Neuropharmacology 2021 Sep 20:108784. Epub 2021 Sep 20.
Centre de Recherche du CHU de Québec, Axe Neurosciences, 2705, Boulevard Laurier, Québec, (Québec), G1V4G2, Canada; Faculté de Pharmacie, Pavillon Ferdinand-Vandry, 1050, avenue de la Médecine, Université Laval, Québec, (Québec) G1V 0A6, Canada. Electronic address:
The maisn neuropathological feature of Parkinson's disease (PD) is degeneration of dopamine neurons (DA) in the substantia nigra (SN); PD prevalence is higher in men, suggesting a role of sex hormones in neuroprotection. This study sought the effects of sex hormones in the brain in a mouse model of PD and modulation of steroid metabolism/synthesis with the 5α-reductase inhibitor dutasteride shown to protect MPTP male mice. Male and female mice were gonadectomized (GDX) or SHAM operated. Read More