110 results match your criteria mitigating contraction

Predicting habitat suitability and niche dynamics of Dactylorhiza hatagirea and Rheum webbianum in the Himalaya under projected climate change.

Sci Rep 2022 Aug 1;12(1):13205. Epub 2022 Aug 1.

Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

In the era of anthropocene, global warming tends to alter the distribution range of the plant species. Highly fragile to such changes are the species that are endemic, inhabit higher elevations and show narrow distribution ranges. Predicting and plotting the appropriate suitable habitats and keeping knowledge of how climate change will affect future distribution become imperative for designing effective conservation strategies. Read More

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Mechanisms of eccentric contraction-induced muscle damage and nutritional supplementations for mitigating it.

J Muscle Res Cell Motil 2022 Jul 19. Epub 2022 Jul 19.

Graduate School of Humanities and Social Sciences, Hiroshima University, 1-7-1 Kagamiyama, 739-8521, Higasihiroshima-shi, Hiroshima, Japan.

Eccentric contraction (ECC) often results in large and long-lasting force deficits accompanied by muscle soreness, primarily due to muscle damage. In this sense, exercises that involve ECC are less desirable. Paradoxically, exercise training that includes a substantial eccentric phase leads to a more powerful activation of the genes responsible for skeletal muscle remodeling (e. Read More

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Antithrombin-III mitigates thrombin-mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow.

Br J Haematol 2022 Jul 13. Epub 2022 Jul 13.

Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin-III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagulation cascade, including thrombin. Here, we utilize a biomimetic microfluidic device to model the morphology and adhesive properties of endothelial cells (ECs) activated by thrombin and examine the efficacy of ATIII in mitigating the adhesion of SCD patient-derived red blood cells (RBCs) and EC retraction. Read More

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Association between SCN5A R225Q variant and dilated cardiomyopathy: potential role of intracellular pH and WNT/β-catenin pathway.

J Med Genet 2022 Jun 14. Epub 2022 Jun 14.

Cardiology Department, Zhong Shan Hospital, Shanghai, China.

Background: The SCN5A variant is a common cause of familial dilated cardiomyopathy (DCM). We previously reported a SCN5A variant (c.674G>A), located in the high-risk S4 segment of domain I (DI-S4) region in patients with idiopathic DCM and R225Q knockin (p. Read More

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Post-surgery Rehabilitative Intervention Based on Imitation Therapy and Mouth-Hand Motor Synergies Provides Better Outcomes in Smile Production in Children and Adults With Long Term Facial Paralysis.

Front Neurol 2022 11;13:757523. Epub 2022 May 11.

Institut des Sciences Cognitives Marc Jeannerod, CNRS, Université de Lyon, Lyon, France.

Rehabilitation after free gracilis muscle transfer (smile surgery, SS) is crucial for a functional recovery of the smiling skill, mitigating social and psychological problems resulting from facial paralysis. We compared two post-SS rehabilitation treatments: the traditional based on teeth clenching exercises and the FIT-SAT (facial imitation and synergistic activity treatment). FIT-SAT, based on observation/imitation therapy and on hand-mouth motor synergies would facilitate neuronal activity in the facial motor cortex avoiding unwanted contractions of the jaw, implementing muscle control. Read More

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Evaluation of carbon sink in the Taklimakan Desert based on correction of abnormal negative CO flux of IRGASON.

Sci Total Environ 2022 Sep 16;838(Pt 1):155988. Epub 2022 May 16.

Xinjiang Information Engineering School, Urumqi 830002, China.

Studies showing that deserts can sequester CO through non-photosynthetic processes have contributed to locating missing carbon sinks. However, the contradiction between the desert CO flux obtained by different observation methods leads to uncertainty in evaluating desert carbon sequestration. This has caused scepticism regarding desert carbon sequestration after years of research. Read More

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September 2022

Effect of Caffeine Ingestion on Indirect Markers of Exercise-Induced Muscle Damage: A Systematic Review of Human Trials.

Nutrients 2022 Apr 23;14(9). Epub 2022 Apr 23.

Postgraduate Program in Physical Education, Center of Physical Education and Sports, Federal University of Espirito Santo, Vitória 29075-910, ES, Brazil.

The effect of caffeine on mitigating exercise-induced muscle damage (EIMD) is still poorly understood, but it was hypothesized that caffeine could contribute to decreasing delayed onset muscle soreness, attenuating temporary loss of strength, and reducing circulating levels of blood markers of muscle damage. However, evidence is not conclusive and beneficial effects of caffeine ingestion on EIMD are not always observed. Factors, such as the type of exercise that induces muscle damage, supplementation protocol, and type of marker analyzed contribute to the differences between the studies. Read More

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Mitigating the photodegradation of all-inorganic mixed-halide perovskite nanocrystals by ligand exchange.

Phys Chem Chem Phys 2022 May 11;24(18):10944-10951. Epub 2022 May 11.

Institut für physikalische und theoretische Chemie, Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.

We show that the decomposition of caesium lead halide perovskite nanocrystals under continuous X-ray illumination depends on the surface ligand. For oleic acid/oleylamine, we observe a fast decay accompanied by the formation of elemental lead and halogen. Upon surface functionalization with a metal porphyrin derivative, the decay is markedly slower and involves the disproportionation of lead to Pb and Pb. Read More

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Improved Cognitive Vigilance Assessment after Artifact Reduction with Wavelet Independent Component Analysis.

Sensors (Basel) 2022 Apr 15;22(8). Epub 2022 Apr 15.

Biomedical Engineering Graduate Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.

Vigilance level assessment is of prime importance to avoid life-threatening human error. Critical working environments such as air traffic control, driving, or military surveillance require the operator to be alert the whole time. The electroencephalogram (EEG) is a very common modality that can be used in assessing vigilance. Read More

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Physical Exercise Restrains Cancer Progression through Muscle-Derived Factors.

Cancers (Basel) 2022 Apr 8;14(8). Epub 2022 Apr 8.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

A growing body of in vitro and in vivo studies suggests that physical activity offers important benefits against cancer, in terms of both prevention and treatment. However, the exact mechanisms implicated in the anticancer effects of exercise remain to be further elucidated. Muscle-secreted factors in response to contraction have been proposed to mediate the physical exercise-induced beneficial effects and be responsible for the inter-tissue communications. Read More

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Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.

Circulation 2022 04 6;145(16):1238-1253. Epub 2022 Apr 6.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (M.R., J.P., Y.R., S.K.D., Y.H., M.W.E., J. Luo, J.H., L.H.Y., D.L.J., Y.Q.), Yale University School of Medicine, New Haven, CT.

Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM manifestations include left ventricular hypertrophy and heart failure, arrythmias, and sudden cardiac death. How dysregulated sarcomeric force production is sensed and leads to pathological remodeling remains poorly understood in HCM, thereby inhibiting the efficient development of new therapeutics. Read More

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EEG-Based Spectral Analysis Showing Brainwave Changes Related to Modulating Progressive Fatigue During a Prolonged Intermittent Motor Task.

Front Hum Neurosci 2022 11;16:770053. Epub 2022 Mar 11.

Center for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.

Repeatedly performing a submaximal motor task for a prolonged period of time leads to muscle fatigue comprising a central and peripheral component, which demands a gradually increasing effort. However, the brain contribution to the enhancement of effort to cope with progressing fatigue lacks a complete understanding. The intermittent motor tasks (IMTs) closely resemble many activities of daily living (ADL), thus remaining physiologically relevant to study fatigue. Read More

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Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture.

Front Bioeng Biotechnol 2022 21;10:803403. Epub 2022 Feb 21.

Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.

Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered simvastatin (SV) and losartan (LS) in two preclinical models of elbow PTJC: an elbow-specific rat injury model and an collagen gel contraction assay. Read More

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February 2022

Effects of arm and leg positions on lumbar multifidus muscle activity while on hands and knees or while standing.

J Physiol Anthropol 2022 Mar 7;41(1). Epub 2022 Mar 7.

Department of Rehabilitation Sciences, Faculty of Allied Health, Kansai University of Welfare Sciences, 3-11-1 Asahigaoka, Kashiwara, Osaka, 582-0026, Japan.

Background: The lumbar multifidus (LMF) muscle, which is involved in the mechanical stability of the lumbar spine, reportedly undergoes atrophy in patients with low back pain. Preventing or mitigating low back pain requires strengthening the LMF muscle; however, methods for triggering selective and significant contraction of this muscle have not been fully studied. This study aims to clarify how, in the hands-and-knees or standing position, the position of the arm and leg on one side affects the activity of the lumbar erector spinae (LES) and LMF muscles. Read More

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High magnesium mitigates the vasoconstriction mediated by different types of calcium influx from monocrotaline-induced pulmonary hypertensive rats.

Exp Physiol 2022 04 7;107(4):359-373. Epub 2022 Mar 7.

Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.

New Findings: What is the central question of this study? What is the involvement of Mg in mitigating the vasoconstriction in pulmonary arteries and smaller pulmonary arteries in the monocrotaline-induced pulmonary arterial hypertension (MCT-PAH) rat model? What are the main finding and its importance? Both store-operated Ca entry- and receptor-operated Ca entry-mediated vasoconstriction were enhanced in the MCT-PAH model. High magnesium inhibited vasoconstriction by directly antagonizing Ca and increasing NO release, and this was more notable in smaller pulmonary arteries.

Abstract: Increased extracellular magnesium concentration has been shown to attenuate the endothelin-1-induced contractile response via the release of nitric oxide (NO) from the endothelium in proximal pulmonary arteries (PAs) of chronic hypoxic mice. Read More

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Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases.

Sci Rep 2022 02 1;12(1):1688. Epub 2022 Feb 1.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan, Russia, 420088.

Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year. The pathways activated during OP compound poisoning via overstimulation of muscarinic acetylcholine receptors (mAChRs) play a decisive role in toxidrome. The antidotal therapy includes atropine, which is a nonspecific blocker of all mAChR subtypes. Read More

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February 2022

A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic laws.

Eur J Oper Res 2022 Jan 8. Epub 2022 Jan 8.

ANION Environmental Ltd, 26 Lykoudi Str., Athens GR 11141.

A critical operations management problem in the ongoing COVID-19 pandemic is cognizance of (a) the number of all carriers at large (CaL) conveying the SARS-CoV-2, including asymptomatic ones and (b) the infection rate (IR). Both are random and unobservable, affecting the spread of the disease, patient arrivals to health care units (HCUs) and the number of victims. A novel, inventory perspective of COVID-19 is proposed, with random inflow, random losses and retrials (recurrent cases) and delayed/distributed exit, with randomly varying fractions of the exit distribution. Read More

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January 2022

Mitigating Initial Orthostatic Hypotension: Mechanistic Roles of Muscle Contraction Versus Sympathetic Activation.

Hypertension 2022 03 6;79(3):638-647. Epub 2022 Jan 6.

Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine (N.A.S., A.A.P., S.R., M.L., K.K., K.M.B., J.G.J., L.Y.L., R.S.S., D.V.E., S.R.R.), University of Calgary, AB, Canada.

Background: Initial orthostatic hypotension (IOH) is defined by a large drop in blood pressure (BP) within 15 s of standing. IOH often presents during an active stand, but not with a passive tilt, suggesting that a muscle activation reflex involving lower body muscles plays an important role. To our knowledge, there is no literature exploring how sympathetic activation affects IOH. Read More

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Self-Selected Motivational Music Enhances Physical Performance in Normoxia and Hypoxia in Young Healthy Males.

Front Psychol 2021 10;12:787496. Epub 2021 Dec 10.

Environmental Ergonomics Research Centre, Loughborough University, Loughborough, United Kingdom.

Humans exposed to hypoxia are susceptible to physiological and psychological impairment. Music has ergogenic effects through enhancing psychological factors such as mood, emotion, and cognition. This study aimed to investigate music as a tool for mitigating the performance decrements observed in hypoxia. Read More

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December 2021

Endoscopy during the peak of COVID-19 pandemic: impact on activity and financial implications for a tertiary referral center in London.

Ann Gastroenterol 2021 Nov-Dec;34(6):829-835. Epub 2021 Jul 2.

Royal Free Unit for Endoscopy, The Royal Free Hospital and University College London Institute for Liver and Digestive Health, Hampstead, London, UK (Alberto Murino, Rocio Chacchi Cahuin, Nikolaos Lazaridis, Alexandros Skamnelos, Jonathan Potts, Charles D. Murray, Douglas Thorburn, Edward J. Despott).

Background: COVID-19 pandemic is an unprecedented global medical emergency. National and international gastrointestinal societies recommended that any endoscopic activity during the lockdown phase of the pandemic should be limited to emergency or non-deferrable procedures only. We assessed the financial implications and impact on endoscopy activity of the lockdown phase in a tertiary referral endoscopy unit. Read More

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Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca channels through BAG3.

Biomed Pharmacother 2022 Jan 17;145:112432. Epub 2021 Nov 17.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. Electronic address:

Calenduloside E (CE) is a saponin isolated from Aralia elata (Miq) Seem, which has anti-cardiovascular disease effects. This study aims to evaluate the anti-myocardial ischemia-reperfusion injury (MIRI) mechanisms of CE and regulation of BAG3 on calcium overload. We adopted siRNA to interfere with BAG3 expression in H9c2 cardiomyocytes and used adenovirus to interfere with BAG3 expression (Ad-BAG3) in primary neonatal rat cardiomyocytes (PNRCMs) to clarify the role of BAG3 in mitigating MIRI by CE. Read More

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January 2022

M-score and wound healing assessment of 2 nonantibiotic topical gel treatments of active digital dermatitis lesions in dairy cattle.

J Dairy Sci 2022 Jan 9;105(1):695-709. Epub 2021 Oct 9.

Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, the Netherlands; University Farm Animal Practice, 3481 LZ, Harmelen, the Netherlands.

This open-label, randomized clinical trial with positive control compared the treatment of active digital dermatitis (DD) lesions (stages M1, M2, and M4.1) on dairy cattle hind feet with an enzyme alginogel or a copper and zinc chelate gel (coppergel). Upon recruitment (d 0), active DD lesions were cleaned, photographed, treated, and bandaged. Read More

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January 2022

Too little but not too late: nowcasting poverty and cash transfers' incidence during COVID-19's crisis.

World Dev 2021 Apr 6;140:105227. Epub 2020 Dec 6.

Instituto de Economía, Facultad de Ciencias Económicas y de Administración, Universidad de la República, Gonzalo Ramírez 1926 CP 11200, Uruguay.

The economic crisis triggered by COVID-19 has caused a world-wide economic downturn, and the deepest GDP contraction in Latin America since the beginning of the XX century. One of the most dramatic outcomes of the crisis is the increase in poverty, but its extent will remain unknown until household income data is collected and analyzed. We propose a simple approach to provide early estimates, micro-simulating the short-run effect of the crisis on the poverty rate. Read More

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Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.

Geroscience 2021 12 25;43(6):2667-2678. Epub 2021 Sep 25.

Medical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Nottingham, Royal Derby Hospital Centre, DE22 3DT, Derby, UK.

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adaptations have been reported across age, including capillarisation and improved endothelial function. Herein, we hypothesised that HIIT would enhance muscle microvascular blood flow and vascular reactivity to acute contractile activity in older adults, reflecting HIIT-induced vascular remodelling. Read More

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December 2021

Sex differences in muscle activation patterns associated with anterior cruciate ligament injury during landing and cutting tasks: A systematic review.

J Electromyogr Kinesiol 2021 Oct 30;60:102583. Epub 2021 Jul 30.

School of Rehabilitation Sciences, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Neuromuscular control is critical for maintaining dynamic joint stability and mitigating the risk of anterior cruciate ligament (ACL) injury. Given the increased risk of ACL injury in females, sex-based differential muscle activation strategies are often associated with this risk. For example, the quadriceps-dominant muscle activation strategy sometimes observed in females has been discussed as a cause of their increased risk of ACL injury. Read More

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October 2021

Comparison of the Effects of Matching and Normalization on the Cervical Vestibular Evoked Myogenic Potential.

Otol Neurotol 2021 12;42(10):e1592-e1599

Neurology Department, Royal Prince Alfred Hospital.

Hypothesis: We compared two means of mitigating the effect of sternocleidomastoid (SCM) contraction strength on the cervical vestibular evoked myogenic potential (cVEMP): contraction matching and amplitude normalization.

Background: SCM muscle contraction strength affects the amplitude of the cVEMP which can impact measures of inter-side asymmetry and diagnostic outcomes.

Methods: In 19 normal subjects, we investigated the effect of muscle contraction variation within a cVEMP recording. Read More

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December 2021

Mobility-based real-time economic monitoring amid the COVID-19 pandemic.

Sci Rep 2021 06 22;11(1):13069. Epub 2021 Jun 22.

Department of Economics and Management, University of Pavia, 27100, Pavia, Italy.

Mobility restrictions have been identified as key non-pharmaceutical interventions to limit the spread of the SARS-COV-2 epidemics. However, these interventions present significant drawbacks to the social fabric and negative outcomes for the real economy. In this paper we propose a real-time monitoring framework for tracking the economic consequences of various forms of mobility reductions involving European countries. Read More

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1ST Cavalry Division Forward's Defender Europe 2020 Plus: Lessons Learned Fighting in a Biological Contested Environment.

Med J (Ft Sam Houst Tex) 2021 Jan-Mar(PB 8-21-01/02/03):144-149

Deputy Division Surgeon/Medical OPS, 1st Cavalry Division.

The 1st Cavalry Division Forward (1CD FWD) along with Polish ally, subordinate brigades, adjacent supporting commands, and the 7th Army Training Command successfully executed large scale combat operations training in the Defender Europe 2020 Plus (DE20P) exercise in a biologically compromised environment. The coronavirus 2019 (COVID-19) presented many unique challenges and opportunities across all warfighting functions. Still, it proved that it is possible to train in a large-scale multinational exercise while effectively mitigating the contraction and contamination of COVID-19. Read More

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Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury.

Am J Physiol Heart Circ Physiol 2021 03 29;320(3):H1170-H1184. Epub 2021 Jan 29.

Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Myocardial ischemia-reperfusion (I/R) injury increases the generation of oxidized phosphatidylcholines (OxPCs), which results in cell death. However, the mechanism by which OxPCs mediate cell death and cardiac dysfunction is largely unknown. The aim of this study was to determine the mechanisms by which OxPC triggers cardiomyocyte cell death during reperfusion injury. Read More

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Harefuah 2020 Dec;159(12):867-869

Oncology Institute, Tel Aviv Medical Center, Israel.

Background: The SARS-COV-2 virus emerged in Israel in March 2020 and compelled restructuring of the Israeli health care system. Despite the paucity of data, it appears that oncology patients suffer from a higher risk of complications due to COVID-19 infection, including hospitalization in the intensive care unit (ICU) and death. A delicate balance exists between the oncologists' obligation to provide optimal and effective cancer treatment and the risks enveloping treatment that may place patients vulnerable to contraction of the virus. Read More

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December 2020