415,348 results match your criteria mixed model

Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

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September 2021

Electrically or chemically tunable photodetector with ultra high responsivity using graphene/InN nanowire based mixed dimensional barristors.

Nanotechnology 2021 Jul 22. Epub 2021 Jul 22.

Clemson University, 221-E Riggs Hall, Clemson, South Carolina, 29634, UNITED STATES.

In this work, an electrically/chemically tunable highly sensitive photodetector based on mixed dimensional heterojunction of graphene and planar InN nanowires (NW) is presented. Controlled partial oxidation of InN has been employed to effectively reduce the high surface carrier concentration of InN, which normally prevents it from forming good rectifying contact with graphene. The resulting surface modified InN NWs have been found to form excellent Schottky junction with graphene, with an increase in effective Schottky barrier height (SBH) by over 1. Read More

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Clinical sympathy - A mixed method study of the relationship between the clinical nurse educator and the graduate nurse.

Nurse Educ Pract 2021 Jul 14;55:103150. Epub 2021 Jul 14.

School of Medicine, University of Notre Dame Australia, Henry Street, Fremantle 6160, Western Australia, Australia.

Aim/objective: This paper sought to investigate the influence of the supernumerary clinical nurse educator role on the newly qualified graduate nurses' professional development and successful transition to competent and confident practitioners in the acute care hospital environment.

Background: The novice nurses learning in the inpatient clinical environment is affected by increasing patient acuity, complex conditions and organisational expectations. The supernumerary clinical nurse educator is uniquely positioned to prioritise these nurses' education through protected and available time to support adaption in the workplace culture and retention in the organisation. Read More

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Residency program directors' perceptions about the impact of the American Board of Anesthesiology's Objective Structured Clinical Examination.

J Clin Anesth 2021 Jul 19;75:110439. Epub 2021 Jul 19.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA. Electronic address:

Study Objective: To describe how the introduction of an Objective Structured Clinical Examination (OSCE) by the American Board of Anesthesiology (ABA) to its initial certification impacted anesthesiology residencies in the United States.

Design And Setting: A sequential mixed-methods design with focus groups and online survey among program directors of Accreditation Council for Graduate Medical Education-accredited anesthesiology residencies.

Patients: No patients were included. Read More

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Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report.

Int J Surg Case Rep 2021 Jul 9;85:106194. Epub 2021 Jul 9.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia. Electronic address:

Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Read More

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Inhibited nanobubble transport in a saturated porous medium: Effects of deposited colloidal particles.

J Contam Hydrol 2021 Jun 29;242:103854. Epub 2021 Jun 29.

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Nanobubbles have recently attracted much interest for their practical use and potential applications in environmental issues. The pre-existence of deposited colloidal particles in porous media commonly occurs when nanobubbles applied to porous media interact with deposited colloidal particles. However, the current understanding of the effect of the interactions with pre-deposited colloidal particles on nanobubble transport in saturated porous media remains incomplete, and the effects are often overlooked. Read More

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Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome.

Pediatr Neurol 2021 Jun 25;122:35-37. Epub 2021 Jun 25.

Department of Paediatric Neurology, APHM La Timone, Marseille, France. Electronic address:

Background: Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented. Read More

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Facing stress: No effect of acute stress at encoding or retrieval on face recognition memory.

Acta Psychol (Amst) 2021 Jul 19;219:103376. Epub 2021 Jul 19.

Department of Clinical Psychological Science, Maastricht University, Maastricht, Netherlands.

Eyewitnesses may experience stress during a crime and when attempting to identify the perpetrator subsequently. Laboratory studies can provide insight into how acute stress at encoding and retrieval affects memory performance. However, previous findings exploring this issue have been mixed. Read More

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Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of, Hematology, Sultan Qaboos University Hospital, Muscat, Oman; Apollo Hospital, Muscat, Oman. Electronic address:

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment. Few patients had been reported so far. Read More

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Envelope following response measurements in young veterans are consistent with noise-induced cochlear synaptopathy.

Hear Res 2021 Jul 10;408:108310. Epub 2021 Jul 10.

VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, Portland, OR, USA. Electronic address:

Animal studies have demonstrated that noise exposure can lead to the loss of the synapses between the inner hair cells and their afferent auditory nerve fiber targets without impacting auditory thresholds. Although several non-invasive physiological measures appear to be sensitive to cochlear synaptopathy in animal models, including auditory brainstem response (ABR) wave I amplitude, the envelope following response (EFR), and the middle ear muscle reflex (MEMR), human studies of these measures in samples that are expected to vary in terms of the degree of noise-induced synaptopathy have resulted in mixed findings. One possible explanation for the differing results is that synaptopathy risk is lower for recreational noise exposure than for occupational or military noise exposure. Read More

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Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers.

Int J Pharm 2021 Jul 19:120903. Epub 2021 Jul 19.

School of Science, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent ME4 4TB, UK. Electronic address:

Recently developed medicated dressings target either bacterial or fungal infection only, which is not effective for the treatment of mixed infections common in diabetic foot ulcers (DFUs). This study aims to develop advanced bioactive alginate-based dressings (films and wafers) to deliver therapeutically relevant doses of ciprofloxacin (CIP) and fluconazole (FLU) to target mixed bacterial and fungal infections in DFUs. The alginate compatibility with the drugs was confirmed by SEM, XRD, FTIR and texture analysis, while the medicated wafers showed better fluid handling properties than the films in the presence of simulated wound fluid. Read More

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Nonoperative and Operative Soft-Tissue, Cartilage, and Bony Regeneration and Orthopaedic Biologics of the Shoulder: An Orthoregeneration Network (ON) Foundation Review.

Arthroscopy 2021 Jul 19. Epub 2021 Jul 19.

Midwest Orthopaedics at Rush, Chicago, IL, USA. Electronic address:

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Read More

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Purification and characterization of an amyloidogenic repeat domain from the functional amyloid Pmel17.

Protein Expr Purif 2021 Jul 19:105944. Epub 2021 Jul 19.

Laboratory of Protein Conformation and Dynamics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, United States. Electronic address:

The pre-melanosomal protein (Pmel17) is a human functional amyloid that supports melanin biosynthesis within melanocytes. This occurs in the melanosome, a membrane-bound organelle with an acidic intraluminal pH. The repeat region of Pmel17 (RPT, residues 315-444) has been previously shown to form amyloid aggregates under acidic melanosomal conditions, but not under neutral cytosolic conditions, when expressed and purified using a C-terminal hexa-histidine tag (RPT-His). Read More

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Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches.

Food Chem Toxicol 2021 Jul 19:112432. Epub 2021 Jul 19.

Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius. Electronic address:

Herbals in the form of medicine are employed extensively around the world. Herbal and conventional medicine combination is a potentially dangerous practice mainly in comorbid, hepato insufficient and frail patients leading to perilous herb-drug interactions (HDI) and toxicity. This study features potential HDI of 15 globally famous plant species through data mining and computational methods. Read More

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Rethinking emotional eating: Retrospective and momentary indices of emotional eating represent distinct constructs.

Appetite 2021 Jul 19:105604. Epub 2021 Jul 19.

Center for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA. Electronic address:

Emotional eating (EE) has been proposed as a key weight loss barrier. However, most investigations of EE rely on retrospective self-reports, which may have poor construct validity. This study evaluated concordance between a common self-report EE measure and a novel method for assessing momentary EE using ecological momentary assessment (EMA). Read More

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Potentially toxic elements in soil and road dust around Sonbhadra industrial region, Uttar Pradesh, India: Source apportionment and health risk assessment.

Environ Res 2021 Jul 19:111685. Epub 2021 Jul 19.

Department of Hydrogeology and Environmental Geology, Institute of Geosciences, Martin Luther University, Halle (Saale), 06120, Germany.

Potentially toxic elements (PTEs) are directly linked with various kinds of adverse health issues. Available reports related to symptoms of mercury contamination in the local population of the study region motivated us to carry out this work in detail. To estimate potentially toxic elements (As, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Zn) contamination status, a total of 48 samples of soil & road dust from industrial clusters were collected and analyzed for source identification and human health risk assessment in the Sonbhadra region of Uttar Pradesh, India. Read More

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DNA sequence-dependent positioning of the linker histone in a nucleosome: a single-pair FRET study.

Biophys J 2021 Jul 19. Epub 2021 Jul 19.

Molecular and Cellular Modelling Group, Heidelberg Institute for Theoretical Studies (HITS), 69118 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany; Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, 69120 Heidelberg, Germany; Interdisciplinary Center for Scientific Computing (IWR), 69120 Heidelberg, Germany. Electronic address:

Linker histones (LH) bind to nucleosomes with their globular domain (gH) positioned in either an on- or an off-dyad binding mode. Here, we study the effect of the linker DNA (L-DNA) sequence on the binding of a full-length LH, Xenopus laevis H1.0b, to a Widom 601 nucleosome core particle (NCP) flanked by two 40 bp long L-DNA arms, by single-pair FRET spectroscopy. Read More

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The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis.

Biochem Pharmacol 2021 Jul 19:114691. Epub 2021 Jul 19.

Clinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, Zhejiang, China. Electronic address:

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease caused by an interaction of genetics, immune responses, and environmental factors. However, the precise pathogenesis of UC remains poorly understood. The aim of the present study was to explore the potential target genes implicated in UC and to elucidate its underlying pathogenic mechanism. Read More

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Attachment Style Mediates the Relationship between Trauma and Somatic Distress among Individuals with Serious Mental Illness.

Psychiatry 2021 ;84(2):150-164

: Individuals with mental illnesses severe enough to require psychiatric hospitalization often have significant trauma histories, have developed maladaptive attachment styles, and experience comorbid somatic distress. Gaining an understanding about the interaction of such factors may lead to prioritizing interventions that target factors that mediate the relationship between trauma and adverse somatic distress. Prior research has examined various mediation models, but results have been mixed and conducted only on outpatient samples. Read More

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January 2021

Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial.

Appl Physiol Nutr Metab 2021 Jul 22. Epub 2021 Jul 22.

Universidade Estadual de Maringa, 42487, Physiological Sciences, Maringa, PR, Brazil;

Evaluate the effect of 12wks of concurrent training (CT) in extracellular matrix (ECM) of subcutaneous adipose tissue (SAT) in people living with HIV/aids (PLWHA). To the non-randomized clinical trial 19 participants, 11 healthy (HIV-) and 18 PLWHA under the use of highly active antiretroviral therapy (HAART) for at least 1 year (HIV+). All participants engaged in a moderate-intensity CT program for 12 weeks, three times a week. Read More

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Trends in home dialysis use differ among age categories in past two decades: a Dutch registry study.

Eur J Clin Invest 2021 Jul 22:e13656. Epub 2021 Jul 22.

Department of Nephrology, Amsterdam UMC, Vrije Universiteit Amsterdam, Research institute Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

Background: Although the number of patients with end stage kidney disease is growing, the number of patients that perform dialysis at home has decreased during the past two decades. The aim of this study is to explore time trends in the use of home dialysis in the Netherlands.

Methods: Dialysis episodes of patients who started dialysis treatment were studied using Dutch registry data (RENINE). Read More

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Oils Rich in α-Linolenic Acid or Docosahexaenoic Acid Have Distinct Effects on Plasma Oxylipin and Adiponectin Concentrations and on Monocyte Bioenergetics in Women with Obesity.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Department of Food and Human Nutritional Sciences, University of Manitoba, Manitoba, Canada.

Background: Omega-3 fatty acids, including DHA and α-linolenic acid (ALA), are proposed to improve metabolic health by reducing obesity-associated inflammation. Their effects are mediated in part by conversion to oxylipins. ALA is relatively understudied, and direct comparisons to other omega-3 fatty acids are limited. Read More

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PrEP monitoring and HIV incidence after PrEP initiation in France: 2016-18 nationwide cohort study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

INSERM U1259, Université de Tours, France.

Background: Clinical trials have demonstrated that oral pre-exposure prophylaxis (PrEP) has high efficacy in preventing HIV transmission. In many countries, HIV testing is recommended prior to PrEP initiation, 1 month after and quarterly thereafter. We assessed the uptake of HIV testing and estimated the incidence of HIV infections after oral PrEP initiation, by using the French national health database (SNDS). Read More

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Global cognitive performance at 4-year follow-up in individuals with atrial fibrillation-findings from The Irish Longitudinal Study on Ageing.

Age Ageing 2021 Jul 21. Epub 2021 Jul 21.

The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland.

Introduction: Atrial fibrillation (AF) has been proposed as a risk factor for cognitive impairment, even in the absence of a history of stroke. This study investigates whether AF is associated with increased risk of cognitive decline in a community-dwelling population of adults over the age of 50.

Methods: Data from the 1st and 3rd waves of The Irish Longitudinal Study on Ageing (TILDA) were used (4-year follow-up period). Read More

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A mixed methods study on the readiness of dental, medical, and nursing students for interprofessional learning.

PLoS One 2021 22;16(7):e0255086. Epub 2021 Jul 22.

Institute of Education, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Interprofessional education (IPE) is crucial in dentistry, medicine, and nursing. However, scant mixed methods studies have compared the IPE outcomes across these disciplines to develop evidence-based IPE. This study explored the differences in the readiness of dental, medical, and nursing students for interprofessional learning before and after IPE workshops and elucidated reasons for this disparity. Read More

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A mathematical investigation into the uptake kinetics of nanoparticles in vitro.

PLoS One 2021 22;16(7):e0254208. Epub 2021 Jul 22.

Department for Applied Mathematics, Liverpool John Moores University, Liverpool, United Kingdom.

Nanoparticles have the potential to increase the efficacy of anticancer drugs whilst reducing off-target side effects. However, there remain uncertainties regarding the cellular uptake kinetics of nanoparticles which could have implications for nanoparticle design and delivery. Polymersomes are nanoparticle candidates for cancer therapy which encapsulate chemotherapy drugs. Read More

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What are the effects of teaching Evidence-Based Health Care (EBHC) at different levels of health professions education? An updated overview of systematic reviews.

PLoS One 2021 22;16(7):e0254191. Epub 2021 Jul 22.

Centre for Evidence-based Health Care, Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, South Africa.

Background: Evidence-based healthcare (EBHC) knowledge and skills are recognised as core competencies of healthcare professionals worldwide, and teaching EBHC has been widely recommended as an integral part of their training. The objective of this overview of systematic reviews (SR) was to update evidence and assess the effects of various approaches for teaching evidence-based health care (EBHC) at undergraduate (UG) and postgraduate (PG) medical education (ME) level on changes in knowledge, skills, attitudes and behaviour.

Methods And Findings: This is an update of an overview that was published in 2014. Read More

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A mixed-methods evaluation of the uptake of novel differentiated ART delivery models in a national sample of health facilities in Uganda.

PLoS One 2021 22;16(7):e0254214. Epub 2021 Jul 22.

Kabale University, School of Medicine, Kabale, Uganda.

Introduction: Since 2017, Uganda has been implementing five differentiated antiretroviral therapy (ART) delivery models to improve the quality of HIV care and to achieve health-system efficiencies. Community-based models include Community Client-Led ART Delivery and Community Drug Distribution Points. Facility-based models include Fast Track Drug Refill, Facility Based Group and Facility Based Individual Management. Read More

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Developing a core outcome set for periodontal trials.

PLoS One 2021 22;16(7):e0254123. Epub 2021 Jul 22.

Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom.

Background: There is no agreement which outcomes should be measured when investigating interventions for periodontal diseases. It is difficult to compare or combine studies with different outcomes; resulting in research wastage and uncertainty for patients and healthcare professionals.

Objective: Develop a core outcome set (COS) relevant to key stakeholders for use in effectiveness trials investigating prevention and management of periodontal diseases. Read More

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