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Recurrence of gastric cancer caused by implantation of tumor cells after curative endoscopic submucosal dissection.

Gastric Cancer 2021 Apr 15. Epub 2021 Apr 15.

Department of Gastroenterology, Omori Red Cross Hospital, 4-30-1, Chuo, Ota-Ku, Tokyo, 143-0024, Japan.

A 93-year-old female underwent curative endoscopic submucosal dissection (ESD) for intramucosal gastric cancer (70 mm in diameter) in the antrum. The lesion showed an irregularly villous structure covered with mucus. En bloc resection was performed. Read More

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PDGFRA Immunohistochemistry Predicts PDGFRA Mutations in Gastrointestinal Stromal Tumors.

Am J Surg Pathol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Platelet-derived growth factor receptor A (PDGFRA) is a receptor tyrosine kinase that is activated by mutations in 10% of gastrointestinal stromal tumors (GISTs) and 55% to 70% of inflammatory fibroid polyps. PDGFRA-mutant GISTs are usually epithelioid and occur predominantly in the stomach. Succinate dehydrogenase-deficient GISTs also arise in the stomach and are usually epithelioid, as are some KIT-mutant GISTs. Read More

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MORPHOLOGICAL FEATURES OF CELLULAR INFILTRATION IN THE MUCOSA OF LARGE INTESTINE IN ULCERATIVE COLITIS AND IRRITABLE BOWEL SYNDROME.

Wiad Lek 2021 ;74(1):57-63

SHUPYK NATIONAL MEDICAL ACADEMY OF POSTGRADUATE EDUCATION, KYIV, UKRAINE.

Objective: The aim is to improve morphological diagnostics, including differential, of UC and IBS, identifying morphological features of cellular infiltration in the mucous membrane ofthe large intestine.

Patients And Methods: Material and methods: Autopsy and biopsy material - fragments of the mucous membrane of the large intestine was used in this study. All the material was divided into 5 groups. Read More

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Application of INSM1 in Diagnosis and Grading of Laryngeal Neuroendocrine Carcinoma.

Laryngoscope 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.

Objective: Chromogranin (CHG), synaptophysin (Syn), and CD56 are generally used in a panel to support diagnoses of laryngeal neuroendocrine carcinomas (NECs). However, the absence of expression of these markers does not completely exclude the diagnosis. INSM1 is a novel marker that is considered sufficiently sensitive and specific for NE differentiation. Read More

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A national trauma data bank analysis of large animal-related injuries.

Injury 2021 Mar 12. Epub 2021 Mar 12.

Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Trauma Services, 1500 Red River St, TX 78701, Austin. Electronic address:

Introduction: Large animal-related injuries (LARI) are relatively uncommon, but, nevertheless, a public hazard. The objective of this study was to better understand LARI injury patterns and outcomes.

Materials And Methods: We performed a retrospective review of the 2016 National Trauma Data Bank and used ICD-10 codes to identify patients injured by a large animal. Read More

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Neurologic Findings Among Inpatients With COVID-19 at a Safety-net US Hospital.

Neurol Clin Pract 2021 Apr;11(2):e83-e91

Boston University Medical Center (PA); and Boston University School of Medicine (LZ, NB, DHH, DMG, AMC-A), MA.

Objective: To characterize the breadth of neurologic findings associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a diverse group of inpatients at an urban, safety-net US medical center.

Methods: Patients were identified through an electronic medical record review from April 15, 2020, until July 1, 2020, at a large safety-net hospital in Boston, MA, caring primarily for underserved, low-income, and elderly patients. All hospitalized adult patients with positive nasopharyngeal swab or respiratory PCR testing for SARS-CoV-2 during their hospitalization or in the 30 days before admission who received an inpatient neurologic or neurocritical care consultation or admission during the study period were enrolled. Read More

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The "Missing 6 dB" Revisited: Influence of Room Acoustics and Binaural Parameters on the Loudness Mismatch Between Headphones and Loudspeakers.

Front Psychol 2021 26;12:623670. Epub 2021 Mar 26.

Medizinische Physik and Cluster of Excellence "Hearing4all", Universität Oldenburg, Oldenburg, Germany.

Generations of researchers observed a mismatch between headphone and loudspeaker presentation: the sound pressure level at the eardrum generated by a headphone has to be about 6 dB higher compared to the level created by a loudspeaker that elicits the same loudness. While it has been shown that this effect vanishes if the same waveforms are generated at the eardrum in a blind comparison, the origin of the mismatch is still unclear. We present new data on the issue that systematically characterize this mismatch under variation of the stimulus frequency, presentation room, and binaural parameters of the headphone presentation. Read More

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Combined Chair-Based Exercises Improve Functional Fitness, Mental Well-Being, Salivary Steroid Balance, and Anti-microbial Activity in Pre-frail Older Women.

Front Psychol 2021 25;12:564490. Epub 2021 Mar 25.

Research Unit in Sport and Physical Activity-CIDAF (UID/PTD/04213/2020), Faculty of Sport Sciences and Physical Education (FCDEF-UC), University of Coimbra, Coimbra, Portugal.

Introduction: Regular exercise has long been shown to positively impact the immune system responsiveness and improve mental well-being (MWB). However, the putative links between biomarkers of mental health and immune efficiency in exercising subjects have been scarcely investigated. The aim of this study was to verify the effect of a 14-week combined chair-based exercise program (CEP) on salivary steroid hormones and anti-microbial proteins, functional fitness, and MWB indexes in pre-frail older women. Read More

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[A case of young hepatocellular carcinoma with non-B, non-C, non-cirrhotic background].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(4):348-357

Department of Internal Medicine, Saiseikai Matsusaka General Hospital.

A man in his 20s visited a local physician because of upper abdominal pain, and an abdominal ultrasonography revealed hepatic tumors. He was then referred to our hospital. The patient had no history of blood transfusion, tattoos, habitual alcohol consumption, or narcotic drug use. Read More

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Theoretical Study on Singlet Fission in Aromatic Diaza -Indacene Dimers.

J Phys Chem A 2021 Apr 9. Epub 2021 Apr 9.

Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.

We theoretically show that diaza (N)-substitution to -indacene with 4 π-electrons, by which the number of π-electrons in N--indacene amounts to 4+2, is a new strategy to design efficient singlet fission (SF) molecules. By N-substitution, the diradical character and the exchange integral are found to be tuned moderately, leading to satisfying the excitation energy level matching condition for SF with a large triplet excitation energy. On the basis of the effective electronic coupling related to the SF rate, we explore the optimal slip-stack dimer packings for fast SF. Read More

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Examination of college student health behaviors and self-reported executive functions.

J Am Coll Health 2021 Apr 8:1-11. Epub 2021 Apr 8.

Department of Psychology, Sam Houston State University, Huntsville, TX, USA.

Objective: Emerging adulthood is characterized by maturation of executive functions (EF) and changes in health behaviors (HB). Interestingly, EF are bi-directionally related to many specific HB; yet how EF performs in relation to overall patterns of HB engagement is unclear. Groupings of HB and the relationship between these HB groupings and EF were examined. Read More

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Prevalence of Effective Audit-and-Feedback Practices in Primary Care Settings: A Qualitative Examination Within Veterans Health Administration.

Hum Factors 2021 Apr 8:187208211005620. Epub 2021 Apr 8.

5228 University of Illinois at Chicago, Champaign, USA.

Objective: The purpose of this study is to uncover and catalog the various practices for delivering and disseminating clinical performance in various Veterans Affairs (VA) locations and to evaluate their quality against evidence-based models of effective feedback as reported in the literature.

Background: Feedback can enhance clinical performance in subsequent performance episodes. However, evidence is clear that the way in which feedback is delivered determines whether performance is harmed or improved. Read More

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Diverging trends for onset of acute myocardial infarction, heart failure, stroke and mortality in young males: role of changes in obesity and fitness.

J Intern Med 2021 Apr 7. Epub 2021 Apr 7.

Region Västra Götaland, Sahlgrenska University Hospital, Östra/MGAÖ, Gothenburg, Sweden.

Background: As opposed to the decreasing overall rates of coronary heart disease (CHD) incidence and overall cardiovascular disease (CVD) mortality, heart failure (HF) and stroke incidence are increasing in young people, potentially due to rising rates of obesity and reduced cardiorespiratory fitness (CRF).

Objectives: We investigated trends in early major CVD outcomes in a large cohort of young men.

Methods: Successive cohorts of Swedish military conscripts from 1971 to 1995 (N = 1,258,432; mean age, 18. Read More

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COVID-19 is not over and age is not enough: Using frailty for prognostication in hospitalized patients.

J Am Geriatr Soc 2021 Apr 5. Epub 2021 Apr 5.

Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Frailty screening using the Clinical Frailty Scale (CFS) has been proposed to guide resource allocation in acute care settings during the pandemic. However, the association between frailty and coronavirus disease 2019 (COVID-19) prognosis remains unclear.

Objectives: To investigate the association between frailty and mortality over 6 months in middle-aged and older patients hospitalized with COVID-19 and the association between acute morbidity severity and mortality across frailty strata. Read More

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Association of Preterm Birth With Long-term Risk of Heart Failure Into Adulthood.

JAMA Pediatr 2021 Apr 5. Epub 2021 Apr 5.

Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: Preterm birth has been associated with increased risk of heart failure (HF) early in life, but its association with new-onset HF in adulthood appears to be unknown.

Objective: To determine whether preterm birth is associated with increased risk of HF from childhood into mid-adulthood in a large population-based cohort.

Design, Setting, And Participants: This national cohort study was conducted in Sweden with data from 1973 through 2015. Read More

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Moderately Queer Programming at an Established LGBTQ Film Festival: A Case Study of BFI Flare: London LGBT Film Festival.

J Homosex 2021 Apr 5:1-21. Epub 2021 Apr 5.

Department of Communication Studies, Campus Aula - Ghent University, Ghent, Belgium.

Many LGBTQ film festivals have transformed from bottom-up, community-driven events into established, profitable organizations. For some, this change has implied downplaying their activist agenda in favor of a celebratory and homonormative approach. This article demonstrates how BFI Flare: London LGBT Film Festival, a long-running European LGBTQ film festival, has dealt with the turn to homonormativity. Read More

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Puma () in the Neighborhood? Records Near Human Settlements and Insights into Human-Carnivore Coexistence in Central Chile.

Animals (Basel) 2021 Mar 31;11(4). Epub 2021 Mar 31.

Unidad de Vida Silvestre, Servicio Agrícola y Ganadero (SAG), Región de O'Higgins, Rancagua 2820000, Chile.

The wildland-urban interface lies at the confluence of human-dominated and wild landscapes-creating a number of management and conservation challenges. Wildlife sightings near human settlements have appeared to increase in the last years. This article reports 51 records of presences, sightings, and livestock attacks of , a large-sized felid, collected from 2012 to 2020 across the O'Higgins region in central Chile. Read More

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Regulation of DNA (de)Methylation Positively Impacts Seed Germination during Seed Development under Heat Stress.

Genes (Basel) 2021 Mar 23;12(3). Epub 2021 Mar 23.

Institut Agro, INRAE, IRHS, SFR QUASAV, University of Angers, F-49000 Angers, France.

Seed development needs the coordination of multiple molecular mechanisms to promote correct tissue development, seed filling, and the acquisition of germination capacity, desiccation tolerance, longevity, and dormancy. Heat stress can negatively impact these processes and upon the increase of global mean temperatures, global food security is threatened. Here, we explored the impact of heat stress on seed physiology, morphology, gene expression, and methylation on three stages of seed development. Read More

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Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic.

Cancers (Basel) 2021 Mar 13;13(6). Epub 2021 Mar 13.

Department of Neurosurgery, Münster University Hospital, 48149 Münster, Germany.

The COVID-19 pandemic is associated with significant morbidity, mortality, and restrictions on everyday life worldwide. This may be especially challenging for brain tumor patients given increased vulnerability due to their pre-existing condition. Here, we aimed to investigate the quality of life (QoL) in brain tumor patients and relatives in this setting. Read More

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Novel Histologic Categorization Based on Lauren Histotypes Conveys Prognostic Information for Gastroesophageal Junction Cancers-Analysis from a Large Single Center Cohort in Germany.

Cancers (Basel) 2021 Mar 15;13(6). Epub 2021 Mar 15.

Department of Surgery, TUM School of Medicine, Ismaninger Strasse 22, 81675 Munich, Germany.

Adenocarcinoma of the gastroesophageal junction (AEG) ranks among the most common cancers in the Western world with increasing incidence. However, the prognostic influence and applicability of the Lauren classification was not examined in detail before. The purpose of this analysis was to analyze the oncologic outcomes of GE-junction cancer related to the Lauren histotype in a large single center cohort. Read More

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Antenna Protein Clustering In Vitro Unveiled by Fluorescence Correlation Spectroscopy.

Int J Mol Sci 2021 Mar 15;22(6). Epub 2021 Mar 15.

Centre Algatech, Institute of Microbiology of the Czech Academy of Sciences, Opatovický Mlýn, 379 81 Třeboň, Czech Republic.

Antenna protein aggregation is one of the principal mechanisms considered effective in protecting phototrophs against high light damage. Commonly, it is induced, in vitro, by decreasing detergent concentration and pH of a solution of purified antennas; the resulting reduction in fluorescence emission is considered to be representative of non-photochemical quenching in vivo. However, little is known about the actual size and organization of antenna particles formed by this means, and hence the physiological relevance of this experimental approach is questionable. Read More

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Infection Alters Intestinal Morphology and Mucosal Innate Immunity in Moderately Malnourished Mice.

Nutrients 2021 Mar 11;13(3). Epub 2021 Mar 11.

Department of Biology, College of Arts and Sciences, Appalachian State University, 572 Rivers St, Boone, NC 28608, USA.

is a protozoan parasite which causes malarial disease in humans. Infections commonly occur in sub-Saharan Africa, a region with high rates of inadequate nutrient consumption resulting in malnutrition. The complex relationship between malaria and malnutrition and their effects on gut immunity and physiology are poorly understood. Read More

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Development of a Computed Tomography Perfusion Protocol to Support Large Animal Resuscitation Research.

J Trauma Acute Care Surg 2021 Mar 23. Epub 2021 Mar 23.

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, Maryland, USA Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Background: Adequate cerebral perfusion is crucial for a positive neurological outcome in trauma; however, it is difficult to characterize in the acute setting with non-invasive methods. Intra-arterial computed tomography perfusion (IA-CTP) may offer a solution. The aim of this study is to develop an IA-CTP protocol for resuscitation research. Read More

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Heritability of brain resilience to perturbation in humans.

Neuroimage 2021 Mar 29;235:118013. Epub 2021 Mar 29.

Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215 USA. Electronic address:

Resilience is the capacity of complex systems to persist in the face of external perturbations and retain their functional properties and performance. In the present study, we investigated how individual variations in brain resilience, which might influence response to stress, aging and disease, are influenced by genetics and/or the environment, with potential implications for the implementation of resilience-boosting interventions. Resilience estimates were derived from in silico lesioning of either brain regions or functional connections constituting the connectome of healthy individuals belonging to two different large and unique datasets of twins, specifically: 463 individual twins from the Human Connectome Project and 453 individual twins from the Colorado Longitudinal Twin Study. Read More

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The Way of the Future: Personalizing Treatment Plans Through Technology.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-12

Yale Cancer Center, Yale School of Medicine, New Haven, CT.

Advances in tissue analysis methods, image analysis, high-throughput molecular profiling, and computational tools increasingly allow us to capture and quantify patient-to patient variations that impact cancer risk, prognosis, and treatment response. Statistical models that integrate patient-specific information from multiple sources (e.g. Read More

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Synteny-based genome assembly for 16 species of Heliconius butterflies, and an assessment of structural variation across the genus.

Genome Biol Evol 2021 Apr 1. Epub 2021 Apr 1.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

Heliconius butterflies (Lepidoptera: Nymphalidae) are a group of 48 neotropical species widely studied in evolutionary research. Despite the wealth of genomic data generated in past years, chromosomal level genome assemblies currently exist for only two species, Heliconius melpomene and H. erato, each a representative of one of the two major clades of the genus. Read More

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Primary Tumor Resection for Rectal Cancer With Unresectable Liver Metastases: A Chance to Cut Is a Chance for Improved Survival.

Front Oncol 2021 15;11:628715. Epub 2021 Mar 15.

Department of Colon and Rectal Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

About half of the patients with rectal cancer will develop liver metastasis during the course of their illness. Unfortunately, a large proportion of these metastases are unresectable. Surgical resection of the primary tumor vs. Read More

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Implantation of rectosigmoid cancer in a preexisting anal fissure.

Int Cancer Conf J 2021 Apr 5;10(2):139-143. Epub 2021 Jan 5.

Department of Surgery, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192 Japan.

Colorectal cancer (CRC) rarely spreads by implantation. We report a case of implantation of rectosigmoid cancer in an anal fissure. A 70-year-old woman with a 15-year medical history of anal fissure was referred to our hospital with anal pain of 3-month duration. Read More

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Scaffold-based analysis of nonpeptide oncogenic FTase inhibitors using multiple similarity matching, binding affinity scoring and enzyme inhibition assay.

J Mol Graph Model 2021 Mar 12;105:107898. Epub 2021 Mar 12.

Department of Chest Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China. Electronic address:

Oncogenic protein farnesyltransferase (FTase) is a key enzyme responsible for the lipid modification of a large and important number of proteins including Ras, which has been recognized as a druggable target of diverse cancers. Here, we report a systematic scaffold-based analysis to investigate the affinity, selectivity and cross-reactivity of nonpeptide inhibitors across ontology-enriched, disease-associated FTase mutants, by integrating multiple similarity matching, binding affinity scoring and enzyme inhibition assay. It is revealed that nonpeptide inhibitors are generally insensitive to FTase mutations; many of them cannot definitely select for wild-type target over mutant enzymes. Read More

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Impact of transjugular intrahepatic portosystemic shunt creation on the central lymphatic system in liver cirrhosis.

Sci Rep 2021 Mar 29;11(1):7065. Epub 2021 Mar 29.

Department of Internal Medicine I, University Hospital of Bonn, Venusberg-Campus 1, 53105, Bonn, Germany.

The puropse of this study was to evaluate associations of cisterna chyli (CCh) diameter with portal hemodynamics and the influence of TIPS-creation in cirrhotic patients. 93 cirrhotic patients (57 male, mean age 59 years) received CT prior to TIPS-creation. 38/93 additionally underwent post-interventional CT. Read More

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