Circulation 2022 04 6;145(16):1238-1253. Epub 2022 Apr 6.
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (M.R., J.P., Y.R., S.K.D., Y.H., M.W.E., J. Luo, J.H., L.H.Y., D.L.J., Y.Q.), Yale University School of Medicine, New Haven, CT.
Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM manifestations include left ventricular hypertrophy and heart failure, arrythmias, and sudden cardiac death. How dysregulated sarcomeric force production is sensed and leads to pathological remodeling remains poorly understood in HCM, thereby inhibiting the efficient development of new therapeutics. Read More