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CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF PATIENTS WITH PLAQUE PSORIASIS.

Georgian Med News 2021 Mar(312):75-78

3Ilia State University, School of Natural Sciences and Medicine, Tbilisi, Georgia.

Psoriasis is a T cell mediated chronic inflammatory skin disease affecting about 2% of the population worldwide. Recently has established the central role of IL-23/Th17 immune axis in the pathogenesis of psoriasis and different subclasses of T cells including Th1 and Th17 cells are involved in initiation and amplification of the skin inflammation process, in addition, in cases of recurrent psoriasis, Th22 cells play the role of memory cells with the help of Th9 cells, which are also important in this process. The main goal was to evaluate the ratio of T cell profile and IL23/Th17 axis by evaluating IL17A, IL22, IL9 in peripheral blood of persons with moderate to severe plaque psoriasis. Read More

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Distribution, behaviour, bioavailability and remediation of poly- and per-fluoroalkyl substances (PFAS) in solid biowastes and biowaste-treated soil.

Environ Int 2021 May 5;155:106600. Epub 2021 May 5.

Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA; Department of Agronomy, Kansas State University, Manhattan, KS 66506, USA.

Aqueous film-forming foam, used in firefighting, and biowastes, including biosolids, animal and poultry manures, and composts, provide a major source of poly- and perfluoroalkyl substances (PFAS) input to soil. Large amounts of biowastes are added to soil as a source of nutrients and carbon. They also are added as soil amendments to improve soil health and crop productivity. Read More

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Inoculation with Bacillus amyloliquefaciens and mycorrhiza confers tolerance to drought stress and improve seed yield and quality of soybean plant.

Physiol Plant 2021 May 8. Epub 2021 May 8.

Department of Agricultural Microbiology, Faculty of Agriculture, Mansoura University, Mansoura, Egypt.

The present study aimed to evaluate the effect of Bacillus amyloliquefaciens and/or Arbuscular Mycorrhizal Fungi (AMF) as natural biofertilizers on biomass, yield and seed nutritive quality of soybean (Giza 111). The conditions investigated include a well-watered (WW) control and irrigation withholding at the seed development stage (R5, after 90 days from sowing) (DS). Co-inoculation with B. Read More

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Pain and rehabilitation after total hip arthroplasty are approach dependent: a multisurgeon, single-center, prospective cohort study.

Arch Orthop Trauma Surg 2021 May 8. Epub 2021 May 8.

ARCUS Sportklinik Pforzheim, Rastatterstr. 17-19, 75179, Pforzheim, Germany.

Purpose: The aim of this study was to assess perioperative pain and mobilization after total hip arthroplasty (THA) using three different surgical approaches.

Methods: This was a multisurgeon, prospective, single-center cohort study. A total of 188 patients who underwent hip arthroplasty (THA) between February 2019 and April 2019 were analyzed according to the surgical approach used (direct anterior, lateral, and posterior approach). Read More

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AIDS and COVID: A tale of two pandemics and the role of statisticians.

Stat Med 2021 May;40(11):2499-2510

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The world has experienced three global pandemics over the last half-century: HIV/AIDS, H1N1, and COVID-19. HIV/AIDS and COVID-19 are still with us and have wrought extensive havoc worldwide. There are many differences between these two infections and their global impacts, but one thing they have in common is the mobilization of scientific resources to both understand the infection and develop ways to combat it. Read More

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National introduction of human papillomavirus (HPV) vaccine in Tanzania: Programmatic decision-making and implementation.

Vaccine 2021 May 4. Epub 2021 May 4.

World Health Organization, Tanzania Country Office, Dar es Salaam, Tanzania.

Background: Cervical cancer is the leading cause of cancer among women in Tanzania, with approximately 10,000 new cases and 7,000 deaths annually. In April 2018, the Government of Tanzania introduced 2 doses of human papillomavirus (HPV) vaccine nationally to adolescent girls to prevent cervical cancer, following a successful 2-year pilot introduction of the vaccine in the Kilimanjaro Region.

Methods: We interviewed key informants at the national level in Tanzania from February to November 2019, using a semi-structured tool to better understand national decision-making and program implementation. Read More

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Enhanced Recovery After Surgery strategies for elective craniotomy: a systematic review.

J Neurosurg 2021 May 7:1-25. Epub 2021 May 7.

1Machine Intelligence in Clinical Neuroscience (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Switzerland.

Objective: Enhanced Recovery After Surgery (ERAS) has led to a paradigm shift in perioperative care through multimodal interventions. Still, ERAS remains a relatively new concept in neurosurgery, and there is no summary of evidence on ERAS applications in cranial neurosurgery.

Methods: The authors systematically reviewed the literature using the PubMed/MEDLINE, Embase, Scopus, and Cochrane Library databases for ERAS protocols and elements. Read More

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Soil legacy of arbuscular mycorrhizal fungus Gigaspora margarita: The potassium-sequestering glomalin improves peanut (Arachis hypogaea) drought resistance and pod yield.

Microbiol Res 2021 Apr 29;249:126774. Epub 2021 Apr 29.

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, China. Electronic address:

In agroecosystems, drought stress severely threatens crops development. Although potassium (K) is required in amounts by crops under drought stress, the mobilization and availablity of K are limited by the soil water status. Arbuscular mycorrhizal (AM) fungi can form mutualistic associations with most crops and play direct or indirect roles in the host drought resistance. Read More

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Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi).

Gen Comp Endocrinol 2021 May 4:113799. Epub 2021 May 4.

Department of Biological Sciences, 50 Sifton Road, University of Manitoba, Winnipeg R3T 2N2, Manitoba, Canada; Bamfield Marine Sciences Centre, 100 Pachena Road, Bamfield R3T 0A8, British Columbia, Canada.

The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. Read More

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Environmental Factors Affecting Early Mobilization and Physical Disability Post-Intensive Care: An Integrative Review Through the Lens of the World Health Organization International Classification of Functioning, Disability, and Health.

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):92-117

Background: Early mobilization (EM) is one of few potential protective factors associated with reduced physical disability post-intensive care (PD PIC). However, only 45% of intensive care units (ICUs) in the United States routinely practice EM despite its recognized benefits.

Objectives: To analyze the evidence on the relationship between critical care EM, PD PIC, and environmental factors, using the theoretical lens of the World Health Organization's (WHO's) International Classification of Functioning, Disability, and Health (ICF). Read More

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Cell Surface Area to Volume Relationship During Apoptosis and Apoptotic Body Formation.

Cell Physiol Biochem 2021 May;55(S1):161-170

Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain,

Apoptosis is a programmed form of cell death culminating in packing cell content and corpse dismantling into membrane sealed vesicles called apoptotic bodies (ABs). Apoptotic bodies are engulfed and disposed by neighboring and immune system cells without eliciting a noxious inflammatory response, thus preventing sterile tissue damage. AB formation requires a total surface area larger than the apparent, initial cell's surface area. Read More

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Evaluation of Operative Notes for Splenic Flexure Mobilization: Are the Key Aspects Being Reported?

J Laparoendosc Adv Surg Tech A 2021 May 6. Epub 2021 May 6.

Department of Surgery, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.

Given the importance of operative documentation, we reviewed operative notes for surgeries that required splenic flexure mobilization (SFM) to determine their accuracy. We performed a retrospective review of 51 operative notes for complete SFMs performed at a single institution from January 2015 to June 2020. None of the operative notes reported a rationale for performing SFM, use of preoperative imaging to guide technical approach, reasoning for the operative method and mobilization approach used, or specific steps taken to ensure that SFM was done safely. Read More

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Predictors of delirium in older patients at the emergency department: a prospective multicentre derivation study.

CJEM 2021 May 4;23(3):330-336. Epub 2021 Jan 4.

Université Laval, Québec, Canada.

Objective: The objective of this study was to identify the predictors of incident delirium in this high-risk population.

Methods: This study was a planned sub-analysis of the INDEED multicentre cohort study. We recruited patients aged ≥ 65, independent/semi-independent, with an emergency department (ED) length of stay ≥ 8 h and admitted to any hospital ward. Read More

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Sleep and its Association With Pain and Depression in Nursing Home Patients With Advanced Dementia - a Cross-Sectional Study.

Front Psychol 2021 20;12:633959. Epub 2021 Apr 20.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Previous research suggests a positive association between pain, depression and sleep. In this study, we investigate how sleep correlates with varying levels of pain and depression in nursing home (NH) patients with dementia. Cross-sectional study ( = 141) with sleep-related data, derived from two multicenter studies conducted in Norway. Read More

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Community surveillance of COVID-19 by village health volunteers, Thailand.

Bull World Health Organ 2021 May 2;99(5):393-397. Epub 2021 Mar 2.

Graduate School of Health Innovation, Kanagawa University of Human Services, 3-25-10 Tonomchi, Kawasaki, Kanagawa 210-0821, Japan.

Problem: To control the increasing spread of coronavirus disease 2019 (COVID-19), the government of Thailand enforced the closure of public and business areas in Bangkok on 22 March 2020. As a result, large numbers of unemployed workers returned to their hometowns during April 2020, increasing the risk of spreading the virus across the entire country.

Approach: In anticipation of the large-scale movement of unemployed workers, the Thai government trained existing village health volunteers to recognize the symptoms of COVID-19 and educate members of their communities. Read More

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Genetic and environmental modulation of transposition shapes the evolutionary potential of Arabidopsis thaliana.

Genome Biol 2021 May 6;22(1):138. Epub 2021 May 6.

Institut de Biologie de l'École Normale Supérieure, ENS, 46 rue d'Ulm, 75005, Paris, France.

Background: How species can adapt to abrupt environmental changes, particularly in the absence of standing genetic variation, is poorly understood and a pressing question in the face of ongoing climate change. Here we leverage publicly available multi-omic and bio-climatic data for more than 1000 wild Arabidopsis thaliana accessions to determine the rate of transposable element (TE) mobilization and its potential to create adaptive variation in natural settings.

Results: We demonstrate that TE insertions arise at almost the same rate as base substitutions. Read More

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Evaluation of a self-help intervention to promote the health and wellbeing of marginalised people including those living with leprosy in Nepal: a prospective, observational, cluster-based, cohort study with controls.

BMC Public Health 2021 May 6;21(1):873. Epub 2021 May 6.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background: People affected by leprosy are at increased risk of ulcers from peripheral nerve damage. This in turn can lead to visible impairments, stigmatisation and economic marginalisation. Health care providers suggest that patients should be empowered to self-manage their condition to improve outcomes and reduce reliance on services. Read More

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Quantitative study of PIMT technique aiming its validation as physical therapy procedure.

Foot (Edinb) 2021 Apr 8;47:101800. Epub 2021 Apr 8.

School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil. Electronic address:

Background: Valgus hindfoot is a very common postural deviation, and the associated foot pronation can be a triggering factor for diseases such as tarsal tunnel syndrome.

Research Question: This work compares two techniques for hindfoot valgus correction: GPR (Global Postural Reeducation) and PIMT (Postural Integration by Manual Therapy).

Methods: Sixty young adult subjects from the Brazilian Army with unilateral hindfoot valgus were selected and divided into two groups of 30 subjects, one treated with GPR and the other treated with PIMT. Read More

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Why did Ghana's national health insurance capitation payment model fall off the policy agenda? A regional level policy analysis.

Health Policy Plan 2021 May 6. Epub 2021 May 6.

Center for Policy Impact in Global Health, Duke Global Health Institute, Duke University, Durham, NC 27701, USA.

Provider payment reforms, such as capitation, are very contentious. Such reforms can drop off the policy agenda due to political and contextual resistance. Using the Shiffman and Smith (Generation of political priority for global health initiatives: a framework and case study of maternal mortality. Read More

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Distribution of Merlin in eukaryotes and first report of DNA transposons in kinetoplastid protists.

PLoS One 2021 6;16(5):e0251133. Epub 2021 May 6.

Laboratório de Ciências e Tecnologias Aplicadas em Saúde (LaCTAS), Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, PR, Brazil.

DNA transposons are defined as repeated DNA sequences that can move within the host genome through the action of transposases. The transposon superfamily Merlin was originally found mainly in animal genomes. Here, we describe a global distribution of the Merlin in animals, fungi, plants and protists, reporting for the first time their presence in Rhodophyceae, Metamonada, Discoba and Alveolata. Read More

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Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease.

Blood Adv 2021 May;5(9):2403-2411

Cellular and Molecular Therapeutics Branch, NHLBI/NIDDK, National Institutes of Health, Bethesda, MD.

Recent studies suggest that plerixafor mobilization and apheresis in patients with sickle cell disease (SCD) is safe and can allow collection of sufficient CD34+ hematopoietic stem cell (HSC) collection for clinical gene therapy applications. However, the quantities of plerixafor-mobilized CD34+ cells vary between different SCD patients for unknown reasons. Twenty-three participants with SCD underwent plerixafor mobilization followed by apheresis, processing, and HSC enrichment under a phase 1 safety and efficacy study conducted at 2 institutions. Read More

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The protective role of PHB and its degradation products against stress situations in bacteria.

FEMS Microbiol Rev 2021 May;45(3)

Ecology and Genetics Research Unit, University of Oulu, Pentti Kaiteran katu 1, P.O. Box 3000, FI-90014 Oulu, Finland.

Many bacteria produce storage biopolymers that are mobilized under conditions of metabolic adaptation, for example, low nutrient availability and cellular stress. Polyhydroxyalkanoates are often found as carbon storage in Bacteria or Archaea, and of these polyhydroxybutyrate (PHB) is the most frequently occurring PHA type. Bacteria usually produce PHB upon availability of a carbon source and limitation of another essential nutrient. Read More

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Decontamination effectiveness and the necessity of innovation in a large-scale disaster simulation.

Am J Disaster Med 2021 Winter;16(1):67-73

Associate Professor, Institute of Health Sciences Education and Department of Medicine, McGill University, Montreal, Canada.

Background: Chemical, biological, radiologic, nuclear, and explosive (CBRNE) events threaten the health and integrity of human populations across the globe. Effective decontamination is a central component of CBRNE disaster response.

Objective: This paper provides an objective determination of wet decontamination effectiveness through the use of a liquid-based contaminant proxy and describes the mobilization and adaptation of easily available materials for the needs of decontamination in pediatric victims. Read More

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Ectopic Expression of a Maize Gene Is Induced by Composite Insertions Generated Through Alternative Transposition.

Genetics 2020 Dec;216(4):1039-1049

Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011-3260.

Transposable elements (TEs) are DNA sequences that can mobilize and proliferate throughout eukaryotic genomes. Previous studies have shown that in plant genomes, TEs can influence gene expression in various ways, such as inserting in introns or exons to alter transcript structure and content, and providing novel promoters and regulatory elements to generate new regulatory patterns. Furthermore, TEs can also regulate gene expression at the epigenetic level by modifying chromatin structure, changing DNA methylation status, and generating small RNAs. Read More

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December 2020

Establishment and Use of Polio Communication Network in Response to Polio in Outbreak Countries of the Horn of Africa: 2013-2014.

J Immunol Sci 2021 Apr;Spec Issue(2):1117

WHO Horn of Africa Coordination Office (HOA), Nairobi KENYA.

Background: Between 2013 and 2014, the Horn of Africa countries experienced a severe and prolonged outbreak of polio viruses. It started in one district in Somalia but quickly became a national and even international disaster, crossing international boundaries into Kenya and Ethiopia. This paper documents experiences in the establishment and contributions of the Polio Communication Network (PCN) to the polio outbreak response in the outbreak countries of Somalia, Kenya and Ethiopia from 2013 to 2015. Read More

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Non-union after Fracture of the Anterior Tibial Spine in a 6-Year-old Child: A Case Report.

J Orthop Case Rep 2020 May-Jun;10(3):27-31

Department of Orthopaedics, Orthopaedics and Traumatology Service, Centro Hospitalar de Vila Nova de Gaia/Espinho, Gaia, Portugal.

Introduction: Fractures of the tibial spines occur in 3/100,000 children per year and are rare in children under 8 years. Non-union after avulsion fracture of the tibial spine is even rarer, especially under 8 years, with only few cases described in the literature.

Case Presentation: A 6-year-old boy with went to the emergency department after suffering trauma in his left knee. Read More

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Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Post-Operative Delirium.

Geriatr Orthop Surg Rehabil 2021 16;12:21514593211004530. Epub 2021 Apr 16.

Department of Anaesthesiology, Queen Mary Hospital, Hong Kong.

Background: Delirium in elderly orthopaedic patients poses an enormous medical, social and financial burden to the healthcare system, and causes significant distress to patients and their caregivers. We examined whether a Multi-component Care Bundle (MCB) could reduce the incidence of post-operative delirium (POD) in fractured hip patients.

Methods: An observational study was conducted, analyzing 154 patients (mean age ± SD, 85 ± 7. Read More

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Rapid response to emerging biomedical challenges and threats.

IUCrJ 2021 May 26;8(Pt 3):395-407. Epub 2021 Mar 26.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.

As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19. Read More

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Structural biology in the time of COVID-19: perspectives on methods and milestones.

IUCrJ 2021 May 23;8(Pt 3):335-341. Epub 2021 Apr 23.

Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA.

The global COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has wreaked unprecedented havoc on global society, in terms of a huge loss of life and burden of morbidity, economic upheaval and social disruption. Yet the sheer magnitude and uniqueness of this event has also spawned a massive mobilization of effort in the scientific community to investigate the virus, to develop therapeutics and vaccines, and to understand the public health impacts. Structural biology has been at the center of these efforts, and so it is advantageous to take an opportunity to reflect on the status of structural science vis-à-vis its role in the fight against COVID-19, to register the unprecedented response and to contemplate the role of structural biology in addressing future outbreak threats. Read More

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Antiplatelet and Antithrombotic Effects of Nakai.

Evid Based Complement Alternat Med 2021 16;2021:7071987. Epub 2021 Apr 16.

Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.

. Nakai is a medicinal plant known for its health beneficial effects on impotence, arrhythmia, oxidation, aging, osteoporosis, and cardiovascular diseases. However, there is no report available that shows its effects on platelet functions. Read More

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