Circ Res 2015 Jul 5;117(2):157-65. Epub 2015 May 5.
From the Institute for Vascular Signaling, Centre for Molecular Medicine, and DZHK (German Centre for Cardiovascular Research) partner site Rhine-Main, Frankfurt, Germany (A.E., L.S., J.H., H.L., V.R., I.F.); Functional Proteomics, SFB 815 Core Unit, Goethe-University, Frankfurt, Germany (I.W.); Walter-Brendel-Centre of Experimental Medicine and DZHK partner site Munich Heart Alliance, Ludwig-Maximilians-Universität, Munich, Germany (J.P.); Endokrinologikum Frankfurt, Frankfurt, Germany (A.M.); and Centre Hospitalier Universitaire de Québec Research Center, and Faculty of Medicine, Université Laval, Quebec, Canada (P.P.).
Rationale: MicroRNAs (miRNAs) are short noncoding RNA species generated by the processing of longer precursors by the ribonucleases Drosha and Dicer. Platelets contain large amounts of miRNA that are altered by disease, in particular diabetes mellitus.
Objective: This study determined why platelet miRNA levels are attenuated in diabetic individuals and how decreased levels of the platelet-enriched miRNA, miR-223, affect platelet function. Read More