15 results match your criteria mir211

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Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.

Mol Brain 2021 03 30;14(1):61. Epub 2021 Mar 30.

Graduate School of Pharmacy, Ritsumeikan University, Kusatsu, Shiga, Japan.

The 15q13.3 microdeletion syndrome is a genetic disorder characterized by a wide spectrum of psychiatric disorders that is caused by the deletion of a region containing 7 genes on chromosome 15 (MTMR10, FAN1, TRPM1, MIR211, KLF13, OTUD7A, and CHRNA7). The contribution of each gene in this syndrome has been studied using mutant mouse models, but no single mouse model recapitulates the whole spectrum of human 15q13. Read More

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The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers.

Front Oncol 2020 8;10:628367. Epub 2021 Feb 8.

Cancer & Blood Disorder Institute, Johns Hopkins All Children's Hospital, South, St. Petersburg, FL, United States.

Cancer initiation, progression, and metastasis leverage many regulatory agents, such as signaling molecules, transcription factors, and regulatory RNA molecules. Among these, regulatory non-coding RNAs have emerged as molecules that control multiple cancer types and their pathologic properties. The human microRNA-211 (MIR211) is one such molecule, which affects several cancer types, including melanoma, glioblastoma, lung adenocarcinomas, breast, ovarian, prostate, and colorectal carcinoma. Read More

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February 2021

Exosomes derived from differentiated Schwann cells inhibit Schwann cell migration via microRNAs.

Neuroreport 2020 05;31(7):515-522

Department of Molecular Neuroscience, College of Medicine, Dong-A University, Busan, South Korea.

Exosomes derived from Schwann cells have been known to have a variety of functions in the development and repair of the peripheral nervous system, and cyclic AMP (cAMP) is a key inducer of Schwann cell differentiation. In the present study, we aimed to study the effect of exosomes derived from differentiated Schwann cells on the expression of microRNAs (miRNAs). To show that miRNAs were altered from exosomes derived from Schwann cells, we conducted next-generation sequencing (NGS) arrays with exosomes derived from cAMP-induced differentiated Schwann cells and control. Read More

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Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation.

Int J Mol Med 2020 Apr 27;45(4):1017-1026. Epub 2020 Jan 27.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Clinical studies have proven that ultraviolet B (UVB) based phototherapy can induce perifollicular and marginal repigmentation patterns in the skin of vitiligo patients. It is, however, difficult to conceive how melanocytes can easily exit from their tightly interconnected epidermal microenvironment to re‑enter a different location in the skin to establish a new network with neighboring keratinocytes. While it is known that matrix metalloprotease 9 (MMP9) is involved in the degradation of the extracellular matrix in physiological or pathological processes, little is known about whether MMP9 affects melanocyte migration in vitiligo repigmentation. Read More

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microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN.

Cell Mol Biol Lett 2019 9;24:48. Epub 2019 Jul 9.

3Department of Spine Surgery, ZhongShan Hospital XiaMen University, No. 201 Hubin South Road, Xiamen, 361004 China.

Background: In recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In this study, the relationship between miR211 and EZRIN was analyzed in human osteosarcoma. Read More

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Chromosome 15q13 microduplication in a fetus with cardiac rhabdomyoma: a case report.

Mol Cytogenet 2019 27;12:24. Epub 2019 May 27.

4Department of Laboratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009 Fujian Province People's Republic of China.

Background: Copy number variation (CNV) is a complex genomic rearrangement that has been linked to a large number of human diseases. Chromosome 15q13 microduplication is a rare form of CNV, which has been proved to be associated with multiple human disorders; however, the association between chromosome 15q13 microduplication and cardiac disorders has not been fully understood.

Case Presentation: A fetus with fetal cardiac developmental defects was detected by Color Doppler ultrasound imaging; however, further chromosomal G-banding revealed no abnormal karyotype. Read More

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A 19‑miRNA Support Vector Machine classifier and a 6‑miRNA risk score system designed for ovarian cancer patients.

Oncol Rep 2019 Jun 10;41(6):3233-3243. Epub 2019 Apr 10.

Department of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Dongcheng, Beijing 100001, P.R. China.

Ovarian cancer (OC) is the most common gynecologic malignancy with high incidence and mortality. The present study aimed to develop approaches for determining the recurrence type and identify potential miRNA markers for OC prognosis. The miRNA expression profile of OC (the training set, including 390 samples with recurrence information) was downloaded from The Cancer Genome Atlas database. Read More

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MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.

Autophagy 2019 03 16;15(3):375-390. Epub 2018 Oct 16.

a Sabanci University , Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering Program , Orhanli-Tuzla , Turkey.

Macroautophagy (autophagy) is an evolutionarily conserved recycling and stress response mechanism. Active at basal levels in eukaryotes, autophagy is upregulated under stress providing cells with building blocks such as amino acids. A lysosome-integrated sensor system composed of RRAG GTPases and MTOR complex 1 (MTORC1) regulates lysosome biogenesis and autophagy in response to amino acid availability. Read More

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microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1.

Mol Med Rep 2018 Jan 7;17(1):1275-1282. Epub 2017 Nov 7.

Department of Gynaecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.

Of gynecological cancers, cervical cancer has the second highest incidence globally and is a major cause of cancer‑associated mortality in women. An increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein‑coding genes. The aim of the present study was to investigate the expression and biological roles of miRNA‑211 (miR‑211) in cervical cancer and its underlying molecular mechanism. Read More

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January 2018

LPS‑induced downregulation of microRNA‑204/211 upregulates and stabilizes Angiopoietin‑1 mRNA in EA.hy926 endothelial cells.

Mol Med Rep 2017 Nov 30;16(5):6081-6087. Epub 2017 Aug 30.

Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.

Angiopoietin‑1 (ANG‑1), a ligand of the endothelial cell‑specific TIE2 surface receptor, acts in a complementary and coordinated manner with vascular endothelial growth factor during the process of angiogenesis. ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. The epithelium‑specific Ets transcription factor 1 can activate ANG‑1 transcription in the setting of inflammation; however, relatively little is known about the regulation of ANG‑1 by microRNAs (miRs). Read More

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November 2017

Association of AKAP6 and MIR2113 with cognitive performance in a population-based sample of older adults.

Genes Brain Behav 2017 04 26;16(4):472-478. Epub 2017 Jan 26.

John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Genetic factors make a substantial contribution to inter-individual variability in cognitive function. A recent meta-analysis of genome-wide association studies identified two loci, AKAP6 and MIR2113, that are associated with general cognitive function. Here, we extend this previous research by investigating the association of MIR2113 and AKAP6 with baseline and longitudinal non-linear change across a broad spectrum of cognitive domains in a community-based cohort of older adults without dementia. Read More

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Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer.

PLoS One 2016 14;11(3):e0151287. Epub 2016 Mar 14.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.

In addition to protein-coding genes, the human genome makes a large amount of noncoding RNAs. Long non-coding RNAs (lncRNAs) have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. In recent years, lncRNAs have been considered to be the key regulators of tumor behavior. Read More

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[MiR-211 promotes invasion of hepatoma cells by targeting estrogen receptor alpha].

Zhonghua Gan Zang Bing Za Zhi 2015 Jul;23(7):527-32

Department of clinical laboratory, Huanhu Hospital of Tianjin, Tianjin 300060, China.

Objective: To investigate the regulatory functions and molecular mechanisms of miR211 in hepatocellular carcinoma (HCC).

Methods: Real-time reverse transcription-PCR was used to analyze the expression of miR-211 in 20 paired clinical specimens of HCC and adjacent noncancerous tissues.QGY7703 and HepG2 cells with stimulation or inhibition of miR-211 expression were used to evaluate the effects on malignant phenotypes with the transwell invasion assay. Read More

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Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer.

Cancer Res 2014 Dec 2;74(23):6890-902. Epub 2014 Oct 2.

State Key Laboratory for Oncogenes and Related Genes; Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

It is increasingly evident that long noncoding RNAs (lncRNA) have causative roles in carcinogenesis. In this study, we report findings implicating a novel lncRNA in gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive long intergenic noncoding RNA), based on the use of global microarray and in situ hybridization (ISH) analyses to identify aberrantly expressed lncRNA in human gastric cancer specimens. GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. Read More

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December 2014

Comprehensive characterization of viral miRNAs involved in white spot syndrome virus (WSSV) infection.

RNA Biol 2012 Jul 1;9(7):1019-29. Epub 2012 Jul 1.

Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Key Laboratory of Animal Virology of Ministry of Agriculture and College of Life Sciences, Zhejiang University, Hangzhou, China.

Guided by miRNAs, RNAi plays an important role in virus-host interactions by fine-tuning gene expression. Many viral and cellular miRNAs are involved in virus infection, though no comprehensive general model for miRNAs derived from invertebrate DNA viruses exists for their function in eukaryotic systems, despite extensive research on miRNAs. To address this issue, the miRNAs from shrimp white spot syndrome virus (WSSV), a DNA virus with a 305 kb double-stranded circular DNA genome, were characterized. Read More

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