239,079 results match your criteria model rats


Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Rehabilitation Medicine Center, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Read More

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Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Jun 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0. Read More

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The antidepressant-like effects of Danggui Buxue Decoction in GK rats by activating CREB/BDNF/TrkB signaling pathway.

Phytomedicine 2021 May 21;89:153600. Epub 2021 May 21.

College of Traditional Chinese Medicine•College of Intergrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. Electronic address:

Background: High rates of co-morbidity have been reported in patients with diabetes mellitus with depression (DD). Danggui Buxue Decoction (DBD), a Traditional Chinese Medicine formula composed of Angelica and Astragalus, has been historically used for the treatment of diabetes.

Purpose: This study aimed to investigated whether DBD and its main active component, ferulic acid (FA) from Angelica, could ameliorate depression-like behavior in DD and the underlying mechanisms. Read More

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Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats.

Mech Ageing Dev 2021 Jun 12:111520. Epub 2021 Jun 12.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy; Department of Obstetrics, Gynecology and Reproductive Science, University of Vermont, Burlington, VT, 05405, USA. Electronic address:

Vascular changes of tone and biomechanical properties induced by ageing increase the risk for cardiovascular diseases. Caloric restriction (CR) has been shown to protect against cardiovascular diseases and improve endothelial dysfunction in cerebral resistance arteries. We hypothesise that CR will enhance vascular tone and structural properties of cerebral resistance arteries and exert comparable beneficial effects on the systemic vasculature of aged rat model. Read More

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Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats.

Eur J Pharmacol 2021 Jun 12:174257. Epub 2021 Jun 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)-induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. Read More

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Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.

Curr Med Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

The role of B7-1 in podocyte injury has received increasing attention. The aim of this study was to investigate whether losartan protects podocytes of patients with diabetic kidney disease (DKD) by regulating B7-1 and the underlying mechanisms. Rats with streptozotocin-induced DKD were treated with losartan for 8 weeks. Read More

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Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress.

Curr Med Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

The oxidative stress response plays an important role in the occurrence and development of diabetic kidney disease (DKD). It has become a new treatment target for DKD. In the current study, the effects of carbamylated erythropoietin (CEPO) on renal oxidative stress and damage in diabetic rats were examined. Read More

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Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction.

Genes Genomics 2021 Jun 15. Epub 2021 Jun 15.

Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), 89 Taoyuan Road, Nanshan District, Shenzhen, 518052, Guangdong, China.

Background: Baicalin has anti-inflammatory, antibacterial, blood platelet aggregation-inhibiting, free oxygen radical-clearing, and endotoxin-decreasing properties. However, its molecular mechanism involved in the treatment of Adriamycin-induced nephrotic syndrome (NS) is still unclear.

Objective: This study aimed to explore the effects of baicalin on Adriamycin-induced nephrotic syndrome (NS) and to characterize the genes involved in this progression. Read More

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A deep convolutional visual encoding model of neuronal responses in the LGN.

Brain Inform 2021 Jun 15;8(1):11. Epub 2021 Jun 15.

Computer and Systems Engineering Department, Faculty of Engineering, Ain Shams University, 1 El-Sarayat St., Abbassia, Cairo, Egypt.

The Lateral Geniculate Nucleus (LGN) represents one of the major processing sites along the visual pathway. Despite its crucial role in processing visual information and its utility as one target for recently developed visual prostheses, it is much less studied compared to the retina and the visual cortex. In this paper, we introduce a deep learning encoder to predict LGN neuronal firing in response to different visual stimulation patterns. Read More

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LA14 Alleviates Liver Injury.

mSystems 2021 Jun 15:e0038421. Epub 2021 Jun 15.

Key Laboratory of Nutrition of Zhejiang Province, Institute of Health Food, Hangzhou Medical College, Hangzhou, China.

Although the probiotic Lactobacillus acidophilus LA14 is used worldwide, its effect on liver diseases remains unelucidated. Here, 32 rats were divided into four groups, gavaged with L. acidophilus LA14 (3 × 10 CFU) or phosphate-buffered saline for 7 days, and then intraperitoneally injected with d-galactosamine or saline. Read More

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In vivo evaluation of temperature-responsive antimicrobial-loaded PNIPAAm hydrogels for prevention of surgical site infection.

J Biomed Mater Res B Appl Biomater 2021 Jun 15. Epub 2021 Jun 15.

Sonoran Biosciences, Tempe, Arizona, USA.

Surgical site infections (SSIs) are a persistent clinical challenge. Local antimicrobial delivery may reduce the risk of SSI by increasing drug concentrations and distribution in vulnerable surgical sites compared to what is achieved using systemic antimicrobial prophylaxis alone. In this work, we describe a comprehensive in vivo evaluation of the safety and efficacy of poly(N-isopropylacrylamide-co-dimethylbutyrolactone acrylamide-co-Jeffamine M-1000 acrylamide) [PNDJ], an injectable temperature-responsive hydrogel carrier for antimicrobial delivery in surgical sites. Read More

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Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research.

Sci Rep 2021 Jun 14;11(1):12451. Epub 2021 Jun 14.

Department of Companion Animals and Horses, Equine Surgery Unit, University of Veterinary Medicine Vienna, VETERM, Veterinaerplatz 1, 1210, Vienna, Austria.

For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importance of inflammation in tendon disease, this study compared the cellular and molecular features of inflammation in tenocytes of humans and four common model species (mouse, rat, sheep, and horse). While mouse and rat tenocytes most closely equalled human tenocytes' low proliferation capacity and the negligible effect of inflammation on proliferation, the wound closure speed of humans was best approximated by rats and horses. Read More

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In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer's disease.

Sci Rep 2021 Jun 14;11(1):12419. Epub 2021 Jun 14.

BRAIN Centre (Biomarker Research and Imaging for Neuroscience), Department of Neuroimaging, King's College London, The James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.

Amyloid plaques are a hallmark of Alzheimer's disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Read More

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Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.

Cell Death Discov 2021 Jun 14;7(1):143. Epub 2021 Jun 14.

Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Congenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the dentate granule cells (DGCs) reside in. However, how CH impairs the cognitive function via affecting DGCs and the underlying mechanisms are not fully elucidated. Read More

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Co-infection by Salmonella enterica subsp. Enterica serovar typhimurium and Entamoeba dispar pathogenic strains enhances colitis and the expression of amoebic virulence factors.

Microb Pathog 2021 Jun 11:105010. Epub 2021 Jun 11.

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Electronic address:

Amebiasis is the most severe protozoan infection affecting the human intestine, and the second leading cause of death among parasitic diseases. The mechanisms of amoebic virulence factors acquisition are poorly understood, and there are few studies showing the interaction between Entamoeba dispar and bacteria. Salmonella enterica subsp. Read More

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Digestive promoting effect and mechanism of Jiao Sanxian in rats.

J Ethnopharmacol 2021 Jun 11:114334. Epub 2021 Jun 11.

Department of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn (Crataegi Fructus), charred malt (Hordei Fructus Germinatus) and Liu Shenqu (Massa Medicata Fermentata), is a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called "Jiao Sanxian" in China because people believe that it is a miracle medicine for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment, the underlying mechanism has not been clarified to date. Read More

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Mineral deposition intervention through reduction of phosphorus intake suppresses osteoarthritic lesions in temporomandibular joint.

Osteoarthritis Cartilage 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University. Electronic address:

Objective: To explore the suppressing impact of low phosphorus intake on osteoarthritic temporomandibular joint and the possible mechanisms of nuclear acid injury in the insulted chondrocytes.

Design: Chondrocytes were loaded with fluid flow shear stress (FFSS) with or without low phosphorus medium. Seventy-two mice (sampled at 3-, 7- and 11-wk, n = 6) and forty-eight rats (sampled at 12-wks for different testing purpose, n = 6) were applied with unilateral anterior crossbite (UAC) with or without low phosphorus diet. Read More

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Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models.

Neurosci Lett 2021 Jun 11:136050. Epub 2021 Jun 11.

Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China. Electronic address:

Atractylenolide III, a major component of the atractylodes macrocephala Koidz, derived from the rhizoma atractylodes, has been reported to produce various pharmacological effects including anti-aging, anti-inflammation, anti-tumor, and other effects. Growing evidence suggests that proinflammatory cytokines, such as interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α, are increased in depressed patients. The present study was aimed at investigating the antidepressant- and anxiolytic-like effects of atractylenolide III in lipopolysaccharide (LPS) challenge and chronic unpredictable mild stress (CUMS) rat model. Read More

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Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder.

Neuropharmacology 2021 Jun 11:108653. Epub 2021 Jun 11.

University of Minnesota Medical School, Department of Pharmacology; Hennepin Healthcare Research Institute; University of Minnesota Medical School, Department of Medicine; University of Minnesota Center for Immunology.

Therapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)-sKLH vaccine in rats. Read More

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Re-investigating the coughing rat model of pertussis to understand pathogenesis.

Infect Immun 2021 Jun 14:IAI0030421. Epub 2021 Jun 14.

Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV.

() is a highly contagious bacterium that is the causative agent of whooping cough (pertussis). Currently, acellular pertussis vaccines (aP; DTaP; Tdap) are used to prevent pertussis disease. However, it is clear that the aP vaccine efficacy quickly wanes, resulting in the re-emergence of pertussis. Read More

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Liposomal Form of L-Dopa and SH-Sy5y Cell-Derived Exosomes Modulate the Tyrosine Hydroxylase/Dopamine Receptor D2 Signaling Pathway in Parkinson's Rat Models.

J Mol Neurosci 2021 Jun 14. Epub 2021 Jun 14.

Biology Department, Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.

Parkinson's disease is a progressive neurodegenerative disorder in which dopaminergic neurons located in the substantia nigra are gradually lost. Currently, combined treatment strategies are receiving increasing attention as potential therapeutic approaches for Parkinson's disease. This study aimed to evaluate the potential effects of exosomes released from SH-Sy5y cells and the liposomal form of L-dopa on Parkinson's rat models. Read More

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Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 14. Epub 2021 Jun 14.

PhD Section, Gujarat Technological University, Chandkheda, Ahmedabad, Gujarat, India.

Breast cancer is the most common malignancy in women worldwide. Strategies for cancer chemotherapy commonly require the use of combination therapy for better outcomes of results. The present work is aimed to evaluate the potential of naringenin and metformin concomitant addition with doxorubicin chemotherapy against experimental breast carcinoma. Read More

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Massive Pontine Hemorrhage by Dual Injection of Autologous Blood.

J Vis Exp 2021 May 29(171). Epub 2021 May 29.

The Second Affiliated Hospital of Guangzhou Medical University;

We provide a protocol to establish a massive pontine hemorrhage model in a rat. Rats weighing about 250 grams were used in this study. One hundred microliters of autologous blood was taken from the tail vein and stereotaxically injected into the pons. Read More

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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats.

J Vis Exp 2021 May 27(171). Epub 2021 May 27.

The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center, Bar-Ilan University;

Motor tics are sudden, rapid, recurrent movements that are the key symptoms of Tourette syndrome and other tic disorders. The pathophysiology of tic generation is associated with abnormal inhibition of the basal ganglia, particularly its primary input structure, the striatum. In animal models of both rodents and non-human primates, local application of GABAA antagonists, such as bicuculline and picrotoxin, into the motor parts of the striatum induces local disinhibition resulting in the expression of motor tics. Read More

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Effect of Local Delivery of Vancomycin and Tobramycin on Bone Regeneration.

Orthop Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Traumatology, Beijing Jishuitan Hospital, Beijing, China.

Objective: A bone defect rat model was established to investigate the osteogenic effect of local delivery two antibiotics (vancomycin and tobramycin powder) on bone regeneration.

Methods: Twenty-four Sprague-Dawley (SD) male rats (6 to 8 weeks, 200 to 250 g) were used in this study. All these rats were randomly divided into four groups. Read More

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Inhibitory Effect of Roflumilast on Experimental Periodontitis.

J Periodontol 2021 Jun 14. Epub 2021 Jun 14.

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Background: Phosphodiesterase-4 (PDE4) has been identified as a valid therapeutic target in several inflammatory diseases. In this study, we assessed PDE4 in gingival tissue from patients with chronic periodontitis and evaluated the therapeutic effects of the PDE4 inhibitor, roflumilast, in an experimental rat model of periodontitis.

Methods: Gingival tissue specimens from 20 healthy subjects and 20 patients with periodontitis were collected, and the mRNA expression levels of PDE4, interleukin (IL)-1β, and IL-6 were assessed. Read More

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Moderate/subclinical calcium deficiency attenuates trabecular mass, microarchitecture and bone growth in growing rats.

Biochem Biophys Rep 2021 Jul 27;26:101033. Epub 2021 May 27.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow -226014, India.

Adequate dietary calcium (Ca) intake is essential for bone accretion, peak bone mass (PBM) attainment, bone quality and strength during the mammalian growth period. Severe Ca deficiency during growing age results in secondary hyperparathyroidism (SHPT) and poor bone quality and strength. However, the impact of moderate Ca deficiency during rats early growth period on bone health and the reversibility with supplementing calcium later in adult life remains unclear. Read More

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Activity-based Anorexia for Modeling Vulnerability and Resilience in Mice.

Bio Protoc 2021 May 5;11(9):e4009. Epub 2021 May 5.

Department of Psychology, Hunter College, CUNY, New York, NY, USA.

Activity-based anorexia (ABA) is a widely used rodent model of anorexia nervosa. It involves combining limited access to food with unlimited access to a running wheel, leading to a paradoxical decrease in food intake, hyperactivity, and life-threatening weight loss. Although initially characterized in rats, ABA has been tested in mice with results that vary based on strain, sex, age, the amount of time food is available, and the number of days of food restriction. Read More

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Development of a Chemical Reproductive Aging Model in Female Rats.

Bio Protoc 2021 Apr 20;11(8):e3994. Epub 2021 Apr 20.

Department of Basic and Oral Science, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.

Women are born with an abundant but finite pool of ovarian follicles, which naturally and progressively decreased during their reproductive years until menstrual periods stop permanently (menopause). Perimenopause represents the transition from reproductive to non-reproductive life. It is usually characterized by neuroendocrine, metabolic and behavioral changes, which result from a follicular depletion and reduced number of ovarian follicles. Read More

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Visualizing the Growth and Division of Rat Gut Bacteria by D-Amino Acid-Based Labeling and FISH Staining.

Front Mol Biosci 2021 28;8:681938. Epub 2021 May 28.

Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Rat is a widely used mammalian model for gut microbiota research. However, due to the difficulties of individual culture of many of the gut bacteria, much information about the microbial behaviors in the rat gut remains largely unknown. Here, to characterize the growth and division of rat gut bacteria, we apply a chemical strategy that integrates the use of sequential tagging with D-amino acid-based metabolic probes (STAMP) with fluorescence hybridization (FISH) to rat gut microbiota. Read More

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