29,222 results match your criteria model pancreatic


Liraglutide improves pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus by inhibiting the IKKε/NF-κB pathway.

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4818-4828

Department of Endocrinology, Affiliated Ren He Hospital of China Three Gorges University, The Second Clinical Medical College of China Three Gorges University, Yichang, China.

Objective: The purpose of this study was to explore the effect of liraglutide on pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus (T2DM) and the potential mechanisms.

Materials And Methods: SD rats were randomly divided into control group, model group, and liraglutide groups (200 and 100 μg/(kg·d)). Rats were fed with high sugar and high-fat diet for 8 weeks, and then streptozotocin (STZ) 40 mg/kg was intraperitoneally injected to establish T2DM model. Read More

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Prediction of Survival and Analysis of Prognostic Factors for Patients With Combined Hepatocellular Carcinoma and Cholangiocarcinoma: A Population-Based Study.

Front Oncol 2021 16;11:686972. Epub 2021 Jul 16.

School of Medicine, Southeast University, Nanjing, China.

Background: Combined hepatocellular carcinoma and cholangiocarcinoma (CHC) is an uncommon subtype of primary liver cancer. Because of limited epidemiological data, prognostic risk factors and therapeutic strategies for patients with CHC tend to be individualized. This study aimed to identify independent prognostic factors and develop a nomogram-based model for predicting the overall survival (OS) of patients with CHC. Read More

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The influence of erythropoietin on apoptosis and fibrosis in the early phase of chronic pancreatitis in rats.

Arch Med Sci 2021 12;17(4):1100-1108. Epub 2020 Oct 12.

Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, Lublin, Poland.

Introduction: Chronic pancreatitis (CP) is a continuing, inflammatory process of the pancreas, characterised by irreversible morphological changes. The identification of pancreatic stellate cells resulted in the development of research on the pathogenesis of CP. Erythropoietin (Epo) regulates the interaction between apoptosis and inflammation of the brain, kidney, and heart muscle. Read More

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October 2020

Herbal Medicines Targeting the Improved -Cell Functions and -Cell Regeneration for the Management of Diabetes Mellitus.

Evid Based Complement Alternat Med 2021 14;2021:2920530. Epub 2021 Jul 14.

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

There is an increasing trend of investigating natural bioactive compounds targeting pancreatic -cells for the prevention/treatment of diabetes mellitus (DM). With the exploration of multiple mechanisms by which -cells involve in the pathogenesis of DM, herbal medicines are gaining attention due to their multitasking ability as evidenced by traditional medicine practices. This review attempts to summarize herbal medicines with the potential for improvement of -cell functions and regeneration as scientifically proven by investigations. Read More

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Construction and Validation of an Immune-Based Prognostic Model for Pancreatic Adenocarcinoma Based on Public Databases.

Front Genet 2021 14;12:702102. Epub 2021 Jul 14.

Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, China.

Background: Pancreatic adenocarcinoma (PAAD) is a highly lethal and aggressive tumor with poor prognoses. The predictive capability of immune-related genes (IRGs) in PAAD has yet to be explored. We aimed to explore prognostic-related immune genes and develop a prediction model for indicating prognosis in PAAD. Read More

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Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients.

Front Endocrinol (Lausanne) 2021 16;12:611512. Epub 2021 Jul 16.

Department of Endocrinology and Diabetes, St. Vincent's Hospital, Fitzroy, VIC, Australia.

The authors' perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received Pancreatic Islet Transplants to treat Type I diabetes (T1D) with Impaired Awareness of Hypoglycemia. The evolutions are described of protocols and models for use in T1D, and Insulin-Requiring Type 2 Diabetes (T2D) that were the basis for studies in the Islet Recipients. In each group, the need for modifications, and how the protocols and models were adapted is discussed. Read More

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Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture.

J Inflamm Res 2021 24;14:3501-3521. Epub 2021 Jul 24.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA.

Background: Exosomes have been reported to mediate activation of the inflammatory response by secretion of inflammasome products such as IL-1β or IL-18 and that changes in exosomes production or secretion may be a therapeutic target for treatment of a variety of different chronic diseases. The present study tested the hypothesis that exosome-mediated release of NLRP3 inflammasome products instigates the inflammatory response in the lung during emphysema, a type of chronic obstructive pulmonary disease (COPD) and that electroacupuncture (EA) may attenuate emphysema by inhibition of NLRP3 inflammasome activation and consequent inflammation.

Methods: The COPD mice model was developed by injecting porcine pancreatic elastase (PPE) via puncture tracheotomy and instillation. Read More

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Incidence and Risk Factors for Diaphragmatic Herniation following Esophagectomy for Cancer.

Ann Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, F-59000 Lille, France Department of Digestive Surgery, Pierre Zobda Quitman Hospital, 97200 Fort de France, France University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, F-59000 Lille, France Department of Digestive and Interventional Radiology. Claude Huriez University Hospital, F-59000 Lille, France Department of digestive and hepatobiliary/pancreatic surgery, AZ Groeninge hospital, Kortrijk, Belgium UMR-S1277 - CANTHER laboratory "Cancer Heterogeneity, Plasticity and Resistance to Therapies", Lille, France.

Objective: To evaluate the incidence and risk factors of diaphragmatic herniation following esophagectomy for cancer (DHEC), and assess the results of surgical repair.

Summary Background Data: The current incidence of DHEC is discussed with conflicting data regarding its treatment and natural course.

Methods: Monocentric retrospective cohort study(2009-2018). Read More

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Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2.

Biol Pharm Bull 2021 ;44(8):1093-1100

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine.

Hydrogen sulfide (HS), an important gaseous messenger, is known to have neuroprotective effects in many neurological disorders. This study examined the neuroprotective effects and the associated mechanisms of HS in the model Sprague-Dawley (SD) rats with spinal cord injury (SCI). We found that HS showed neuroprotective effects in SCI model rats, improved the symptoms of neurological impairment, reduced the secretion of inflammatory factors, nerve cell apoptosis, and endoplasmic reticulum (ER), and oxidative stresses. Read More

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January 2021

Development and validation of a radiomics nomogram to discriminate advanced pancreatic cancer with liver metastases or other metastatic patterns.

Cancer Biomark 2021 Jul 23. Epub 2021 Jul 23.

Department of Oncology, Shanghai JingAn District ZhaBei Central Hospital, Shanghai, China.

Background: Patients with advanced pancreatic cancer (APC) and liver metastases have much poorer prognoses than patients with other metastatic patterns.

Objective: This study aimed to develop and validate a radiomics model to discriminate patients with pancreatic cancer and liver metastases from those with other metastatic patterns.

Methods: We evaluated 77 patients who had APC and performed texture analysis on the region of interest. Read More

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Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy - a retrospective observational study.

J Pharm Health Care Sci 2021 Aug 2;7(1):27. Epub 2021 Aug 2.

Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, Japan.

Background: Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between moderate-to-severe AEs and quality of life (QOL) in patients with APC who received outpatient chemotherapy.

Methods: We recruited APC patients who received outpatient chemotherapy in Gifu University Hospital between September 2017 and December 2018. Read More

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[Study on the prognostic value of preoperative anti hepatitis B virus therapy in patients with hepatocellular carcinoma complicated with microvascular tumor thrombus and establishment of survival prediction model].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(28):2203-2209

Department of Pancreatic-Hepato-Biliary Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

To explored the effect of preoperative antiviral therapy on the prognosis of microvascular tumor thrombi patients, and to established a prognostic prediction model for these patients after radical resection of liver cancer. The clinicopathological and survival data of hepatocellular carcinoma patients with microvascular tumor thrombus who underwent radical resection in the Third Affiliated Hospital of Sun Yat-sen University from January 1, 2013 to December 31, 2015 were retrospectively collected. Kaplan-Meier method was used to calculate the survival curve, and log-rank test was used to compare the prognosis of patients with and without antiviral treatment before operation. Read More

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Initiating pancreatic neuroendocrine tumour (pNET) screening in young MEN1 patients: results from the DutchMEN Study Group.

J Clin Endocrinol Metab 2021 Aug 1. Epub 2021 Aug 1.

Department of Endocrine Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.

Context: Non-functioning pancreatic neuroendocrine tumours (NF-pNETs) are highly prevalent and constitute an important cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). Still, the optimal age to initiate screening for pNETs is under debate.

Objective: To assess the age of occurrence of clinically relevant NF-pNETs in young MEN1 patients. Read More

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History of Hepatic Encephalopathy Is Not a Contraindication to Transjugular Intrahepatic Portosystemic Shunt Placement for Refractory Ascites.

Clin Transl Gastroenterol 2021 Aug 1;12(8):e00378. Epub 2021 Aug 1.

Division of Liver and Pancreas Transplantation, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Los Angeles, California, USA.

Introduction: The outcomes of transjugular intrahepatic portosystemic shunt (TIPS) placement in patients with hepatic encephalopathy (HE) are controversial. We studied the relationship of pre-TIPS HE in patients undergoing TIPS for refractory ascites on all-cause mortality and development of post-TIPS HE.

Methods: A single-center retrospective comparison study was performed for patients undergoing TIPS for refractory ascites. Read More

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Comprehensive meta-analysis of randomized controlled trials of Lactated Ringer's versus Normal Saline for acute pancreatitis.

Pancreatology 2021 Jul 26. Epub 2021 Jul 26.

Division of Gastroenterology, University of Southern California, USA. Electronic address:

Introduction: Fluid resuscitation is the keystone of treatment for acute pancreatitis. Though clinical guidelines and expert opinions agree on large volume resuscitation, debate remains on the optimal fluid type. The most commonly used fluids are Lactated Ringer's (LR) and Normal Saline (NS), but the studies published to date comparing LR vs NS yield conflicting results. Read More

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Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma.

BMC Cancer 2021 Jul 31;21(1):876. Epub 2021 Jul 31.

Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230032, Anhui, China.

Background: m6A is the most prevalent and abundant form of mRNA modifications and is closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try to conduct an effective prediction model to investigated the function of m6A RNA methylation modulators in pancreatic adenocarcinoma and estimated the potential association between m6A RNA methylation modulators and tumor microenvironment infiltration for optimization of treatment.

Methods: Expression of 28 m6A RNA methylation modulators and clinical data of patients with pancreatic adenocarcinoma and normal samples were obtained from TCGA and GTEx database. Read More

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promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome.

Horm Mol Biol Clin Investig 2020 Dec 22;42(2):159-165. Epub 2020 Dec 22.

Institute of Biomedicine Research, Central University of Ecuador, Quito, Ecuador.

Objectives: Reduced gene expression of in subjects with insulin resistance (IR) has been reported. Insulin resistance occurs early on the course of Turner syndrome (TS). The main objective of this study was to evaluate the relationship between promoter DNA methylation status in lymphocytes and insulin sensitivity and secretion in Ecuadorian females with TS. Read More

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December 2020

A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.

Neoplasia 2021 Jul 28;23(9):939-950. Epub 2021 Jul 28.

Department of Clinical Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan; Institute for Biomedical Sciences Molecular Pathophysiology, Iwate Medical University, Yahaba, Iwate, Japan; Division of Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan. Electronic address:

An antibody-drug conjugate (ADC) is a promising therapeutic modality because selective and effective delivery of an anti-cancer drug is achieved by drug-conjugated antibody-targeting cancer antigen. Glypican 1 (GPC1) is highly expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC) and esophageal squamous cell carcinoma (ESCC). Herein, we describe the usefulness of GPC1-targeting ADC. Read More

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A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy.

J Colloid Interface Sci 2021 Jul 20;605:263-273. Epub 2021 Jul 20.

The Seventh Hospital of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China. Electronic address:

Calcium based biomaterials were widely used for drug delivery application due to their biodegradability, biocompatibility, and high drug loading capacity. Herein, amino-capped polyamidoamine (PAMAM) dendrimer was applied as a macromolecular template to form amino-modified calcium phosphate hollow sphere (CaPO-NH). After loading with 5-fluorouracil (5Fu), this system performed synergistic cancer chemotherapy. Read More

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Combined therapy of adenovirus vector mediated IGF-1 gene with anti-CD20 mAbs exerts potential beneficial role on type 1 diabetes in nonobese diabetic mice.

Life Sci 2021 Jul 28:119853. Epub 2021 Jul 28.

Department of Medical College, Shenzhen Polytechnic, Shenzhen 518055, Guangdong Province, PR China. Electronic address:

Aims: To assess the protective effects of combined treatment with anti-CD20 monoclonal antibody (mAb) and adenovirus mediated mouse insulin-like growth factor 1 (Adv-mIGF-1) gene on type 1 diabetes (T1D) in nonobese diabetic (NOD) mice at early stage.

Methods: To simultaneously restore the proportion of Th cells and block the interaction of B cells, NOD model mice were assigned to four groups which received PBS, Adv-mIGF-1 gene and anti-CD20 mAbs alone or combination, respectively. After 16 weeks of therapeutic intervention, blood samples and pancreatic tissues of mice were measured via the methods of ELISA, RT-PCR, western blotting, H&E staining, TUNEL and immunohistochemistry assays. Read More

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Systematic review and meta-analysis of diagnostic performance of CT imaging for assessing resectability of pancreatic ductal adenocarcinoma after neoadjuvant therapy: importance of CT criteria.

Abdom Radiol (NY) 2021 Jul 31. Epub 2021 Jul 31.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Purpose: To assess the CT diagnostic performance for evaluating resectability of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy and identify the factor(s) that affect(s) diagnostic performance.

Methods: Databases were searched to identify studies published from January 1, 2000, to November 5, 2019 that evaluated the CT diagnostic performance for assessing resectability of post-neoadjuvant PDAC. Two reviewers independently extracted data and assessed the study quality. Read More

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Longitudinal analysis of human pancreatic adenocarcinoma development reveals transient gene expression signatures.

Mol Cancer Res 2021 Jul 30. Epub 2021 Jul 30.

Cell and Developmental Biology, University of Pennsylvania.

Previous transcriptome studies of human pancreatic ductal adenocarcinoma (PDAC) compare non-cancerous pancreatic intraepithelial neoplasias (PanINs) with late-stage PDAC obtained from different patients, thus have limited ability to discern network dynamics that contribute to the disease progression. We demonstrated previously that the 10-22 cell line, an induced pluripotent stem cell (iPS)-like line reprogrammed from late-stage human PDAC cells, recapitulated the progression from PanNs to PDAC upon transplantation into NOD/LtSz-scid/IL2R-gammanull mice. Herein, we investigated the transition from precursor to PDAC using the isogenic model. Read More

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The influence of severe radiation-induced lymphopenia on overall survival in solid tumors: a systematic review and meta-analysis.

Int J Radiat Oncol Biol Phys 2021 Jul 27. Epub 2021 Jul 27.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Emerging evidence suggests a detrimental prognostic association between radiation-induced lymphopenia (RIL) and pathologic response, progression-free and overall survival (OS) in patients who undergo radiotherapy for cancer. The aim of this study was to systematically review and meta-analyze the prognostic impact of RIL on OS in patients with solid tumors.

Methods: PubMed/MEDLINE and Embase were systematically searched. Read More

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Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients.

Diabetes Res Clin Pract 2021 Jul 27:108987. Epub 2021 Jul 27.

Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address:

Aims: Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the increased serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters.

Methods: A total of 172 participants were recruited, including 86 patients with newly diagnosed type 2 diabetes and 86 subjects with normal glucose tolerance according to oral glucose tolerance test. Read More

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Coordinate regulation of feeding, metabolism, and growth: Perspectives from studies in fish.

Authors:
Mark A Sheridan

Gen Comp Endocrinol 2021 Jul 28;312:113873. Epub 2021 Jul 28.

Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

This paper develops a model for coordinate regulation of feeding, metabolism, and growth based on studies in fish. Many factors involved with the control of feeding [e.g. Read More

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A narrative review: has regionalization truly achieved its intended goal in the surgical management of pancreatic cancer?

Chin Clin Oncol 2021 Jul 30. Epub 2021 Jul 30.

Department of General Surgery, Division of Surgical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.

Objective: The purpose of this narrative review is to present the data to date on the volume-outcome association in pancreas cancer surgery and describe the prevalence of and barriers to regionalized pancreas cancer care in western health systems.

Background: Numerous studies have demonstrated an association between increasing hospital or surgeon volume and improved patient morbidity and mortality in patients undergoing surgery for pancreas cancer. However, since the initial promotion of minimum volume standards, regionalization has remained difficult to establish. Read More

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WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape.

J Immunother Cancer 2021 Jul;9(7)

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USA

Background: Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor cells and cytotoxic T lymphocytes tumor infiltration in the tumor microenvironment, human pancreatic cancer stands out as one of the human cancers that does not respond to immune checkpoint inhibitor (ICI) immunotherapy. Epigenome dysregulation has emerged as a major mechanism in T cell exhaustion and non-response to ICI immunotherapy, we, therefore, aimed at testing the hypothesis that an epigenetic mechanism compensates PD-L1 function to render pancreatic cancer non-response to ICI immunotherapy.

Methods: Two orthotopic pancreatic tumor mouse models were used for chromatin immunoprecipitation-Seq and RNA-Seq to identify genome-wide dysregulation of H3K4me3 and gene expression. Read More

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ABO-Incompatible Living Donor Liver Transplantation With a Simplified Desensitization and Immunosuppression Protocol: A Single-Center Retrospective Study.

Exp Clin Transplant 2021 Jul;19(7):676-685

From the Division of Hepatobiliary Pancreas and Transplant Surgery, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.

Objectives: New desensitization strategies have made ABO-incompatible living donor liver transplant an attractive option for patients with end-stage liver disease. We aimed to report our experience with 20 consecutive patients who underwent ABO-incompatible living donor liver transplant using a simplified desensitization and immunosuppression regimen.

Materials And Methods: We retrospectively analyzed 20 ABO-incompatible living donor liver transplant cases (August 2015 to July 2019). Read More

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NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Stomatology, Wenzhou Medical University, Wenzhou 110013, China.

NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role in pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 in PC. We employed Western blot and quantitative real-time polymerase chain reaction to assess NUDCD1 expression in cells and PC tissues. Read More

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CD8 T Cells Involved in Metabolic Inflammation in Visceral Adipose Tissue and Liver of Transgenic Pigs.

Front Immunol 2021 12;12:690069. Epub 2021 Jul 12.

State Key Laboratory of Animal Nutrition, Ministry of Agriculture Key Laboratory of Animal Genetics Breeding and Reproduction, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.

Anti-inflammatory therapies have the potential to become an effective treatment for obesity-related diseases. However, the huge gap of immune system between human and rodent leads to limitations of drug discovery. This work aims at constructing a transgenic pig model with higher risk of metabolic diseases and outlining the immune responses at the early stage of metaflammation by transcriptomic strategy. Read More

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