1,812 results match your criteria misclassification rate

A predictive model for identifying low medication adherence among older adults with hypertension: A classification and regression tree model.

Geriatr Nurs 2021 Sep 21;42(6):1309-1315. Epub 2021 Sep 21.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Department of Nursing, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:

Various individual characteristics may affect medication adherence; however, few studies have investigated the effect of interrelationships among these various individual characteristics on medication adherence. This cross-sectional study explored the interrelationships among risk factors for medication adherence and established a predictive model of low medication adherence among older adults with hypertension. Convenience sampling was used to recruit 300 older adults with hypertension. Read More

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September 2021

Race, Genetic Ancestry, and Estimating Kidney Function in CKD.

N Engl J Med 2021 Sep 23. Epub 2021 Sep 23.

From the Division of Nephrology, Department of Medicine (C.H., A.N.M., A.S.G.), and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, San Francisco, the Division of Research, Kaiser Permanente Northern California, Oakland (C.H., R.V.P., T.C.T., A.S.G.), the Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena (A.S.G.), and the Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto (A.S.G.) - all in California; the Department of Biostatistics, Epidemiology, and Informatics and the Center for Clinical Epidemiology and Biostatistics (W.Y., J.W., H.I.F.), the Division of Division of Renal-Electrolyte and Hypertension (D.L.C.), and the Department of Medicine (R.R.T.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia; the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine (A.H.A., J.H., K.T.M.) and the Tulane University Translational Science Institute (A.H.A., J.H., K.T.M.), New Orleans; the Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, and the Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore (T.K.C.), and the Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda (A.P.) - all in Maryland; the Division of Nephrology, Department of Internal Medicine, Wayne State University, Detroit (M.J.M.); the Division of Nephrology, Department of Medicine, University of Illinois at Chicago (J.P.L.), and the Section of General Internal Medicine, Department of Medicine, University of Chicago (M.R.S.) - both in Chicago; the Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson (T.S.); the Section of Nephrology, Boston University School of Medicine and Boston Medical Center, Boston (S.S.W.); and the Division of Nephrology, Department of Medicine, and Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.W.).

Background: The inclusion of race in equations to estimate the glomerular filtration rate (GFR) has become controversial. Alternative equations that can be used to achieve similar accuracy without the use of race are needed.

Methods: In a large national study involving adults with chronic kidney disease, we conducted cross-sectional analyses of baseline data from 1248 participants for whom data, including the following, had been collected: race as reported by the participant, genetic ancestry markers, and the serum creatinine, serum cystatin C, and 24-hour urinary creatinine levels. Read More

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September 2021

Erosion and deposition vulnerability of small (<5,000 km2) tropical islands.

PLoS One 2021 16;16(9):e0253080. Epub 2021 Sep 16.

School of Earth Sciences, The Ohio State University, Columbus, Ohio, United States of America.

The tropics are naturally vulnerable to watershed erosion. This region is rapidly growing (projected to be 50% of the global population by 2050) which exacerbates erosional issues by the subsequent land use change. The issue is particularly of interest on the many (~45,000) small tropical (<5,000 km2) islands, and their >115M residents, where ecotourism and sediment intolerant ecosystems such as coral reefs are the main driver of their economies. Read More

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September 2021

Historical and Recent Changes in Maternal Mortality Due to Hypertensive Disorders in the United States, 1979 to 2018.

Hypertension 2021 Sep 13:HYPERTENSIONAHA12117661. Epub 2021 Sep 13.

School of Population and Public Health, University of British Columbia, Vancouver, Canada. (K.S.J.).

We evaluated the contributions of maternal age, year of death (period), and year of birth (cohort) on trends in hypertension-related maternal deaths in the United States. We undertook a sequential time series analysis of 155 710 441 live births and 3287 hypertension-related maternal deaths in the United States, 1979 to 2018. Trends in pregnancy-related mortality rate (maternal mortality rate [MMR]) due to chronic hypertension, gestational hypertension, and preeclampsia/eclampsia, were examined. Read More

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September 2021

Training Programs for Fundamental and Clinician-Scientists: Balanced Outcomes for Graduates by Gender.

Can J Kidney Health Dis 2021 2;8:20543581211033405. Epub 2021 Sep 2.

Department of Internal Medicine, Nephrology, University of Manitoba, Winnipeg, Canada.

Background: Women scientists are less likely to obtain Assistant Professorship and achieve promotion, and obtain less grant funding than men. Scientist/clinician-scientist training programs which provide salary awards as well as training and mentorship are a potential intervention to improve outcomes among women scientists. We hypothesized whether a programmatic approach to scientist/clinician-scientist training is associated with improved outcomes for women scientists in Canada when compared with salary awards alone. Read More

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September 2021

Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients.

BMC Geriatr 2021 09 4;21(1):481. Epub 2021 Sep 4.

Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, 510080, China.

Background: The accuracy of the estimated glomerular filter rate (eGFR) in elderly patients is debatable. In 2020, a new creatinine-based equation by European Kidney Function Consortium (EKFC) was applied to all age groups. The objective of this study was to assess the appropriateness of the new EKFC equation with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised (LMR), Berlin Initiative Study 1 (BIS1), and full age spectrum (FAS) equations based on serum creatinine (SCR) for elderly Chinese patients. Read More

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September 2021

Preventive strategy of flatfoot deformity using fully automated procedure.

Med Eng Phys 2021 Sep 9;95:15-24. Epub 2021 Jul 9.

School of Engineering, RMIT University, Australia. Electronic address:

A non-invasive, no radiation, out-of-hospital automated system is proposed to identify low arch integrated in the design and manufacturing of personalized orthoses using parametric modelling. The aim of the design process is to integrate assistive technology with assessment and prevent low arch progressing to a more serious case - flatfoot. In the automated procedure, we developed an assessment method including reliable thresholds of foot type classification and test protocol to reduce interferences due to preceding activities, an automation to translate scanned data into parametric design for orthotic customization, finite element model evaluating effectiveness of the personalized design, and a personalized comparative test to evaluate the long-term improvement of foot arch shape. Read More

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September 2021

A Clinicopathological Analysis of Melanocytic Nevi: A Retrospective Series.

Front Med (Lausanne) 2021 10;8:681668. Epub 2021 Aug 10.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Melanocytic nevi are common cutaneous lesions. This study aimed to demonstrate the concordance and discordance between clinical and histopathological diagnoses of melanocytic nevi and the importance of histological evaluation in differentiating malignant lesions from diseases with similar clinical manifestations. We studied 4,561 consecutive patients with a clinical diagnosis of melanocytic nevi from 2014 to 2019. Read More

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Why cumulative loading calculated using non-weighted integration may not be suitable for assessing physical stress of the lower back: an empirical investigation of strain during lifting and lowering tasks.

Ergonomics 2021 Aug 24:1-13. Epub 2021 Aug 24.

Chair and Institute of Industrial Engineering and Ergonomics, RWTH Aachen University, Aachen, Germany.

When work-related physical stress is assessed using non-weighted integration, it is assumed that different loading conditions have a sufficiently comparable effect on the human body as long as the area under the loading curve is the same. Growing evidence cast doubt on whether this simple calculation can adequately estimate physical work-related strain. This study investigates in vivo, focussing on the lower back, whether the non-weighted method adequately reflects work-related physical strain of the lower back. Read More

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The detection value of PD-L1 expression in biopsy specimens and surgical resection specimens in non-small cell lung cancer: a meta-analysis.

J Thorac Dis 2021 Jul;13(7):4301-4310

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: The detection value of different types of specimens for programmed death ligand-1 (PD-L1) expression remains controversial. As such, the purpose of this meta-analysis was to compare the detection value of biopsy specimens and surgical resection specimens for PD-L1 expression in patients with non-small cell lung cancer (NSCLC).

Methods: PubMed and Web of Science were searched prior to December 2020 to identify studies that compared the detection value of biopsy specimens and surgical resection specimens for PD-L1 expression in NSCLC. Read More

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A simple assessment of lung nodule location for reduction in unnecessary invasive procedures.

J Thorac Dis 2021 Jul;13(7):4207-4216

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Background: CT screening for lung cancer results in a significant mortality reduction but is complicated by invasive procedures performed for evaluation of the many detected benign nodules. The purpose of this study was to evaluate measures of nodule location within the lung as predictors of malignancy.

Methods: We analyzed images and data from 3,483 participants in the National Lung Screening Trial (NLST). Read More

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Association Between Deceased Donor Acute Kidney Injury Assessed Using Baseline Serum Creatinine Back-Estimation and Graft Survival: Results From the French National CRISTAL Registry.

Am J Kidney Dis 2021 Aug 5. Epub 2021 Aug 5.

Department of Nephrology, Lille University Hospital, Lille, France.

Rationale & Objective: While deceased donor acute kidney injury (AKI) frequently leads to kidney discards, its impact on long-term graft survival in kidney transplant recipients remains unclear. We investigated the association between deceased donor AKI assessed using back-estimation of baseline serum creatinine (Scr) and graft survival.

Study Design: Observational cohort study. Read More

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Classification for avian malaria parasite Plasmodium gallinaceum blood stages by using deep convolutional neural networks.

Sci Rep 2021 Aug 19;11(1):16919. Epub 2021 Aug 19.

Department of Electrical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.

The infection of an avian malaria parasite (Plasmodium gallinaceum) in domestic chickens presents a major threat to the poultry industry because it causes economic loss in both the quality and quantity of meat and egg production. Computer-aided diagnosis has been developed to automatically identify avian malaria infections and classify the blood infection stage development. In this study, four types of deep convolutional neural networks, namely Darknet, Darknet19, Darknet19-448 and Densenet201 are used to classify P. Read More

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Neonatal adverse outcome in twin pregnancies complicated by small-for-gestational age: twin vs singleton reference chart.

Ultrasound Obstet Gynecol 2021 Aug 18. Epub 2021 Aug 18.

Twins Trust Centre for Research and Clinical Excellence, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London, SW17 0RE, UK.

Objective: The use of twin-specific versus singleton charts in the assessment of twin pregnancies has been controversial. The aim of the study was to assess whether a diagnosis of small for gestational age (SGA) made using twin specific estimated fetal weight (EFW) and birthweight (BW) charts is more strongly associated with adverse neonatal outcomes compared to singleton charts in twin pregnancies.

Methods: This was a cohort study of twin pregnancies delivered at St George's Hospital in London between January 2007 and May 2020. Read More

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Effectiveness of Aspirin in COPD: Biases in the Observational Studies.

COPD 2021 Aug 16;18(4):449-455. Epub 2021 Aug 16.

Centre for Clinical Epidemiology, Lady Davis Institute-Jewish General Hospital; Departments of Epidemiology and Biostatistics, and Medicine, McGill University, Montreal, Quebec, Canada.

Several observational studies report decreased incidence of mortality and of exacerbations with aspirin use in patients with chronic obstructive pulmonary disease (COPD), with calls for a large randomized trial. Aspirin does have local and systemic pulmonary mechanisms of action that could make this drug beneficial in the treatment of COPD. However, the potential for biases in the observational studies has not been examined. Read More

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Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors.

JACC CardioOncol 2020 Dec 15;2(5):690-706. Epub 2020 Dec 15.

Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Despite known clinical risk factors, predicting anthracycline cardiotoxicity remains challenging.

Objectives: This study sought to develop a clinical and genetic risk prediction model for anthracycline cardiotoxicity in childhood cancer survivors.

Methods: We performed exome sequencing in 289 childhood cancer survivors at least 3 years from anthracycline exposure. Read More

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December 2020

Mid-infrared spectral classification of endometrial cancer compared to benign controls in serum or plasma samples.

Analyst 2021 Sep 13;146(18):5631-5642. Epub 2021 Sep 13.

Mid-Infrared Photonics Group, George Green Institute for Electromagnetics' Research, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.

This study demonstrates a discrimination of endometrial cancer (non-cancerous) benign controls based on mid-infrared (MIR) spectroscopy of dried plasma or serum liquid samples. A detailed evaluation was performed using four discriminant methods (LDA, QDA, kNN or SVM) to execute the classification task. The discriminant methods used in the study comprised methods that are widely used in the statistics (LDA and QDA) and machine learning literature (kNN and SVM). Read More

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September 2021

A Study of Deep Learning-Based Face Recognition Models for Sibling Identification.

Sensors (Basel) 2021 Jul 27;21(15). Epub 2021 Jul 27.

Centre of Visual Computing, University of Bradford, Bradford BD7 1DP, UK.

Accurate identification of siblings through face recognition is a challenging task. This is predominantly because of the high degree of similarities among the faces of siblings. In this study, we investigate the use of state-of-the-art deep learning face recognition models to evaluate their capacity for discrimination between sibling faces using various similarity indices. Read More

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Visceral Adiposity in Relation to Body Adiposity and Nutritional Status in Elderly Patients with Stable Coronary Artery Disease.

Nutrients 2021 Jul 9;13(7). Epub 2021 Jul 9.

Department of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences, Medical University of Silesia, 41-902 Bytom, Poland.

: The accumulation of visceral abdominal tissue (VAT) seems to be a hallmark feature of abdominal obesity and substantially contributes to metabolic abnormalities. There are numerous factors that make the body-mass index (BMI) a suboptimal measure of adiposity. The visceral adiposity index (VAI) may be considered a simple surrogate marker of visceral adipose tissue dysfunction. Read More

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Fuzzy -Means Clustering Algorithm-Based Magnetic Resonance Imaging Image Segmentation for Analyzing the Effect of Edaravone on the Vascular Endothelial Function in Patients with Acute Cerebral Infarction.

Contrast Media Mol Imaging 2021 14;2021:4080305. Epub 2021 Jul 14.

Department of Encephalopathy, Qingdao Fifth People's Hospital, Qingdao 266002, China.

This paper aimed to discuss the denoising ability of magnetic resonance imaging (MRI) images based on fuzzy C-means clustering (FCM) algorithm and the influence of Butylphthalide combined with Edaravone treatment on nerve function and vascular endothelial function in patients with acute cerebral infarction (ACI). Based on FCM algorithm, Markov Random Field (MRF) model algorithm was introduced to obtain a novel algorithm (NFCM), which was compared with FCM and MRF algorithm in terms of misclassification rate (MCR) and difference of Kappa index (KI). 90 patients with ACI diagnosed in hospital from December 2018 to December 2019 were selected as subjects, who were divided into combined treatment group (conventional treatment + Edaravone + Butylphthalide) and Edaravone group (conventional treatment + Edaravone) randomly, each consisting of 45 cases. Read More

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Assessment of kidney function: clinical indications for measured GFR.

Clin Kidney J 2021 Aug 22;14(8):1861-1870. Epub 2021 Feb 22.

Institute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.

In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. Read More

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Levels of pneumococcal conjugate vaccine coverage and indirect protection against invasive pneumococcal disease and pneumonia hospitalisations in Australia: An observational study.

PLoS Med 2021 Aug 3;18(8):e1003733. Epub 2021 Aug 3.

Asia-Pacific Health Research Group, Murdoch Children's Research Institute, Melbourne, Australia.

Background: There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV coverage and indirect protection against invasive pneumococcal disease (IPD) and pneumonia hospitalisations among undervaccinated Australian children.

Methods And Findings: Birth and vaccination records, IPD notifications, and hospitalisations were individually linked for children aged <5 years, born between 2001 and 2012 in 2 Australian states (New South Wales and Western Australia; 1. Read More

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Automatic Prediction of Recurrence of Major Cardiovascular Events: A Text Mining Study Using Chest X-Ray Reports.

J Healthc Eng 2021 9;2021:6663884. Epub 2021 Jul 9.

Department of Methodology and Statistics, Faculty of Social Sciences, Utrecht University, Utrecht, Netherlands.

Methods: We used EHR data of patients included in the Second Manifestations of ARTerial disease (SMART) study. We propose a deep learning-based multimodal architecture for our text mining pipeline that integrates neural text representation with preprocessed clinical predictors for the prediction of recurrence of major cardiovascular events in cardiovascular patients. Text preprocessing, including cleaning and stemming, was first applied to filter out the unwanted texts from X-ray radiology reports. Read More

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Prevalence of low birth weight and macrosomia estimates based on heaping adjustment method in China.

Sci Rep 2021 Jul 22;11(1):15016. Epub 2021 Jul 22.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Nanwei road No.29, Xicheng district, Beijing, 100050, China.

Low birth weight (< 2500 g; LBW) and macrosomia (> 4000 g) are both adverse birth outcomes with high health risk in short- or long-term period. However, national prevalence estimates of LBW and macrosomia varied partially due to methodology limits in China. The aim of this study is to estimate the prevalence of LBW and macrosomia after taking potential birth weight heaping into consideration in Chinese children under 6 years in 2013. Read More

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Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors.

J Immunother Cancer 2021 07;9(7)

Harvard Medical School, Boston, Massachusetts, USA.

Expanding the US Food and Drug Administration-approved indications for immune checkpoint inhibitors in patients with cancer has resulted in therapeutic success and immune-related adverse events (irAEs). Neurologic irAEs (irAE-Ns) have an incidence of 1%-12% and a high fatality rate relative to other irAEs. Lack of standardized disease definitions and accurate phenotyping leads to syndrome misclassification and impedes development of evidence-based treatments and translational research. Read More

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An Ensemble-Based Scalable Approach for Intrusion Detection Using Big Data Framework.

Big Data 2021 08 16;9(4):303-321. Epub 2021 Jul 16.

Department of Electrical and Communication Engineering, The PNG University of Technology, Lae, Papua New Guinea.

In this study, we set up a scalable framework for large-scale data processing and analytics using the big data framework. The popular classification methods are implemented, tuned, and evaluated by using intrusion datasets. The objective is to select the best classifier after optimizing the hyper-parameters. Read More

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Improved window adaptive gray level co-occurrence matrix for extraction and analysis of texture characteristics of pulmonary nodules.

Comput Methods Programs Biomed 2021 Sep 3;208:106263. Epub 2021 Jul 3.

Basic Medical College, Anhui Medical University, Hefei 230032, P.R. China. Electronic address:

Background And Objective: Identifying benign and malignant pulmonary nodules is essential for the early diagnosis of lung cancer and targeted surgical resection. This study aimed to differentiate benign from malignant pulmonary nodules based on computed tomography (CT) plain scan texture analysis technique.

Methods: A total of 47 pulmonary nodules use the improved window adaptive gray level co-occurrence matrix (GLCM) algorithm to extract the texture characteristics of the area of interest. Read More

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September 2021

Value of Conventional MRI Texture Analysis in the Differential Diagnosis of Phyllodes Tumors and Fibroadenomas of the Breast.

Breast Care (Basel) 2021 Jun 23;16(3):283-290. Epub 2020 Jun 23.

Department of Radiology, Daping Hospital, Army Medical University, Chongqing, China.

Background: There is substantial overlap in MRI findings between phyllodes tumors (PTs) and fibroadenomas (FAs). Our study was performed to investigate the value of conventional MRI texture analysis in the differential diagnosis of PTs and FAs.

Methods: Preoperative MRI data - including axial T1WI, T2WI (T2WI with fat suppression), dynamic contrast-enhanced (DCE)-T1WI and DCE-T1WI (T1WI post-strengthened for 2 and 7 min, respectively, on DCE-MRI) - of 45 patients with PTs and 67 patients with FAs were retrospectively analyzed. Read More

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Detecting and predicting changes in milk homogeneity using data from automatic milking systems.

J Dairy Sci 2021 Oct 1;104(10):11009-11017. Epub 2021 Jul 1.

DeLaval International AB, PO Box 39, SE-147 21 Tumba, Sweden.

To ensure milk quality and detect cows with signs of mastitis, visual inspection of milk by prestripping quarters before milking is recommended in many countries. An objective method to find milk changed in homogeneity (i.e. Read More

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October 2021