115,593 results match your criteria model inflammatory


Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Department of Ophthalmology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasizes its protective behavior in retinal cells that help to provide new information about the development of treatment for retinal complications.

Objectives: This study analyzes the effect of in vitro changes associated with the cell survival and rescue mechanism in IGF2 inhibition and activation using chromeceptin and IGF2 peptides in ARPE-19 cells cultured in high glucose conditions. Read More

View Article and Full-Text PDF

Peptide-coated polyurethane material reduces wound infection and inflammation.

Acta Biomater 2021 May 2. Epub 2021 May 2.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE, 22184 Lund, Sweden. Electronic address:

There is an urgent need for treatments that not only reduce bacterial infection that occurs during wounding but that also target the accompanying excessive inflammatory response. TCP-25, a thrombin-derived antibacterial peptide, scavenges toll-like receptor agonists such as endotoxins and lipoteichoic acid and prevents toll-like receptor-4 dimerization to reduce infection-related inflammation in vivo. Using a combination of biophysical, cellular, and microbiological assays followed by experimental studies in mouse and pig models, we show that TCP-25, when delivered from a polyurethane (PU) material, exerts anti-infective and anti-inflammatory effects in vitro and in vivo. Read More

View Article and Full-Text PDF

IL-10 producing B cells regulated 1,3-β-glucan induced Th responses in coordinated with Treg.

Immunol Lett 2021 May 2. Epub 2021 May 2.

Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, PR China. Electronic address:

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-β-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-β-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. Read More

View Article and Full-Text PDF

Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.

Immunity 2021 Apr 28. Epub 2021 Apr 28.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. Electronic address:

Tissue macrophages self-renew during homeostasis and produce inflammatory mediators upon microbial infection. We examined the relationship between proliferative and inflammatory properties of tissue macrophages by defining the impact of the Wnt/β-catenin pathway, a central regulator of self-renewal, in alveolar macrophages (AMs) . Activation of β-catenin by Wnt ligand inhibited AM proliferation and stemness, but promoted inflammatory activity. Read More

View Article and Full-Text PDF

Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia.

J Cachexia Sarcopenia Muscle 2021 May 5. Epub 2021 May 5.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Background: Cancer cachexia is a multifactorial debilitating syndrome that directly accounts for more than 20% of cancer deaths while there is no effective therapeutic approach for treatment of cancer cachexia. Carnosol (CS) is a bioactive diterpene compound present in Lamiaceae spp., which has been demonstrated to have antioxidant, anti-inflammatory, and anticancer properties. Read More

View Article and Full-Text PDF

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway.

CNS Neurosci Ther 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Aim: Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to explore whether zinc can inhibit ferroptosis, reduce inflammation, and then exert a neuroprotective effect. Read More

View Article and Full-Text PDF

Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration.

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

CellTec-UB, Department of Cell Biology, University of Barcelona, Barcelona, Spain.

Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering corneal neovascularization and blindness. Adipose tissue-derived mesenchymal stem cells (AT-MSC) have shown promise in animal models to treat LSC deficiency (LSCD), but there are not studies showing their efficacy when primed with different media before transplantation. Read More

View Article and Full-Text PDF

Rhesus monkeys as a translational model for late-onset Alzheimer's disease.

Aging Cell 2021 May 5:e13374. Epub 2021 May 5.

Division of Geriatrics, Department of Medicine, SMPH, Madison, WI, USA.

Age is a major risk factor for late-onset Alzheimer's disease (AD) but seldom features in laboratory models of the disease. Furthermore, heterogeneity in size and density of AD plaques observed in individuals are not recapitulated in transgenic mouse models, presenting an incomplete picture. We show that the amyloid plaque microenvironment is not equivalent between rodent and primate species, and that differences in the impact of AD pathology on local metabolism and inflammation might explain established differences in neurodegeneration and functional decline. Read More

View Article and Full-Text PDF

Gestational diabetes mellitus and inflammatory biomarkers of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio: a systematic review and meta-analysis.

Biomarkers 2021 May 5:1-21. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To evaluate the association between two inflammatory biomarkers of neutrophil -lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) with gestational diabetes mellitus (GDM).

Methods And Materials: Systematic search was performed up to June 2020 in databases such as PubMed, Embase, Scopus, Web of Science, and Google scholar. The random-effects model was utilized to combine the weighted mean differences (WMDs) and their 95% confidence intervals (CIs). Read More

View Article and Full-Text PDF

Bipolar disorder: an association of body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation.

Trends Psychiatry Psychother 2021 May 4. Epub 2021 May 4.

Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre (HCPA). Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria e Medicina Legal da Universidade Federal do Rio Grande do Sul, Brazil.

Objective: To investigate body mass index (BMI) associations with white matter fractional anisotropy (FA) and C-reactive protein (CRP) in individuals with bipolar disorder (BD) during euthymia in comparison with a control group of healthy subjects (CTR).

Methods: The sample consisted of 101 individuals (BD n=35 and CTR n=66). Regions of interest (ROI) were defined through machine learning approach. Read More

View Article and Full-Text PDF

A shared frailty model for multivariate longitudinal data on adverse event of radiation therapy.

Biom J 2021 May 5. Epub 2021 May 5.

School of Mathematics, University of Edinburgh, James Clark Maxwell Building, The King's Buildings, Edinburgh, UK.

Oral mucositis is an inflammatory adverse event when treating head and neck cancer patients with radiation therapy (RT). The severity of its occurrence is believed to mainly depend on its site and the distribution of a cumulative radiation dose in the mouth area. The motivating study investigating differences in radiosensitivities (mucositis progression) at distinct sites where the severity of mucositis is assessed regularly at eight distinct sites on an ordinal scale results in multivariate longitudinal data and thus poses certain challenges. Read More

View Article and Full-Text PDF

Lipid nanoparticles loaded with butamben and designed to improve anesthesia at inflamed tissues.

Biomater Sci 2021 May;9(9):3378-3389

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

The most frequently used local anesthetics (LA) for local infiltration have an ionizable amine in the range of pH 7.6-8.9. Read More

View Article and Full-Text PDF

Combine effect of exposure to petrol, kerosene and diesel fumes: On hepatic oxidative stress and haematological function in rats.

Toxicol Ind Health 2021 May 5:7482337211012498. Epub 2021 May 5.

Cancer Immunology and Biotechnology Center, The University of Nottingham, Nottingham, UK.

Petroleum product fumes (PPFs) containing toxic organic components are pervasive in the environment, emanating from anthropogenic activities, including petroleum exploration and utilization by end-user activities from petrol-gasoline stations. Petrol station attendants are exposed to PPF through inhalation and dermal contact with consequent toxicological implications. We investigated the effects of chronic exposure (60 and 90 days) to petrol (P), kerosene (K) and diesel (D) alone and combined exposure to petrol, kerosene and diesel (PKD) fumes on hepatotoxicity, haematological function and oxidative stress in rats. Read More

View Article and Full-Text PDF

p55PIK Deficiency and its N-terminal Derivative inhibit Inflammation and Emphysema in COPD mouse model.

Am J Physiol Lung Cell Mol Physiol 2021 May 5. Epub 2021 May 5.

Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.

Background: Chronic obstructive pulmonary disease (COPD) is comprised of chronic inflammation and emphysema. Recent studies show that Class IA phosphatidylinositol 3-kinases (PI3Ks) play an important role in the regulation of inflammation and emphysema. However, there are few studies on their regulatory subunits. Read More

View Article and Full-Text PDF

Impact of environmental factors in predicting daily severity scores of atopic dermatitis.

Clin Transl Allergy 2021 Apr;11(2):e12019

Department of Bioengineering, Imperial College London, London, UK.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 20% of children worldwide. Environmental factors including weather and air pollutants have been shown to be associated with AD symptoms. However, the time-dependent nature of such a relationship has not been adequately investigated. Read More

View Article and Full-Text PDF

Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NF kB/IKK signaling pathway.

J Biochem Mol Toxicol 2021 May 5:e22799. Epub 2021 May 5.

Department of Emergency, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China.

The anti-inflammatory activity of cirsilineol in in vivo condition was assessed by measuring the relative organ weight, lung dry/wet weight ratio, protein concentration, and infiltration of inflammatory cells in bronchoalveolar lavage fluid. We estimated the myeloperoxidase activity and levels of cytokines, chemokines, and inflammatory markers to analyze the efficacy of cirsilineol against lipopolysaccharide (LPS)-induced lung inflammation. Furthermore, we quantified the gene expression of NF kB/IKK signaling molecules in cirsilineol-treated and untreated acute lung injury mice to confirm the anti-inflammatory property of cirsilineol. Read More

View Article and Full-Text PDF

Surgery Start Time and Early Implant Failure: A Case-Control Study.

Clin Oral Implants Res 2021 May 4. Epub 2021 May 4.

Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA, USA.

Objective: To evaluate the influence of surgery start time (SST) and other patient- and therapy-related variables on the risk for early implant failure (EIF) in an academic setting.

Material And Methods: Data were extracted from the electronic health records of 61 patients who had at least one EIF and 140 age- and gender-matched, randomly selected, non-EIF controls. Bivariate and multivariable analyses were performed to identify relevant associations between EIF and different variables, such as SST. Read More

View Article and Full-Text PDF

Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study.

J Racial Ethn Health Disparities 2021 May 4. Epub 2021 May 4.

Cardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.

Purpose: We examined if childhood socioeconomic status (SES) was related to adult leucocyte telomere length (TL) using the data of 361 African American (AA) participants from the GENE-FORECAST Study. We also assessed the mediating role of behavioral and psychosocial factors in the association between childhood SES and adult TL.

Methods: Childhood SES was assessed individually by using participant's mother's education and occupation, father's education and occupation, parental home ownership, and family structure. Read More

View Article and Full-Text PDF

Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis.

Dig Dis Sci 2021 May 4. Epub 2021 May 4.

Center for Inflammatory Bowel Disease, Columbia University Irving Medical Center/New York Presbyterian Hospital, Herbert Irving Pavilion-Rm 843, 161 Fort Washington Ave, New York, NY, 10032, USA.

Background: Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis.

Aim: To evaluate the association between PVT and other demographic and clinical factors and pouchitis. Read More

View Article and Full-Text PDF

Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?

Biol Philos 2021 30;36(3):27. Epub 2021 Apr 30.

Wellcome Centre for Human Neuroimaging, London, UK.

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. Read More

View Article and Full-Text PDF

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis.

Sci Rep 2021 May 4;11(1):9520. Epub 2021 May 4.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Read More

View Article and Full-Text PDF

Treatment of experimental aneurysms with a GPX embolic agent prototype: preliminary angiographic and histological results.

J Neurointerv Surg 2021 May 4. Epub 2021 May 4.

Department of Neuroradiology, Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Saarland, Germany

Background: Recently, liquid embolic agents have emerged for the endovascular treatment of cerebral aneurysms. Here we describe the in vivo performance of a novel liquid embolization agent (GPX Embolic Device).

Methods: Elastase-induced aneurysms were embolized with a GPX prototype under balloon assistance. Read More

View Article and Full-Text PDF

A Quorum Sensing System Enables Suppression of Innate Immunity.

mBio 2021 May 4;12(3). Epub 2021 May 4.

Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

Some bacterial pathogens utilize cell-cell communication systems, such as quorum sensing (QS), to coordinate genetic programs during host colonization and infection. The human-restricted pathosymbiont (group A streptococcus [GAS]) uses the Rgg2/Rgg3 QS system to modify the bacterial surface, enabling biofilm formation and lysozyme resistance. Here, we demonstrate that innate immune cell responses to GAS are substantially altered by the QS status of the bacteria. Read More

View Article and Full-Text PDF

Alginate/chitosan modified immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo.

Mater Sci Eng C Mater Biol Appl 2021 May 31;124:112087. Epub 2021 Mar 31.

Key Laboratory of Advanced Technology for Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. Electronic address:

The essentiality of macrophages for biomaterial-mediated osteogenesis has been increasingly recognized. However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis. As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials. Read More

View Article and Full-Text PDF

Nano-encapsulation of hydroxytyrosol into formulated nanogels improves therapeutic effects against hepatic steatosis: An in vitro study.

Mater Sci Eng C Mater Biol Appl 2021 May 27;124:112080. Epub 2021 Mar 27.

Department of Engineering, Università Campus Bio-Medico di Roma, via Álvaro del Portillo 21, 00128 Rome, Italy; Institute of Nanotechnology (NANOTEC), National Research Council (CNR), via Monteroni, 73100 Lecce, Italy. Electronic address:

Nanomaterials hold promise as a straightforward approach for enhancing the performance of bioactive compounds in several healthcare scenarios. Indeed, nanoencapsulation represents a valuable strategy to preserve the bioactives, maximizing their bioavailability. Here, a nanoencapsulation strategy for the treatment of nonalcoholic fatty liver disease (NAFLD) is presented. Read More

View Article and Full-Text PDF

Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model.

Mater Sci Eng C Mater Biol Appl 2021 May 20;124:112038. Epub 2021 Mar 20.

Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India. Electronic address:

Inflammatory Bowel Disease (IBD) is a complex inflammatory condition arising due to interactions of environmental and genetic factors that lead to dysregulated immune response and inflammation in intestine. Complementary and alternative medicine approaches have been utilized to treat IBD. However, chronic inflammatory diseases are not medically curable. Read More

View Article and Full-Text PDF

Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways.

Stem Cell Res Ther 2021 May 4;12(1):268. Epub 2021 May 4.

Department of Orthopedics Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.

Background: Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. Read More

View Article and Full-Text PDF

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts.

J Transl Med 2021 May 4;19(1):192. Epub 2021 May 4.

Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β, IL-6, IL-17, and TNF-α play important roles in the pathogenesis of scleroderma. Read More

View Article and Full-Text PDF

ZFP90 drives the initiation of colitis-associated colorectal cancer via a microbiota-dependent strategy.

Gut Microbes 2021 Jan-Dec;13(1):1-20

State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Chronic inflammation and gut microbiota dysbiosis are risk factors for colorectal cancer. In clinical practice, patients with inflammatory bowel disease (IBD) have a greatly increased risk of developing colitis-associated colorectal cancer (CAC). However, the underlying mechanism of the initiation of CAC remains unknown. Read More

View Article and Full-Text PDF

Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer.

Biomolecules 2021 Apr 29;11(5). Epub 2021 Apr 29.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram 695014, India.

Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264. Read More

View Article and Full-Text PDF