Sci Rep 2021 Jun 14;11(1):12451. Epub 2021 Jun 14.
Department of Companion Animals and Horses, Equine Surgery Unit, University of Veterinary Medicine Vienna, VETERM, Veterinaerplatz 1, 1210, Vienna, Austria.
For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importance of inflammation in tendon disease, this study compared the cellular and molecular features of inflammation in tenocytes of humans and four common model species (mouse, rat, sheep, and horse). While mouse and rat tenocytes most closely equalled human tenocytes' low proliferation capacity and the negligible effect of inflammation on proliferation, the wound closure speed of humans was best approximated by rats and horses. Read More