AJNR Am J Neuroradiol 2020 10 27;41(10):1809-1815. Epub 2020 Aug 27.
From the Department of Neurology (T.Y., Y.Y., H.J., T.H., H.T., F.S., J.L.S., D.S.L.), David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Background And Purpose: When mapping the ischemic core and penumbra in patients with acute ischemic stroke using perfusion imaging, the core is currently delineated by applying the same threshold value for relative CBF at all time points from onset to imaging. We investigated whether the degree of perfusion abnormality and optimal perfusion parameter thresholds for defining ischemic core vary with time from onset to imaging.
Materials And Methods: In a prospectively maintained registry, consecutive patients were analyzed who had ICA or M1 occlusion, baseline perfusion and diffusion MR imaging, treatment with IV tPA and/or endovascular thrombectomy, and a witnessed, well-documented time of onset. Read More