2,423 results match your criteria missed opportunity


Male bias in ACE2 basic science research: Missed opportunity for discovery in the time of COVID-19.

Am J Physiol Regul Integr Comp Physiol 2021 Apr 13. Epub 2021 Apr 13.

Medicine, Georgetown University Medical Center, United States.

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting-enzyme-2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin-system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin-type-1-receptor. Read More

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Treatment usage patterns of oral appliances for obstructive sleep apnea over the first 60 days: a cluster analysis.

J Clin Sleep Med 2021 Apr 13. Epub 2021 Apr 13.

Sleep Research Group, Charles Perkins Centre & Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.

Study Objectives: Oral appliance (OA) therapy usage can be objectively measured through temperature-sensing data chips embedded in the appliance. Initial reports of group data for short-term treatment usage suggest good nightly hours of usage. However, individual variability in treatment usage patterns has not been assessed. Read More

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Osteoporosis is under recognized and undertreated in adult spinal deformity patients.

J Spine Surg 2021 Mar;7(1):1-7

Department of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Adult spinal deformity (ASD) patients may have osteoporosis, predisposing them to an increased risk for surgical complications. Prior studies have demonstrated that treating osteoporosis improves surgical outcomes. In this study we determine the prevalence of osteoporosis in ASD patients undergoing long spinal fusions and the rate at which osteoporosis is treated. Read More

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Smoking Cessation and Hospitalized Patients: A Missed Opportunity to Avoid Premature Deaths.

Ochsner J 2021 ;21(1):10-13

Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX.

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January 2021

Oscillometry of the Respiratory System. A Translational Opportunity Not to be Missed.

Am J Physiol Lung Cell Mol Physiol 2021 Apr 6. Epub 2021 Apr 6.

Research, SCIREQ Scientific Respiratory Equipment Inc, Canada.

Airway oscillometry has become the de facto standard for quality assessment of lung physiology in laboratory animals and has demonstrated its usefulness in understanding diseases of small airways. Nowadays, it is seeing extensive use in daily clinical practice and research, however, a question that remains unanswered is how well physiological findings in animals and humans correlate? Methodological and device differences are obvious between animal and human studies. However, all devices deliver an oscillated airflow test signal and output respiratory impedance. Read More

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30 years of repeat expansion disorders: What have we learned and what are the remaining challenges?

Am J Hum Genet 2021 Mar 29. Epub 2021 Mar 29.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; Centre National de la Recherche Scientifique, UMR 7104, Illkirch 67400, France; Institut National de la Santé et de la Recherche Médicale, U 1258, Illkirch 67400, France; Université de Strasbourg, Illkirch 67400, France; USIAS University of Strasbourg Institute of Advanced study, 67000 Strasbourg, France. Electronic address:

Tandem repeats represent one of the most abundant class of variations in human genomes, which are polymorphic by nature and become highly unstable in a length-dependent manner. The expansion of repeat length across generations is a well-established process that results in human disorders mainly affecting the central nervous system. At least 50 disorders associated with expansion loci have been described to date, with half recognized only in the last ten years, as prior methodological difficulties limited their identification. Read More

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Early Detection of Freezing of Gait during Walking Using Inertial Measurement Unit and Plantar Pressure Distribution Data.

Sensors (Basel) 2021 Mar 23;21(6). Epub 2021 Mar 23.

Department of Systems Design Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

Freezing of gait (FOG) is a sudden and highly disruptive gait dysfunction that appears in mid to late-stage Parkinson's disease (PD) and can lead to falling and injury. A system that predicts freezing before it occurs or detects freezing immediately after onset would generate an opportunity for FOG prevention or mitigation and thus enhance safe mobility and quality of life. This research used accelerometer, gyroscope, and plantar pressure sensors to extract 861 features from walking data collected from 11 people with FOG. Read More

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Assessing the Need for Multiplex and Multifunctional Tick-Borne Disease Test in Routine Clinical Laboratory Samples from Lyme Disease and Febrile Patients with a History of a Tick Bite.

Trop Med Infect Dis 2021 Mar 17;6(1). Epub 2021 Mar 17.

Tezted Ltd., Mattilaniemi 6-8, 40100 Jyväskylä, Finland.

Human polymicrobial infections in tick-borne disease (TBD) patients is an emerging public health theme. However, the requirement for holistic TBD tests in routine clinical laboratories is ambiguous. TICKPLEX PLUS is a holistic TBD test utilized herein to assess the need for multiplex and multifunctional diagnostic tools in a routine clinical laboratory. Read More

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Deconstructing Racialized Experiences in Healthcare: What a Missed Opportunity for Healing Looks Like and Healthcare Resources for Children and Their Families.

Asian Pac Isl Nurs J 2021 ;5(4):227-235

Washington State University College of Nursing in Vancouver, Washington, United States.

Some patients and families of color, including Asian Americans, face significant adverse stressors due to living within a White-dominant society. Xenophobia and racism can impact health. Research evidence points to early exposure to adverse childhood experiences such as racial discrimination as being detrimental and having significant short-term and long-term impact on physical and mental health. Read More

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January 2021

Racially equitable diagnosis of cystic fibrosis using next-generation DNA sequencing: a case report.

BMC Pediatr 2021 Mar 31;21(1):154. Epub 2021 Mar 31.

Cloudnine Hospitals, 1533, 3rd Block, Jayanagar, Bengaluru, Karnataka, India.

Background: Cystic Fibrosis (CF) is one of the most prevalent autosomal recessive inherited disease in Caucasians. Rates of CF were thought to be negligible in non-Caucasians but growing epidemiological evidence shows CF is more common in Indian, African, Hispanic, Asian, and other ethnic groups than previously thought. Almost all second-tier molecular diagnostic tools currently used to confirm the diagnosis of CF consist of panels of the most common CF-causing DNA variants in Caucasians. Read More

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Low rates of thiamine prescribing in adult patients with alcohol-related diagnoses in the emergency department.

Am J Drug Alcohol Abuse 2021 Mar 29:1-7. Epub 2021 Mar 29.

Department of Emergency Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Alcohol use disorder (AUD) is associated with thiamine deficiency and Wernicke-Korsakoff Syndrome (WKS). Thiamine supplementation for the prevention of WKS in patients with suspected AUD in the Emergency Department (ED) is generally recommended. As alcohol-related diagnoses are frequent reasons for visits to EDs, ED thiamine prescribing practices are relevant to the overall management and prevention of WKS in patients with AUD. Read More

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Pooled saliva CMV DNA detection: A viable laboratory technique for universal CMV screening of healthy newborns.

J Clin Virol 2021 Mar 17;138:104798. Epub 2021 Mar 17.

Bnai Zion Medical Center, Haifa, Israel.

Background: Most infants with congenital cytomegalovirus (cCMV) have no overt manifestations at birth, yet may later develop CMV-related sensorineural hearing loss (SNHL). With targeted screening, many asymptomatic neonates are missed and lose the opportunity for timely anti-viral treatment to ameliorate SNHL. Saliva is the preferred screening specimen given its ease of collection. Read More

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Insight into the current practice of ototoxicity monitoring during cisplatin therapy.

J Otolaryngol Head Neck Surg 2021 Mar 25;50(1):19. Epub 2021 Mar 25.

University of California Davis Department of Otolaryngology-Head and Neck Surgery, 2521 Stockton Blvd., Sacramento, CA, 95817, USA.

Background: The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity guidelines.

Methods: Case series including retrospective medical records review of patients (age > 18) treated with cisplatin at University of California Davis Medical Center between January 2014 and August 2017. Patient and ototoxicity related variables were analyzed. Read More

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Managing Back to School Anxiety During a COVID-19 Outbreak.

J Nerv Ment Dis 2021 04;209(4):244-245

Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

Abstract: The outbreak of the coronavirus is becoming an international crisis these days, overshadowing everything. The outbreak of this disease in different countries, including Iran, has caused a lot of concern. In addition to the dangers it poses to human health, the spread of the virus has become a major challenge and a stressful test, putting additional pressure on these countries. Read More

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Central line placement at ECMO decannulation: A missed opportunity.

J Pediatr Surg 2021 Feb 25. Epub 2021 Feb 25.

Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Introduction: ECMO is a support modality for refractory critical illness. This study reviews the incidence and utility of central venous line (CVL) placement at pediatric ECMO decannulation.

Methods: A single-institution retrospective study of patients undergoing open neck decannulation from 2015 to 2019. Read More

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February 2021

Missed Opportunity for Fall Prevention: A Teachable Moment.

JAMA Intern Med 2021 Mar 22. Epub 2021 Mar 22.

Division of Hospital Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora.

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Unmet Need for Equipment to Help With Bathing and Toileting Among Older US Adults.

JAMA Intern Med 2021 Mar 22. Epub 2021 Mar 22.

Division of Geriatrics, Department of Medicine, University of California, San Francisco.

Importance: Home modification through seemingly mundane equipment, such as grab bars and shower seats, mitigates injury, dependence, and reduced quality of life in older adults coping with increasing disability. However, whether these interventions are underused in the US is unclear.

Objective: To estimate how many older adults who need equipment to help with bathing and toileting do not have it, describe factors associated with not having equipment, and describe how many who did not initially have equipment acquired equipment over time. Read More

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Underreporting of Hepatic Steatosis in Children: A Missed Opportunity for Early Detection.

J Pediatr 2021 Mar 18. Epub 2021 Mar 18.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine. Electronic address:

Objective: To determine the prevalence of underreporting of hepatic steatosis found incidentally on computer tomography (CT).

Study Design: Retrospective cross-sectional study including patients <18 years of age who had undergone unenhanced abdominal CT for evaluation of nephrolithiasis. Hepatic and splenic attenuation were independently measured by two reviewers. Read More

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Preoperative misdiagnosis of pancreatic and periampullary cancer in patients undergoing pancreatoduodenectomy: A multicentre retrospective cohort study.

Eur J Surg Oncol 2021 Mar 15. Epub 2021 Mar 15.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

Introduction: Whereas neoadjuvant chemo(radio)therapy is increasingly used in pancreatic cancer, it is currently not recommended for other periampullary (non-pancreatic) cancers. This has important implications for the relevance of the preoperative diagnosis for pancreatoduodenectomy. This retrospective multicentre cohort study aimed to determine the frequency of clinically relevant misdiagnoses in patients undergoing pancreatoduodenectomy for pancreatic or other periampullary cancer. Read More

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Single injection serratus anterior plane blocks for traumatic rib fractures. A good start but a missed opportunity.

Am J Emerg Med 2021 Mar 14. Epub 2021 Mar 14.

Sunshine Coast University Hospital, Queensland, Australia.

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Telerheumatology: before, during, and after a global pandemic.

Curr Opin Rheumatol 2021 05;33(3):262-269

Center to Improve Veteran Involvement in Care, VA Portland Health Care System.

Purpose Of Review: In early 2020, the COVID-19 global pandemic shifted most healthcare to remote delivery methods to protect patients, clinicians, and hospital staff. Such remote care delivery methods include the use of telehealth technologies including clinical video telehealth or telephone visits. Prior to this, research on the acceptability, feasibility, and efficacy of telehealth applied to rheumatology, or telerheumatology, has been limited. Read More

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Understanding physician behaviour in the 6-8 weeks hip check in primary care: a qualitative study using the COM-B.

BMJ Open 2021 Mar 19;11(3):e044114. Epub 2021 Mar 19.

Institute of Child Health, University College London, London, UK

Objectives: A compulsory hip check is performed on an infant at 6-8 weeks in primary care for the detection of developmental dysplasia of the hip (DDH). Missed diagnoses and infants incorrectly labelled with DDH remain an important problem. The nature of physician behaviour as a likely source of this problem has not been explored. Read More

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Too little, too late: Palliation and end-stage liver disease.

J Gastroenterol Hepatol 2021 Mar 19. Epub 2021 Mar 19.

Mater Adult Hospital, Brisbane, Queensland, Australia.

Background And Aim: End-stage liver disease is a leading cause of mortality. Fewer than 60% of patients with decompensated cirrhosis survive after 2 years, with patients often experiencing distressing symptoms impairing quality of life. Early advanced care planning and timely palliative care referral can improve quality of life and the end of life experience. Read More

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The long-term cardiovascular impact of hypertension in pregnancy - A missed opportunity.

Aust N Z J Obstet Gynaecol 2021 Mar 18. Epub 2021 Mar 18.

Department of Renal Medicine, St George Hospital, Sydney, New South Wales, Australia.

Women who have had hypertension in pregnancy, both pre-eclampsia and gestational hypertension, have a two- to three-fold increased risk of cardiovascular disease later in life. It is unclear whether this is an unmasking of latent risk, the result of damage to the vascular tree during pregnancy, or both. Irrespective of the underlying pathophysiology, these women are uniquely identified sufficiently early in their lives for lifestyle interventions, if adopted, to improve their long-term health. Read More

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A standardized protocol improves testing rates for Helicobacter Pylori among inpatients with peptic ulcer disease.

Helicobacter 2021 Mar 15:e12800. Epub 2021 Mar 15.

Division of Gastroenterology and Hepatology, University of Vermont Medical Center, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

Background: Despite a strong link between Helicobacter Pylori infection and peptic ulcer disease (PUD), rates of testing for H. Pylori in hospitalized patients with PUD remain largely unexplored. We aimed to determine H. Read More

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Imaging modalities to inform the detection and diagnosis of early caries.

Cochrane Database Syst Rev 2021 03 15;3:CD014545. Epub 2021 Mar 15.

Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Background: The detection and diagnosis of caries at the earliest opportunity is fundamental to the preservation of tooth tissue and maintenance of oral health. Radiographs have traditionally been used to supplement the conventional visual-tactile clinical examination. Accurate, timely detection and diagnosis of early signs of disease could afford patients the opportunity of less invasive treatment with less destruction of tooth tissue, reduce the need for treatment with aerosol-generating procedures, and potentially result in a reduced cost of care to the patient and to healthcare services. Read More

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Paediatric tuberculosis - new advances to close persistent gaps.

Int J Infect Dis 2021 Mar 11. Epub 2021 Mar 11.

The Indus Hospital, Karachi, Pakistan.

Young children are most vulnerable to develop severe forms of tuberculosis (TB) and are over-represented among TB deaths. Almost all children estimated to have died from TB were never diagnosed or offered TB treatment. Improved access to TB preventive treatment (TPT) requires major upscaling of household contact investigation with allocation of adequate resources. Read More

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