109,089 results match your criteria models presented


Mathematical modeling and numerical simulation of sulfamethoxazole adsorption onto sugarcane bagasse in a fixed-bed column.

Chemosphere 2021 Apr 27;280:130687. Epub 2021 Apr 27.

Center for Environmental Studies, Department of Applied Chemistry and Production Systems, Faculty of Chemical Sciences, University of Cuenca, 010203, Cuenca, Ecuador. Electronic address:

Having rigorous mathematical models is essential for the design and scaling of adsorption columns. In this study, the dynamic behavior of the sulfamethoxazole adsorption on sugarcane bagasse was studied and compared using analytical models and a theoretical mechanistic model. Initially, fixed-bed column tests were carried out at different flow rates and bed heights. Read More

View Article and Full-Text PDF

Impact of emergency medical service delays on time to reperfusion and mortality in STEMI.

Open Heart 2021 May;8(1)

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

Objectives: To explore the relationship between emergency medical service (EMS) delay time, overall time to reperfusion and clinical outcome in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).

Methods: This was a retrospective observational study of 2976 patients with STEMI who presented to EMS and underwent PPCI between January 2014 and December 2017. We performed multivariable logistic models to assess the relationship between EMS delay time and 30-day mortality and to identify factors associated with system delay time. Read More

View Article and Full-Text PDF

The challenging scenario of beliefs and attitudes toward chronic low back pain among final year undergraduate students: A cross-sectional investigation.

Musculoskelet Sci Pract 2021 Mar 31;53:102375. Epub 2021 Mar 31.

Department of Physical Therapy, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.

Objective: To identify the beliefs and attitudes of students in four health courses about chronic low back pain (CLBP) management, and to investigate personal and undergraduate training-related factors associated with their beliefs.

Methods: Cross-sectional study conducted with 173 Brazilian medicine, physiotherapy, nursing and pharmacy students. Participants provided information on age, personal experience with LPB, training or class on CLBP management, and contact with patients with CLBP, followed by their first therapeutic choices. Read More

View Article and Full-Text PDF

Understating complex interactions in socio-ecological systems using system dynamics: A case in the tropical Andes.

J Environ Manage 2021 May 4;291:112675. Epub 2021 May 4.

Universidad Nacional de Colombia - Sede Medellín, Facultad de Minas, Departamento de Ciencias de la decisión y la computación, Cra 80 No 65-223, Bloque M8, Colombia. Electronic address:

The high dependence of human communities on ecosystems' well-functioning has transformed and degraded ecosystems at alarming rates. Strategies for sustainability are an urgent need and requires the understanding of the complex interactions between human and ecological systems in the territories. For such understanding several modelling approaches have been proposed, but still face important challenges. Read More

View Article and Full-Text PDF

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis.

Am J Physiol Heart Circ Physiol 2021 May 7. Epub 2021 May 7.

Department of Physiology and Pharmacology and Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United Statesgrid.264756.4.

Until recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculation is impacted by the hemodynamic consequences of an epicardial, flow-limiting stenosis. Read More

View Article and Full-Text PDF

Finite-Size Effects and Optimal System Sizes in Simulations of Surfactant Micelle Self-Assembly.

J Phys Chem B 2021 May 7. Epub 2021 May 7.

Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

The spontaneous formation of micelles in aqueous solutions is governed by the amphipathic nature of surfactants and is practically interesting due to the regular use of micelles as membrane mimics, for the characterization of protein structure, and for drug design and delivery. We performed a systematic characterization of the finite-size effect observed in single-component dodecylphosphocholine (DPC) micelles with the coarse-grained MARTINI model. Of multiple coarse-grained solvent models investigated using large system sizes, the nonpolarizable solvent model was found to most accurately reproduce SANS spectra of 100 mM DPC in aqueous solution. Read More

View Article and Full-Text PDF

On Fixed Marginal Distributions and Psychometric Network Models.

Multivariate Behav Res 2021 May 7:1-19. Epub 2021 May 7.

Florida St. University.

This reply addresses the commentary by Epskamp et al. (in press) on our prior work, of using fixed marginals for sampling the data for testing hypothesis in psychometric network application. Mathematical results are presented for expected column (e. Read More

View Article and Full-Text PDF

Transfer Learning to CCSD(T): Accurate Anharmonic Frequencies from Machine Learning Models.

J Chem Theory Comput 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.

The calculation of the anharmonic modes of small- to medium-sized molecules for assigning experimentally measured frequencies to the corresponding type of molecular motions is computationally challenging at sufficiently high levels of quantum chemical theory. Here, a practical and affordable way to calculate coupled-cluster quality anharmonic frequencies using second-order vibrational perturbation theory (VPT2) from machine-learned models is presented. The approach, referenced as "NN + VPT2", uses a high-dimensional neural network (PhysNet) to learn potential energy surfaces (PESs) at different levels of theory from which harmonic and VPT2 frequencies can be efficiently determined. Read More

View Article and Full-Text PDF

Thickness-modulated lateral MoS diodes with sub-terahertz cutoff frequency.

Nanoscale 2021 May 7. Epub 2021 May 7.

School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.

Thickness-modulated lateral MoS2 diodes with an extracted benchmark cutoff frequency (fc) of up to 126 GHz are implemented and fully characterised. Fabricated diodes demonstrate an on-off current ratio of more than 600 and a short circuit current responsivity at zero-bias of 7 A/W. The excellent performance achieved in our device is attributed to reduced contact resistance from using In/Au contacts and low junction capacitance due to the lateral device structure. Read More

View Article and Full-Text PDF

Crude probability of death for cancer patients by spread of disease in New South Wales, Australia 1985 to 2014.

Cancer Med 2021 May 6. Epub 2021 May 6.

Cancer Research Centre, Cancer Council Queensland, Brisbane, Queensland, Australia.

Background: To estimate trends in the crude probability of death for cancer patients by sex, age and spread of disease over the past 30 years in New South Wales, Australia.

Methods: Population-based cohort of 716,501 people aged 15-89 years diagnosed with a first primary cancer during 1985-2014 were followed up to 31 December 2015. Flexible parametric relative survival models were used to estimate the age-specific crude probability of dying from cancer and other causes by calendar year, sex and spread of disease for all solid tumours combined and cancers of the colorectum, lung, female breast, prostate and melanoma. Read More

View Article and Full-Text PDF

Stage-dependent conditional survival and failure hazard of non-metastatic nasopharyngeal carcinoma after intensity-modulated radiation therapy: Clinical implications for treatment strategies and surveillance.

Cancer Med 2021 May 6. Epub 2021 May 6.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Conditional survival (CS) and failure hazard estimations can provide important dynamic prognostic information for clinical decision-making and surveillance counseling. The current study aimed to investigate the CS and dynamic failure hazard in non-metastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).

Methods: Conditional overall survival (COS) and progression-free survival (CPFS) estimates adjusted for age and gender against each AJCC 8th stage were calculated. Read More

View Article and Full-Text PDF

An Investigation Into the Role of Strain and Structure on Vascular Smooth Muscle Cell Growth.

Front Bioeng Biotechnol 2021 20;9:641794. Epub 2021 Apr 20.

Trinity Centre for Biomedical Engineering, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland.

The orientation of vascular cells can greatly influence the mechanical properties and functionality of soft vascular tissues. How cell orientation mediates the growth response of cells is of critical importance in understanding the response of soft tissues to mechanical stimuli or injury. To date, considerable evidence has shown that cells align with structural cues such as collagen fibers. Read More

View Article and Full-Text PDF

Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis.

Clin Kidney J 2021 May 24;14(5):1371-1378. Epub 2020 Aug 24.

UCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Background: DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free DNA (cfDNA) and the relationship with inflammation, anaemia, oxidative stress and haemostatic disturbances in ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed to evaluate the predictive value of cfDNA for the outcome of ESRD patients. Read More

View Article and Full-Text PDF

Matched Filter Cyclone Maximum Wind Retrievals Using CYGNSS: Progress Update and Error Analysis.

IEEE J Sel Top Appl Earth Obs Remote Sens 2021 17;14:3591-3601. Epub 2021 Mar 17.

Constellation Observing System for Meteorology, Ionosphere, and Climate Program, University Corporation for Atmospheric Research, Boulder, CO 80301 USA.

This article describes progress relating to a previously reported matched filter retrieval approach for the estimation of hurricane maximum winds using delay Doppler map (DDM) measurements of the Cyclone Global Navigation Satellite System (CYGNSS) mission. The retrievals presented are based on comparisons of these measured DDMs, and their simulated counterparts as a set of storm parameters are varied. The analysis presented examines the dependencies of retrieval performance on the synthetic storm model used as part of the forward modeling process using a set of CYGNSS storm-observing full DDM downlinks containing 68 tracks and spanning 18 storms over the period 2017-2020. Read More

View Article and Full-Text PDF

Circulating Galectin-1 and Galectin-3 in Sera From Patients With Systemic Sclerosis: Associations With Clinical Features and Treatment.

Front Pharmacol 2021 20;12:650605. Epub 2021 Apr 20.

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, Argentina.

Systemic Sclerosis (SSc) is a rheumatic disease characterized by fibrosis, microvascular damage and immune dysregulation. Two major subsets, limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc) can be defined, according to the extent of skin involvement. Increasing evidence indicates a role for galectins in immune and vascular programs, extracellular matrix remodeling and fibrosis, suggesting their possible involvement in SSc. Read More

View Article and Full-Text PDF

Voxel-Wise Feature Selection Method for CNN Binary Classification of Neuroimaging Data.

Front Neurosci 2021 20;15:630747. Epub 2021 Apr 20.

IRCCS SDN, Naples, Italy.

Voxel-wise group analysis is presented as a novel feature selection (FS) technique for a deep learning (DL) approach to brain imaging data classification. The method, based on a voxel-wise two-sample -test and denoted as -masking, is integrated into the learning procedure as a data-driven FS strategy. t-Masking has been introduced in a convolutional neural network (CNN) for the test bench of binary classification of very-mild Alzheimer's disease vs. Read More

View Article and Full-Text PDF

First-Order Learning Models With the GDINA: Estimation With the EM Algorithm and Applications.

Appl Psychol Meas 2021 May 15;45(3):143-158. Epub 2021 Feb 15.

University of Illinois at Urbana-Champaign, USA.

In learning environments, understanding the longitudinal path of learning is one of the main goals. Cognitive diagnostic models (CDMs) for measurement combined with a transition model for mastery may be beneficial for providing fine-grained information about students' knowledge profiles over time. An efficient algorithm to estimate model parameters would augment the practicality of this combination. Read More

View Article and Full-Text PDF

External Validation of the R2eD AVM Score to Predict the Likelihood of Rupture Presentation of Brain Arteriovenous Malformations.

Neurosurgery 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Geisinger, Danville, Pennsylvania, USA.

Background: The R2eD AVM scoring system has been recently proposed to predict the risk of hemorrhagic presentation of brain arteriovenous malformations (AVMs).

Objective: To perform the first external validation of this R2eD AVM score.

Methods: Over a retrospective 10-yr period from 2009 to 2019, 122 patients with brain AVMs fit the inclusion criteria. Read More

View Article and Full-Text PDF

Photon-in/Photon-out Spectroscopy at the I20-Scanning Beamline at Diamond Light Source.

J Phys Condens Matter 2021 May 6. Epub 2021 May 6.

Science Division, Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, Oxon, OX11 0DE, Didcot, Oxfordshire, OX11 0DE, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

A scanning multi-crystal x-ray emission spectrometer to perform photon-in/photon-out spectroscopy at the I20-Scanning beamline at Diamond Light Source is described. The instrument, equipped with three analyzer crystals, is based on a 1m Rowland circle spectrometer operating in the vertical plane. The energy resolution of the spectrometer is of the order of 1 eV, having sufficient resolving power to overcome the core-hole lifetime broadening of most of the transition metals K-edges. Read More

View Article and Full-Text PDF

Multi-platform integration based on NIR and UV-Vis spectroscopies for the geographical traceability of the fruits of Amomum tsao-ko.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 24;258:119872. Epub 2021 Apr 24.

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming 650200, China; School of Agriculture, Yunnan University, Kunming 650500, China. Electronic address:

Due to the world-wide concern relating to herb quality and safety, there is a momentum to authenticate the geographical origin of herb with multi-platform techniques. This study attempted to assess multi-platform information as a practical strategy for the geographical traceability of the fruits of Amomum tsao-ko. To this aim, one hundred and eighty dried fruits of A. Read More

View Article and Full-Text PDF

Core liver homeostatic co-expression networks are preserved but respond to perturbations in an organism- and disease-specific manner.

Cell Syst 2021 Apr 29. Epub 2021 Apr 29.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia. Electronic address:

Findings about chronic complex diseases are difficult to extrapolate from animal models to humans. We reason that organs may have core network modules that are preserved between species and are predictably altered when homeostasis is disrupted. To test this idea, we perturbed hepatic homeostasis in mice by dietary challenge and compared the liver transcriptome with that in human fatty liver disease and liver cancer. Read More

View Article and Full-Text PDF

Prognostic models for predicting relapse or recurrence of major depressive disorder in adults.

Cochrane Database Syst Rev 2021 May 6;5:CD013491. Epub 2021 May 6.

Mental Health and Addiction Research Group, Department of Health Sciences, University of York, York, UK.

Background: Relapse (the re-emergence of depressive symptoms after some level of improvement but preceding recovery) and recurrence (onset of a new depressive episode after recovery) are common in depression, lead to worse outcomes and quality of life for patients and exert a high economic cost on society. Outcomes can be predicted by using multivariable prognostic models, which use information about several predictors to produce an individualised risk estimate. The ability to accurately predict relapse or recurrence while patients are well (in remission) would allow the identification of high-risk individuals and may improve overall treatment outcomes for patients by enabling more efficient allocation of interventions to prevent relapse and recurrence. Read More

View Article and Full-Text PDF

Gender Differences and Mortality Trends After Transcatheter Aortic Valve Implantation: A 10-Year Analysis From a Single Tertiary Center.

J Invasive Cardiol 2021 May 6. Epub 2021 May 6.

Division of Interventional Cardiology of MedStar, Cardiovascular Research Network at MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, D.C., 20010.

Aim: To evaluate gender differences and mortality trends in a population undergoing transcatheter aortic valve implantation (TAVI) and to analyze the correlates to all-cause mortality at follow-up.

Methods: The study comprises a prospective cohort of 592 TAVI patients (53.4% female) treated between 2008 and 2018. Read More

View Article and Full-Text PDF

Prognostic factor analysis of patients with small cell lung cancer: Real-world data from 988 patients.

Thorac Cancer 2021 May 6. Epub 2021 May 6.

Department of Thoracic Oncology II, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, China.

Background: Small cell lung cancer (SCLC) is characterized by aggressive spread and poor prognosis, but has limited treatment options. Results of prognostic factors from randomized trials on treatment arrangement are conflicting and large-scale real-world analysis is lacking.

Methods: Patients diagnosed SCLC between 2008 and 2018 in Peking University Cancer Hospital were included in this study. Read More

View Article and Full-Text PDF

Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics.

Adv Mater 2021 May 6:e2100425. Epub 2021 May 6.

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

The low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood-brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Read More

View Article and Full-Text PDF

Survival models induced by zero-modified power series discrete frailty: Application with a melanoma data set.

Stat Methods Med Res 2021 May 6:9622802211011187. Epub 2021 May 6.

Institute of Mathematics and Statistics, Federal University of Goiás, Goiânia, Brazil.

Survival models with a frailty term are presented as an extension of Cox's proportional hazard model, in which a random effect is introduced in the hazard function in a multiplicative form with the aim of modeling the unobserved heterogeneity in the population. Candidates for the frailty distribution are assumed to be continuous and non-negative. However, this assumption may not be true in some situations. Read More

View Article and Full-Text PDF

Knowledge distillation in deep learning and its applications.

PeerJ Comput Sci 2021 14;7:e474. Epub 2021 Apr 14.

Department of Information and Computer Science, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.

Deep learning based models are relatively large, and it is hard to deploy such models on resource-limited devices such as mobile phones and embedded devices. One possible solution is knowledge distillation whereby a smaller model (student model) is trained by utilizing the information from a larger model (teacher model). In this paper, we present an outlook of knowledge distillation techniques applied to deep learning models. Read More

View Article and Full-Text PDF

Anti-Sway and Positioning Adaptive Control of a Double-Pendulum Effect Crane System With Neural Network Compensation.

Front Robot AI 2021 19;8:639734. Epub 2021 Apr 19.

College of Logistics Engineering, Shanghai Maritime University, Shanghai, China.

Cranes are widely used in the field of construction, logistics, and the manufacturing industry. Cranes that use wire ropes as the main lifting mechanism are deeply troubled by the swaying of heavy objects, which seriously restricts the working efficiency of the crane and even cause accidents. Compared with the single-pendulum crane, the double-pendulum effect crane model has stronger nonlinearity, and its controller design is challenging. Read More

View Article and Full-Text PDF

Retrospective study on admission trends of Californian hummingbirds found in urban habitats (1991-2016).

PeerJ 2021 13;9:e11131. Epub 2021 Apr 13.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.

Background: Hummingbirds are frequently presented to California wildlife rehabilitation centers for medical care, accounting for approximately 5% of overall admissions. Age, sex, and reason for admission could impact hummingbird survivability, therefore identification of these factors could help maximize rehabilitation efforts.

Methods: Mixed-effects logistic regression models were used to identify specific threats to the survival of 6908 hummingbirds (1645 nestlings and 5263 non-nestlings) consisting of five species (), found in urban settings, and admitted to California wildlife rehabilitation centers over 26 years. Read More

View Article and Full-Text PDF

Enhancing deep-learning training for phase identification in powder X-ray diffractograms.

IUCrJ 2021 May 1;8(Pt 3):408-420. Epub 2021 Apr 1.

Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Germany.

Within the domain of analyzing powder X-ray diffraction (XRD) scans, manual examination of the recorded data is still the most popular method, but it requires some expertise and is time consuming. The usual workflow for the phase-identification task involves software for searching databases of known compounds and matching lists of spacings and related intensities to the measured data. Most automated approaches apply some iterative procedure for the search/match process but fail to be generally reliable yet without the manual validation step of an expert. Read More

View Article and Full-Text PDF