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Systematic review of missed nursing care or nursing care left undone.

Enferm Clin 2021 Apr;31 Suppl 2:S301-S306

Faculty of Nursing Universitas Indonesia, Depok, West Java, Indonesia. Electronic address:

Comprehensive nursing cares are important to provide total healthcare for the patient. However, there are miss nursing cares that nurses left to be done. This research is aim to discover the varieties of missed nursing care and to understand their possible impacts on nurses and patients. Read More

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Reporting Quality of Cost-Effectiveness Analyses Conducted in Saudi Arabia: A Systematic Review.

Value Health Reg Issues 2021 Apr 10;25:99-103. Epub 2021 Apr 10.

Clinical Pharmacy Department, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.

Objectives: Pharmacoeconomics and health economics in general is a new field that is still developing and emerging, not only in Saudi Arabia but all over the world. The objective of this study is to collect all published cost-effectiveness analysis (CEA) studies conducted based on Saudi settings and to evaluate their reporting quality.

Methods: We used PRISMA guidelines to search for all English-language CEAs conducted in Saudi Arabia in 3 databases: Medline, Embase, and Scopus. Read More

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Male bias in ACE2 basic science research: Missed opportunity for discovery in the time of COVID-19.

Am J Physiol Regul Integr Comp Physiol 2021 Apr 13. Epub 2021 Apr 13.

Medicine, Georgetown University Medical Center, United States.

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting-enzyme-2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin-system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin-type-1-receptor. Read More

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A survey demonstrating that the procedural experience of residents in internal medicine, critical care and emergency medicine is poor: training in ultrasound is required to rectify this.

Ultrasound J 2021 Apr 13;13(1):20. Epub 2021 Apr 13.

Department of Cardiac Sciences, King Abdulaziz Medical City, King Abdulaziz International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.

Background: Training in procedural skills is often suboptimal. The aim of this study was to quantify the needs of residents in internal medicine (IM), critical care (CC), and emergency medicine (EM) for instruction in ultrasound-guided procedures.

Methods: All IM, EM and CC residents (n = 200) at King Abdulaziz Medical City, Riyadh, Saudi Arabia, were invited to participate in a questionnaire-based survey to identify skill and experience gaps. Read More

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Treatment usage patterns of oral appliances for obstructive sleep apnea over the first 60 days: a cluster analysis.

J Clin Sleep Med 2021 Apr 13. Epub 2021 Apr 13.

Sleep Research Group, Charles Perkins Centre & Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.

Study Objectives: Oral appliance (OA) therapy usage can be objectively measured through temperature-sensing data chips embedded in the appliance. Initial reports of group data for short-term treatment usage suggest good nightly hours of usage. However, individual variability in treatment usage patterns has not been assessed. Read More

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Malaria infection is common and associated with perinatal mortality and preterm delivery despite widespread use of chemoprevention in Mali: an observational study 2010 to 2014.

Clin Infect Dis 2021 Apr 13. Epub 2021 Apr 13.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.

Background: In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed during pregnancy, since many women with placental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association between malaria and pregnancy outcomes Severe maternal anemia and low birthweight deliveries are well-established sequelae, but few studies have confirmed the relationship between malaria infection and severe outcomes like perinatal mortality in high transmission zones.

Methods: Pregnant women of any gestational age enrolled at antenatal clinic into a longitudinal cohort study in Ouelessebougou, Mali, an area of high seasonal malaria transmission. Read More

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Use of community-based reference ranges to estimate the prevalence of polycystic ovary syndrome by the recognised diagnostic criteria, a cross-sectional study.

Hum Reprod 2021 Apr 8. Epub 2021 Apr 8.

Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Study Question: Does the application of reference ranges for sex steroids and the modified Ferriman-Gallwey (mFG) scale established in the community from which the study sample was drawn, combined with the most conservative polycystic ovary morphology (PCOM) criteria to the recognised diagnostic criteria for polycystic ovary syndrome (PCOS) improve the certainty of diagnosis of PCOS in non-healthcare-seeking women?

Summary Answer: Despite application of the stringent definitions of the elements used to diagnose PCOS in a non-healthcare seeking community-based sample, the risk of diagnostic uncertainty remains.

What Is Known Already: There is heterogeneity in prevalence estimates for PCOS due, in part, to lack of standardisation of the elements comprising the recognised National Institutes of Health (NIH), Rotterdam and Androgen Excess Society (AE-PCOS) diagnostic criteria. The AE-PCOS Society proposed refinements to the definitions of biochemical androgen excess and PCOM that can now be incorporated into these sets of diagnostic criteria to estimate PCOS prevalence. Read More

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Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology.

Nat Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.

Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity and reproducibility of ctDNA assays is poorly understood. Here we report the findings of a multi-site, cross-platform evaluation of the analytical performance of five industry-leading ctDNA assays. We evaluated each stage of the ctDNA sequencing workflow with simulations, synthetic DNA spike-in experiments and proficiency testing on standardized, cell-line-derived reference samples. Read More

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Impact of image compression on deep learning-based mammogram classification.

Sci Rep 2021 Apr 12;11(1):7924. Epub 2021 Apr 12.

Healthcare AI Team, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.

Image compression is used in several clinical organizations to help address the overhead associated with medical imaging. These methods reduce file size by using a compact representation of the original image. This study aimed to analyze the impact of image compression on the performance of deep learning-based models in classifying mammograms as "malignant"-cases that lead to a cancer diagnosis and treatment-or "normal" and "benign," non-malignant cases that do not require immediate medical intervention. Read More

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Golimumab improves work productivity in patients suffering from moderate to severe ulcerative colitis: results of a prospective study over 24 months.

BMC Gastroenterol 2021 Apr 12;21(1):161. Epub 2021 Apr 12.

Medical Affairs, MSD Sharp & Dohme GmbH, Lindenplatz 1, 85540, Haar, Germany.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with recurrent episodes of debilitating symptoms negatively affecting work productivity and health-related quality of life (HRQoL). The use of biologics in UC treatment improves work and HRQoL but prospective long-term data concerning the treatment with TNFα inhibitor golimumab in UC patients are still rare. Therefore, our study aimed to evaluate the change in work productivity, capacity for daily activities and HRQoL in UC patients treated with golimumab in Germany. Read More

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Prediction model that combines with multidisciplinary analysis for clinical evaluation of malignancy risk of solid breast nodules.

J Int Med Res 2021 Apr;49(4):3000605211004681

Department of ultrasonography, Zhejiang Provincial People's Hospital & People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Objective: Few studies have systematically developed predictive models for clinical evaluation of the malignancy risk of solid breast nodules. We performed a retrospective review of female patients who underwent breast surgery or puncture, aiming to establish a predictive model for evaluating the clinical malignancy risk of solid breast nodules.

Method: Multivariable logistic regression was used to identify independent variables and establish a predictive model based on a model group (207 nodules). Read More

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