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Adjustment of key lane change parameters to develop microsimulation models for representative assessment of safety and operational impacts of adverse weather using SHRP2 naturalistic driving data.

J Safety Res 2022 Jun 1;81:9-20. Epub 2022 Feb 1.

University of Wyoming, Department of Civil & Architectural Engineering & Construction Management, 1000 E University Ave, Dept. 3295, Laramie, WY 82071, United States. Electronic address:

Introduction: Adverse weather has a considerable negative impact on safety and mobility of transportation networks. Microsimulation models are one of the potential tools that could be used to evaluate the safety and operational impacts of adverse weather. The development of a realistic microsimulation model requires the adjustment of driving behavior parameters with disaggregate trajectory-level data. Read More

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Reliability and validity of an employer-completed safety hazard and management assessment questionnaire.

J Safety Res 2022 Jun 23;81:283-296. Epub 2022 Mar 23.

Ohio Bureau of Workers' Compensation, 30 West Spring Street, Columbus, OH 43215-2256, USA. Electronic address:

Introduction: Managing and improving occupational safety and health requires evaluating performance. Organizations are encouraged to use both lagging indicators (such as injury rates and costs) and leading indicators (such as questionnaire-assessed safety hazards and management practices) for this purpose, but the association between types of indicators over time can be complex. Longitudinal data can assist in clarifying these associations and increasing indicator utility. Read More

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Organizational factors and specific risks on construction sites.

J Safety Res 2022 Jun 21;81:270-282. Epub 2022 Mar 21.

Department of Psychology, University of the Balearic Islands, Guillem Cifre Building, Ctra. de Valldemossa, km. 7.5, 07122 Palma de Mallorca, Spain. Electronic address:

Introduction: This study develops an empirical test of two theoretical models using the approach of Structural Equation Model (SEM) to test the relationships between specific organizational factors of safety management system (SMS) and specific risk variables.

Method: Two SEM models with two and four latent variables, respectively, and 10 observed risk variables were used to identify the strongest relationships that may lead to an accident on site. A random sample of 474 construction sites were visited and assessed in Spain from 2003 to 2010. Read More

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Modeling the risk of wrong-way driving at the exit ramp terminals of partial cloverleaf interchanges.

J Safety Res 2022 Jun 22;81:249-258. Epub 2022 Mar 22.

Department of Civil and Environmental Engineering, Auburn University, 108D Ramsay Hall, Auburn, AL 36849, United States. Electronic address:

Introduction: Partial cloverleaf (parclo) interchanges with closely spaced parallel entrance and exit ramps are more prone to wrong-way driving (WWD) compared to other interchange types. In this study, a logistic regression model was developed to predict the risk of WWD at the exit ramp terminals of parclo interchanges.

Method: The logistic regression model was developed using Firth's penalized likelihood techniques based on the predictor variables such as exit ramp geometric design features, wrong-way related traffic control devices, area type, and traffic volume. Read More

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Thalamus L-Sign: A Potential Biomarker of Neonatal Partial, Prolonged Hypoxic-Ischemic Brain Injury or Hypoglycemic Encephalopathy?

AJNR Am J Neuroradiol 2022 May 19. Epub 2022 May 19.

School of Medicine (A.J.B.), University of California, San Francisco, San Francisco, California.

Background And Purpose: Considerable overlap exists in the MR imaging features of hypoglycemic injury and hypoxic-ischemic brain injury, with similar predilections for the occipital and parietal lobes. In partial, prolonged hypoxia-ischemia, there is cortical destruction at the interarterial watershed zones, and in concomitant hypoglycemia and hypoxia-ischemia, an exaggerated final common pathway injury occurs. We interrogated secondary white matter tract-based thalamic injury as a tool to separate pure injuries in each group. Read More

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Psychometric Characteristics of the Visual Communication and Sign Language Checklist.

J Deaf Stud Deaf Educ 2022 May 20. Epub 2022 May 20.

Department of Psychology, Gallaudet University, Washington, DC, USA.

Since its publication in 2013, the Visual Communication and Sign Language (VCSL) Checklist has been widely utilized to assess the development of early American Sign Language skills of deaf children from birth to age 5. However, little research has been published using the results of VCSL assessments. Notably, no psychometric analyses have been conducted to verify the validity of the VCSL in a population whose characteristics are different from those of the small sample of native signing children from whom the published norms were created. Read More

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Necrosulfonamide improves post-resuscitation myocardial dysfunction via inhibiting pyroptosis and necroptosis in a rat model of cardiac arrest.

Eur J Pharmacol 2022 May 16:175037. Epub 2022 May 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, VA, USA; Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address:

The systemic inflammatory response following global myocardial ischemia/reperfusion (I/R) injury is a critical driver of poor outcomes. Both pyroptosis and necroptosis are involved in the systemic inflammatory response and contribute to regional myocardial I/R injury. This study aimed to explore the effect of necrosulfonamide (NSA) on post-resuscitation myocardial dysfunction in a rat model of cardiac arrest. Read More

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Identification and quantification of chemical reactions in a coastal aquifer to assess submarine groundwater discharge composition.

Sci Total Environ 2022 May 16:155978. Epub 2022 May 16.

Associated Unit: Hydrogeology group (UPC-CSIC), Spain; Department of Civil and Environment Engineering, Universitat Politècnica de Catalunya (UPC), Jordi Girona 1-3, 08034 Barcelona, Spain.

In coastal aquifers, two opposite but complementary processes occur: Seawater intrusion (SWI), which may salinize heavily exploited aquifers, and Submarine groundwater discharge (SGD) which transports oligo-elements to the sea. Aquifers are expected to be chemically reactive, both because they provide abundant surfaces to catalyze reactions and the mixing of very different Fresh Water (FW) and Sea Water (SW) promote numerous reactions. Characterizing and quantifying these reactions is essential to assess the quality and composition of both aquifer water, and SGD. Read More

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A Bayesian learning model to predict the risk for cannabis use disorder.

Drug Alcohol Depend 2022 Apr 29;236:109476. Epub 2022 Apr 29.

Department of Mathematical Sciences, University of Texas at Dallas, Richardson, TX, USA. Electronic address:

Background: The prevalence of cannabis use disorder (CUD) has been increasing recently and is expected to increase further due to the rising trend of cannabis legalization. To help stem this public health concern, a model is needed that predicts for an adolescent or young adult cannabis user their personalized risk of developing CUD in adulthood. However, there exists no such model that is built using nationally representative longitudinal data. Read More

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Increased vitamin B6 turnover is associated with greater mortality risk in the general US population: A prospective biomarker study.

Clin Nutr 2022 May 2;41(6):1343-1356. Epub 2022 May 2.

Heidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg, Germany; Institute for Global Food Security (IGFS), Queen's University Belfast, Belfast, United Kingdom. Electronic address:

Background & Aims: Vitamin B6 status and mortality risk are inversely associated in different patient groups, while prospective studies in the general population are lacking. Here, for the first time, we evaluated the association between biomarkers of vitamin B6 status and mortality risk in a large population-based study.

Methods: The vitamin B6 vitamers pyridoxal-5'-phosphat (PLP) and 4-pyridoxic acid (4-PA) were measured by high-performance liquid chromatography in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2010. Read More

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Determinants of hospital outcomes for patients with COVID-19 in the University of Pennsylvania Health System.

PLoS One 2022 19;17(5):e0268528. Epub 2022 May 19.

Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

There is growing evidence that racial and ethnic minorities bear a disproportionate burden from COVID-19. Temporal changes in the pandemic epidemiology and diversity in the clinical course require careful study to identify determinants of poor outcomes. We analyzed 6255 hospitalized individuals with PCR-confirmed SARS-CoV-2 infection from one of 5 hospitals in the University of Pennsylvania Health System between March 2020 and March 2021, using electronic health records to assess risk factors and outcomes through 8 weeks post-admission. Read More

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Association of hypertension with helicobacter pylori: A systematic review and meta‑analysis.

PLoS One 2022 19;17(5):e0268686. Epub 2022 May 19.

Department of Clinical Laboratory, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen University, Xiamen, China.

Background And Aims: The number of hypertensive population rises year by year recently, and their age becomes more youthful. For a long time, hypertension has long been regarded as a multi-factorial disease. In addition to smoking, genetics, diet and other factors, helicobacter pylori (H. Read More

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Open-source electronic health record systems: A systematic review of most recent advances.

Health Informatics J 2022 Apr-Jun;28(2):14604582221099828

College of Health and Human Services, Governors State University, University Park, IL, University Park, USA.

Open-source Electronic Health Records (OS-EHRs) are of pivotal importance in the management, operations, and administration of any healthcare organization. With the advancement of health informatics, researchers and healthcare practitioners have proposed various frameworks to assess the maturation of Open-source EHRs. The significance of OS-EHRs stems from the fact that vendor-based EHR implementations are becoming financially burdensome, with some vendors raking in more than $1 billion with one contract. Read More

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Psychometric testing of the Icelandic Occupational Self-Assessment (OSA-IS).

Scand J Occup Ther 2022 May 19:1-11. Epub 2022 May 19.

Department of Occupational Therapy, Massachusetts General Hospital, Institute of Health Professions, Boston, MA, USA.

Background: The Occupational Self-Assessment (OSA) is a self-report measure of occupational competence and values used to identify goals and assess outcomes. The Icelandic version of the OSA (OSA-IS) has been through several developmental stages to evaluate its psychometric properties. Through each stage, revisions have been made. Read More

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The effect of COVID-19 on poor treatment control among ambulatory Hypertensive and/or Diabetic patients in Northwest Ethiopia.

PLoS One 2022 19;17(5):e0266421. Epub 2022 May 19.

Epidemiology & Biostatistics Department, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Diabetes and hypertension have emerged as important clinical and public health problems in Ethiopia. The need to have long-term sustainable healthcare services for patients with diabetes and hypertension is essential to enhance good treatment control among those patients and subsequently delay or prevent complications. A collective shift towards acute care for COVID-19 patients combined with different measures to contain the pandemic had disrupted ambulatory care. Read More

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Diagnostic value of smartphone in obstructive sleep apnea syndrome: A systematic review and meta-analysis.

PLoS One 2022 19;17(5):e0268585. Epub 2022 May 19.

Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: To assess the diagnostic utility of smartphone-based measurement in detecting moderate to severe obstructive sleep apnea syndrome (OSAS).

Methods: Six databases were thoroughly reviewed. Random-effect models were used to estimate the summary sensitivity, specificity, negative predictive value, positive predictive value, diagnostic odds ratio, summary receiver operating characteristic curve and measured the areas under the curve. Read More

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Texture analysis of magnetic resonance image to differentiate benign from malignant myxoid soft tissue tumors: A retrospective comparative study.

PLoS One 2022 19;17(5):e0267569. Epub 2022 May 19.

Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.

It is important to differentiate between benign and malignant myxoid tumors to establish the treatment plan, determine the optimal surgical extent, and plan postoperative surveillance, but differentiation may be complicated by imaging-feature overlap. Texture analysis is used for quantitative assessment of imaging characteristics based on mathematically calculated pixel heterogeneity and has been applied to the discrimination of benign from malignant soft tissue tumors (STTs). In this study, we aimed to assess the diagnostic value of the texture features of conventional magnetic resonance images for the differentiation of benign from malignant myxoid STTs. Read More

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Natural radioactivity assessment and geophysical interpretation of parts of Igarra area, Southern Nigeria.

Environ Monit Assess 2022 May 19;194(6):438. Epub 2022 May 19.

Department of Geology, Federal University of Technology, Owerri, Nigeria.

To evaluate the concentration of natural radionuclides and to carry out geophysical interpretation of part of Igarra area, Southern Nigeria, an integrated geophysical approach was adopted involving radiometric, gravity, and magnetic methods. The RS-230 Super-Spec spectrometer, G-512 Lacoste and Romberg gravimeter, and the GSM-19v7.0 Overhauser instrument were used for the radiometric, gravity, and magnetic data acquisitions, respectively, along a specified traverse within the area. Read More

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Radiomics can differentiate high-grade glioma from brain metastasis: a systematic review and meta-analysis.

Eur Radiol 2022 May 19. Epub 2022 May 19.

Department of Radiology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, Guangdong, People's Republic of China.

Objective: (1) To evaluate the diagnostic performance of radiomics in differentiating high-grade glioma from brain metastasis and how to improve the model. (2) To assess the methodological quality of radiomics studies and explore ways of embracing the clinical application of radiomics.

Methods: Studies using radiomics to differentiate high-grade glioma from brain metastasis published by 26 July 2021 were systematically reviewed. Read More

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Cultural factors related to childhood and adolescent obesity in Mexico: A systematic review of qualitative studies.

Obes Rev 2022 May 19:e13461. Epub 2022 May 19.

School of Computing, Robert Gordon University, Aberdeen, UK.

Culture and culturally specific beliefs or practices may influence perceptions and decisions, potentially contributing to childhood obesity. The objective of this study is to identify the cultural factors (expressed through decisions, behaviors, individual experiences, perceptions, attitudes, or views) related to childhood and adolescent obesity in Mexico. Ten databases and one search engine were searched from 1995 onwards for qualitative studies. Read More

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Investigating the relationship between the five-factor model of distress tolerance, anxiety and anxiety sensitivity.

Anxiety Stress Coping 2022 May 19:1-13. Epub 2022 May 19.

School of Psychology, Université Laval, Québec, Canada.

Background: Distress tolerance (DT) has been conceptualized as a vulnerability factor for several psychopathologies. A five factor model of DT has been suggested, but its associations with anxiety and anxiety sensitivity have yet to be explored.

Objectives: This study aimed to further validate the five-factor model of DT, identify the associations between its factors and elevated anxiety, and assess if anxiety sensitivity mediates the association between DT and anxiety. Read More

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Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.

PLoS Med 2022 May 19;19(5):e1003981. Epub 2022 May 19.

Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Background: Type 2 diabetes (T2D) is highly prevalent in British South Asians, yet they are underrepresented in research. Genes & Health (G&H) is a large, population study of British Pakistanis and Bangladeshis (BPB) comprising genomic and routine health data. We assessed the extent to which genetic risk for T2D is shared between BPB and European populations (EUR). Read More

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Enhancing long-term forecasting: Learning from COVID-19 models.

PLoS Comput Biol 2022 May 19;18(5):e1010100. Epub 2022 May 19.

Department of Industrial and Systems Engineering, Virginia Tech, Falls Church, Virginia, United States of America.

While much effort has gone into building predictive models of the COVID-19 pandemic, some have argued that early exponential growth combined with the stochastic nature of epidemics make the long-term prediction of contagion trajectories impossible. We conduct two complementary studies to assess model features supporting better long-term predictions. First, we leverage the diverse models contributing to the CDC repository of COVID-19 USA death projections to identify factors associated with prediction accuracy across different projection horizons. Read More

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Association of Extreme Heat With All-Cause Mortality in the Contiguous US, 2008-2017.

JAMA Netw Open 2022 May 2;5(5):e2212957. Epub 2022 May 2.

Penn Cardiovascular Outcomes, Quality, and Evaluative Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: The number of extreme heat events is increasing because of climate change. Previous studies showing an association between extreme heat and higher mortality rates generally have been limited to urban areas, and whether there is heterogeneity across different populations is not well studied; understanding whether this association varies across different communities, particularly minoritized racial and ethnic groups, may allow for more targeted mitigation efforts.

Objective: To the assess the association between extreme heat and all-cause mortality rates in the US. Read More

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Topical clonidine for neuropathic pain in adults.

Cochrane Database Syst Rev 2022 May 19;5:CD010967. Epub 2022 May 19.

Department of Interdisciplinary Intensive Care, Jagiellonian University Collegium Medicum, Krakow, Poland.

Background: Clonidine is a presynaptic alpha-2-adrenergic receptor agonist that has been used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs has been gaining interest since the beginning of the century, as it may limit adverse events without loss of analgesic efficacy. Read More

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Effectiveness of Pain Neuroscience Education in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis.

Pain Med 2022 May 19. Epub 2022 May 19.

Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain.

Purpose: To assess the effects of pain neuroscience education (PNE) on patients with fibromyalgia (FM) in terms of pain intensity, fibromyalgia impact, anxiety, and pain catastrophizing.

Methods: A systematic review and meta-analysis of randomized controlled trials was conducted. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated with RStudio software for relevant outcomes and were pooled in a meta-analysis using the random effects model. Read More

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Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population-Based Cohort Study.

Laryngoscope 2022 May 19. Epub 2022 May 19.

Departments of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea.

Objective: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases. The effect of chronic inflammation caused by CRS on the occurrence of various cancers has not been thoroughly evaluated. This study aimed to investigate the increased incidences of 10 types of cancers among CRS patients with/without nasal polyps (NP) using a national population-based database from the Korean Health Insurance Review and Assessment Service. Read More

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CaCO-based carriers with prolonged release properties for antifungal drug delivery to hair follicles.

Biomater Sci 2022 May 19. Epub 2022 May 19.

Science Medical Center, Saratov State University, 410012 Saratov, Russia.

Superficial fungal infections are of serious concern worldwide due to their morbidity and increasing distribution across the globe in this era of growing antimicrobial resistance. The delivery of antifungals to the target regions of the skin and sustaining the effective drug concentration are essential for successful treatment of such mycoses. Topical formulations get extra benefits here if they penetrate into the hair follicles since fungal hyphae can proliferate and produce spores in such reservoirs. Read More

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The effect of statin on major adverse cardiovascular events and mortality in patients with rheumatoid arthritis - a systematic review and meta-analysis.

Eur Rev Med Pharmacol Sci 2022 May;26(9):3171-3178

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.

Objective: The aim of this systematic review and meta-analysis is to assess the effect of statin on major adverse cardiovascular events (MACE) and mortality in patients with RA.

Materials And Methods: A systematic literature search was performed using PubMed, Scopus, Embase, and Clinicaltrials.gov for studies investigating the effect of statin on MACE and mortality in RA patients up until 6 February 2022. Read More

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Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation.

Larry A Tucker

Biomed Res Int 2022 9;2022:2146596. Epub 2022 May 9.

College of Life Sciences, Brigham Young University, Provo, Utah 84602, USA.

The purpose of this investigation was to evaluate the association between insulin resistance and biological aging in a randomly selected sample of 2,596 U.S. women and men. Read More

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