36,563 results match your criteria moderate pain


Corneal nerve loss is related to the severity of painful diabetic neuropathy.

Eur J Neurol 2021 Sep 27. Epub 2021 Sep 27.

Division of Cardiovascular Sciences, Cardiac Centre, Faculty of Biology, Medicine and Health, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester, UK.

Background And Aim: Previously we have shown that patients with painful diabetic neuropathy have greater corneal nerve loss compared to patients with painless diabetic neuropathy. This study investigated if the severity of corneal nerve loss was related to the severity of painful diabetic neuropathy (PDN).

Methods: Participants with diabetic neuropathy (n=118) and healthy controls (n=38) underwent clinical and neurological evaluation, quantitative sensory testing, nerve conduction testing and corneal confocal microscopy (CCM) and were categorized into those with no (n=43), mild (n=34) and moderate-to-severe (n=41) neuropathic pain. Read More

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September 2021

Sling Exercise in the Management of Chronic Low Back Pain: A Systematic Review and Meta-Analysis.

J Strength Cond Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Physical Therapy, Long Island University, Brooklyn, New York.

Abstract: Drummond, C, Lebedeva, V, Kirker, K, and Masaracchio, M. Sling exercise in the management of chronic low back pain: A systematic review and meta-analysis. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this systematic review is to assess the effectiveness of sling exercise therapy (SET) in individuals with chronic low back pain (LBP). Read More

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September 2021

[Clinical oberservation on rotator cuff suture threader and strapping suture in meniscus tear under arthroscopy].

Zhongguo Gu Shang 2021 Sep;34(9):851-5

Department of Joint, Zhoushan Hospital of TCM, Zhoushan 316000, Zhejiang, China.

Objective: To explore clinical effect of arthroscopic meniscus tear strapping suture by rotator cuff suture threader.

Methods: Forty patients with meniscus tear injury admitted from July 2015 to May 2019, including 27 males and 13 females, aged from 20 to 55 years old with an average of (36.0±1. Read More

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September 2021

Measurement properties of brief neuropathy screening items in cancer patients receiving taxanes, platinums, or proteasome inhibitors.

J Patient Rep Outcomes 2021 Sep 26;5(1):101. Epub 2021 Sep 26.

Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.

Background: Timely detection of chemotherapy-induced peripheral neuropathy (CIPN) is critical to effectively tailor chemotherapy dose levels and offer supportive care. The purpose of this secondary analysis was to determine the reliability and validity of the two Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) numbness and tingling severity and interference items to screen for CIPN in patients receiving taxanes, platinums, or proteasome inhibitors.

Methods: Participants (N = 142) completed the two PRO-CTCAE items, a 0-10 numerical rating scale of worst CIPN pain intensity, and the Quality of Life Questionnaire-CIPN20 (QLQ-CIPN20) prior to three clinical visits (T1, T2, T3) during neurotoxic chemotherapy. Read More

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September 2021

Interrater Reliability of the Prone Apprehension Relocation Test.

Orthop J Sports Med 2021 Sep 20;9(9):23259671211032229. Epub 2021 Sep 20.

Department of Orthopedic Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: The Prone Apprehension Relocation Test (PART) augments existing radiographic measures and clinical provocative maneuvers in diagnosing hip instability. One measure of the potential clinical utility of the PART depends on the reproducibility of test results by evaluating providers including physicians, licensed athletic trainers, and physical therapists.

Purpose: To determine the interrater reliability of the PART among health care providers. Read More

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September 2021

Safe and appropriate use of diclofenac in chronic kidney disease: An Indian perspective.

J Family Med Prim Care 2021 Jul 30;10(7):2450-2456. Epub 2021 Jul 30.

Head Medical Affairs, Novartis India Limited, Mumbai, Maharashtra, India.

Pain is most common symptom associated with progressive disorder, chronic kidney disease (CKD), and is usually undertreated during the early stages of CKD. So, present review was conducted to evaluate the challenges for the management of pain in CKD patients and addresses the scope for considering Diclofenac as suitable alternative for pain management in CKD patient. The database PubMed and Google Scholar were searched from 1970 to Dec 2020 for literature published in English and all studies, review articles that examined the use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in pain management in CKD patients were included. Read More

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Measurement of acetabular wall indices: comparison between CT and plain radiography.

J Hip Preserv Surg 2021 Jan 19;8(1):51-57. Epub 2021 Jul 19.

University of California Irvine School of Medicine, 1001 Health Sciences Rd, Irvine, CA 92617, USA.

The purpose of this study was to compare measurements of anterior wall index (AWI) and posterior wall index (PWI) on computed tomography (CT) to those on radiographs (XR). A consecutive cohort of 33 patients (45 hips total) being evaluated for hip pain with both XR and CT was examined. Preoperative measurements of AWI and PWI were performed utilizing supine anteroposterior pelvic XR and coronal and swiss axial CT scans by two independent raters. Read More

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January 2021

Topical ALA-Photodynamic Therapy Combined with Acne Debridement and Meticulous Nursing for the Treatment of Moderate-Severe Acne in Adolescent Patients.

Clin Cosmet Investig Dermatol 2021 18;14:1303-1310. Epub 2021 Sep 18.

Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Objective: The present study aims to explore the effect of acne debridement + meticulous nursing on 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in adolescent patients with moderate-severe acne.

Methods: A total of 60 adolescent patients with moderate-severe acne who were admitted to our plastic surgery outpatient clinic between January 2018 and January 2020 were selected as the subjects of the present retrospective study. The patients were divided into two groups: the observation group and the control group (n = 30, each). Read More

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September 2021

Efficacy of and in the management of w.s.r. to dry eye syndrome: An open labelled randomized comparative clinical trial.

Ayu 2020 Jan-Mar;41(1):52-57. Epub 2021 Jul 30.

Department of Shalakya Tantra, National Institute of Ayurveda, Jaipur, Rajasthan, India.

Background: is one of the eight branches of Ayurveda, which also includes ophthalmology. (dry eye syndrome) is one of the diseases, involving all parts of eye () characterized by (gritty feeling), (pricking type of pain), (photophobia), (blurred vision), (burning sensation) and (congestion in the eye). All these symptoms are similar to the symptoms of dry eye syndrome. Read More

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Comparison of Depressive Symptom Outcomes in Hospitalized Adult Cancer Patients Receiving Music Therapy or Massage Therapy.

J Pain Symptom Manage 2021 Sep 23. Epub 2021 Sep 23.

Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Context: Depressive symptoms are prevalent and associated with greater healthcare utilization among hospitalized adults with cancer. Music therapy and massage therapy are available at many National Cancer Institute (NCI)-Designated Cancer Centers and recommended by the American Society of Clinical Oncology for depressive symptoms, but a paucity of studies have compared these two therapies.

Objective: We conducted a retrospective, multi-method program evaluation of single, first-time music therapy and massage therapy sessions delivered to hospitalized adults with cancer. Read More

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September 2021

Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlled trial.

Lancet Infect Dis 2021 Sep 23. Epub 2021 Sep 23.

Novavax, Gaithersburg, MD, USA.

Background: Improved seasonal influenza vaccines for older adults that can induce broadly cross-reactive antibodies and enhanced T-cell responses, particularly against A H3N2 viruses, while avoiding egg-adaptive antigenic changes, are needed. We aimed to show that the Matrix-M-adjuvanted quadrivalent nanoparticle influenza vaccine (qNIV) was immunologically non-inferior to a licensed, standard-dose quadrivalent inactivated influenza vaccine (IIV4) in older adults.

Methods: This was a phase 3 randomised, observer-blinded, active-comparator controlled trial done across 19 US community-based clinical research sites during the 2019-20 influenza season. Read More

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September 2021

The effect of an eye mask on midazolam requirement for sedation during spinal anesthesia: a randomized controlled trial.

BMC Anesthesiol 2021 Sep 25;21(1):232. Epub 2021 Sep 25.

Department of Anesthesiology and Pain Medicine, Jeonbuk National University Medical School and Hospital, 20, Geonji-ro, Deokjin-gu, Jeonju, 54907, South Korea.

Background: Midazolam is frequently used for sedation during spinal anesthesia. However, external environmental factors, such as bright surgical lights, may hamper patient relaxation, which may lead to an increase in the dose of midazolam required and the likelihood of adverse drug effects. We investigated whether using an eye mask to block the external environment could reduce midazolam requirements during spinal anesthesia. Read More

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September 2021

Hepatic hemangioendothelioma - A rare case report.

Int J Surg Case Rep 2021 Sep 20;87:106424. Epub 2021 Sep 20.

Pir Abdul Qadir shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.

Introduction And Importance: Hepatic hemangioendothelioma (HHE) is a very rare mild-moderate malignant tumor of the hepatic vascular endothelium. The etiology is yet not fully understood. Patients can be asymptomatic or may present with non-specific symptoms or hepatic insufficiency. Read More

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September 2021

YouTube as a source of information on bladder pain syndrome: A contemporary analysis.

Neurourol Urodyn 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurosciences, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.

Aim: To evaluate the quality of YouTube™ videos on bladder pain syndrome (BPS) and to investigate whether they can be used as a reliable source of information.

Methods: The search term "bladder pain syndrome" was used on YouTube platform. The first 100 videos were selected. Read More

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September 2021

Instruments for assisted vaginal birth.

Cochrane Database Syst Rev 2021 Sep 24;9:CD005455. Epub 2021 Sep 24.

Keele University & Department of Obstetrics and Gynaecology, University Hospitals of North Midlands, Stoke-on-Trent, UK.

Background: Assisted vaginal births are carried out to expedite birth for the benefit of mothers and babies but are sometimes associated with significant morbidity for both. Various instruments are available, broadly divided into forceps and vacuum cups, and choice may be influenced by clinical circumstances, operator preference, experience and availability.  OBJECTIVES: To evaluate the different instruments in terms of success in achieving a vaginal birth, and the risk of morbidity for mother and baby. Read More

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September 2021

Routine Coronary Angiography in Adults Undergoing Percutaneous Atrial Septal Defect Closure: Implications for Practice Guidelines.

J Invasive Cardiol 2021 Sep 23. Epub 2021 Sep 23.

Toronto General Hospital, 200 Elizabeth St, 6E - Room 249, Toronto, Ontario, M5G 2C4.

Objectives: Secundum atrial septal defect (ASD) is a common adult congenital heart lesion for which percutaneous closure offers treatment in patients with suitable anatomy. We sought to determine the outcomes of coronary angiography in a population of adults >40 years of age who were undergoing percutaneous ASD closure.

Methods: Patients >40 years of age who underwent ASD closure between 2009-2016 were included in this retrospective chart review. Read More

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September 2021

Clinical performance of rheumatoid arthritis impact of disease score: a real-life evidence from the multicenter nationwide registry BioStaR.

Rheumatol Int 2021 Sep 24. Epub 2021 Sep 24.

Rheumatology Clinic, Aydin State Hospital, Aydın, Turkey.

The rheumatoid arthritis impact of disease (RAID) score was developed as a patient-derived composite response index for the evaluation of the disease impact on cases with rheumatoid arthritis (RA). The aim of this study was to evaluate the psychometric properties and performance of RAID score in the real-life settings. Cases with RA from our multi-center, nationwide registry called Biologic and targeted Synthetic antirheumatic drugs Registry RA (BioStaR RA) were included in this cross-sectional observational study. Read More

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September 2021

Transcatheter Aortic Valve Replacement versus Sutureless Aortic Valve Replacement: A Single Center Retrospective Cohort Study.

Yonsei Med J 2021 Oct;62(10):885-894

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study sought to compare clinical outcomes between transcatheter aortic valve replacement (TAVR) and sutureless aortic valve replacement (SU-AVR).

Materials And Methods: In total, 320 patients with symptomatic severe aortic stenosis who underwent TAVR (n=254) or SU-AVR (n=66) at Severance Cardiovascular Hospital between July 2011 and September 2019 were included for analysis. Propensity score matching and inverse probability weighted adjustment were performed to adjust for confounding baseline characteristics. Read More

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October 2021

Association of poor sleep burden in middle age and older adults with risk for delirium during hospitalization.

J Gerontol A Biol Sci Med Sci 2021 Sep 24. Epub 2021 Sep 24.

Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.

Background: Delirium is a distressing neurocognitive disorder recently linked to sleep disturbances. However, the longitudinal relationship between sleep and delirium remains unclear. This study assessed the associations of poor sleep burden, and its trajectory, with delirium risk during hospitalization. Read More

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September 2021

Influence of regular climbing on depression, generalized anxiety and lower back pain.

Ann Agric Environ Med 2021 Sep 30;28(3):463-468. Epub 2020 Jun 30.

Department of Sports Medicine, Medical University, Lublin, Poland.

Introduction And Objective: Anxiety and depression disorders are increasingly affecting society. Anxiety disorders are the most prevalent psychiatric disorders, and depressive disorders are increasing in society worldwide. Lower back pain is one of the common health problems experienced by 50-80% of adults at some point in their lives. Read More

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September 2021

variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience.

Brain Commun 2021 8;3(3):fcab212. Epub 2021 Sep 8.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.

There is a pressing need for understanding of factors that confer resilience to pain. Gain-of-function mutations in sodium channel Nav1.7 produce hyperexcitability of dorsal root ganglion neurons underlying inherited erythromelalgia, a human genetic model of neuropathic pain. Read More

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September 2021

Leading from Behind: An Educational Intervention to Address Faculty and Learner Preparedness for Competence By Design in Psychiatry.

J Multidiscip Healthc 2021 16;14:2587-2595. Epub 2021 Sep 16.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Purpose: Residency training programs across Canada are beginning to implement the Royal College of Physicians and Surgeons of Canada's new Competence By Design (CBD) framework in medical education. The objective of the current research was to assess faculty members' and learners' understanding of, and preparedness for, the national shift to CBD in psychiatry before and after an educational intervention.

Methods: The current research implemented a pre-test/post-test design to investigate faculty members' and learners' perceptions and attitudes towards competency-based medical education (CBME) and CBD before and after a one-hour educational session delivered by an expert on CBME. Read More

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September 2021

Paracetamol use during pregnancy - a call for precautionary action.

Nat Rev Endocrinol 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Read More

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September 2021

Normobaric oxygen treatment for mild-to-moderate depression: a randomized, double-blind, proof-of-concept trial.

Sci Rep 2021 Sep 23;11(1):18911. Epub 2021 Sep 23.

Department of Nursing, Faculty of Health Sciences, School for Community Health Professions, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beer-Sheva, Israel.

Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects even in subjects without lung disease. Consistently, several studies demonstrated that normobaric oxygen treatment has clinical benefits in some neurological conditions. This study examined the efficacy of normobaric oxygen treatment in subjects with depression. Read More

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September 2021

Chewing gum as a non-pharmacological alternative for orthodontic pain relief: A randomized clinical trial using an intention-to-treat analysis.

Korean J Orthod 2021 Sep;51(5):346-354

Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Objective: To compare the effectiveness of ibuprofen, acetaminophen, and chewing gum for orthodontic pain relief and to assess if chewing gum can be a non-pharmacological alternative for orthodontic pain relief.

Methods: The study enrolled 106 patients of both sexes, aged ≥ 12 years, with body weight > 50 kg, and mild-to-moderate dental crowding in the upper arch. After randomization and allocation concealment, the intervention groups were either administered with ibuprofen (400 mg) or acetaminophen (500 mg) or chewed sugar-free chewing gum immediately after initial archwire placement and every 6 hours for 1 week if the pain persisted. Read More

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September 2021

Evaluation of Cold Sensitivity in Patients With Upper Extremity Nerve Compression Syndromes: A Scoping Review.

J Hand Surg Am 2021 Sep 20. Epub 2021 Sep 20.

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Toronto Western Hospital Hand Program, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Purpose: The aim of this study was to review the literature to determine the prevalence of cold sensitivity in upper extremity nerve compression syndromes and the impact of treating nerve compression syndromes on cold sensitivity.

Methods: Following a standardized scoping review protocol, this study included interventional and observational study designs assessing patients with cold sensitivity and upper extremity nerve compression syndromes. Review articles, case reports, and small case series (n < 5) were excluded. Read More

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September 2021

Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.

PLoS Negl Trop Dis 2021 Sep 23;15(9):e0009794. Epub 2021 Sep 23.

National Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Federal University of Uberlandia, Uberlândia, Brazil.

Background: Neuropathic pain (NP) is one of the main complications of leprosy, and its management is challenging. Infrared thermography (IRT) has been shown to be effective in the evaluation of peripheral autonomic function resulting from microcirculation flow changes in painful syndromes. This study used IRT to map the skin temperature on the hands and feet of leprosy patients with NP. Read More

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September 2021

Cross-Cultural Adaption and Psychometric Evaluation of the German Craniofacial Pain and Disability Inventory (CF-PDI).

Pain Physician 2021 Sep;24(6):E857-E866

Department of Physical Therapy and Rehabilitation science, University of Applied Science Osnabruck, Germany.

Background: The Craniofacial Pain and Disability Inventory (CF-PDI) is a cross-culturally adapted instrument designed from a biopsychosocial perspective to measure pain, disability, and function in orofacial head and neck pain with shown psychometric properties; however, the German cross-cultural adaption is lacking.

Objectives: To carry out a transcultural translation of CF-PDI into German and assess its psychometric properties in patients with painful temporomandibular disorders (TMD) with respect to construct and clinical validity, internal consistency and reproducibility.

Study Design: Multicenter, prospective, cross-sectional design. Read More

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September 2021

24-month Real-World Study of Spinal Cord Stimulation in Failed Back Surgery Patients with Refractory Pain.

Pain Physician 2021 Sep;24(6):479-488

Pain Unit, La Princesa University Hospital, Madrid, Spain; Clinical Pharmacology, La Princesa University Hospital, Madrid, Spain.

Background: Failed Back Surgery Syndrome (FBSS) causes disability and lowers health-related quality of life (HRQoL) for patients. Many patients become refractory to Conventional Medical Management (CMM) and Spinal Cord Stimulation (SCS) is advised. However, comparative effectiveness research of both clinical approaches still lacks further evidence. Read More

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September 2021

Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy.

Birth Defects Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

Objectives: Tramadol, an atypical opioid, is clinically efficacious in treating moderate to severe pain. The aim of current study was to find out the toxicological effects of tramadol exposure to pregnant rats and fetuses during the late phase of pregnancy.

Methods: Wistar pregnant rats were exposed to 1. Read More

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September 2021