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Quantification of a New Antifungal Drug Based on 1,3,4-Thiadiazole by HPLC-ESI/MS: Method Development, Validation and Pharmacokinetic Application.

Drug Res (Stuttg) 2021 Sep 17. Epub 2021 Sep 17.

St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, Russia.

The high sensitive HPLC-ESI/MS method for quantitative determination of a new antifungal drug - 2-[(1Z)-1-(3,5-diphenyl-1,3,4-thiadiazol-2(3Н)-ylidene)methyl]-3,5-diphenyl-1,3,4-thiadiazol-3-ium chloride (TDZ) - was developed and fully validated. TDZ was separated from plasma and urine samples by acetonitrile deproteinization and extraction without time-consuming sample preparation. The reversed-phase high-performance liquid chromatography on Kromasil 100-3. Read More

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September 2021

Recognition of general anesthesia-induced loss of consciousness based on the spatial pattern of the brain networks.

J Neural Eng 2021 Sep 17. Epub 2021 Sep 17.

University of Electronic Science and Technology of China, No.2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, 610054, CHINA.

Objective: Unconsciousness is a key feature related to general anesthesia (GA) but is difficult to be evaluated accurately by anesthesiologists clinically.

Approach: To tracking the loss of consciousness (LOC) and recovery of consciousness (ROC) under GA, in this study, by investigating functional connectivity of the scalp electroencephalogram (EEG), we explore any potential difference in brain networks among anesthesia induction, anesthesia recovery, and the resting state.

Main Results: The results of this study demonstrated significant differences among the three periods, concerning the corresponding brain networks. Read More

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September 2021

Aerosolization risk during endoscopic transnasal surgery: a prospective qualitative and quantitative microscopic analysis of particles spreading in the operating room.

J Neurosurg 2021 Sep 17:1-9. Epub 2021 Sep 17.

1Division of Otorhinolaryngology, Department of Surgical Specialties, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Objective: The coronavirus disease 2019 (COVID-19) pandemic represents the greatest public health emergency of this century. The primary mode of viral transmission is droplet transmission through direct contact with large droplets generated during breathing, talking, coughing, and sneezing. However, the virus can also demonstrate airborne transmission through smaller droplets (< 5 μm in diameter) generated during various medical procedures, collectively termed aerosol-generating procedures. Read More

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September 2021

Resting-state functional connectivity predictors of treatment response in schizophrenia - A systematic review and meta-analysis.

Schizophr Res 2021 Sep 14;237:153-165. Epub 2021 Sep 14.

Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, United States of America.

We aimed to systematically synthesize and quantify the utility of pre-treatment resting-state functional magnetic resonance imaging (rs-fMRI) in predicting antipsychotic response in schizophrenia. We searched the PubMed/MEDLINE database for studies that examined the magnitude of association between baseline rs-fMRI assessment and subsequent response to antipsychotic treatment in persons with schizophrenia. We also performed meta-analyses for quantifying the magnitude and accuracy of predicting response defined continuously and categorically. Read More

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September 2021

Enhanced nitrogen removal by partial nitrification-anammox process with a novel high-frequency micro-aeration (HFMA) mode: Metabolic interactions among functional bacteria.

Bioresour Technol 2021 Sep 8;342:125917. Epub 2021 Sep 8.

School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710049, China; School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an, Shaanxi Province 710055, China.

A novel high-frequency micro-aeration (HFMA) mode with aeration frequency of 15 times/h and DO concentration lower than 0.5 mg/L was proposed. Advanced partial nitrification-anammox (PN-A) performance was achieved in a two-stage sequencing batch reactor-integrated fixed-film activated sludge reactor with the HFMA mode. Read More

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September 2021

Enhancing higher-order eigenmodes of AFM using bridge/cantilever coupled system.

Micron 2021 Sep 8;150:103147. Epub 2021 Sep 8.

School of Physics, Beihang University, Beijing 100083, China.

The wide application of multi-frequency atomic force microscopy (AFM) places higher demands on the higher-order modes response of the cantilever. The response of the higher modes however is generally weaker than that of the fundamental mode in air. Researchers have proposed many methods, most of which involve cantilever modification, to enhance higher-order eigenmodes response. Read More

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September 2021

Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.

Eur J Med Chem 2021 Sep 11;226:113845. Epub 2021 Sep 11.

Weifang Medical University, No.7166 Baotong Road, Weifang, 261053, PR China. Electronic address:

To resolve the problem of drug resistance caused by epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer, we used the principle of collocation to design and synthesize a series of aminopyrimidine derivatives with 4,5,6,7-tetrahydrothieno [3,2-c]pyridine side chains (according to the binding mode of AZD9291 to EGFR) for use as EGFR kinase inhibitors. The most promising compound A12, a non-covalently bound reversible inhibitor, showed excellent kinase inhibitory activity against EGFR, with an IC value of 4.0 nM and more than 42-fold selectivity for EGFR (IC = 170. Read More

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September 2021

Efficient utilization of Iris pseudacorus biomass for nitrogen removal in constructed wetlands: Combining alkali treatment.

Environ Pollut 2021 Sep 13;291:118170. Epub 2021 Sep 13.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China.

Aquatic plant biomass like Iris pseudacorus can be used as electron donor to improve denitrification performance in subsurface constructed wetlands. However, the phenomenon that the nitrogen removal rate declined in the terminal stage restricted the utilization of litters. In terms of this problem, this study investigated the performance of the used biomass through alkali treatment on nitrogen removal and analyzed the effect of alkali treatment on the component and structure of biomass and microbial community. Read More

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September 2021

Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules.

Biochem Biophys Res Commun 2021 Sep 10;578:15-20. Epub 2021 Sep 10.

Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata, 700054, India. Electronic address:

Interaction between human positive coactivator 4 (PC4), an abundant nuclear protein, and the tumor suppressor protein p53 plays a crucial role in initiating apoptosis. In certain neurodegenerative diseases PC4 assisted-p53-dependent apoptosis may play a central role. Thus, disruption of p53-PC4 interaction may be a good drug target for certain disease pathologies. Read More

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September 2021

Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

J Acad Consult Liaison Psychiatry 2021 Sep 14. Epub 2021 Sep 14.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences. Electronic address:

Background: Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI. Read More

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September 2021

Size-segregated physicochemical properties of inhalable particulate matter in a tunnel-ventilated layer house in China.

Environ Res 2021 Sep 14:112064. Epub 2021 Sep 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China. Electronic address:

This study investigated the physicochemical properties of the particles in a typical commercial laying hen barn in Southeast China. Mass concentrations and size distributions of the particulate matter (PM) and the key components (incl. organic carbon (OC), element carbon (EC), and the water-soluble inorganic ions (WSIIs)) were analyzed. Read More

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September 2021

An Early Cretaceous enantiornithine bird with a pintail.

Curr Biol 2021 Sep 10. Epub 2021 Sep 10.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.

Enantiornithes are the most successful group of Mesozoic birds, arguably representing the first global avian radiation, and commonly resolved as the sister to the Ornithuromorpha, the clade within which all living birds are nested. The wealth of fossils makes it feasible to comparatively test evolutionary hypotheses about the pattern and mode of eco-morphological diversity of these sister clades that co-existed for approximately 65 Ma. Here, we report a new Early Cretaceous enantiornithine, Yuanchuavis kompsosoura gen. Read More

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September 2021

The quality of intrapartum cardiotocography in preterm labour.

J Perinat Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics and Gynaecology, Amsterdam University Medical Centre Location VUmc, Amsterdam, The Netherlands.

Objectives: The aim of this study is to determine the quality of the foetal heart rate (FHR) recording, defined as signal loss, during preterm labour below 28 weeks gestational age (GA) and contribute to the discussion if cardiotocography (CTG) is of value for the extreme preterm foetus.

Methods: From January 2010 to December 2019 a retrospective study was conducted with data of 95 FHR recordings of singletons born between 24 and 28 weeks GA at the Amsterdam University Medical Centre, location VUmc. FHR tracings had a duration of at least 30 min and were obtained via external ultrasound mode. Read More

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September 2021

An interactive eye-tracking system for measuring radiologists' visual fixations in volumetric CT images: Implementation and initial eye-tracking accuracy validation.

Med Phys 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology.

Purpose: Eye tracking approaches have been used to understand the visual search process in radiology. However, previous eye tracking work in computer tomography (CT) has been limited largely to single cross-sectional images or video playback of the reconstructed volume, which do not accurately reflect radiologists' visual search activities and their interactivity with 3-dimensional image data at a computer workstation (e.g. Read More

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September 2021

Do I build or do I move? Adaptation by habitat construction versus habitat choice.

Evolution 2021 Sep 17. Epub 2021 Sep 17.

Department of Biology, University of Florida, Gainesville, FL, 32611.

Trait adaptation to a heterogeneous environment can occur through six modes: genetic differentiation of those traits, a jack-of-all-trades phenotypic uniformity, diversified bet-hedging, phenotypic plasticity, habitat choice, and habitat construction. A key question is what circumstances favor one mode over another, and how they might interact if a system can express more than one mode at a time. We examined the joint evolution of habitat choice and habitat construction using individual-based simulations. Read More

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September 2021

Viral RNA and infectious influenza virus on mobile phones of influenza patients in Hong Kong and the United States.

J Infect Dis 2021 Sep 17. Epub 2021 Sep 17.

Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, Maryland, USA.

Mobile phones are among the most highly touched personal objects. As part of a broader study on the contribution of fomites to influenza transmission, between 2017-19, we swabbed mobile phones from 138 influenza patients in two locations. Influenza viral RNA detection rates were 23% (23/99) and 36% (14/39) in Hong Kong and Maryland, respectively. Read More

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September 2021

Retention Force of Glass Ionomer Based Luting Cements with Posterior Primary Zirconium Crowns - A Comparative in Vitro Study.

J Clin Pediatr Dent 2021 Oct;45(4):259-264

Objective: To determine the retentive force of three glass-ionomer luting cements used with prefabricated primary zirconium crowns (PPZCs) and to assess whether the retentive force was dependent on cementation material or different PPZCs brands.

Study Design: Four mandibular right second molar PPZCs were selected, one each from four manufacturers-NuSmile®ZR, Sprig Crowns, Cheng Crowns and Kinder Krowns. Silicone impressions of the outer surface of crowns were taken; stone dies prepared and reduced to fit the corresponding brand. Read More

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October 2021

Neutrophils in cardiovascular disease: Warmongers, peacemakers or both?

Cardiovasc Res 2021 Sep 17. Epub 2021 Sep 17.

Dept. of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Neutrophils, the most abundant of all leukocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple one-dimensional cells with an un-restrained mode of action to a cell type that display maturity and complex behavior. Read More

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September 2021

Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence.

Biol Reprod 2021 Sep 17. Epub 2021 Sep 17.

Fertility & Research Centre, School of Women's & Children's Health, University of New South Wales Sydney, NSW 2052, Australia.

Oocytes are maintained in a state of meiotic arrest following the first meiotic division until ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a process facilitated by the cyclic nucleotides cGMP and cAMP. If removed from this inhibitory follicular environment and cultured in vitro, mammalian oocytes undergo spontaneous meiotic resumption in the absence of the usual stimulatory follicular stimuli, leading to asynchronicity with oocyte cytoplasmic maturation and lower developmental competence. Read More

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September 2021

Macro and micro analysis on coal-bearing soil slopes instability based on CFD-DEM coupling method.

PLoS One 2021 17;16(9):e0257362. Epub 2021 Sep 17.

School of Civil and Architectural Engineering, Nanchang Institute of Technology, Nanchang, China.

By combining the discrete element method (DEM) with computational fluid dynamics (CFD), this study proposes a three-dimensional CFD-DEM fluid-solid coupling microscopic computational model for analyzing the micromechanisms of instability and failure in a coal-bearing soil slope during rainfall. The CFD-DEM fluid-solid coupling model indicated that the main failure mode of the coal-bearing soil slopes was rainwater washing, and the slope sliding surface was predicted as an approximately linear segment. The adaptability of this numerical method was verified by comparing its results with those of rain-washed slopes in an outdoor model test. Read More

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September 2021

Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice.

PLoS One 2021 17;16(9):e0257395. Epub 2021 Sep 17.

Department of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo, Japan.

Sensory experience modulates proliferation, differentiation, and migration of oligodendrocyte progenitor cells (OPCs). In the mouse primary visual cortex (V1), visual deprivation-dependent modulation of OPCs has not been demonstrated. Here, we demonstrate that undifferentiated OPCs developmentally peaked around postnatal day (P) 25, and binocular enucleation (BE) from the time of eye opening (P14-15) elevated symmetrically-divided undifferentiated OPCs in a reversible G0/G1 state even more at the bottom lamina of the cortex by reducing maturing oligodendrocyte (OL) lineage cells. Read More

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September 2021

Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons.

PLoS Comput Biol 2021 Sep 17;17(9):e1009371. Epub 2021 Sep 17.

Department of Cell Biology and Anatomy, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.

Two subpopulations of midbrain dopamine (DA) neurons are known to have different dynamic firing ranges in vitro that correspond to distinct projection targets: the originally identified conventional DA neurons project to the dorsal striatum and the lateral shell of the nucleus accumbens, whereas an atypical DA population with higher maximum firing frequencies projects to prefrontal regions and other limbic regions including the medial shell of nucleus accumbens. Using a computational model, we show that previously identified differences in biophysical properties do not fully account for the larger dynamic range of the atypical population and predict that the major difference is that originally identified conventional cells have larger occupancy of voltage-gated sodium channels in a long-term inactivated state that recovers slowly; stronger sodium and potassium conductances during action potential firing are also predicted for the conventional compared to the atypical DA population. These differences in sodium channel gating imply that longer intervals between spikes are required in the conventional population for full recovery from long-term inactivation induced by the preceding spike, hence the lower maximum frequency. Read More

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September 2021

Advanced hybrid electro-oxidation & O technology for water reuse in the fruit and vegetable process industry.

Water Sci Technol 2021 Sep;84(5):1159-1169

Leitat Technological Center, Carrer de la Innovacio 5, Terrassa 08225, Spain E-mail:

Alternative sanitising agents are required in the fruit and vegetable processing industry, capable of effectively disinfecting both the product and the washing water to increase its reuse, while not producing harmful by-products like chlorine-based agents. In the present work, electro-oxidation (EO) and ozone are proposed for vegetable process water reuse, being optimised for their individual and combined application. The application of hybrid electro-oxidation and ozone achieved 7 log reduction after 15 min of treatment in batch using boron-doped diamond (BDD) as anode material, showing important synergistic effects when compared with the individual treatments. Read More

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September 2021

Moderate obstructive sleep apnea and cardiovascular outcomes in older adults: a propensity score matched multicenter study (CPAGE-MODE Study).

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Hospital Universitario Ramon y Cajal, Sleep Unit, Respiratory Department.

Study Objectives: Obstructive sleep apnea (OSA) has been associated with cardiovascular events (CVE) although recent randomized controlled trials have not demonstrated that long-term continuous positive airway pressure (CPAP) prevents CVEs. Our objective was to determine the effect of CPAP on older adults with moderate OSA regarding CVE reduction.

Methods: An observational and multicentric study of a cohort of older adults (>70 years of age) diagnosed with moderate OSA (apnea hypopnea index 15. Read More

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September 2021

Dual Iron Sites in Activation of N by Iron-Sulfur Cluster Anions FeS and FeS.

J Phys Chem Lett 2021 Sep 17:9269-9274. Epub 2021 Sep 17.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Inspired by the fact that the active centers of natural nitrogenases are polynuclear iron-sulfur clusters, the reactivity of isolated iron-sulfur clusters toward N has received considerable attention to gain fundamental insights into the activation of the N≡N triple bond. Herein, a series of gas-phase iron-sulfur cluster anions FeS ( = 1-8, 0-) were prepared and their reactivities toward N were investigated systematically by mass spectrometry. Among the 44 investigated clusters, only FeS and FeS showed superior reactivity toward N. Read More

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September 2021

Score equivalence of paper-, tablet-, and interactive voice response system-based versions of PROMIS, PRO-CTCAE, and numerical rating scales among cancer patients.

J Patient Rep Outcomes 2021 Sep 17;5(1):95. Epub 2021 Sep 17.

Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: The study tests the effects of data collection modes on patient responses associated with the multi-item measures such as Patient-Reported Outcomes Measurement System (PROMIS), and single-item measures such as Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), and Numerical Rating Scale (NRS) measures.

Methods: Adult cancer patients were recruited from five cancer centers and administered measures of anxiety, depression, fatigue, sleep disturbance, pain intensity, pain interference, ability to participate in social roles and activities, global mental and physical health, and physical function. Patients were randomized to complete the measures on paper (595), interactive voice response (IVR, 596) system, or tablet computer (589). Read More

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September 2021

Research progress in predicting DNA methylation modifications and the relation with human diseases.

Curr Med Chem 2021 Sep 16. Epub 2021 Sep 16.

School of Computer Science and Technology, Xidian University, Xi'an, China.

DNA methylation is an important mode of regulation in epigenetic mechanisms, and it is one of the research foci in the field of epigenetics. DNA methylation modification affects a series of biological processes, such as eukaryotic cell growth, differentiation and transformation mechanisms, by regulating gene expression. In this review, we systematically summarized the DNA methylation databases, prediction tools for DNA methylation modification, machine learning algorithms for predicting DNA methylation modification, and the relationship between DNA methylation modification and diseases such as hypertension, Alzheimer's disease, diabetic nephropathy, and cancer. Read More

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September 2021

Quantum Speed Limit Quantified by the Changing Rate of Phase.

Phys Rev Lett 2021 Sep;127(10):100404

School of Physics, Shandong University, Jinan 250100, China.

The quantum speed limit is important in determining the minimum evolution time of a quantum system, and thus is essential for quantum community. In this Letter, we derive a novel unified quantum speed limit bound for Hermitian and non-Hermitian quantum systems. The bound is quantified by the changing rate of phase of the quantum system, which represents the transmission mode of the quantum states over their evolution. Read More

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September 2021

Seamless High-Q Microwave Cavities for Multimode Circuit Quantum Electrodynamics.

Phys Rev Lett 2021 Sep;127(10):107701

James Franck Institute, University of Chicago, Chicago, Illinois 60637, USA.

Multimode cavity quantum electrodynamics-where a two-level system interacts simultaneously with many cavity modes-provides a versatile framework for quantum information processing and quantum optics. Because of the combination of long coherence times and large interaction strengths, one of the leading experimental platforms for cavity QED involves coupling a superconducting circuit to a 3D microwave cavity. In this work, we realize a 3D multimode circuit QED system with single photon lifetimes of 2 ms across 9 modes of a novel seamless cavity. Read More

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September 2021

Buckling-Fracture Transition and the Geometrical Charge of a Crack.

Phys Rev Lett 2021 Sep;127(10):105501

The Racah Institute of Physics, The Hebrew Univewrsity of Jerusalem, Jerusalem, 91904, Israel.

We present a unifying approach that describes both surface bending and fracture in the same geometrical framework. An immediate outcome of this view is a prediction for a new mechanical transition: the buckling-fracture transition. Using responsive gel strips that are subjected to nonuniform osmotic stress, we show the existence of the transition: Thin plates do not fracture. Read More

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September 2021