484 results match your criteria misinterpretation primary

Challenge of food allergy testing and avoidance in children with atopic dermatitis.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Atopic dermatitis (AD) is a common presenting complaint by children and their caretakers to their primary care providers. On testing, children with AD frequently exhibit positive food-specific IgE levels in the absence of immediate allergic reactions. Misinterpretation of these false positive tests can lead to unnecessary food avoidance, which can have tremendous psychosocial, economic and nutritional consequences and, in some cases, facilitate the development of an immediate hypersensitivity to the food. Read More

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Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial.

J Immunother Cancer 2021 Jun;9(6)

Johns Hopkins Bloomberg-Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.

Background: Head and neck squamous cell carcinomas (HNSCCs) are common malignancies caused by carcinogens, including tobacco and alcohol, or infection with human papillomavirus (HPV). Immune checkpoint inhibitors targeting the programmed cell death 1 (PD-1) pathway are effective against unresectable recurrent/metastatic HNSCC. Here, we explored the safety and efficacy of anti-PD-1 therapy in at-risk resectable HPV-positive and HPV-negative HNSCC in the neoadjuvant setting. Read More

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Oncologic Errors in Diagnostic Radiology: A 10-Year Analysis Based on Medical Malpractice Claims.

J Am Coll Radiol 2021 May 28. Epub 2021 May 28.

Chair of the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: To retrospectively analyze the nature and extent of oncology-related errors accounting for malpractice allegations in diagnostic radiology.

Methods: The Comparative Benchmarking System of the Controlled Risk Insurance Company, a database containing roughly 30% of medical malpractice claims in the United States, was searched retrospectively for the period 2008 to 2017. Claims naming radiology as a primary service were identified and were stratified and compared by oncologic versus nononcologic status, allegation type (diagnostic versus nondiagnostic), and imaging modality. Read More

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Data sharing-trialists' plans at registration, attitudes, barriers and facilitators: A cohort study and cross-sectional survey.

Res Synth Methods 2021 May 31. Epub 2021 May 31.

NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.

Data unavailability impedes research transparency and is a major problem for individual participant data (IPD) meta-analyses as it reduces statistical power, increases risk of bias, and may even preclude completion. The primary objectives of this study were to determine IPD sharing plans reported in recently registered clinical trial registration records, how data sharing commitment relates to clinical trial characteristics, and principal investigators' attitudes, motivations and barriers to data sharing. The secondary objective was to derive recommendations to overcome identified barriers to data sharing. Read More

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var. Enteritidis osteomyelitis with pulmonary involvement in an immunocompetent young woman.

IDCases 2021 18;24:e01127. Epub 2021 Apr 18.

Department of Infectious Diseases, Japanese Red Cross Ise Hospital, Ise, 516-8512, Japan.

Primary bacteremia due to non-typhoid often occurs in immunocompromised individuals, but may also occur in immunocompetent individuals. Contrastingly, vertebral osteomyelitis with respiratory involvement caused by non-typhoid in immunocompetent individuals is extremely rare. A 21-year-old healthy woman with histories of eating ready-to-eat roasted beef and a recent vertebral compression fracture developed high-grade fever and was diagnosed with bacteremia, complicated by vertebral osteomyelitis with pulmonary involvement characterized as an extra-intestinal infection. Read More

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Realities and challenges of breastfeeding policy in the context of HIV: a qualitative study on community perspectives on facilitators and barriers related to breastfeeding among HIV positive mothers in Baringo County, Kenya.

Int Breastfeed J 2021 May 8;16(1):39. Epub 2021 May 8.

Maternal and Child Wellbeing Unit, African Population and Health Research Center, Nairobi, Kenya.

Background: Although recent policies have sought to increase the rates of exclusive breastfeeding (EBF) and continued breastfeeding for HIV exposed infants, few programs have considered the multiple social and cultural barriers to the practice. Therefore, to generate evidence for exclusive and continued breastfeeding policies in Kenya, we examined community perspectives on the facilitators and barriers in adherence to EBF for the HIV positive mothers.

Methods: Qualitative research was conducted in Koibatek, a sub-County in Baringo County Kenya, in August 2014 among 205 respondents. Read More

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Musculoskeletal Soft-Tissue Sarcoma: Quality Assessment of Initial MRI Reports Shows Frequent Deviation from ESSR Guidelines.

Diagnostics (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Soft-tissue sarcomas (STS) are a rare subtype of soft-tissue mass and are frequently misinterpreted as benign lesions. Magnetic resonance imaging (MRI) is the primary recommended type of diagnostics. To assess the quality of primary radiology reports, we investigated whether recommended MRI report elements were included in compliance with European Society of Musculoskeletal Radiology (ESSR) guidelines. Read More

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Impact of the COVID-19 Outbreak on Emergency Care Utilization in Patients with Acute Myocardial Infarction: a Nationwide Population-based Study.

J Korean Med Sci 2021 Apr 26;36(16):e111. Epub 2021 Apr 26.

Department of Emergency Medicine, Inha University College of Medicine, Incheon, Korea.

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted various aspects of daily living and has influenced the life of every individual in a unique way. Acute myocardial infarction (AMI) is associated with high morbidity and mortality; thus, timely treatment is crucial to prevent poor prognosis. Therefore, an immediate emergency department (ED) visit is required; however, no domestic studies have reported the effect of COVID-19 on ED visits by patients with AMI. Read More

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Evaluation of spin in the abstracts of systematic reviews and meta-analyses focused on treatments of alcohol use disorder.

Am J Drug Alcohol Abuse 2021 Apr 26:1-10. Epub 2021 Apr 26.

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

: With 14.4 million U.S. Read More

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Cervical Cancer Screening in Postmenopausal Women: Is It Time to Move Toward Primary High-Risk Human Papillomavirus Screening?

J Womens Health (Larchmt) 2021 Apr 7. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology and Oregon Health and Science University, Portland, Oregon, USA.

Cervical cytology in postmenopausal women is challenging due to physiologic changes of the hypoestrogenic state. Misinterpretation of an atrophic smear as atypical squamous cells of uncertain significance (ASCUS) is one of the most common errors. We hypothesize that high-risk human papillomavirus (hrHPV) testing may be more accurate with fewer false positive results than co-testing of hrHPV and cervical cytology for predicting clinically significant cervical dysplasia in postmenopausal women. Read More

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A grey zone of hyperamylasemia following endoscopic retrograde cholangiopancreatography: follow-up and differential diagnosis from acute pancreatitis.

Wideochir Inne Tech Maloinwazyjne 2021 Mar 18;16(1):38-44. Epub 2020 Apr 18.

Department of General Surgery, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a tool often used for treating and diagnosing pancreaticobiliary diseases. One of the important complications of ERCP is pancreatitis. Even though transient hyperamylasemia is a more common and benign situation, it must be distinguished from post-ERCP pancreatitis. Read More

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Motivation to Participate in Precision Health Research and Acceptability of Texting as a Recruitment and Intervention Strategy Among Vietnamese Americans: Qualitative Study.

JMIR Mhealth Uhealth 2021 03 11;9(3):e23058. Epub 2021 Mar 11.

College of Health and Human Services, George Mason University, Fairfax, VA, United States.

Background: The largest effort undertaken in precision health research is the Precision Medicine Initiative (PMI), also known as the All of Us Research Program, which aims to include 1 million or more participants to be a part of a diverse database that can help revolutionize precision health research studies. Research participation from Asian Americans and Pacific Islanders in precision health research is, however, limited; this includes Vietnamese Americans, especially those with limited English proficiency. PMI engagement efforts with underserved communities, including members of minority populations or individuals who have experienced health disparities such as Vietnamese Americans with limited English proficiency, may help to enrich the diversity of the PMI. Read More

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Considerations in evaluating the thyroid gland in a primary care setting.

Jose Humphreys

J Family Med Prim Care 2020 Dec 31;9(12):5833-5836. Epub 2020 Dec 31.

Department of Clinical Research, Jubilee Regional Medical Center Inc., St. John's, Antigua, USA.

The evaluation of the thyroid can be a very involved process. A misinterpretation of the results of a thyroid function test can lead to serious complexities in a patient's management and outcome. The nuances in diagnostic approaches necessitates that standardized protocols for assessing thyroid function are established. Read More

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December 2020

Pre-hospital Delay and Its Reasons in Patients With Acute Myocardial Infarction Presenting to a Primary Percutaneous Coronary Intervention-Capable Center.

Cureus 2021 Jan 28;13(1):e12964. Epub 2021 Jan 28.

Statistics, National Institute of Cardiovascular Diseases, Karachi, PAK.

Objective This study aimed to assess the duration of pre-hospital delay among ST-Segment Elevation Myocardial Infarction (STEMI) patients and its contributing factors. Methodology A cross-sectional study was conducted at Rural Satellite Center in Larkana, Pakistan from May to September 2020. A total of 240 STEMI patients who underwent primary percutaneous coronary intervention (P-PCI) were included. Read More

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January 2021

Are seminal vesicles a potential pitfall during pelvic exploration using point-of-care ultrasound (POCUS)?

Ultrasound J 2021 Mar 1;13(1):14. Epub 2021 Mar 1.

Department of Emergency Medicine, Cliniques Universitaires Saint Luc, 1200, Brussels, Belgium.

Background: Trauma is a major cause of death among the working population. Many countries have now adopted a structured approach to trauma management in which ultrasound is used as a primary evaluation tool. While its use has direct therapeutic benefits, many artifacts and pitfalls are inherent to the technique. Read More

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Effect of bovine viral diarrhea virus on subsequent infectivity of bovine gammaherpesvirus 4 in endometrial cells in primary culture: An in vitro model of viral co-infection.

J Virol Methods 2021 05 15;291:114097. Epub 2021 Feb 15.

Instituto Nacional de Tecnología Agropecuaria (INTA), Grupo de Sanidad Animal. Instituto de Innovación para la Producción Agropecuaria y Desarrollo Sostenible (IPADS, CONICET-INTA). Ruta 226 km 73.5, Balcarce, 7620, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rivadavia 1917, C1033AAJ, Buenos Aires, Argentina. Electronic address:

Bovine viral diarrhea virus (BVDV) and bovine gammaherpesvirus 4 (BoHV-4) infect the uterus of cattle, being responsible for huge economic losses. Most of the pathogenesis of BoHV-4 in the bovine reproductive tract has been elucidated by conducting tests on primary cultures. Thus, it is important to have optimal in vitro conditions, avoiding the presence of other pathogens that can alter the results. Read More

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Patients' reflections on prehospital symptom recognition and timely treatment of myocardial infarction.

Eur J Cardiovasc Nurs 2021 Jan 17. Epub 2021 Jan 17.

Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, NO-5021 Bergen, Norway.

Aims: Early treatment is crucial to successful therapy in patients with acute myocardial infarction (MI). Prehospital delay is associated with increased morbidity and mortality. There is little empirical evidence of patients' reflections on prehospital symptoms of MI and timely treatment at the time of discharge from hospital. Read More

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January 2021

The promise of direct-to-consumer COVID-19 testing: ethical and regulatory issues.

J Law Biosci 2020 Jan-Jun;7(1):lsaa069. Epub 2020 Sep 23.

Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Widespread diagnostic and serological (antibody) testing is one key to mitigating the COVID-19 pandemic. While at first, the majority of COVID-19 diagnostic testing in the USA took place in healthcare settings, quickly a direct-to-consumer (DTC) testing market also emerged. In these DTC provision models, the test is initiated by a consumer and the sample collection occurs at home or in a commercial laboratory. Read More

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September 2020

Enhancing Language Access: A Pilot Study to Examine the Importance of Understanding the Language Preference and Acculturalization Level in the Provision of Healthcare for Hispanics Veterans With Traumatic Brain Injury.

Mil Med 2021 01;186(Suppl 1):572-578

ACOS/Research and Development Service, Nuclear Medicine & Molecular Imaging Service, Physical Medicine & Rehabilitation Service, Audiology and Speech Pathology Service, and Psychiatry Service, VA Caribbean Healthcare System, San Juan, PR 00921, USA.

Introduction: The purpose of this pilot study was to obtain preliminary data to culturally adapt the Veteran Health Administration Traumatic Brain Injury (TBI) assessment instruments for the Hispanic Veteran population. A qualitative analysis explored the cognitive processes used by Hispanic Veterans whose preferred language was Spanish to understand a specific set of screening questions within the Initial TBI Screening, the Comprehensive TBI Evaluation, the Neurobehavioral Symptom Inventory (NSI), and the La Trobe Communication Questionnaire (LTCQ).

Materials And Methods: A certified translator completed translation of the TBI instruments, an expert panel resolved inadequate expressions of the translations, and translated instruments were back translated. Read More

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January 2021

The effect of medication on the aldosterone-to-renin ratio. A critical review of the literature.

J Clin Hypertens (Greenwich) 2021 Feb 18;23(2):208-214. Epub 2021 Jan 18.

Department of Internal Medicine, Maastricht University Medical Center+ & Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.

The aldosterone-to-renin ratio (ARR) is a common screening test for primary aldosteronism in hypertensives. However, patients often use medications that could confound the ARR and, thereby, reduce the interpretability of the test. Since it is not always feasible to stop such medication, several drugs that are supposedly neutral with respect to the ARR have been recommended as alternative treatment. Read More

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February 2021

Trabodenoson on trabecular meshwork rejuvenation: a comprehensive review of clinical data.

Expert Opin Investig Drugs 2021 Mar 21;30(3):227-236. Epub 2021 Jan 21.

Principal/Chief Strategic Development, Ophthalmic Therapeutic Innovation, Peabody, MA, USA.

Introduction: Trabodenoson is an adenosine mimetic acting selectively at the A1 receptor (A1R) subtype, involved in multiple signaling pathways including matrix metalloproteinase (MMP-2) associated with glaucoma pathological processes. It has been developed as a Phase 3 candidate for the treatment of patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH).

Area Covered: This review summarizes the molecular traits of Trabodenoson in intraocular pressure (IOP) regulations and provides a scientific interpretation of the Phase 2 clinical study results. Read More

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Confounders of the aldosterone-to-renin ratio when used as a screening test in hypertensive patients: A critical analysis of the literature.

J Clin Hypertens (Greenwich) 2021 Feb 27;23(2):201-207. Epub 2020 Dec 27.

Department of Internal Medicine, Maastricht University Medical Center & Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.

The aldosterone-to-renin ratio (ARR) is a common screening test for primary aldosteronism in hypertensives. However, there are many factors which could confound the ARR test result and reduce the accuracy of this test. The present review's objective is to identify these factors and to describe to what extent they affect the ARR. Read More

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February 2021

Driver versus navigator causation in biology: the case of insulin and fasting glucose.

PeerJ 2020 11;8:e10396. Epub 2020 Dec 11.

Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India.

Background: In biomedicine, inferring causal relation from experimental intervention or perturbation is believed to be a more reliable approach than inferring causation from cross-sectional correlation. However, we point out here that even in interventional inference there are logical traps. In homeostatic systems, causality in a steady state can be qualitatively different from that in a perturbed state. Read More

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December 2020

The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.

J Neurosci 2021 02 11;41(6):1157-1173. Epub 2020 Dec 11.

Institute for Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, 37073, Germany

The activity and the metabolism of the brain change rhythmically during the day/night cycle. Such rhythmicity is also observed in cultured neurons from the suprachiasmatic nucleus, which is a critical center in rhythm maintenance. However, this issue has not been extensively studied in cultures from areas less involved in timekeeping, as the hippocampus. Read More

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February 2021

Conventional immunomarkers stain a fraction of astrocytes in vitro: A comparison of rat cortical and spinal cord astrocytes in naïve and stimulated cultures.

J Neurosci Res 2021 03 8;99(3):806-826. Epub 2020 Dec 8.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.

Astrocytes are responsible for a wide variety of essential functions throughout the central nervous system. The protein markers glial fibrillary acidic protein (GFAP), glutamate aspartate transporter (GLAST), glutamate transporter-1 (GLT-1), glutamine synthetase (GS), 10-formyltetrahydrofolate dehydrogenase (ALDH1L1), and the transcription factor SOX9 are routinely used to label astrocytes in primary rodent cultures. However, GLAST, GLT-1, GS, and SOX9 are also produced by microglia and oligodendrocytes and GFAP, GLAST, GLT-1, and GS production levels are affected by astrocyte phenotypic changes associated with reactive astrogliosis. Read More

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Lung radiofrequency ablation: post-procedure imaging patterns and late follow-up.

Eur J Radiol Open 2020 11;7:100276. Epub 2020 Nov 11.

Radiology Department, Hospital Sírio-Libanês, Adma Jafet 91, São Paulo, SP, 01308-050, Brazil.

Purpose: To describe expected imaging features on chest computed tomography (CT) after percutaneous radiofrequency ablation (RFA) of lung tumors, and their frequency over time after the procedure.

Methods: In this double-center retrospective study, we reviewed CT scans from patients who underwent RFA for primary or secondary lung tumors. Patients with partial ablation or tumor recurrence during the imaging follow-up were not included. Read More

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November 2020

Empiricism in non-communicable disease mortality measurement for the Asia-Pacific: lost in translation.

BMJ Glob Health 2020 11;5(11)

Department of Global Health, Research School of Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.

Control of non-communicable diseases (NCDs) is a key target for the United Nations Sustainable Development Goals (SDGs) for 2030. Available information indicates that countries in the Asia-Pacific Region accounted for 63% of the global NCD mortality burden in 2016. The United Nations Economic and Social Commission for the Asia Pacific (UNESCAP) Regional SDG progress report for 2020 included estimates of trends in NCD mortality rates from 2000 to 2016, which showed considerable variation in national NCD mortality by sex and location. Read More

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November 2020

Investigating the impact of a β-lactam allergy label on preoperative antibiotic prophylaxis administration.

Infect Control Hosp Epidemiol 2021 Jun 17;42(6):710-714. Epub 2020 Nov 17.

Department of Medicine, Section of Infectious Diseases and Global Health, University of Chicago Medicine, Chicago, Illinois.

Objective: Surgical site infection (SSI) is a common postprocedure complication that may be prevented by adhering to established recommendations, including administration of preoperative antibiotic prophylaxis. Patients with a β-lactam allergy (BLA) label have an increased risk of SSI. We sought to evaluate the appropriateness of preoperative antibiotic prophylaxis in patients labeled with a BLA compared those without a BLA. Read More

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Artificial Intelligence for Intraoperative Guidance: Using Semantic Segmentation to Identify Surgical Anatomy During Laparoscopic Cholecystectomy.

Ann Surg 2020 Nov 13. Epub 2020 Nov 13.

Department of Surgery, University of California - San Francisco, San Francisco, CA, USA.

Objective: To develop and evaluate the performance of artificial intelligence (AI) models that can identify safe and dangerous zones of dissection, and anatomical landmarks during laparoscopic cholecystectomy (LC).

Summary Background Data: Many adverse events during surgery occur due to errors in visual perception and judgment leading to misinterpretation of anatomy. Deep learning, a subfield of AI, can potentially be used to provide real-time guidance intraoperatively. Read More

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November 2020

Primary care and mental health providers' perceptions of implementation of pharmacogenetics testing for depression prescribing.

BMC Psychiatry 2020 10 28;20(1):518. Epub 2020 Oct 28.

VISN 4 Mental Illness, Research, Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.

Background: Pharmacogenetic testing (PGx) has the potential to improve the quality of psychiatric prescribing by considering patients' genetic profile. However, there is limited scientific evidence supporting its efficacy or guiding its implementation. The Precision Medicine in Mental Health (PRIME) Care study is a pragmatic randomized controlled trial evaluating the effectiveness of a specific commercially-available pharmacogenetic (PGx) test to inform antidepressant prescribing at 22 sites across the U. Read More

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October 2020