3,291 results match your criteria mir-155

Relationship between miR-155 expression and clear cell papillary renal cell carcinoma in the dialyzed kidney.

IJU Case Rep 2021 May 15;4(3):127-131. Epub 2021 Mar 15.

Department of Urology School of Medicine Iwate Medical University Yahaba Japan.

Introduction: Clear cell papillary renal cell carcinoma often develops in the context of the dialyzed kidney (end-stage renal disease). However, the relationship between clear cell papillary renal cell carcinoma and microRNA expression in patients with end-stage renal disease remains unclear.

Case Presentation: A left renal tumor measuring 22 mm was detected and a radical nephrectomy was performed on a 50-year-old man who had received hemodialysis for the past 6 years. Read More

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lncRNA NORAD promotes the progression of osteosarcoma via targeting of miR-155-5p.

Exp Ther Med 2021 Jun 18;21(6):645. Epub 2021 Apr 18.

Department of Orthopedics, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.

Osteosarcoma (OS) is the most common malignant bone tumor in teens. Non-coding RNA activated by DNA damage (NORAD), a long non-coding RNA (lncRNA), has been reported to be involved in cancer biology, although its role in OS remains largely unknown. In the present study reverse transcription-quantitative PCR (RT-qPCR) was used to determine the expression levels of NORAD and miR-155-5p in samples from patients with OS. Read More

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Potential biomarkers of infertility associated with microbiome imbalances.

Am J Reprod Immunol 2021 May 6:e13438. Epub 2021 May 6.

Microgenesis Co, US.

Problem: The aim of this study was to investigate the possible relationship between vaginal/rectal microbiome disbalances and miRNA expression with infertility.

Method Of Study: Observational, exploratory, preliminary study. A total of 287 multiple IVF failure infertile patients were recruited. Read More

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Decreased microRNA-155 in Behcet's disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production.

Arthritis Res Ther 2021 May 6;23(1):135. Epub 2021 May 6.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.

Background: Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet's disease (BD) patients was decreased and affected cytokine production of DCs. In this study, we investigated the mechanisms whereby miR-155 regulates cytokine production by DCs.

Methods: The formation of autophagosomes in DCs was detected by transmission electron microscopy. Read More

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Use of a panel of four microRNAs in CSF as a predicted biomarker for postoperative neoangiogenesis in moyamoya disease.

CNS Neurosci Ther 2021 May 4. Epub 2021 May 4.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Introduction And Aims: At present, the treatment for moyamoya disease (MMD) primarily consists of combined direct and indirect bypass surgery. Nevertheless, more than half of indirect bypass surgeries fail to develop good collaterals from the dura and temporal muscle. This study aimed to investigate whether microRNAs (miRNAs) in cerebrospinal fluid (CSF) could serve as biomarkers for the prediction of postoperative collateral formation. Read More

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Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.

Exp Ther Med 2021 Jun 14;21(6):620. Epub 2021 Apr 14.

Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China.

MicroRNA-155 (miR-155) is associated with various diseases. However, the potential role of miR-155 in early glomerular disease (EGD) remains elusive. In the present study, the clinical significance of urinary miR-155 expression was explored in patients with EGD using receiver operating characteristic curve analysis. Read More

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Expression of ssa-miR-155 during ISAV infection in vitro: Putative role as a modulator of the immune response in Salmo salar.

Dev Comp Immunol 2021 Apr 27;122:104109. Epub 2021 Apr 27.

Instituto de Biologia, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. Electronic address:

Multiple cellular components are involved in pathogen-host interaction during viral infection; in this context, the role of miRNAs have become highly relevant. We assessed the expression of selected miRNAs during an in vitro infection of a Salmo salar cell line with Infectious Salmon Anemia Virus (ISAV), the causative agent of a severe disease by the same name. Salmon orthologs for miRNAs that regulate antiviral responses were measured using RT-qPCR in an in vitro time-course assay. Read More

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Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA.

Pathogens 2021 Apr 27;10(5). Epub 2021 Apr 27.

Centre de Recherche du CHU de Québec-Université Laval, T1-49, 2705 boulevard Laurier, Québec, QC G1V 4G2, Canada.

Extracellular vesicles (EVs) and their contents (proteins, lipids, messenger RNA, microRNA, and DNA) are viewed as intercellular signals, cell-transforming agents, and shelters for viruses that allow both diagnostic and therapeutic interventions. EVs circulating in the blood of individuals infected with human immunodeficiency virus (HIV-1) may provide insights into pathogenesis, inflammation, and disease progression. However, distinguishing plasma membrane EVs from exosomes, exomeres, apoptotic bodies, virions, and contaminating proteins remains challenging. Read More

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MicroRNAs Regulating Tumor and Immune Cell Interactions in the Prediction of Relapse in Early Stage Breast Cancer.

Biomedicines 2021 Apr 13;9(4). Epub 2021 Apr 13.

Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71003 Crete, Greece.

MicroRNAs (miRNAs) are involved in the regulation of immune response and hold an important role in tumor immune escape. We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse. Blood samples were obtained from healthy women ( = 20) and patients with early stage breast cancer ( = 140) before adjuvant chemotherapy. Read More

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Diurnal Variation of Plasma Extracellular Vesicle Is Disrupted in People Living with HIV.

Pathogens 2021 Apr 24;10(5). Epub 2021 Apr 24.

Axe de Recherche Maladies Infectieuses et Immunitaires, CHUL, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1V 4G2, Canada.

Background: Several types of extracellular vesicles (EVs) secreted by various immune and non-immune cells are present in the human plasma. We previously demonstrated that EV abundance and microRNA content change in pathological conditions, such as HIV infection. Here, we investigated daily variations of large and small EVs, in terms of abundance and microRNA contents in people living with HIV (PLWH) receiving antiretroviral therapy (HIV+ART) and uninfected controls (HIV-). Read More

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MicroRNA Changes in Gastric Carcinogenesis: Differential Dysregulation during and EBV Infection.

Genes (Basel) 2021 Apr 19;12(4). Epub 2021 Apr 19.

Medizinische Klinik 2, Helios Universitätsklinikum Wuppertal, 42283 Wuppertal, Germany.

Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection with () and viral infection with the Epstein-Barr virus (EBV) are associated with the development of both distal and proximal gastric cancer. Therefore, the detection of these infections and the prediction of further cancer development could be clinically significant. Read More

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The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer.

Int J Mol Sci 2021 Apr 12;22(8). Epub 2021 Apr 12.

John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18-25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. Read More

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miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review.

Int J Mol Sci 2021 Apr 21;22(9). Epub 2021 Apr 21.

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Multiple sclerosis (MS) is a chronic, immune-mediated disease and the leading cause of disability among young adults. MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. Of them, miR-155 is a crucial regulator of inflammation and plays a role in modulating the autoimmune response in MS. Read More

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Dysregulation of MicroRNAs in Hypertrophy and Ossification of Ligamentum Flavum: New Advances, Challenges, and Potential Directions.

Front Genet 2021 12;12:641575. Epub 2021 Apr 12.

Orthopaedic Department, Peking University Third Hospital, Beijing, China.

Pathological changes in the ligamentum flavum (LF) can be defined as a process of chronic progressive aberrations in the nature and structure of ligamentous tissues characterized by increased thickness, reduced elasticity, local calcification, or aggravated ossification, which may cause severe myelopathy, radiculopathy, or both. Hypertrophy of ligamentum flavum (HLF) and ossification of ligamentum flavum (OLF) are clinically common entities. Though accumulated evidence has indicated both genetic and environmental factors could contribute to the initiation and progression of HLF/OLF, the definite pathogenesis remains fully unclear. Read More

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Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors.

Int J Gen Med 2021 21;14:1469-1484. Epub 2021 Apr 21.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: "Micro RNAs and their target genes recently have been identified to play a crucial role in the molecular pathogenesis of post-stroke ischemic cellular injury, which elucidates their new role in ischemic stroke diagnosis and therapy". Thus, we evaluated the relative serum expression of miR-155, an inflammatory micro RNA, and the mRNAs (JAK2/STAT3) in acute ischemic stroke patients and its associations with the inflammatory cytokine TNF-α and different stroke risk factors.

Subjects And Methods: The relative expression of serum miR-155 and mRNAs (JAK2/STAT3) was assessed using RT-PCR, serum TNF-α was measured using ELIZA in 46 acute ischemic stroke patients and 50 control subjects. Read More

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Research on the effect of interfering with miRNA-155 on triple-negative breast cancer cells.

Genes Genomics 2021 Apr 28. Epub 2021 Apr 28.

Department of Thyroid and Breast Diagnosis and Treatment Center, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, 310000, China.

Background: Triple negative breast cancer (TNBC) is a poor prognosis breast cancer with the highest mutation rate and limited treatment options. MiR-155 is highly expressed in TNBC, but its role and potential mechanism in TNBC remain to be elucidated.

Objective: The aim of this study is to examine the effect of interfering with miRNA-155 on the inflammatory pathway of NLRP 3 in TNBC (MDA-MB-231). Read More

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Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3.

Hum Cell 2021 Apr 27. Epub 2021 Apr 27.

Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, No.1 Minde Road, Nanchang, 330006, Jiangxi, China.

Allergic rhinitis (AR) is a familiar respiratory allergic inflammatory disease with higher incidence. The pathogenesis of AR is particularly complex. Therefore, a lot of work is acquired to excavate deep mechanisms, thereby providing effective strategies for AR diagnose and treatment. Read More

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Up-regulation of miR-155 potentiates CD34+ CML stem/progenitor cells to escape from the growth-inhibitory effects of TGF-ß1 and BMP signaling.

EXCLI J 2021 15;20:748-763. Epub 2021 Apr 15.

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

microRNAs (miRNAs or miRs) play key roles in different stages of chronic myeloid leukemia (CML) pathogenesis. The present study aimed to demonstrate whether miR-155 enables CD34 CML cells to escape from the growth-inhibitory effects of TGF-β1 and bone morphogenetic protein (BMP) signaling. Among differentially expressed miRNAs in CD34 CML cells, miR-155 was highly up-regulated. Read More

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Pap Smear miR-92a-5p and miR-155-5p as potential diagnostic biomarkers of squamous intraepithelial cervical cancer.

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1271-1277. Epub 2021 Apr 1.

Department of Obstetrics and Gynecology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: one of the female-specific diseases with a high incidence and mortality is cervical cancer. The main cause of cervical cancer is infection with Human papilloma virus (HPV). Low-grade squamous intraepithelial lesions (LSIL) and High-grade squamous intraepithelial lesions (HSIL) usually is caused by an HPV infection. Read More

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Exosomal MicroRNAs as Biomarkers in Allergic Asthma.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):160-168. Epub 2021 Apr 17.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Allergy and Clinical Immunology, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Exosomes are extracellular vesicles that are involved in intracellular communication and different biological processes. Recently, the importance of microRNAs (miRNAs) in exosomes has been considered as biomarkers in asthma diagnosis. This study aimed to determine the expression of selective miRNAs from plasma-derived exosomes in moderate and severe asthmatic patients compared with healthy controls. Read More

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MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation.

Front Cell Dev Biol 2021 9;9:670531. Epub 2021 Apr 9.

Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, MI, United States.

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that develop in the thymus through three maturation stages to acquire effector function and differentiate into MAIT1 (T-bet) and MAIT17 (RORγt) subsets. Upon activation, MAIT cells release IFN-γ and IL-17, which modulate a broad spectrum of diseases. Recent studies indicate defective MAIT cell development in microRNA deficient mice, however, few individual miRNAs have been identified to regulate MAIT cells. Read More

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Myeloid MKL1 Disseminates Cues to Promote Cardiac Hypertrophy in Mice.

Front Cell Dev Biol 2021 9;9:583492. Epub 2021 Apr 9.

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China.

Cardiac hypertrophy is a key pathophysiological process in the heart in response to stress cues. Although taking place in cardiomyocytes, the hypertrophic response is influenced by other cell types, both within the heart and derived from circulation. In the present study we investigated the myeloid-specific role of megakaryocytic leukemia 1 (MKL1) in cardiac hypertrophy. Read More

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Identification of Metastasis-Associated MicroRNAs in Metastatic Melanoma by miRNA Expression Profile and Experimental Validation.

Front Genet 2021 9;12:663110. Epub 2021 Apr 9.

Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

It is reported that microRNAs (miRNA) have paramount functions in many cellular biological processes, development, metabolism, differentiation, survival, proliferation, and apoptosis included, some of which are involved in metastasis of tumors, such as melanoma. Here, three metastasis-associated miRNAs, miR-18a-5p (upregulated), miR-155-5p (downregulated), and miR-93-5p (upregulated), were identified from a total of 63 different expression miRNAs (DEMs) in metastatic melanoma compared with primary melanoma. We predicted 262 target genes of miR-18a-5p, 904 miR-155-5p target genes, and 1220 miR-93-5p target genes. Read More

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Profiling changes in microRNAs of immature dendritic cells differentiated from human monocytes.

Cent Eur J Immunol 2021 18;46(1):10-16. Epub 2021 Apr 18.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

MicroRNAs (miRNAs) critically impact a wide array of eukaryotic developmental and physiologic processes through post-transcriptional gene silencing. In this study, we employed miRNA array and investigated in vitro the miRNA profile of immature dendritic cells (iDCs) derived from monocytes isolated from human venous blood. Our results showed that there were 379 miRNAs which were detectable in both monocytes and iDCs among the 856 miRNAs assayed, of which 155 miRNAs were detectable in monocytes while 224 miRNAs were detectable in iDCs. Read More

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Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis.

Int J Hematol 2021 Apr 24. Epub 2021 Apr 24.

Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti Paramedical School, Shahid Beheshti University of Medical Sciences, Darband St, Tehran, Iran.

The involvement of microRNAs in the regulation of hematopoietic stem cells paves the way for their use in the management of autologous HSC transplantation (AHSCT). We aimed to evaluate the predictive value of circulatory microRNAs in extracellular vesicles (EVs) and plasma in platelet and neutrophil engraftment. Circulatory miR-125b, mir-126, miR-150, and miR-155 expression was assessed in isolated EVs and plasma in samples collected from AHSCT candidates. Read More

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Acute and post-acute phase of COVID-19: Analyzing expression patterns of miRNA-29a-3p, 146a-3p, 155-5p, and let-7b-3p in PBMC.

Int Immunopharmacol 2021 Apr 6;97:107641. Epub 2021 Apr 6.

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: When a new pathogen, such as severe acute respiratory syndrome coronavirus 2, appears all novel information can aid in the process of monitoring and in the diagnosis of the coronavirus disease (COVID-19). The aim of the current study is to elucidate the specific miRNA profile which can act as new biomarkers for distinguishing acute COVID-19 disease from the healthy group and those in the post-acute phase of the COVID-19 disease.

Methods: The expression level of selected miRNAs including let-7b-3p, miR-29a-3p, miR-146a-3p and miR-155-5p were evaluated in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients, in both the acute and post-acute COVID-19 phase of the disease and healthy groups, by real-time PCR assays. Read More

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Tumor-associated macrophages secret exosomal miR-155 and miR-196a-5p to promote metastasis of non-small-cell lung cancer.

Transl Lung Cancer Res 2021 Mar;10(3):1338-1354

Department of Thoracic Surgery, Jiangsu Province People's Hospital and the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Understanding the molecular basis underlying metastasis of non-small cell lung cancer (NSCLC) may provide a new therapeutic modality for the treatment of NSCLC. However, the mechanisms by which tumor-associated macrophages (TAMs) affect NSCLC metastasis remain undefined. In this study, we aimed to discover a novel regulatory pathway involved in NSCLC metastasis. Read More

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Determination of the key ccRCC-related molecules from monolayer network to three-layer network.

Cancer Genet 2021 Apr 19;256-257:40-47. Epub 2021 Apr 19.

School of Science, Jiangnan University, Wuxi, Jiangsu 214122, PR China; Laboratory of Media Design and Software Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China.

Clear cell renal cell carcinoma (ccRCC), with an increasing incidence rate, is one of the ubiquitous cancers. Its pathogenic factors are complicated and the molecular mechanism is not clear. It is essential to analyze the potential key genes related to ccRCC carcinogenesis. Read More

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MicroRNAs Expression Induces Apoptosis of Macrophages in Response to (MRHO/IR/75/ER): An In-Vitro and In-Vivo Study.

Iran J Parasitol 2020 Oct-Dec;15(4):475-487

Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: We aimed to investigate the effect of miR-15a mimic and inhibitor of miR-155 expression on apoptosis induction in macrophages infected with Iranian strain of in-vitro and in-vivo.

Methods: RAW 264.7 cells were infected with promastigotes (MRHO/IR/75/ER), and then were treated with miRNAs. Read More

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miR-155-5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway.

Noncoding RNA Res 2021 Jun 8;6(2):59-69. Epub 2021 Mar 8.

Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved in foam cell atherosclerosis (CD36, Vav3, and SOCS1). A total number of three hundred and sixty-seven miRNAs were recognized and only miR-155-5p was selected for further evaluation based on Venn analysis. Read More

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