8 results match your criteria mlav

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Impact of Měnglà Virus Proteins on Human and Bat Innate Immune Pathways.

J Virol 2020 06 16;94(13). Epub 2020 Jun 16.

Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA

Měnglà virus (MLAV), identified in bats, is a phylogenetically distinct member of the family Because the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) modulate host innate immunity, MLAV VP35, VP40, and VP24 proteins were compared with their EBOV and MARV homologs for innate immune pathway modulation. In human and cells, MLAV VP35 behaved like EBOV and MARV VP35s, inhibiting virus-induced activation of the interferon beta (IFN-β) promoter and interferon regulatory factor 3 (IRF3) phosphorylation. MLAV VP35 also interacted with PACT, a host protein engaged by EBOV VP35 to inhibit RIG-I signaling. Read More

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Crystal structure of the Měnglà virus VP30 C-terminal domain.

Biochem Biophys Res Commun 2020 04 22;525(2):392-397. Epub 2020 Feb 22.

School of Biological Science and Technology, University of Jinan, Jinan, China. Electronic address:

The family Filoviridae contains many important human viruses, including Marburg virus (MARV) and Ebola virus (EBOV). Měnglà virus (MLAV), a newly discovered filovirus, is considered a potential human pathogen. The VP30 C-terminal domain (CTD) of these filoviruses plays an essential role in virion assembly. Read More

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Characterization of a filovirus (Měnglà virus) from Rousettus bats in China.

Nat Microbiol 2019 03 7;4(3):390-395. Epub 2019 Jan 7.

CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality. The risk of future outbreaks is exacerbated by the discovery of other bat-borne filoviruses of wide genetic diversity globally. Here we report the characterization of a phylogenetically distinct bat filovirus, named Měnglà virus (MLAV). Read More

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Minimum local anesthetic volumes for a selective saphenous nerve block: a dose-finding study.

Minerva Anestesiol 2017 Feb 11;83(2):183-190. Epub 2016 Nov 11.

Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: Saphenous nerve block contributes to analgesia after knee and lower leg surgery. However, literature reports a wide range of volumes of local anesthetic being used for this block.

Methods: A non-randomized controlled trial in a single university hospital in March 2015. Read More

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February 2017

Hyaluronidase reduces local anaesthetic volumes for sub-Tenon's anaesthesia.

Br J Anaesth 2007 Nov 24;99(5):717-20. Epub 2007 Sep 24.

Department of Anaesthesia, D Floor, Jubilee Building, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.

Background: Volumes of local anaesthetics for sub-Tenon's anaesthesia vary. Lower volumes produce less akinesia, whereas higher volumes increase chemosis and intra-ocular pressures. Hyaluronidase is often added to local anaesthetics to improve akinesia without increasing the volume of the injection, but this is controversial. Read More

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November 2007

A comparison of minimum local anesthetic volumes and doses of epidural bupivacaine (0.125% w/v and 0.25% w/v) for analgesia in labor.

Anesth Analg 2007 Feb;104(2):412-5

Department of Obstetric Anaesthesia, St James University Hospital, Leeds, UK.

Background: In this study we sought to determine and compare the minimum local anesthetic volumes (MLAV) and doses (MLAD) of two concentrations of bupivacaine for epidural pain relief in labor, and to quantify the effect on dose.

Methods: Eighty women were randomized in a double-blind manner to receive a first bolus of either plain bupivacaine 0.125% (w/v) or 0. Read More

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February 2007

[The P loop in atrioventricular septal defect. Embryologico-vectorcardiographic correlation].

Arch Inst Cardiol Mex 1988 Nov-Dec;58(6):517-23

Cátedra de Cardiología, Universidad de Padua, Italia.

Atrial vectorcardiograms (vcg) were analysed in 23 patients with partial (n = 15) or complete (n = 8) forms of atrioventricular septal defect (AVSD). The rotation and the projection of the maximum left atrial vector (MLAV) on the frontal plane (FP) and on the horizontal plane (HP) were noted. To assess the possible influence of the degree of left-to-right shunting and the right atrial and right ventricular pressures on the rotation and MLAV projection, these vcg data were correlated with hemodynamic values obtained at the time of preoperative cardiac catheterization. Read More

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Effects of insulin, dexamethasone and phorbol ester on virus production in cultivated DBA/2 mouse leukemia (MLA) cells.

Acta Virol 1983 Nov;27(6):457-62

The in vitro production of intracytoplasmic oncovirus A-particles and of atypical mammary tumor virus (MLAV) from a line of DBA/2 mouse leukemia (MLA) cells were compared in the presence of insulin, dexamethasone and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), which are known to stimulate the synthesis of mouse mammary tumor virus. High amounts of A-particles were recovered from cells cultivated in the presence of dexamethasone (1 microgram/ml) as compared to untreated controls; in contrast, the production of MLAV was suppressed. Insulin and TPA did not show any significant effects. Read More

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November 1983
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