6,981 results match your criteria modern opinion

Apoferritin: a potential nanocarrier for cancer imaging and drug delivery.

Expert Rev Anticancer Ther 2021 Apr 12:1-13. Epub 2021 Apr 12.

Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, China.

: As a protein-based biomaterial for potential cancer targeting delivery, apoferritin has recently attracted interest.: In this review, we discuss the development of this cage-like protein as an endogenous nanocarrier that can hold molecules in its cavity. We present the specific characterizations and formulations of apoferritin nanocarriers, and outline the recent progress of the protein as an appropriate tumor-delivery vehicle in different therapeutic strategies to treat solid tumors. Read More

View Article and Full-Text PDF

[Prosthetic repair of aortic valve cusps with autopericardium in children. State of the art and prospects].

Angiol Sosud Khir 2021 ;27(1):191-198

Department of Hospital Surgery of the Medical Faculty, I.M. Sechenov First Moscow Medical University of the RF Ministry of Public Health, Moscow, Russia; Institute of Cardioaortic Surgery, Petrovsky National Research Centre of Surgery, Moscow, Russia.

According to the results of modern researchers, the main techniques used in congenital pathology of the aortic valve in children include balloon catheter dilatation of the aortic valve, surgical valvuloplasty, the Ross procedure and replacement of the aortic valve with a mechanical prosthesis. Many surgeons point out that these techniques in congenital pathology of the aortic valve yield suboptimal results. This is often due to the lack of a clear-cut definition between surgeons as to what operation should be performed in a particular age group. Read More

View Article and Full-Text PDF

The impact of violence against women courses on the attitudes of nursing students toward violence against women and their professional roles.

Ruşen Öztürk

Nurse Educ Pract 2021 Mar 19;52:103032. Epub 2021 Mar 19.

Ege University Faculty of Nursing, Women Health and Disease Nursing Department, İzmir, Turkey. Electronic address:

This study determines whether the inclusion of violence against women (VAW) education in nursing curricula would improve attitudes and professional help toward victims of violence. Research was carried out as cross-sectional and comparative quasi-experimental study. The research included 524 students; 262 students were trained and 262 were untrained. Read More

View Article and Full-Text PDF

Changes of first-aid attitude during the COVID–19 pandemic

Orv Hetil 2021 04 2;162(15):571-578. Epub 2021 Apr 2.

1 Pécsi Tudományegyetem, Egészségtudományi Kar, Sürgősségi Ellátási és Egészségpedagógiai Intézet, Pécs, Vörösmarty u. 4., 7621.

Összefoglaló. Az új típusú koronavírus (SARS-CoV-2 ) okozta járvány hirtelen megnövekedett betegszámai és halálozásai komoly kihívás elé állították az egészségügyi ellátás minden színterét. A magas időfaktorú kórképek ellátásában a laikusok által végzett elsősegélynyújtás alapvető fontosságú a beteg túlélése és maradandó egészségkárosodásának elkerülése szempontjából. Read More

View Article and Full-Text PDF

Experience and prospects for the use of off-label drugs in oncology.

Exp Oncol 2021 03;43(1):1-5

National University of Pharmacy, Kharkiv 61002, Ukraine.

According to the World Health Organization, half of all drugs available on the global pharmaceutical market are sometimes used for indications that are not included in the instruction for use. This method of therapy has the term "off-label use" which means the use "out of instruction". Today, off-label drugs are also prescribed for cancer treatment. Read More

View Article and Full-Text PDF

Charcot: Buddhist Leanings?

Eur Neurol 2021 Mar 30:1-4. Epub 2021 Mar 30.

Reta Lila Weston Institute of Neurological Studies, London, United Kingdom.

Jean-Martin Charcot, considered the father of modern neurology, had a complex personality featuring well-defined characteristics of introversion, competitiveness, irony, and skepticism. While biographers have described him as Republican, anticlerical, and agnostic, the literature also presents evidence that he came to admire Buddhism toward the end of his life; Charcot's involvement with numerous patients suffering from incurable and insidious neurological diseases may have contributed to this change in attitude. Read More

View Article and Full-Text PDF

Attitude toward personal genomics: A nation-wide survey of public and professionals in Pakistan.

Ann Hum Genet 2021 Mar 30. Epub 2021 Mar 30.

Centre for Human Genetics, Hazara University, Mansehra, Pakistan.

With the emergence of modern genetic testing and profiling techniques, it has become imperative to assess the general public awareness and attitudes toward such developments. The public's perspective and possible responses are necessary for planning commercial, legal, medical, or healthcare initiatives. The purpose of this study was to assess the perception of the general public and professionals about the personal genome testing and genetic profiling. Read More

View Article and Full-Text PDF

From dyad to triad: a survey on fathers' knowledge and attitudes toward breastfeeding.

Eur J Pediatr 2021 Mar 29. Epub 2021 Mar 29.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, NICU, Milan, Italy.

Fathers are known to impact breastfeeding outcomes. We aimed to explore paternal knowledge and attitude toward breastfeeding, and possible association with breastfeeding rates at discharge. In this cross-sectional study, we enrolled 200 fathers of healthy term neonates. Read More

View Article and Full-Text PDF

Setting and maintaining standards for patient-reported outcome measures: Can we rely on the COSMIN checklists?

J Med Econ 2021 Mar 24. Epub 2021 Mar 24.

Galen Research, Manchester, United Kingdom.

As test-developers we have often been troubled by published reviews of patient-reported outcome measures (PROMs). Too often minor issues are judged important while other reviews exclude the best measures available. Perhaps this led several groups to make recommendations for evaluating the quality of PROMs. Read More

View Article and Full-Text PDF

[Surgical treatment of common bile duct malformations in children].

Khirurgiia (Mosk) 2021 (4):92-97

Pirogov Russian National Research Medical University, Moscow, Russia.

The review is devoted to the current classifications of common bile duct malformations, authors' opinion regarding surgical approach and reconstruction of the bile ducts. The authors describe the modern modifications of bile duct reconstructions and estimate their effectiveness. PubMed database, Google Scholar and National Scientific Electronic Library eLIBRARY. Read More

View Article and Full-Text PDF
January 2021

Surgical Management of Skull Base and Spine Chordomas.

Curr Treat Options Oncol 2021 Mar 20;22(5):40. Epub 2021 Mar 20.

Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 442, Houston, TX, 77030-4009, USA.

Opinion Statement: Management of chordoma along the cranial-spinal axis is a major challenge for both skull base and spinal surgeons. Although chordoma remains a rare tumor, occurring in approximately 1 per 1 million individuals, its treatment poses several challenges. These tumors are generally poorly responsive to radiation and chemotherapy, leading to surgical resection as the mainstay of treatment. Read More

View Article and Full-Text PDF

There Is Hope After All: Quantifying Opinion and Trustworthiness in Neural Networks.

Front Artif Intell 2020 31;3:54. Epub 2020 Jul 31.

Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States.

Artificial Intelligence (AI) plays a fundamental role in the modern world, especially when used as an autonomous decision maker. One common concern nowadays is "how trustworthy the AIs are." Human operators follow a strict educational curriculum and performance assessment that could be exploited to quantify how much we entrust them. Read More

View Article and Full-Text PDF

Use of prescription drug samples in the US and implications for pharmacoepidemiologic research: a systematic search of the literature.

Expert Rev Pharmacoecon Outcomes Res 2021 Mar 17. Epub 2021 Mar 17.

Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA.

Introduction: Free drug samples are not captured in the pharmacy claims databases used in many pharmacoepidemiologic studies, which could lead to misclassification of drug exposure status and thus bias study results.

Areas Covered: We systematically searched the literature in PubMed/MEDLINE, Embase, and Scopus from database inception to August 2020 for studies assessing the magnitude of exposure misclassification in pharmacy claims data associated with uncaptured drug sample utilization. Our review identified five US-based studies with substantially different characteristics, contexts, methods, and results. Read More

View Article and Full-Text PDF

The Stress of the COVID-19 Pandemic: Beyond the Data.

Samina Salim

Curr Neuropharmacol 2021 Mar 10. Epub 2021 Mar 10.

Department of Pharmacological & Pharmaceutical Sciences, University of Houston, Houston, TX. United States.

Background: The year 2020 will go down in modern history as the one ravaged by a pandemic, the one which humbled the entire world. From the richest and most advanced nations to the poorest and least developed it exposed all of our vulnerabilities. The loss of life, health disparities and economic adversities, aggravated by political and ideological tensions, added multiple layers of stress and anxieties to an already stressed American society. Read More

View Article and Full-Text PDF

Will Confucian Values Help or Hinder the Crisis of Elder Care in Modern Singapore?

Kathryn Muyskens

Asian Bioeth Rev 2020 Jun 24;12(2):117-134. Epub 2020 May 24.

Nanyang Technological University, Singapore, Singapore.

The unique mix of modern Western and traditional Confucian values in Singapore presents young people with contradictory views on duties to aging parents. It remains to be seen whether the changing demands of modern life will result in new generations giving up Confucian family ethics or whether the Confucian dynamic will find a way to adapt to the new pressures. It is the opinion of this author that the Confucian family structure has mixed potential for the growing crisis of elder care. Read More

View Article and Full-Text PDF

Teledermatology in times of COVID-19.

J Dermatol 2021 Mar 14. Epub 2021 Mar 14.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany.

Remote consultations are likely to grow in importance in the following years, especially if the coronavirus disease 2019 (COVID-19) pandemic continues. Patients' opinions on teledermatology have already been analyzed, but a current analysis during the COVID-19 pandemic is lacking. The purpose of this survey was to investigate the satisfaction of patients who had received dermatological advice via telephone during the COVID-19 pandemic and to analyze their general opinion about eHealth as well as possible limitations for a broad implementation. Read More

View Article and Full-Text PDF

Is Bauman's "liquid modernity" influencing the way we are doing science?

J Gen Physiol 2021 May;153(5)

Centro de Investigaciones Cardiovasculares, Centro Científico Tennológico-La Plata-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Médicas, Uiversidad Nacional de La Plata, La Plata, Argentina.

This commentary analyzes the possible effects of lightness-a typical attribute of modern (liquid) society, according to Bauman-on the way we are doing science. We share our opinion in an attempt to discern whether some unwanted practices that may affect our scientific results (such as technology misuse, bonus rewards, publishing under pressure, or indolence for getting accurate results) can be attributed, at least partially, to the liquid characteristic of modern society. We also examine whether the different systems that support science favor these actions, conspiring against what should be the primary goal of science: the search for truth. Read More

View Article and Full-Text PDF

Mucosal coronally positioned flap technique for management of excessive gingival display.

Pan Afr Med J 2020 30;36:235. Epub 2020 Jul 30.

Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia.

Improvement of smile esthetics is a major goal of modern dentistry. Various treatment modalities have been proposed to correct excessive gingival display, depending on intraoral or extraoral etiologies. This report aimed to document the use of mucosal coronally positioned flap called surgical lip repositioning technique for the management of a gummy smile associated with vertical maxillary excess. Read More

View Article and Full-Text PDF

Potential therapeutic and pharmacological strategies for SARS-CoV2.

J Pharm Investig 2021 Mar 5:1-16. Epub 2021 Mar 5.

Pharmaceutical and Fermentation Industries Development Centre (PFIDC), City of Scientific Research and Technological Applications (SRTA-City), Borg Al-Arab, Alexandria Egypt.

Background: At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic. Read More

View Article and Full-Text PDF

Risk Attitude in the DuLong Minority Ethnicity of China.

Front Psychol 2021 18;12:596745. Epub 2021 Feb 18.

School of Basic Medicine, Kunming Medical University, Kunming, China.

Prospect theory predicts a four-fold risk attitude, which means that people are risk seeking for low-probability gain and high-probability loss and risk averse for low-probability loss and high-probability gain because they overweight probability when it is low. The four-fold pattern of risk attitude has been supported by several former studies with mainstream industrialized populations but has never previously been tested in a non-industrialized society. In this work, we examined the robustness of the four-fold risk attitude in the DuLong minority ethnicity in China, which is a small society with only 4,000 members that is isolated from modern civilization. Read More

View Article and Full-Text PDF
February 2021

Assessment of the Propulsion System Operation of the Ships Equipped with the Air Lubrication System.

Sensors (Basel) 2021 Feb 14;21(4). Epub 2021 Feb 14.

Faculty of Marine Engineering, Gdynia Maritime University, 81-234 Gdynia, Poland.

This paper is an attempt to evaluate the effectiveness of the ship's hull air lubrication system in order to reduce the drag leading to fuel consumption reduction by ships. The available papers and reports were analyzed, in which records of the operation parameters of the propulsion system of ships equipped with this system were presented. These reports clearly show the advantages of using air lubrication system. Read More

View Article and Full-Text PDF
February 2021

Mental well-being in ancient Greece: Comment on Graiver (2021).

Yulia Ustinova

Hist Psychol 2021 02;24(1):17-21

In her thought-provoking article, Graiver (see record 2021-21903-001) argues that many early Christian monks achieved sustained psychological health, perceived as joyful serenity by their contemporaries, and admired within their milieu and the society at large. This state was attained by means of dispassion (apatheia) and culminated in spiritual enlightenment. In the author's opinion, conclusions of this historical research call for a reassessment of modern attitudes to psychological health that can be construed only "in a culturally sensitive manner" (p. Read More

View Article and Full-Text PDF
February 2021

Causes of global extinctions in the history of life: facts and hypotheses.

Vavilovskii Zhurnal Genet Selektsii 2020 Jul;24(4):407-419

Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Paleontologists define global extinctions on Earth as a loss of about three-quarters of plant and animal species over a relatively short period of time. At least five global extinctions are documented in the Phanerozoic fossil record (~500-million-year period): ~65, 200, 260, 380, and 440 million years ago. In addition, there is evidence of global extinctions in earlier periods of life on Earth - during the Late Cambrian (~500 million years ago) and Ediacaran periods (more than 540 million years ago). Read More

View Article and Full-Text PDF

The semantic of a pandemic: Are cardiovascular patients dying "with" or "from" COVID-19? Reflections from a case report.

Medicine (Baltimore) 2021 Mar;100(9):e25072

Centro Cardiologico Monzino IRCCS.

Rationale: Northern Italy has been particularly hit by the current Covid-19 pandemic. Italian deceased patients have a mean age of 78.5 years and only 1. Read More

View Article and Full-Text PDF

Young People's Behavioral Intentions towards Low-Carbon Travel: Extending the Theory of Planned Behavior.

Int J Environ Res Public Health 2021 Feb 26;18(5). Epub 2021 Feb 26.

Jiangsu Key Laboratory of Urban ITS, Southeast University, Nanjing 210096, China.

With the rapid development of China's economy and the rapid growth of the population, the demand for traffic is gradually changing from slow to fast, and the traffic congestion, air pollution, climate change and public health problems are becoming increasingly prominent. As residents' willingness for low-carbon travel plays a crucial role in alleviating the problems caused by traffic, many studies pay attention to this aspect, but young people are still an obviously neglected group in the study of willingness for low-carbon travel. The novelty of this study lies in the extension of environmental concern and perceived moral obligation to the theory of planned behavior to explore the factors influencing young people's low-carbon travel behavioral intention. Read More

View Article and Full-Text PDF
February 2021

The Role of Masculinity Threat in Homonegativity and Transphobia.

J Homosex 2021 Apr 6;68(5):802-829. Epub 2019 Sep 6.

Faculty of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.

According to the precarious manhood perspective, masculinity threat triggers various compensatory mechanisms and heightens motivation to restore and reaffirm masculinity via typically masculine attitudes and behaviors. Four experiments aiming to examine the effect of masculinity threat on prejudices toward sexual and gender minorities were undertaken, controlling for adherence to sex role stereotypes. Our studies showed that Polish men representing university and high school students exposed to gender threat experienced increased negative affect (Experiment 1) and expressed higher prejudices toward gay people (Experiment 2) and transgender individuals (Experiments 3a and 3b). Read More

View Article and Full-Text PDF

Machine learning in asthma research: moving toward a more integrated approach.

Expert Rev Respir Med 2021 Mar 16:1-13. Epub 2021 Mar 16.

National Heart and Lung Institute, Imperial College London, UK.

: Big data are reshaping the future of medicine. The growing availability and increasing complexity of data have favored the adoption of modern analytical and computational methodologies in every area of medicine. Over the past decades, asthma research has been characterized by a shift in the way studies are conducted and data are analyzed. Read More

View Article and Full-Text PDF

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Adv Drug Deliv Rev 2021 Feb 18;171:289-331. Epub 2021 Feb 18.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. Electronic address:

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc. Read More

View Article and Full-Text PDF
February 2021