9 results match your criteria mirv

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Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I.

Ann Oncol 2021 Mar 2. Epub 2021 Mar 2.

Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA.

Background: Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate comprising a folate receptor alpha (FRα)-binding antibody, cleavable linker, and the maytansinoid DM4, a potent tubulin-targeting agent. The randomized, open-label, phase III study FORWARD I compared MIRV and investigator's choice chemotherapy in patients with platinum-resistant epithelial ovarian cancer (EOC).

Patients And Methods: Eligible patients with 1-3 prior lines of therapy and whose tumors were positive for FRα expression were randomly assigned, in a 2 : 1 ratio, to receive MIRV (6 mg/kg, adjusted ideal body weight) or chemotherapy (paclitaxel, pegylated liposomal doxorubicin, or topotecan). Read More

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Effects of Game Pitch Count and Body Mass Index on Pitching Biomechanics in 9- to 10-Year-Old Baseball Athletes.

Orthop J Sports Med 2018 Apr 13;6(4):2325967118765655. Epub 2018 Apr 13.

Biomedical Engineering Department, California Polytechnic State University, San Luis Obispo, California, USA.

Background: Pitching while fatigued and body composition may increase the injury risk in youth and adult pitchers. However, the relationships between game pitch count, biomechanics, and body composition have not been reported for a study group restricted to 9- to 10-year-old athletes.

Hypothesis: During a simulated game with 9- to 10-year-old athletes, (1) participants will experience biomechanical signs of fatigue, and (2) shoulder and elbow kinetics will correlate with body mass index (BMI). Read More

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New Virus Genome Sequences of the Guama Serogroup (Genus , Family ), Isolated in the Brazilian Amazon Region.

Genome Announc 2017 Mar 2;5(9). Epub 2017 Mar 2.

Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.

This is the first announcement of two nearly complete viral genome sequences belonging to the Guama serogroup (genus , family ) isolated in the Brazilian Amazon region: (MIRV; BEAN7722) and (ANUV; BEAN109303). Read More

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Intersegmental dynamics of 3D upper arm and forearm longitudinal axis rotations during baseball pitching.

Hum Mov Sci 2014 Dec 7;38:116-32. Epub 2014 Oct 7.

Graduate School of Decision Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.

The shoulder internal rotation (IR) and forearm pronation (PR) are important elements for baseball pitching, however, how rapid rotations of IR and PR are produced by muscular torques and inter-segmental forces is not clear. The aim of this study is to clarify how IR and PR angular velocities are maximized, depending on muscular torque and interactive torque effects, and gain a detailed knowledge about inter-segmental interaction within a multi-joint linked chain. The throwing movements of eight collegiate baseball pitchers were recorded by a motion capture system, and induced-acceleration analysis was used to assess the respective contributions of the muscular (MUS) and interactive torques associated with gyroscopic moment (GYR), and Coriolis (COR) and centrifugal forces (CEN) to maximum angular velocities of IR (MIRV) and PR (MPRV). Read More

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December 2014

Assessing the relationship between antigenicity and immunogenicity of human rabies vaccines when administered by intradermal route: results of a metaanalysis.

Hum Vaccin 2010 Jul 1;6(7):562-5. Epub 2010 Jul 1.

Department of Community Medicine, Kempegowda Institute of Medical Sciences, Bangalore, India.

The metadata of 10 published studies and 3 vaccine trial reports comprising of 19 vaccine cohorts from four countries conducted over a period of 23 years (1986 - 2009) was used for metaanalysis. The vaccines studied were purified chick embryo cell vaccine (Rabipur, India & Germany), purified vero cell rabies vaccine (Verorab, France; Indirab, India) & human diploid cell vaccine (MIRV, France).The potency of these vaccines varied from 0. Read More

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An immunogenicity, safety and post-marketing surveillance of a novel adsorbed human diploid cell rabies vaccine (Rabivax) in Indian subjects.

Hum Vaccin 2008 Jul-Aug;4(4):275-9

Department of Community Medicine and Rabies, Epidemiology Unit, Kempegowda Institute of Medical Sciences, Bangalore, India.

In 1999, Serum Institute of India indigenously developed an adsorbed human diploid cell rabies vaccine (Rabivax). During 2000-04, this new vaccine was subjected to a series of immunogenecity and safety studies. Initially, an experimental batch of Rabivax (adsorbed) was assessed on ten healthy adult volunteers and its response was comparable with that of Merieux inactivated rabies vaccine (MIRV, lyophilized) which was used as a control. Read More

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November 2008

Assessing the relationship between antigenicity and immunogenicity of human rabies vaccines. Results of a meta-analysis.

Hum Vaccin 2005 Sep-Oct;1(5):187-90. Epub 2005 Sep 18.

Department of Community Medicine and Rabies Epidemiology Unit, Kempegowda Institute of Medical Sciences, Bangalore, India.

A meta-analysis was done to study the relationship between antigenecity and immunogenecity of human rabies vaccines. The data of ten cell culture human rabies vaccine studies conducted at a single centre during 1993-2004 were used in the study. The vaccines studied included Purified Chick Embryo Cell Vaccine (Kaketsuken, Japan and Rabipur, India), Purified Vero cell Rabies Vaccine (Verorab, France), Human Diploid Cell Vaccine (MIRV, France and Rabivax, Adsorbed and Lyophilized, India) and Rhesus Diploid Rabies Vaccine (adsorbed, USA). Read More

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January 2007
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