Antioxid Redox Signal 2021 Jun 22. Epub 2021 Jun 22.
State University of Campinas Faculty of Medical Sciences, 67791, Pathology, Rua Tessália Vieira de Camargo, 126., Campinas, Campinas, SP, Brazil, 13083-887;
Significance: Proton-translocating NAD(P)+ transhydrogenase, also known as nicotinamide nucleotide transhydrogenase (NNT), catalyzes a reversible reaction coupling the protonmotive force across the inner mitochondrial membrane and hydride (H-, a proton plus two electrons) transfer between the mitochondrial pools of NAD(H) and NADP(H). The forward NNT reaction is a source of NADPH in the mitochondrial matrix, fueling antioxidant and biosynthetic pathways with reductive potential. Despite the greater emphasis given to the net forward reaction, the reverse NNT reaction that oxidizes NADPH also occurs in physiological and pathological conditions. Read More