineering.

Nat Commun 2021 Dec 3;12(1):7071. Epub 2021 Dec 3.

Department of Health and Experimental Sciences, Pompeu Fabra University, Barcelona, Spain.

While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) combining the precision of a CRISPR-Cas9 (find module), and the payload transfer efficiency of an engineered piggyBac transposase (cut-and-transfer module). FiCAT combines the functionality of Cas9 DNA scanning and targeting DNA, with piggyBac donor DNA processing and transfer capacity. Read More

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December 2021

How concerned significant others experience Community Reinforcement and Family Training (CRAFT) - a qualitative study.

BMC Fam Pract 2021 Dec 3;22(1):241. Epub 2021 Dec 3.

Unit of Clinical Alcohol Research, Clinical Institute, University of Southern Denmark, J.B. Winsløws vej 18, 5000, Odense C, Denmark.

Introduction: Heavy drinking causes serious harm, not only to the drinker but also to relationships and concerned significant others (CSOs). Community Reinforcement and Family Training (CRAFT) is an intervention developed to help the CSOs of substance users. The aim of this study was to investigate the drivers and aims underlying CSO participation in CRAFT, as well as their experience of the intervention itself and their module preferences. Read More

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December 2021

Identification of four hub genes in venous thromboembolism via weighted gene coexpression network analysis.

BMC Cardiovasc Disord 2021 Dec 3;21(1):577. Epub 2021 Dec 3.

Department of Vascular Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Hexi District, Tianjin, 300211, China.

Background: The pathogenic mechanisms of venous thromboembolism (VT) remain to be defined. This study aimed to identify differentially expressed genes (DEGs) that could serve as potential therapeutic targets for VT.

Methods: Two human datasets (GSE19151 and GSE48000) were analyzed by the robust rank aggregation method. Read More

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December 2021

Transmembrane signaling molecules play a key role in the pathogenesis of IgA nephropathy: a weighted gene co-expression network analysis study.

BMC Immunol 2021 Dec 3;22(1):73. Epub 2021 Dec 3.

Regenerative Medicine Research Center, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 81746-73461, Isfahan, Iran.

Background: Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulonephritis and a serious health concern worldwide; though still the underlying molecular mechanisms of IgAN are yet to be known and there is no efficient treatment for this disease. The main goal of this study was to explore the IgAN underlying pathogenic pathways, plus identifying the disease correlated modules and genes using the weighted gene co-expression network analysis (WGCNA) algorithm.

Results: GSE104948 dataset (the expression data from glomerular tissue of IgAN patients) was analyzed and the identified differentially expressed genes (DEGs) were introduced to the WGCNA algorithm for building co-expression modules. Read More

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December 2021

Using an Online Disturbance Rejection and Anticipation System to Reduce Hyperglycemia in a Fully Closed-Loop Artificial Pancreas System.

J Diabetes Sci Technol 2021 Dec 3:19322968211059159. Epub 2021 Dec 3.

Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA.

Introduction: Hyperglycemia following meals is a recurring challenge for people with type 1 diabetes, and even the most advanced available automated systems currently require manual input of carbohydrate amounts. To progress toward fully automated systems, we present a novel control system that can automatically deliver priming boluses and/or anticipate eating behaviors to improve postprandial full closed-loop control.

Methods: A model predictive control (MPC) system was enhanced by an automated bolus system reacting to early glucose rise and/or a multistage MPC (MS-MPC) framework to anticipate historical patterns. Read More

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December 2021

IMIIN: An inter-modality information interaction network for 3D multi-modal breast tumor segmentation.

Comput Med Imaging Graph 2021 Nov 29;95:102021. Epub 2021 Nov 29.

Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Breast tumor segmentation is critical to the diagnosis and treatment of breast cancer. In clinical breast cancer analysis, experts often examine multi-modal images since such images provide abundant complementary information on tumor morphology. Known multi-modal breast tumor segmentation methods extracted 2D tumor features and used information from one modal to assist another. Read More

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November 2021

Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases.

Curr Opin Chem Biol 2021 Nov 30;66:102101. Epub 2021 Nov 30.

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

With advances in high-throughput sequencing technologies, quantitative genetics approaches have provided insights into genetic basis of many complex diseases. Emerging in-depth multi-omics profiling technologies have created exciting opportunities for systematically investigating intricate interaction networks with different layers of biological molecules underlying disease etiology. Herein, we summarized two main categories of biological networks: evidence-based and statistically inferred. Read More

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November 2021

SWAT-SF: A flexible SWAT-based model for watershed-scale water and soil salinity modeling.

J Contam Hydrol 2021 Oct 12;244:103893. Epub 2021 Oct 12.

Department of Environmental Conservation, College of Natural Sciences, University of Massachusetts, Amherst, United States. Electronic address:

Natural and anthropogenic complex processes release salts into the environment. These change the balances of natural systems in the watersheds. Models can assist study of salinity processes throughout watersheds. Read More

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October 2021

The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns.

J Biol Chem 2021 Nov 30:101457. Epub 2021 Nov 30.

Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei, Anhui 230026, China; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China. Electronic address:

Toxin-antitoxin (TA) systems are ubiquitous regulatory modules for bacterial growth and cell survival following stress. YefM-YoeB, the most prevalent type II TA system, is present in a variety of bacterial species. In Staphylococcus aureus, the YefM-YoeB system exists as two independent paralogous copies. Read More

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November 2021

Topical retinoic acid induces corneal strengthening by upregulating transglutaminase 2 in murine cornea.

Exp Eye Res 2021 Nov 30:108850. Epub 2021 Nov 30.

Department of Ophthalmology, The Third Medical Center, Chinese PLA General Hospital, Beijing, 100089, China. Electronic address:

Transglutaminase 2 (TG2) is the most abundant crosslinking enzyme in murine and human cornea, while retinoids are well-known inducers of TG2 expression. This study aims to determine if the retinoic acid supplementation can increase corneal stiffness by crosslinking through upregulating the corneal TG2 expression. The right eyes of C57BL/6 mice were treated with 2×10M retinol palmitate (VApal) eyedrops or control eyedrops and hold for 30 min, once a day for 28 consecutive days. Read More

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November 2021

RFARN: Retinal vessel segmentation based on reverse fusion attention residual network.

PLoS One 2021 3;16(12):e0257256. Epub 2021 Dec 3.

College of Computer Science and Engineering, Northwest Normal University, Lanzhou Gansu, China.

Accurate segmentation of retinal vessels is critical to the mechanism, diagnosis, and treatment of many ocular pathologies. Due to the poor contrast and inhomogeneous background of fundus imaging and the complex structure of retinal fundus images, this makes accurate segmentation of blood vessels from retinal images still challenging. In this paper, we propose an effective framework for retinal vascular segmentation, which is innovative mainly in the retinal image pre-processing stage and segmentation stage. Read More

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December 2021

Use and Appreciation of a Web-Based, Computer-Tailored Diet and Physical Activity Intervention Based on the Self-determination Theory: Evaluation Study of Process and Predictors.

JMIR Form Res 2021 Dec 2;5(12):e22390. Epub 2021 Dec 2.

Department of Health Psychology, Faculty of Psychology, Open University of the Netherlands, Heerlen, Netherlands.

Background: eHealth is a promising tool for promoting lifestyle behaviors such as a healthy diet and physical activity (PA). However, making people use interventions is a crucial and challenging problem in eHealth. More insight into use patterns and predicting factors is needed to improve future interventions. Read More

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December 2021

A Clustering Ensemble Method for Cell Type Detection by Multiobjective Particle Optimization.

IEEE/ACM Trans Comput Biol Bioinform 2021 Dec 3;PP. Epub 2021 Dec 3.

Single-cell RNA sequencing (scRNA-seq) is a new technology different from previous sequencing methods that measure the average expression level for each gene across a large population of cells. Thus, new computational methods are required to reveal cell types among cell populations. We present a clustering ensemble algorithm using optimized multiobjective particle (CEMP). Read More

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December 2021

Improving the classification ability of network utilizing fusion technique in contrast enhanced spectral mammography.

Med Phys 2021 Dec 3. Epub 2021 Dec 3.

School of Information Science and Engineering, Shandong Normal University, Jinan, 250358, China.

Purpose: Contrast enhanced spectral mammography (CESM) is an effective tool for diagnosing breast cancer with the benefit of its multiple types of images. However, few models simultaneously utilize this feature in deep learning-based breast cancer classification methods. To combine multiple features of CESM and thus aid physicians in making accurate diagnoses, we propose a hybrid approach by taking advantages of both fusion and classification models. Read More

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December 2021

Identification of cancer-related module in protein-protein interaction network based on gene prioritization.

J Bioinform Comput Biol 2021 Dec 3:2150031. Epub 2021 Dec 3.

Guangxi Key Lab of Multi-Source Information Mining & Security, Guangxi Normal University, Guilin 541004, P. R. China.

With the rapid development of deep sequencing technologies, a large amount of high-throughput data has been available for studying the carcinogenic mechanism at the molecular level. It has been widely accepted that the development and progression of cancer are regulated by modules/pathways rather than individual genes. The investigation of identifying cancer-related active modules has received an extensive attention. Read More

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December 2021

3D asymmetric expectation-maximization attention network for brain tumor segmentation.

NMR Biomed 2021 Dec 3:e4657. Epub 2021 Dec 3.

International School of Information Science and Engineering (DUT-RUISE), Dalian University of Technology, Dalian, China.

Automatic brain tumor segmentation on MRI is a prerequisite to provide a quantitative and intuitive assistance for clinical diagnosis and treatment. Meanwhile, 3D deep neural network related brain tumor segmentation models have demonstrated considerable accuracy improvement over corresponding 2D methodologies. However, 3D brain tumor segmentation models generally suffer from high computation cost. Read More

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December 2021

Muscle Coordination during Archery Shooting: A Comparison of Archers with Different Skill Levels.

Eur J Sport Sci 2021 Dec 3:1-14. Epub 2021 Dec 3.

School of Sport Science, Beijing Sport University, Beijing, China, No. 48 Xinxi Road, Haidian District, Beijing,China,10084.

This study aimed to compare the muscle coordination of different skill level archers by using the concept of muscle synergies. A total of 28 archers (8 elite, 12 mid-level, and 8 novices) were recruited to participate in this study. Electromyography (EMG) signals were recorded using a 13-channel (Trigno EMG sensor, Delsys Inc. Read More

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December 2021

Coordinated Anionic Inorganic Module - An Efficient Approach Towards Highly Efficient Blue-Emitting Copper Halide Ionic Hybrid Structures.

Angew Chem Int Ed Engl 2021 Dec 2. Epub 2021 Dec 2.

Sun Yat-Sen University, School of Chemistry and Chemical Engineering, CHINA.

Copper halide based organic-inorganic hybrid semiconductors exhibit great potentials as light-emitting materials with excellent structural variety and optical tunability. Among them, copper halide hybrid molecular compounds with discrete inorganic modules are particularly interesting due to their high quantum efficiency, however, synthesizing highly efficient blue-emitting molecular clusters remains challenging. Here, we report a novel and facile strategy for the design and synthesis of highly luminescent copper halide hybrid structures by fabricating coordinated anionic inorganic modules in these ionic species. Read More

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December 2021

Common Deficiencies Found in the Active Pharmaceutical Ingredient (API) Section of Non-sterile Generic Products Submitted for Registration by SAHPRA.

Ther Innov Regul Sci 2021 Dec 2. Epub 2021 Dec 2.

School of Pharmacy, University of the Western Cape, Robert Sobukwe Road, Bellville, Cape Town, 7535, South Africa.

Purpose: This research study aims to determine the qualitative and quantitative common deficiencies included in the API section of dossiers submitted to SAHPRA. The study was conducted retrospectively over a 7-year period (2011-2017) for non-sterile generic products that were finalised by the Pharmaceutical and Analytical pre-registration Unit. In this period, the restricted part of the CTD was evaluated when needed therefore this was not conducted on all applications. Read More

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December 2021

Reducing Calibration Time in PET Systems Based on Monolithic Crystals.

Front Med (Lausanne) 2021 10;8:734476. Epub 2021 Nov 10.

Instituto de Instrumentación para Imagen Molecular, Centro Mixto CSIC-Universitat Politècnica de València, Valencia, Spain.

In the past years, the gamma-ray detector designs based on the monolithic crystals have demonstrated to be excellent candidates for the design of high-performance PET systems. The monolithic crystals allow to achieve the intrinsic detector resolutions well below state-of-the-art; to increase packing fraction thus, increasing the system sensitivity; and to improve lesion detectability at the edges of the scanner field of view (FOV) because of their intrinsic depth of interaction (DOI) capabilities. The bottleneck to translate to the clinical PET systems based on a large number of monolithic detectors is eventually the requirement of mechanically complex and time-consuming calibration processes. Read More

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November 2021

Functional Analysis of the "Green Revolution" Gene and Its Selection Trends During Bread Wheat Breeding.

Front Plant Sci 2021 11;12:745411. Epub 2021 Nov 11.

College of Agriculture, Ludong University, Yantai, China.

Flowering is central to the transformation of plants from vegetative growth to reproductive growth. The circadian clock system enables plants to sense the changes in the external environment and to modify the growth and development process at an appropriate time. (), which is controlled by the output signal of the circadian clock, has played an important role in the wheat "Green Revolution. Read More

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November 2021

Design and Implementation of Intelligent Learning System Based on Big Data and Artificial Intelligence.

Authors:
Yawen Yang

Front Psychol 2021 11;12:726978. Epub 2021 Nov 11.

Academy of Arts, Southwest Minzu University, Chengdu, China.

In order to improve the level of education development in remote areas of China, help minority schools to better play the advantages of multimedia network teaching resources provided by the state, and further improve the level of multimedia network management, a multimedia network teaching management system is studied and developed. The teaching information and business process of the school is analyzed, the division of the structure of the film and television multimedia information management system is completed, and the overall structure, functional structure, and database of the system are designed; Tornado technology, NoSQL database technology, jQuery technology, and Ajax technology are used to complete the development of the system. The results show that the real system can provide a highly automated platform for the school multimedia network-teaching management. Read More

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November 2021

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

Nat Commun 2021 Dec 2;12(1):7032. Epub 2021 Dec 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2) domain is characteristic of the SOCS family proteins and is an important module that facilitates recognition of targets bearing phosphorylated tyrosine (pTyr) residues. Here we identify an exosite on the SOCS2-SH2 domain which, when bound to a non-phosphorylated peptide (F3), enhances SH2 affinity for canonical phosphorylated ligands. Read More

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December 2021

Addressing cultural competence and bias in treating migrant workers in pharmacies: Pharmacy students learning and changing norms.

Res Social Adm Pharm 2021 Nov 26. Epub 2021 Nov 26.

Beirut Arab University Faculty of Pharmacy, P.O. Box: 11 5020, Beirut, Lebanon; AlAlamein International University Faculty of Pharmacy, AlAlamein City Main Road, Matrouh, Egypt. Electronic address:

Objective: Little research addressed training pharmacy students on bias towards vulnerable patients such as migrant domestic workers (MDWs). This study evaluates a module addressing bias and cultural competence when working with MDWs in community pharmacies.

Methods: Two cohorts of Lebanese Bachelor of pharmacy students completed this module as part of a core Public Health class. Read More

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November 2021

Teaching what matters: Integrating health equity education into the core surgery clerkship.

Surgery 2021 Nov 29. Epub 2021 Nov 29.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Surgery, Penn Medicine Washington Square, Philadelphia, PA. Electronic address:

Background: Significant disparities in surgical outcomes exist. It is imperative to prepare future doctors to eliminate disparities. Our team of senior medical students developed a surgical clerkship module examining equity in prostate cancer. Read More

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November 2021

Engineering chitosan nano-cocktail containing iron oxide and ceria: A two-in-one approach for treatment of inflammatory diseases and tracking of material delivery.

Mater Sci Eng C Mater Biol Appl 2021 Dec 18;131:112477. Epub 2021 Oct 18.

Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane 4111, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, Australia; School of Environment and Science, Griffith University, Brisbane 4111, Australia. Electronic address:

In this study, modular two-in-one nano-cocktails were synthesised to provide treatment of inflammatory diseases and also enable tracking of their delivery to the disease sites. Chitosan nano-cocktails loaded with treatment module (cerium oxide nanoparticles) and imaging module (iron oxide nanoparticles) were synthesised by electrostatic self-assembly (Chit-IOCO) and ionic gelation method (Chit-TPP-IOCO), respectively. Their MRI capability, anti-inflammatory and anti-fibrosis ability were investigated. Read More

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December 2021