5,370 results match your criteria mir‑922

Gross alpha activity in urban sediments as an important indicator of urban environmental processes on the example of three Russian cities.

J Environ Manage 2021 Jun 8;294:113011. Epub 2021 Jun 8.

Zavaritsky Institute of Geology and Geochemistry UB RAS, 15 Akademika Vonsovskogo Str., Ekaterinburg, 620016, Russia.

The protection of the urban environment from radioactive wastes (including technologically enhanced natural radionuclides) and potentially harmful elements have recently become very critical. Thus, the present study aimed to assess the radioactive levels in low-volume samples of dust and fine sand fractions of the urban surface deposited sediments (USDS) collected in three Russian cities. The detection was conducted via CR-39 and LR-115 type II solid-state nuclear track detectors (SSNTDs) have been used to detect gross alpha activity concentrations. Read More

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Benzimidazoazapurines: Design, Synthesis, and Photophysical Study.

J Org Chem 2021 Jun 7. Epub 2021 Jun 7.

Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia.

A highly efficient approach to a new class of polycyclic 8-azapurines, benzo[4,5]imidazo[1,2-][1,2,3]triazolo[4,5-]pyrimidines (BITPs), with good photophysical characteristics is proposed. The approach comprises condensation of aminobenzimidazoles with 3-oxo-2-phenylazopropionitrile to form 3-(arylazo)benzo[4,5]imidazo[1,2-]pyrimidine-4-amines, which undergo oxidative cyclization by the catalytic action of copper(II) acetate, resulting in BITPs with 73-84% yield. Spectral investigations demonstrated the fluorescent properties of BITPs, exhibiting good quantum yields (up to 60%) with maxima absorption at 379-399 and emission at 471-505 nm. Read More

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Effective Doses and Radiation Risks From Common Dental Radiographic, Panoramic and CBCT Examinations.

I Shatskiy

Radiat Prot Dosimetry 2021 Jun 4. Epub 2021 Jun 4.

Laboratory of radiation hygiene of medical facilities, St-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Mira st. 8, St-Petersburg 197101, Russia.

This study was aimed at the estimation of the effective doses and radiation risks from dental X-ray examinations based on the data collection in St. Petersburg and the Leningrad Region. The range of mean values of effective doses for intraoral examinations on the X-ray units with film detectors was from 3. Read More

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Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units.

BMJ Open 2021 06 3;11(6):e046909. Epub 2021 Jun 3.

Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Dusseldorf, Dusseldorf, Germany

Objectives: In Europe, there is a distinction between two different healthcare organisation systems, the tax-based healthcare system (THS) and the social health insurance system (SHI). Our aim was to investigate whether the characteristics, treatment and mortality of older, critically ill patients in the intensive care unit (ICU) differed between THS and SHI.

Setting: ICUs in 16 European countries. Read More

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Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast .

Antibiotics (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Centro de Química Estrutural (CQE), Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

Currently there is a gap between the rate of new antifungal development and the emergence of resistance among clinical strains, particularly threatened by the extreme adhesiveness of to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OCHN(CH)NCHO}] (compound P) and [{Ag(OCHNCHCH-p)}(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of and clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by and colonize the surface of indwelling medical devices, resulting in persistent infections. Read More

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A Family of Ethyl -Salicylideneglycinate Dyes Stabilized by Intramolecular Hydrogen Bonding: Photophysical Properties and Computational Study.

Molecules 2021 May 23;26(11). Epub 2021 May 23.

Institute of Chemistry, University of Tyumen, Volodarskogo Str. 6, 625003 Tyumen, Russia.

In this work we report solvatochromic and luminescent properties of ethyl -salicylideneglycinate (), ethyl -(5-methoxysalicylidene)glycinate (), ethyl -(5-bromosalicylidene)glycinate (), and ethyl -(5-nitrosalicylidene)glycinate () dyes. - correspond to a class of -salicylidene aniline derivatives, whose photophysical properties are dictated by the intramolecular proton transfer between the OH-function and the imine N-atom, affording tautomerization between the enol-imine and keto-enamine forms. Photophysical properties of - were studied in different pure non-polar and (a)protic polar solvents as well as upon gradual addition of NEt, NaOH, and CHSOH. Read More

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Solvent-Induced Formation of Novel Ni(II) Complexes Derived from Bis-Thiosemicarbazone Ligand: An Insight from Experimental and Theoretical Investigations.

Int J Mol Sci 2021 May 19;22(10). Epub 2021 May 19.

Institute of Chemistry, University of Tyumen, Volodarskogo Str. 6, 625003 Tyumen, Russia.

In this work, we report solvent-induced complexation properties of a new NS tetradentate bis-thiosemicarbazone ligand (), prepared by the condensation of 4-phenylthiosemicarbazide with bis-aldehyde, namely 2,2'-(ethane-1,2-diylbis(oxy)dibenzaldehyde, towards nickel(II). Using ethanol as a reaction medium allowed the isolation of a discrete mononuclear homoleptic complex (), for which its crystal structure contains three independent molecules, namely , and , in the asymmetric unit. The doubly deprotonated ligand in the structure of is coordinated in a cis-manner through the azomethine nitrogen atoms and the thiocarbonyl sulfur atoms. Read More

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Quantifying the Charge Carrier Interaction in Metallic Twisted Bilayer Graphene Superlattices.

Nanomaterials (Basel) 2021 May 15;11(5). Epub 2021 May 15.

M. N. Mikheev Institute of Metal Physics, Ural Branch, Russian Academy of Sciences, 18, S. Kovalevskoy St., 620108 Ekaterinburg, Russia.

The mechanism of charge carrier interaction in twisted bilayer graphene (TBG) remains an unresolved problem, where some researchers proposed the dominance of the electron-phonon interaction, while the others showed evidence for electron-electron or electron-magnon interactions. Here we propose to resolve this problem by generalizing the Bloch-Grüneisen equation and using it for the analysis of the temperature dependent resistivity in TBG. It is a well-established theoretical result that the Bloch-Grüneisen equation power-law exponent, p, exhibits exact integer values for certain mechanisms. Read More

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U.S. trainees' experiences of ethical challenges during research in low- and middle-income countries: A mixed methods study.

Glob Public Health 2021 Jun 1:1-17. Epub 2021 Jun 1.

Yale School of Public Health, New Haven, CT, USA.

High-income country (HIC) trainees are participating in research in low- and middle-income countries (LMIC) in increasing numbers, yet the ethical challenges they face have not been well described. We conducted a mixed methods study of U.S. Read More

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The correlation of estrogen receptor 1 and progesterone receptor genes polymorphisms with recurrent pregnancy loss in a cohort of Egyptian women.

Mol Biol Rep 2021 Jun 1. Epub 2021 Jun 1.

Human Genetics and Genome Research Division, Prenatal and Fetal Medicine Department, National Research Centre, Cairo, Egypt.

Recurrent pregnancy loss (RPL) represents one of the pregnancy complications affecting 1-3% of women. Sex hormones, progesterone and estrogen play a critical role in the maintenance of pregnancy; they are mediated by estrogen receptor 1 (ESR1) and progesterone receptor (PR) genes respectively. Polymorphisms of (ESR1) and (PR) genes are linked to RPL. Read More

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Synthesis, structure, and antiviral properties of novel 2-adamantyl-5-aryl-2-tetrazoles.

Chem Heterocycl Compd (N Y) 2021 May 26:1-6. Epub 2021 May 26.

Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia.

The reaction of 5-aryl--tetrazoles with adamantan-1-ol in concentrated sulfuric acid proceeds regioselectively with the formation of the corresponding 2-adamantyl-5-aryl-2-tetrazoles. Nitration of these compounds leads to 2-(adamantan-1-yl)-5-(3-nitroaryl)-2tetrazoles. The structures and composition of the obtained novel 2-adamantyl-5-aryltetrazoles were proven by IR spectroscopy, H and C NMR spectroscopy, high-resolution mass spectrometry, and also by X-ray structural analysis. Read More

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Regulation of hippocampal postnatal and adult neurogenesis by adenosine A receptor: Interaction with brain-derived neurotrophic factor.

Stem Cells 2021 May 27. Epub 2021 May 27.

Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Adenosine A receptor (A R) activation modulates several brain processes, ranging from neuronal maturation to synaptic plasticity. Most of these actions occur through the modulation of the actions of the neurotrophin brain-derived neurotrophic factor (BDNF). In this work we studied the role of A Rs in regulating postnatal and adult neurogenesis in the rat hippocampal dentate gyrus (DG). Read More

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Management of complex retinal detachment from intraocular invasion of MIRAgel-a case report.

Am J Ophthalmol Case Rep 2021 Sep 14;23:101103. Epub 2021 May 14.

Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.

Purpose: To retrospectively report a case of complex retinal detachment secondary to an intraocular episcleral hydrogel explant (MIRAgel, MIRA Inc., Waltham, MA, USA) invasion.

Observations: The severe vitreous inflammation, shifting nature of the subretinal fluid, and absence of proliferative vitreopathy 2 months following multiple surgeries for removal of fragmented MIRA gel in the present case made the diagnosis of complex retinal detachment. Read More

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September 2021

Pyrimido[1,2-]benzimidazoles: synthesis and perspective of their pharmacological use.

Chem Heterocycl Compd (N Y) 2021 May 15:1-27. Epub 2021 May 15.

Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.

The review presents data on the synthesis as well as studies of biological activity of new derivatives of pyrimido[1,2-]benzimidazoles published over the last decade. The bibliography of the review includes 136 sources. Read More

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Unique collaboration of modern medicine and traditional faith-healing for the treatment of mental illness: Best practice from Gujarat.

J Family Med Prim Care 2021 Jan 30;10(1):521-526. Epub 2021 Jan 30.

Indian Institute of Public Health, Gandhinagar, Gujarat, India.

Background And Aims: Modern psychiatry brings tremendous value to the treatment of mental illness, however, at times is inadequate in providing holistic care within a patient's broader cultural framework. Traditional healing and modern psychiatry together offer a comprehensive, patient-centred approach to treatment, which encompass a patient's spiritual and religious beliefs. In this context, "Dava-Dua" intervention-combination of psychiatric medicine and faith healing-is implemented by the Government of Gujarat at Mira Data Dargah in Mehsana District. Read More

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January 2021

Saving time in the radiotherapy procedures for COVID-19 pneumonia treatment. A single-institution experience.

Clin Transl Oncol 2021 May 19. Epub 2021 May 19.

Radiation Oncology Department, Hospital Universitari Arnau de Vilanova, Av. Alcalde Rovira Roure, 80, 25198, Lleida, Spain.

Background: The use of low dose radiotherapy (LD-RT) for the treatment of COVID-19 pneumonia is supported by biological rationale for its immunomodulatory effect. Some institutions have started to treat these patients showing encouraging results. To shorten procedure times is crucial for the comfort of symptomatic patients receiving respiratory support and to optimize institutional facilities. Read More

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Avoidable Adverse Events Related to Ignoring the Do-Not-Do Recommendations: A Retrospective Cohort Study Conducted in the Spanish Primary Care Setting.

J Patient Saf 2021 Apr 7. Epub 2021 Apr 7.

From the Health District Alicante-Sant Joan, Alicante Miguel Hernández University, Elche Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Sant Joan d'Alacant Patient Safety Observatory, Andalusian Agency for Health Care Quality, Seville Family and Community Medicine, "La Jota" Health Centre, Zaragoza I Sector, Aragonese Health Service (SALUD) University of Zaragoza, Aragon Health Research Institute (IISA), Zaragoza Agency for Health Quality and Assessment of Catalonia (AQuAS), Barcelona Hospital Clínico San Carlos, Madrid Health Service, Madrid Healthcare Effectiveness and Safety Service, Navarre Health Service-Osasunbidea Institute of Public Health and Labour of Navarre, Pamplona Preventive Medicine Service, Hospital Universitario Ramón y Cajal Institute Ramón y Cajal for Health Research (IRYCIS), Madrid, Spain.

Objective: This study aimed to measure the frequency and severity of avoidable adverse events (AAEs) related to ignoring do-not-do recommendations (DNDs) in primary care.

Methods: A retrospective cohort study analyzing the frequency and severity of AAEs related to ignoring DNDs (7 from family medicine and 3 from pediatrics) was conducted in Spain. Data were randomly extracted from computerized electronic medical records by a total of 20 general practitioners and 5 pediatricians acting as reviewers; data between February 2018 and September 2019 were analyzed. Read More

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Biological activity and synthesis of 5,6-dihydroxyindole-2-carboxylic acid - biosynthetic precursor of melanins (microreview).

Chem Heterocycl Compd (N Y) 2021 May 14:1-3. Epub 2021 May 14.

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St, Yekaterinburg, 620108 Russia.

The microreview considers the biological activity and methods of obtaining natural melanin pigments and their biosynthetic precursor 5,6-dihydroxyindole-2-carboxylic acid. The key methods for the synthesis of 5,6-dihydroxyindole-2-carboxylic acid, published over the past 8 years (2012-2020), are presented. Read More

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Antiviral Agents - Benzazine Derivatives.

Chem Heterocycl Compd (N Y) 2021 May 14:1-9. Epub 2021 May 14.

Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.

The review outlines the results of studies of the antiviral activity of quinoline, quinoxaline, and quinazoline derivatives published over the past 5 years. The supplied data indicate the enormous potential of benzazines for the design of effective antiviral drugs. Read More

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Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines.

Chem Heterocycl Compd (N Y) 2021 May 14:1-7. Epub 2021 May 14.

Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia.

Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine. Read More

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Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-][1,2,4]Triazin-4-ols.

Chem Heterocycl Compd (N Y) 2021 May 12:1-6. Epub 2021 May 12.

Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.

An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Supplementary Information: The online version contains supplementary material available at 10.1007/s10593-021-02926-2. Read More

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Antiviral drug Triazavirin, selectively labeled with H, C, and N stable isotopes. Synthesis and properties.

Chem Heterocycl Compd (N Y) 2021 May 12:1-4. Epub 2021 May 12.

Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002 Russia.

Isotope-labeled antiviral drug Triazavirin containing H, C, and N atoms in its structure has been synthesized. CHI and KSCN served as donors of C isotopes. The use of С-MeI containing H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. Read More

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Borderline Changes in Renal Transplantation: Are We Aware of the Real Impact in Graft Survival?

Transplant Proc 2021 May 13. Epub 2021 May 13.

Nephrology Department, Coimbra Hospital and University Centre, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Background: Borderline changes suspicious for acute T-cell-mediated rejection (BC) are frequently seen on biopsy specimens, but their clinical significance and clinical management are still controversial. Our goal was to compare clinical outcomes of kidney transplant recipients with biopsy-proven BC vs acute T-cell-mediated rejection (aTCMR) and the influence of treating BC on graft outcomes.

Methods: A retrospective cohort study was performed in all kidney transplant recipients with biopsy-proven BC and aTCMR between January 2012 and December 2018, according to Banff 2017 criteria; patients with concomitant antibody-mediated rejection were excluded. Read More

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Firibastat: A Novel Brain Aminopeptidase Inhibitor - A New Era of Antihypertensive therapy.

Curr Probl Cardiol 2021 Apr 3:100859. Epub 2021 Apr 3.

Lehigh Valley Heart Institute, Lehigh Valley Health Network, Allentown, PA.

Global incidence and prevalence of hypertension continues to increase and remains a significant challenge. The ever-increasing number of cases are due to comorbid conditions such as obesity and diabetes, as well as lifestyle indiscretions such as excessive salt intake. Hypertension, congestive heart failure, and kidney disease are all conditions resulting from abnormal Renin-Angiotensin-Aldosterone activation and adverse remodeling. Read More

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Estimation of the Effective Doses from Typical Fluoroscopic Examinations with Barium Contrast.

Radiat Prot Dosimetry 2021 May 15. Epub 2021 May 15.

Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Inga-Marie Nilssons gata 49, Malmö 205 02, Sweden.

The current study aimed to estimate the effective doses and conversion coefficients (CCs) for typical barium swallow (BS), barium meal (BM) and barium enema (BE) protocols and to evaluate the impact of different examination parameters on the resulting CCs. Data were collected in surgical and therapy departments in St. Petersburg Urban Mariinsky Hospital. Read More

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The impact of memory effect on space fractional strong quantum couplers with tunable decay behavior and its numerical simulation.

Sci Rep 2021 May 13;11(1):10275. Epub 2021 May 13.

Dean's Office of the Faculty of Medicine and Health Sciences, Ghent University, C. Heymanslaan 10, Ghent, 9000, Belgium.

The nontrivial behavior of wave packets in the space fractional coupled nonlinear Schrödinger equation has received considerable theoretical attention. The difficulty comes from the fact that the Riesz fractional derivative is inherently a prehistorical operator. In contrast, nonlinear Schrödinger equation with both time and space nonlocal operators, which is the cornerstone in the modeling of a new type of fractional quantum couplers, is still in high demand of attention. Read More

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Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.

Arch Virol 2021 Jul 13;166(7):1965-1976. Epub 2021 May 13.

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.

A series of compounds containing a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment were evaluated for their antiviral activity against influenza A virus strain A/Puerto Rico/8/34 (H1N1) in vitro. Read More

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Impact of early low-calorie low-protein versus standard-calorie standard-protein feeding on outcomes of ventilated adults with shock: design and conduct of a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3).

BMJ Open 2021 05 11;11(5):e045041. Epub 2021 May 11.

Service de Médecine Intensive Réanimation, Centre Hospitalier de Valenciennes, Valenciennes, France.

Introduction: International guidelines include early nutritional support (≤48 hour after admission), 20-25 kcal/kg/day, and 1.2-2 g/kg/day protein at the acute phase of critical illness. Recent data challenge the appropriateness of providing standard amounts of calories and protein during acute critical illness. Read More

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Facial Vegetating Lesions in a Patient With Kidney Failure.

JAMA Dermatol 2021 Jun;157(6):725-726

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal.

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