11,889 results match your criteria mitigate potential


Digital Pathology in Cameroon.

JCO Glob Oncol 2021 Aug;7:1380-1389

University of Florida, College of Medicine, Gainesville, FL.

Purpose: Cancer is becoming increasingly prevalent among the group of treatable diseases in African countries. There is a shortage of clinicians and pathologists available for cancer diagnosis and treatment. These limited resources must be efficiently used to maximize the number of patients treated. Read More

View Article and Full-Text PDF

Diagnosis and treatment of polycystic ovary syndrome in adolescents.

JAAPA 2021 Sep 13. Epub 2021 Sep 13.

J. Leocadia Conlon is the clinical director of Hawai'i CARES, a partnership between the Hawai'i Department of Health and the University of Hawai'i in Honolulu, Hawai'i, and an adjunct assistant professor in the George Washington University School of Medicine and Health Sciences in Washington, D.C. She is a recent graduate of the PhD program in translational health science at George Washington University, where her dissertation research focused on polycystic ovary syndrome in adolescents. Sharyn Malcolm is an attending physician in adolescent and young adult medicine, and co-medical director and director of reproductive health services at the Adolescent Health Center at Children's National Health System in Washington, D.C. She also is an assistant professor of pediatrics at George Washington University School of Medicine and Health Sciences. Maureen Monaghan is a clinical psychologist and an associate professor of psychiatry and behavioral sciences at Children's National Health System and George Washington University School of Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Abstract: Polycystic ovary syndrome (PCOS), characterized by ovulatory dysfunction and hyperandrogenism, is one of the most common endocrine disorders in women of reproductive age. Early diagnosis can help clinicians address associated longterm metabolic and reproductive health complications and mitigate the negative effects of PCOS on a patient's mental health and quality of life. Clinicians often are challenged by the diagnosis and management of PCOS because of controversies around diagnostic criteria, especially for adolescents. Read More

View Article and Full-Text PDF
September 2021

Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients.

ASAIO J 2021 Sep 9. Epub 2021 Sep 9.

From the Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium Institute of Clinical Physiology, National Research Council, Pisa, Italy Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.

Ventricular suction is a common adverse event in ventricular assist device (VAD) patients and can be due to multiple underlying causes. The aim of this study is to analyze the potential of different therapeutic interventions to mitigate suction events induced by different pathophysiological conditions. To do so, a suction module was embedded in a cardiovascular hybrid (hydraulic-computational) simulator reproducing the entire cardiovascular system. Read More

View Article and Full-Text PDF
September 2021

Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.

Biosci Rep 2021 Sep 15. Epub 2021 Sep 15.

Wuhan University of Science and Technology, Wuhan, China.

Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of allergic diseases such as asthma and allergic rhinitis during the first several years of life is often referred to as the atopic march. Although the phenomenon of atopic march has been recognized for decades, how asthma stems from AD is still not fully understood, confounding a universal strategy to effectively protect people from the atopic march.

Methods: We established experimental atopic march mice by first inducing allergic dermatitis with 0. Read More

View Article and Full-Text PDF
September 2021

Supervision of a self-driving vehicle unmasks latent sleepiness relative to manually controlled driving.

Sci Rep 2021 Sep 14;11(1):18530. Epub 2021 Sep 14.

Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA.

Human error has been implicated as a causal factor in a large proportion of road accidents. Automated driving systems purport to mitigate this risk, but self-driving systems that allow a driver to entirely disengage from the driving task also require the driver to monitor the environment and take control when necessary. Given that sleep loss impairs monitoring performance and there is a high prevalence of sleep deficiency in modern society, we hypothesized that supervising a self-driving vehicle would unmask latent sleepiness compared to manually controlled driving among individuals following their typical sleep schedules. Read More

View Article and Full-Text PDF
September 2021

COBRA PzF™ coronary stent in clinical and preclinical studies: setting the stage for new antithrombotic strategies?

Future Cardiol 2021 Sep 15. Epub 2021 Sep 15.

CVPath Institute, 19 Firstfield Road, Gaithersburg, MD 20878, USA.

Major advances have been made in coronary artery stent technology over the last decades. Drug-eluting stents reduced in-stent restenosis and have shown better outcomes compared with bare metal stents, yet some limitations still exist to their use. Because they delay healing of the vessel wall, longer dual antiplatelet therapy is mandatory to mitigate against stent thrombosis and this limitation is most concerning in subjects at high risk for bleeding. Read More

View Article and Full-Text PDF
September 2021

Understanding racial differences in attitudes about public health efforts during COVID-19 using an explanatory mixed methods design.

Soc Sci Med 2021 Sep 8;287:114379. Epub 2021 Sep 8.

University of Michigan Department of Learning Health Sciences, 300 N Ingalls St, Ann Arbor, MI, 48109, USA. Electronic address:

Efforts to mitigate the spread of COVID-19 rely on trust in public health organizations and practices. These practices include contact tracing, which requires people to share personal information with public health organizations. The central role of trust in these practices has gained more attention during the pandemic, resurfacing endemic questions about public trust and potential racial trust disparities, especially as they relate to participation in public health efforts. Read More

View Article and Full-Text PDF
September 2021

Post-COVID Public Health Surveillance and Privacy Expectations in the United States: A Scenario-Based Interview Study.

JMIR Mhealth Uhealth 2021 Aug 5. Epub 2021 Aug 5.

Department of Informatics, Indiana University, 901 E. 10th Street, Bloomington, US.

Background: Smartphone-based apps designed and deployed to mitigate the COVID-19 pandemic may become an infrastructure for post-pandemic public health surveillance in the United States. Through the lenses of privacy concerns and user expectations of digital pandemic-mitigation techniques, we identify possible long-term sociotechnical implications of such an infrastructure.

Objective: We explore how people in the United States perceive the possible routinization of pandemic-tracking apps for public health surveillance in general. Read More

View Article and Full-Text PDF

Rapid microgeographic evolution in response to climate change.

Evolution 2021 Sep 14. Epub 2021 Sep 14.

Yale University, School of the Environment.

Environmental change is predicted to accelerate into the future and will exert strong selection pressure on biota. While many species may be fated to extinction, others may survive through their capacity to evolve rapidly at highly localized (i.e. Read More

View Article and Full-Text PDF
September 2021

Clinical prediction models for hospital falls: a scoping review protocol.

BMJ Open 2021 Sep 13;11(9):e051047. Epub 2021 Sep 13.

Australian Centre for Health Services Innovation and Centre for Healthcare Translation, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Introduction: Falls remain one of the most prevalent adverse events in hospitals and are associated with substantial negative health impacts and costs. Approaches to assess patients' fall risk have been implemented in hospitals internationally, ranging from brief screening questions to multifactorial risk assessments and complex prediction models, despite a lack of clear evidence of effect in reducing falls in acute hospital environments. The increasing digitisation of hospital systems provides new opportunities to understand and predict falls using routinely recorded data, with potential to integrate fall prediction models into real-time or near-real-time computerised decision support for clinical teams seeking to mitigate fall risk. Read More

View Article and Full-Text PDF
September 2021

Lessons learnt from the rapid implementation of reusable personal protective equipment for COVID-19 in Malawi.

BMJ Glob Health 2021 09;6(9)

Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK

The SARS-CoV-2 pandemic has challenged health systems and healthcare workers worldwide. Access to personal protective equipment (PPE) is essential to mitigate the risk of excess mortality in healthcare providers. In Malawi, the cost of PPE represents an additional drain on available resources. Read More

View Article and Full-Text PDF
September 2021

The risk of future waves of COVID-19: modeling and data analysis.

Math Biosci Eng 2021 06;18(5):5409-5426

Department of Mathematics, University of Florida, Gainesville, 32611, USA.

After a major outbreak of the coronavirus disease (COVID-19) starting in late December 2019, there were no new cases reported in mainland China for the first time on March 18, 2020, and no new cases reported in Hong Kong Special Administrative Region on April 20, 2020. However, these places had reported new cases and experienced a second wave since June 11, 2020. Here we develop a stochastic discrete-time epidemic model to evaluate the risk of COVID-19 resurgence by analyzing the data from the beginning of the outbreak to the second wave in these three places. Read More

View Article and Full-Text PDF

A nanophytosomes formulation based on elderberry anthocyanins and Codium lipids to mitigate mitochondrial dysfunctions.

Biomed Pharmacother 2021 Sep 10;143:112157. Epub 2021 Sep 10.

REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, nº 228, Porto 4050-313, Portugal. Electronic address:

The development of nanomedicines to modulate the mitochondrial function is a great scientific challenge since mitochondrial dysfunction is a pathological hallmark of many chronic diseases, including degenerative brain pathologies like Parkinson's and Alzheimer's diseases. To address this challenge, the mitochondriotropic features of the elderberry anthocyanin-enriched extract (Sambucus nigra) were combined with the self-assembling properties of the membrane polar lipids from Codium tomentosum in an innovative SC-Nanophytosomes formulation. Membrane polar lipids, obtained by a new procedure as chlorophyll-free extract, are characterized by 26% of non-phosphorus polar lipids and 74% of phospholipids (dominated by anionic lipids) containing a high degree of polyunsaturated fatty acids. Read More

View Article and Full-Text PDF
September 2021

Forest understorey plant responses to long-term experimental warming, light and nitrogen addition.

Plant Biol (Stuttg) 2021 Sep 13. Epub 2021 Sep 13.

Forest & Nature Lab, Department of Environment, Faculty of Bioscience Engineering, Ghent University, Gontrode-Melle, Belgium.

Climate change, eutrophication and intensified forest management are affecting forest understorey plants, a major component of forest biodiversity. The main impacts of these drivers have often been studied, but we lack a good understanding of how key understorey species are affected by potential interactive effects of these drivers and which species drive community changes. Here we assessed the responses of 15 species occurring in the understorey of a deciduous temperate forest to experimental warming, light addition and enhanced nitrogen inputs in permanent plots surveyed for 9 years. Read More

View Article and Full-Text PDF
September 2021

Variation in mineral types of uroliths from ferrets () submitted for analysis in North America, Europe, or Asia over an 8-year period.

J Am Vet Med Assoc 2021 Oct;259(7):757-763

Objective: To compare mineral types of naturally occurring uroliths in ferrets () from North America, Europe, and Asia and to identify potential risk factors associated with cystine urolithiasis in ferrets.

Samples: 1,054 laboratory submission records of uroliths obtained from ferrets between January 1, 2010, and December 31, 2018.

Procedures: For this cross-sectional study, the medical records databases at 4 diagnostic laboratories were searched for records of submissions of uroliths obtained from ferrets. Read More

View Article and Full-Text PDF
October 2021

Pathways from child maltreatment to proactive and reactive aggression: The role of posttraumatic stress symptom clusters.

Psychol Trauma 2021 Sep 13. Epub 2021 Sep 13.

Department of Curriculum and Instruction, Jacksonville State University.

Objective: Childhood aggression is related to a myriad of negative concurrent and long-term outcomes. To mitigate the risks associated with childhood aggression, it is important to understand risk factors that might predispose 1 to aggressive behaviors. One risk factor commonly associated with aggression is the experience of child maltreatment. Read More

View Article and Full-Text PDF
September 2021

Diethylzinc-Assisted Atomic Surface Reduction to Stabilize Li and Mn-Rich NCM.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

Department of Chemistry, Bar-Ilan University, Ramat Gan 5290002, Israel.

Li and Mn-rich nickel cobalt manganese oxide (LMR-NCM) is one of the most promising cathode materials for realizing next-generation Li-ion batteries due to its high specific capacity of >250 mA h g and operating potential > 4.5 V. Nevertheless, being plagued by severe capacity fading and voltage decay, the commercialization of LMR-NCM appears to be a distant goal. Read More

View Article and Full-Text PDF
September 2021

Surgery in South Africa - the attitudes toward mentorship in facilitating general surgical training.

S Afr J Surg 2021 Sep;59(3):82-85

Department of Surgery, Inkosi Albert Luthuli Hospital, KwaZulu-Natal Department of Health, South Africa.

Background: There are many barriers to pursuing a surgical career in South Africa, some of which are unique to females. Mentorship has been proposed as a solution to mitigate these barriers. The value of mentorship has not been formally assessed among South African general surgeons and trainees. Read More

View Article and Full-Text PDF
September 2021

Nanotherapeutics for Alzheimer's Disease with Preclinical Evaluation and Clinical Trials: Challenges, Promises and Limitations.

Curr Drug Deliv 2021 Sep 10. Epub 2021 Sep 10.

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014. Saudi Arabia.

Alzheimer's disease (AD), a progressive and irreversible neurodegenerative disorder, is the most common form of dementia worldwide. Currently, there is no disease-modifying AD drug, and the development of effective treatments is made even harder by the highly selective nature of the blood-brain barrier (BBB) that allows the passage only of molecules with specific chemical-physical properties. In this context, nanomedicine and its nanoparticles (NPs) offer potential solutions to the challenge of AD therapy, in particular, the requirements for i) BBB crossing, ii) multitarget therapy iii) enhancement of pharmacokinetics; and iv) more precise delivery. Read More

View Article and Full-Text PDF
September 2021

A Randomized Controlled Trial of Goal-Focused Emotion-Regulation Therapy for Young Adult Survivors of Testicular Cancer: Effects on Salivary and Inflammatory Stress Markers.

Am J Mens Health 2021 Sep-Oct;15(5):15579883211044557

Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, New York, USA.

Despite the substantial adverse psychological impact of testicular cancer, few interventions have sought to improve psychosocial functioning and stress-related biomarkers in young adult survivors. oal-focused motion-regulation herapy (GET) is designed to improve distress symptoms, emotion regulation, and goal navigation skills, which would be expected to improve regulation of stress-sensitive biomarkers. The aim was to examine the effects of GET versus an active control intervention on salivary stress and circulating inflammatory markers in young adult survivors of testicular cancer. Read More

View Article and Full-Text PDF
September 2021

Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms.

Int J Toxicol 2021 Oct;40(5):403-412

Charles River Laboratories, Laval, Quebec, Canada.

A broad spectrum of chemical entities have been associated with drug-induced seizure (DIS), emphasizing the importance of this potential liability across various drug classes (e.g., antidepressants, antipsychotics, antibiotics, and analgesics among others). Read More

View Article and Full-Text PDF
October 2021

Addictive Behaviours among University Students in Malaysia during COVID-19 Pandemic.

Addict Behav Rep 2021 Sep 4:100375. Epub 2021 Sep 4.

Department of Psychology, Roehampton University, London.

Introduction: Preventative measures to stop the spread of the COVID-19 have affected university students in an unprecedented manner. During the pandemic, their well-being and mental health are being shaped by online learning, home confinement, and uncertainty about their future. The overall aim of this study was to examine the frequency of three addictive-like behaviors (i. Read More

View Article and Full-Text PDF
September 2021

First, Do No Harm: Understanding Primary Care Providers' Perception of Risks Associated With Discussing Weight With Pediatric Patients.

Glob Pediatr Health 2021 7;8:2333794X211040979. Epub 2021 Sep 7.

University of Minnesota Medical School, Minneapolis, MN, USA.

Many health care providers struggle with if- and how-to discuss weight with their pediatric patients. This study used one-on-one interviews with primary care providers (n = 20) to better understand their: (1) perception of risks associated with talking about weight with pediatric patients, (2) commitment to adhering to best practices of pediatric weight management, and (3) approaches to mitigate perceived risks. Providers felt concerned that discussing weight with children during clinic visits may have unintended negative impacts. Read More

View Article and Full-Text PDF
September 2021

Computational approach towards the design of artemisinin-thymoquinone hybrids against main protease of SARS-COV-2.

Futur J Pharm Sci 2021 6;7(1):185. Epub 2021 Sep 6.

Theoretical and Electrochemical Chemistry Research Group/FAFIDAM, State University of Ceará, Limoeiro do Norte, CE CEP 62930-000 Brazil.

Background: The sanitary emergency installed in the world, generated by the pandemic of COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 199 million people were reported with the infection. Of these, more than 4 million died. Read More

View Article and Full-Text PDF
September 2021

Measuring the Value of a Practical Text Mining Approach to Identify Patients With Housing Issues in the Free-Text Notes in Electronic Health Record: Findings of a Retrospective Cohort Study.

Front Public Health 2021 27;9:697501. Epub 2021 Aug 27.

Center for Population Health IT, Johns Hopkins School of Public Health, Baltimore, MD, United States.

Despite the growing efforts to standardize coding for social determinants of health (SDOH), they are infrequently captured in electronic health records (EHRs). Most SDOH variables are still captured in the unstructured fields (i.e. Read More

View Article and Full-Text PDF

Characterization of A4, an Almond-Derived Plant Growth-Promoting Endophyte.

Front Microbiol 2021 25;12:687971. Epub 2021 Aug 25.

Sierra Nevada Research Institute, University of California, Merced, Merced, CA, United States.

The rapidly increasing global population and anthropogenic climate change have created intense pressure on agricultural systems to produce increasingly more food under steadily challenging environmental conditions. Simultaneously, industrial agriculture is negatively affecting natural and agricultural ecosystems because of intensive irrigation and fertilization to fully utilize the potential of high-yielding cultivars. Growth-promoting microbes that increase stress tolerance and crop yield could be a useful tool for helping mitigate these problems. Read More

View Article and Full-Text PDF

Effectiveness of Telerehabilitation on Motor Impairments, Non-motor Symptoms and Compliance in Patients With Parkinson's Disease: A Systematic Review.

Front Neurol 2021 26;12:627999. Epub 2021 Aug 26.

Istituti Clinici Scientifici Maugeri Spa - Società Benefit, Neurologic Rehabilitation Unit of Veruno Institute, Veruno, Italy.

Parkinson's disease (PD) is a chronic neurodegenerative disease involving a progressive alteration of the motor and non-motor function. PD influences the patient's daily living and reduces participation and quality of life in all phases of the disease. Early physical exercise can mitigate the effects of symptoms but access to specialist care is difficult. Read More

View Article and Full-Text PDF

Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes.

Front Pharmacol 2021 25;12:741485. Epub 2021 Aug 25.

Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.

[This corrects the article DOI: 10.3389/fphar.2021. Read More

View Article and Full-Text PDF

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice.

Front Aging Neurosci 2021 25;13:686506. Epub 2021 Aug 25.

Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, Nanjing, China.

General anesthetics can induce cognitive impairments and increase the risk of Alzheimer's disease (AD). However, the underlying mechanisms are still unknown. Our previous studies shown that long-term isoflurane exposure induced peripheral and central insulin resistance (IR) in adult mice and aggravated IR in type 2 diabetes mellitus (T2DM) mice. Read More

View Article and Full-Text PDF

Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity.

Front Hum Neurosci 2021 26;15:708481. Epub 2021 Aug 26.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Deep brain stimulation (DBS) represents an important treatment modality for movement disorders and other circuitopathies. Despite their miniaturization and increasing sophistication, DBS systems share a common set of components of which the implantable pulse generator (IPG) is the core power supply and programmable element. Here we provide an overview of key hardware and software specifications of commercially available IPG systems such as rechargeability, MRI compatibility, electrode configuration, pulse delivery, IPG case architecture, and local field potential sensing. Read More

View Article and Full-Text PDF