281 results match your criteria mir-129-5p


Exosomes derived from miR-129-5p modified bone marrow mesenchymal stem cells represses ventricular remolding of mice with myocardial infarction.

J Tissue Eng Regen Med 2021 Nov 23. Epub 2021 Nov 23.

Department of cardiology, Shijiazhuang People's Hospital, 5 Fangbei Road, Shijiazhuang, Hebei, 050011, China.

Background: Myocardial infraction (MI) is a severe disease with great mortality. Mesenchymal stem cells (MSCs)-derived exosomes display protection against MI. MicroRNA-129-5p was reported to exert anti-inflammation activity by targeting high mobility group box 1 (HMGB1). Read More

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November 2021

Lack of miRNA-17 family mediates high glucose-induced PAR-1 upregulation in glomerular mesangial cells.

Naunyn Schmiedebergs Arch Pharmacol 2021 Nov 18. Epub 2021 Nov 18.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, No. 209, Tongshan Road, Xuzhou, 221004, Jiangsu, China.

Upregulation of thrombin receptor protease-activated receptor 1 (PAR-1) is verified to contribute to chronic kidney diseases, including diabetic nephropathy; however, the mechanisms are still unclear. In this study, we investigated the effect of PAR-1 on high glucose-induced proliferation of human glomerular mesangial cells (HMCs), and explored the mechanism of PAR-1 upregulation from alteration of microRNAs. We found that high glucose stimulated proliferation of the mesangial cells whereas PAR-1 inhibition with vorapaxar attenuated the cell proliferation. Read More

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November 2021

A miR-129-5P/ARID3A Negative Feedback Loop Modulates Diffuse Large B Cell Lymphoma Progression and Immune Evasion Through Regulating the PD-1/PD-L1 Checkpoint.

Front Cell Dev Biol 2021 27;9:735855. Epub 2021 Oct 27.

Fujian Provincial Key Laboratory on Hematology, Fujian Medical Center of Hematology, Fujian Institute of Hematology, Clinical Research Center for Hematological Malignancies of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.

The activated B cell (ABC) and germinal center B cell (GCB) subtypes of diffuse large B cell lymphoma (DLBCL) have different gene expression profiles and clinical outcomes, and miRNAs have been reported to play important roles in tumorigenesis, progression, and metastasis. This study aimed to explore the differentially expressed miRNAs and target genes in the two main subtypes of DLBCL. Hub miRNAs were identified by constructing a regulatory network, and experiments and peripheral blood samples of DLBCL were used to explore the functions and mechanisms of differential miRNAs and mRNAs. Read More

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October 2021

Human Bone Marrow Mesenchymal Stromal Cell-Derived Extracellular Vesicles Promote Proliferation of Degenerated Nucleus Pulposus Cells and the Synthesis of Extracellular Matrix Through the SOX4/Wnt/β-Catenin Axis.

Front Physiol 2021 28;12:723220. Epub 2021 Oct 28.

Department of Spinal Surgery, Dalian Municipal Central Hospital, Dalian, China.

Intervertebral disk degeneration (IDD) is a major cause of pain in the back, neck, and radiculus. Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) are therapeutic in musculoskeletal degenerative diseases such as IDD. This study explored the effect and functional mechanism of human bone MSCs (hBMSCs)-derived EVs in proliferation and apoptosis of degenerated nucleus pulposus cells (DNPCs) and extracellular matrix (ECM) synthesis. Read More

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October 2021

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer.

Cell Death Dis 2021 11 2;12(11):1043. Epub 2021 Nov 2.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.

Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and progression in bladder cancer. Read More

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November 2021

Relationship of the Levels of microRNA Gene Methylation with the Level of Their Expression and Pathomorphological Characteristics of Breast Cancer.

Bull Exp Biol Med 2021 Oct 27;171(6):764-769. Epub 2021 Oct 27.

Research Institute of General Pathology and Pathophysiology, Moscow, Russia.

We studied the relationship of the levels of microRNA group expression and methylation with clinical and pathomorphological parameters of breast cancer and its immunohistochemical status. Quantitative methylation specific PCR analysis showed a significant (p<0.001) increase in the methylation level of 4 microRNA genes (MIR127, MIR129-2, MIR132, and MIR148A) and a significant (p<0. Read More

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October 2021

Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization.

J Immunol Res 2021 15;2021:5857214. Epub 2021 Oct 15.

Department of Clinical Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. Up to now, the detailed function of FGD5-AS1 in cervical cancer and its underlying molecular mechanisms remain uninvestigated. Read More

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October 2021

EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p.

J Gene Med 2021 Oct 19:e3395. Epub 2021 Oct 19.

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P. R. China.

Background: This study was designed to verify whether enhancer of zeste homolog 2 (EZH2) affects intervertebral disc degeneration (IVDD) development through regulation of microRNA (miR)-129-5p/MAPK1.

Methods: Initially, we collected lumbar nucleus pulposus (NP) tissue samples from patients with juvenile idiopathic scoliosis (n = 14) and IVDD (n = 34). We measured the expression of related genes in clinical IVDD tissues and a lipopolysaccharide (LPS)-induced NP cell model. Read More

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October 2021

Pancreatic Cancer Progression Is Regulated by IPO7/p53/LncRNA MALAT1/MiR-129-5p Positive Feedback Loop.

Front Cell Dev Biol 2021 1;9:630262. Epub 2021 Oct 1.

Department of Gastroenterology, Affiliated Hainan Hospital, Hainan Medical University, Hainan General Hospital, Hainan, China.

Pancreatic cancer is a malignancy with poor prognosis. Importin 7 (IPO7) is a soluble nuclear transport factor, which has been linked to the pathogenesis of several human diseases. However, its role and underlying mechanism in pancreatic cancer are still obscure. Read More

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October 2021

Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver Disease.

Horm Metab Res 2021 Oct 15;53(10):692-698. Epub 2021 Sep 15.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital,Tongji University School of Medicine, Shanghai, China.

This study was to evaluate the expression of miR-129-5p in non-alcoholic fatty liver (NAFLD) patients and its clinical value and explore its regulatory effect on insulin resistance (IR). A total of 117 NAFLD patients and 110 healthy controls were included. The levels of miR-129-5p were detected by qRT-PCR. Read More

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October 2021

The role of miR-129-5p in cancer: a novel therapeutic target.

Curr Mol Pharmacol 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China),College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001. China.

MiRNA-129-5p belongs to the microRNA-129 (miRNA-129) family. MiRNA-129-5p is expressed in many tissues and organs of the human body, and it regulates a wide range of biological functions. The abnormal expression of miRNA-129-5p is related to the occurrence and development of a variety of malignant tumors. Read More

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September 2021

Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma.

Bioengineered 2021 12;12(1):6579-6593

Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.

We aimed to identify novel circular RNAs (circRNAs) as prognostic competing endogenous RNAs (ceRNAs) to serve as genetic biomarkers and therapeutic targets for renal cell carcinoma (RCC). High-throughput sequencing data of circRNAs from Gene Expression Omnibus (GEO) and of microRNAs (miRNAs) and messenger RNAs (mRNAs) from The Cancer Genome Atlas (TCGA) were retrieved to identify differentially expressed RNAs (DERNAs). DEmRNAs were subjected to weighted gene coexpression network analysis (WGCNA) to identify prognostic DEmRNA (proDEmRNA) modules. Read More

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December 2021

Clinical significance of serum miR-129-5p in patients with diabetes mellitus presenting macrovascular complications.

World J Diabetes 2021 Aug;12(8):1282-1291

Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Background: Diabetic macrovascular complications (DMCs) are the most common complications encountered during the course of diabetes mellitus (DM) with extremely high mortality rates. Therefore, there is an urgent need to identify specific and sensitive biomarkers for the early diagnosis of DMCs.

Aim: To investigate the expression and significance of serum miR-129-5p in patients with DM and macrovascular complications. Read More

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MiR-129-5p prevents depressive-like behaviors by targeting MAPK1 to suppress inflammation.

Exp Brain Res 2021 Nov 4;239(11):3359-3370. Epub 2021 Sep 4.

The Third Department of Psychiatry, Huai'an No. 3 People's Hospital, 272 Huaihai West Road, Huaian, Jiangsu, China.

Depression is a complex etiological disease with limited effective treatments. Previous studies have indicated the involvement of miRNAs in the pathophysiology of mood disorders. In this study, we focused on the role and mechanisms of miR-129-5p in depression by successfully constructing mice models of depressive-like behavior via chronic unpredictable mild stress (CUMS) exposure. Read More

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November 2021

MicroRNA expression in animal models of amyotrophic lateral sclerosis and potential therapeutic approaches.

Neural Regen Res 2022 Apr;17(4):728-740

Department of Anatomy, University of Otago, Dunedin, New Zealand.

A review of recent animal models of amyotrophic lateral sclerosis showed a large number of miRNAs had altered levels of expression in the brain and spinal cord, motor neurons of spinal cord and brainstem, and hypoglossal, facial, and red motor nuclei and were mostly upregulated. Among the miRNAs found to be upregulated in two of the studies were miR-21, miR-155, miR-125b, miR-146a, miR-124, miR-9, and miR-19b, while those downregulated in two of the studies included miR-146a, miR-29, miR-9, and miR-125b. A change of direction in miRNA expression occurred in some tissues when compared (e. Read More

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MiR-129-5p/DLX1 signalling axis mediates functions of prostate cancer during malignant progression.

Andrologia 2021 Dec 1;53(11):e14230. Epub 2021 Sep 1.

Department of Urology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China.

We mainly corroborated the potential mechanism of DLX1 and miR-129-5p in prostate cancer cells. DLX1 was upregulated in cancer cells according to qRT-PCR assay. We evaluated the functional changes of the transfected cells via Transwell assay, CCK-8 assay and wound healing assay. Read More

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December 2021

Inhibiting miR-129-5p alleviates inflammation and modulates autophagy by targeting ATG14 in fungal keratitis.

Exp Eye Res 2021 10 17;211:108731. Epub 2021 Aug 17.

From the Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China. Electronic address:

To investigate the role of miR-129-5p in inflammation and autophagy in fungal keratitis, we established a keratitis mouse model infected with Fusarium solani (F. solani) and conducted experiments on corneal stromal cells infected with F. solani. Read More

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October 2021

Aerobic exercise modulates noncoding RNA network upstream of FNDC5 in the Gastrocnemius muscle of high-fat-diet-induced obese mice.

J Physiol Biochem 2021 Nov 18;77(4):589-600. Epub 2021 Aug 18.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

The purpose of the study was to determine the influence of aerobic exercise with a fat-rich diet on ncRNAs expression associated with FNDC5 in the Gastrocnemius muscle of the obese mice. Twenty-five male mice were grouped into two categories of normal diet (ND) and high-fat diet (HF) treatments for three months. For the subsequent treatment, HF-fed animals (obese) were proceeded in four groups: HF-Trained (n = 5), HF-Untrained (n = 5), ND-Trained (n = 5), and ND-Untrained (n = 5). Read More

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November 2021

microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.

J Tissue Eng 2021 Jan-Dec;12:20417314211021679. Epub 2021 Jul 29.

Department of Spine Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China.

Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been reported to deliver exogenous microRNAs (miRNAs or miRs) to reduce the progression of intervertebral disc degeneration (IDD). The purpose of the current study was to investigate the therapeutic potential of MSC-derived EVs delivering miR-129-5p in IDD. First, miR-129-5p expression levels were quantified in nucleus pulposus (NP) tissues of IDD patients. Read More

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miR-129-5p Ameliorates Ischemic Brain Injury by Binding to SIAH1 and Activating the mTOR Signaling Pathway.

J Mol Neurosci 2021 Sep 5;71(9):1761-1771. Epub 2021 Aug 5.

Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun, 130000, P. R. China.

Aberrant expression of microRNAs (miRNAs) has been linked with ischemic brain injury (IBI), but the mechanistic actions behind the associated miRNAs remain to be determined. Of note, miR-129-5p was revealed to be downregulated in the serum of patients with IBI. In silico prediction identified a putative target gene, siah E3 ubiquitin protein ligase 1 (SIAH1), of miR-129-5p. Read More

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September 2021

miR-129-5p Promotes Osteogenic Differentiation of BMSCs and Bone Regeneration via Repressing Dkk3.

Stem Cells Int 2021 15;2021:7435605. Epub 2021 Jul 15.

Department of Orthodontics, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Objective: Accumulating evidence indicates that microRNAs (miRNAs) play crucial roles in osteogenic differentiation. However, the associated mechanisms remain elusive. This paper is aimed at exploring the role of miR-129-5p in regulating bone marrow mesenchymal stem cell (BMSC) differentiation and bone regeneration in vivo and in vitro. Read More

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functions as a key mediator of to promote osteogenic differentiation of renal interstitial fibroblasts.

Epigenomics 2021 Aug 30;13(15):1171-1186. Epub 2021 Jul 30.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

To clarify the mechanism of , an aberrantly upregulated lncRNA in Randall's plaques (RP) similar to biomineralization, in mediating osteogenic differentiation of human renal interstitial fibroblasts. A comprehensive strategy of bioinformatic analysis and experimental verification was performed. silence abolished the osteogenic differentiation of human renal interstitial fibroblasts promoted by . Read More

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LncRNA PCGEM1 mediates oxaliplatin resistance in hepatocellular carcinoma via miR-129-5p/ETV1 axis in vitro.

Adv Clin Exp Med 2021 Aug;30(8):831-838

Department Of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Hepatocellular carcinoma (HCC) is one of the most severe malignant cancers that leads to high death rate worldwide. Recent research revealed that long non-coding RNAs (lncRNAs) exert a critical role regarding chemoresistance in numerous cancers, including HCC.

Objectives: Our research aimed to explore the function and molecular mechanism of lncRNA PCGEM1 on oxaliplatin resistance of HCC in vitro. Read More

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Dysregulated lncRNA TUG1 in different pulmonary artery cells under hypoxia.

Ann Transl Med 2021 May;9(10):879

Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.

Background: At present, the role of lncRNAs in the pathogenesis of hypoxia-induced pulmonary hypertension (HPH) is not fully understood. This study aimed to explore differences in the hypoxia-induced expression of lncRNAs and their potential role in multiple pulmonary artery cells.

Methods: LncRNA expression in pulmonary artery smooth muscle cells (PASMCs), pulmonary microvascular endothelial cells (PMECs), and pericytes (PCs) was analyzed by high-throughput sequencing and compared between normoxic and hypoxic cells. Read More

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MiR equal than others: MicroRNA enhancement for cutaneous wound healing.

Authors:
Kehinde Ross

J Cell Physiol 2021 Jun 23. Epub 2021 Jun 23.

School of Pharmacy and Biomolecular Science, Liverpool John Moores University, Liverpool, England, UK.

Keratinocyte migration is vital in the re-epithelialisation of the skin during wound healing. Multiple factors conspire to impair closure of chronic wounds such as diabetic foot ulcers, venous leg ulcers and pressure wounds. Despite deep mechanistic understanding of microRNA (miRNA) biogenesis and function, the translational potential of these small genetic molecules has not been exploited to promote wound repair. Read More

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Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2.

Cell Biol Toxicol 2021 Jun 16. Epub 2021 Jun 16.

Department of Neurosurgery, Union Hospital of Tongji Medical College Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Jianghan District, Wuhan, 430022, Hubei, China.

Objective: Long non-coding RNAs (lncRNAs) and miRNAs (miRNAs) participate in tumors, while the effects of lncRNA OIP5 antisense RNA 1 (OIP5-AS1) and miR-129-5p on glioblastoma (GBM) remain to be further studied. We aim to explore the role of OIP5-AS1/miR-129-5p/insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) axis in GBM progression.

Methods: OIP5-AS1, miR-129-5p and IGF2BP2 expression in tissues was determined. Read More

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miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4.

Biochem Biophys Res Commun 2021 08 10;566:87-93. Epub 2021 Jun 10.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Diabetes mellitus (DM) influence induces poor osseointegration. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is a critical factor in successful dental implants. Certain microRNAs play important roles during bone development, and others are deregulated in diabetes. Read More

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BRAF/EZH2 Signaling Represses miR-129-5p Inhibition of SOX4 Thereby Modulating BRAFi Resistance in Melanoma.

Cancers (Basel) 2021 May 15;13(10). Epub 2021 May 15.

Department of Dermatology and Venereology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany.

Many melanomas are associated with activating BRAF mutation. Targeted therapies by inhibitors of BRAF and MEK (BRAFi, MEKi) show marked antitumor response, but become limited by drug resistance. The mechanisms for this are not fully revealed, but include miRNA. Read More

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Withdrawn: 'Circular RNA PTGR1 regulates 5-FU resistance and development of hepatocellular carcinoma cells by modulating miR-129-5p/ABCC1 axis' by, Xiuxiu Li, and Ti Zhang.

Authors:

Cell Biol Int 2021 Nov 12;45(11):2391. Epub 2021 Oct 12.

The above article from Cell Biology International, published online as Accepted Article on May 18, 2021, in Wiley Online Library (https://doi.org/10.1002/cbin. Read More

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November 2021

miR-129-5p inhibits clear cell renal cell carcinoma cell proliferation, migration and invasion by targeting SPN.

Cancer Cell Int 2021 May 17;21(1):263. Epub 2021 May 17.

Department of Urology, Tangshan Central Hospital, East of Guangming Road, South of Longfu South Road, West of Youyi Road West Auxiliary Road, North of Changning Road, Tangshan, 063000, China.

Objective: Our study aims to investigate the mechanism of the miR-129-5p/SPN axis in clear cell renal cell carcinoma (ccRCC), providing a novel direction for the targeted therapy of ccRCC.

Methods: Bioinformatics methods were implemented to find the differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed to detect miR-129-5p and SPN mRNA expression, while western bot was carried out for the detection of protein expression of SPN. Read More

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