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Intraocular Pressure Variations after Intravitreal Injections Measured with an Implanted Suprachoroidal Telemetry Sensor.

J Glaucoma 2021 May 12. Epub 2021 May 12.

Glaucoma Research Center, Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland Department of Ophthalmology, University of Colorado School of Medicine, Denver, CO, USA.

Purpose: Intravitreal injections (IVI) may create transient intraocular pressure (IOP) elevation. This report describes continuous IOP fluctuations following multiple IVI measured with a permanent implantable sensor.

Patient And Methods: We report the case of a 49-year-old Caucasian glaucomatous male with refractory macular edema secondary to central retinal vein occlusion in his left eye who underwent deep sclerectomy combined with the implantation of a suprachoroidal tonometry sensor. Read More

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Measurement of the conformational switching of azobenzenes from the macro- to attomolar scale in self-assembled 2D and 3D nanostructures.

Phys Chem Chem Phys 2021 May 12. Epub 2021 May 12.

Institute of Organic Synthesis and Photoreactivity (ISOF) - (CNR), via Gobetti 101, 40129 Bologna, Italy. and Department of Industrial and Materials Science, Chalmers University of Technology, Hörsalvägen 7, 41296 Gothenburg, Sweden.

It is important, but challenging, to measure the (photo)induced switching of molecules in different chemical environments, from solution through thin layers to solid bulk crystals. We compare the cis-trans conformational switching of commercial azobenzene molecules in different liquid and solid environments: polar solutions, liquid polymers, 2D nanostructures and 3D crystals. We achieve this goal by using complementary techniques: optical absorption spectroscopy, femtosecond transient absorption spectroscopy, Kelvin probe force microscopy and reflectance spectroscopy, supported by density functional theory calculations. Read More

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Laparoendoscopic single-site simultaneous bilateral nephrectomy: first reported case series.

Cent European J Urol 2021 15;74(1):44-47. Epub 2021 Jan 15.

Clinic Institute of Nephrology and Urology (ICNU), Universidad de Barcelona, Barcelona, Spain.

Bilateral renal tumors in patients on dialysis are usually managed with bilateral nephrectomy. With traditional laparoscopy, this procedure requires the insertion of multiple trocars. Laparoendoscopic single-site surgery (LESS) uses a single umbilical incision to insert multiple instruments and is also employed for extraction of specimens. Read More

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January 2021

[A Case of Stage Ⅳ Cholangiocarcinoma with an Improved Quality of Life after Resection of a Symptomatic Giant Ovarian Teratoma].

Gan To Kagaku Ryoho 2021 Apr;48(4):557-559

Dept. of Surgery, Takaoka City Hospital.

An 82‒year‒old female presented to our hospital with abdominal fullness and loss of appetite. Abdominal computed tomography revealed a cholangiocarcinoma(Stage Ⅳ)with liver metastases and multiple lymph node metastases. In addition, we found a left ovarian teratoma(approximately 33 cm in diameter)occupying most of the abdominal cavity. Read More

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Unilateral Pulmonary Edema After Robotically Assisted Mitral Valve Repair Requiring Veno-Venous Extracorporeal Membrane Oxygenation.

J Cardiothorac Vasc Anesth 2021 Apr 5. Epub 2021 Apr 5.

Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL. Electronic address:

Unilateral pulmonary edema (UPE) is an uncommon yet potentially life-threatening complication of minimally invasive cardiac surgery (MICS). Most frequently described after robotically assisted mitral valve (MV) repair, it is characterized by right lung edema, hypoxemia, hypercapnia, pulmonary hypertension, and hemodynamic instability beginning minutes-to-hours after separation from cardiopulmonary bypass (CPB). The authors describe a severe case with refractory hypoxemia requiring veno-venous (VV) extracorporeal membrane oxygenation (ECMO) after robotically assisted MV repair. Read More

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Application of a new hyperbaric oxygen therapy protocol in patients with arterial and venous gas embolism due to hydrogen peroxide poisoning.

Undersea Hyperb Med 2021 Second Quarter;48(2):187-193

Department of Emergency Medicine and Research Institute of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Hydrogen peroxide (H2O2) ingestion can cause vascular gas embolism (GE). Hyperbaric oxygen therapy (HBO2) is known to improve neurological abnormalities in patients with arterial gas embolism (AGE). Previously, HBO2 based on the U. Read More

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Bringing Down the Door-to-needle Time: Patient Thrombolysed in 6 Minutes-A Case Report.

Perm J 2021 May;25

Introduction: It has been clearly established that thrombolysis using recombinant tissue plasminogen activator is strongly beneficial for acute stroke patients. The sensitivity of brain tissue to ischemia causes this time dependence on the effectiveness of recombinant tissue plasminogen activator. Early recognition of stroke and activation of a stroke alert/code are imperative to treat acute stroke patients effectively and to realize positive outcomes. Read More

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Comparison of Ultrasonic Dissection and Suture Ligation for Mesoappendix in Laparoscopic Appendectomy.

Cureus 2021 Apr 6;13(4):e14316. Epub 2021 Apr 6.

Surgery, Rawalpindi Medical University, Rawalpindi, PAK.

Objective To compare the use of ultrasonic dissector and suture ligation for mesoappendix in laparoscopic appendectomy in terms of mean operative time and per-operative bleed. Methodology This was a randomized controlled trial conducted at Surgical Unit II, Holy Family Hospital over a period of six months. All patients with the diagnosis of acute appendicitis who presented in the emergency department of Holy Family Hospital on the call days of Surgical Unit II undergoing laparoscopic appendectomy were included in the study. Read More

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Optimization for Locating Emergency Medical Service Facilities: A Case Study for Health Planning from China.

Risk Manag Healthc Policy 2021 30;14:1791-1802. Epub 2021 Apr 30.

HEOA Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Purpose: Rational location of emergency medical service (EMS) facilities could improve access to EMS, and thus assist in saving patients' lives and improving their health outcomes. A considerable amount of spatial optimization research has been devoted to the development of models to support location planning in the context of EMS, with extensive applications in policy making around the world. However, in China, studies on the location of EMS facilities have not been paid enough attention to, let alone their practical applications. Read More

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Clinical Implementation of Second-generation Minimally Invasive Image-guided Cochlear Implantation Surgery.

Otol Neurotol 2021 Jun;42(5):702-705

Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee.

Objective: Minimally invasive, image-guided cochlear implantation (CI) surgery consists of drilling a precise tunnel from the surface of the mastoid cortex through the facial recess to target the scala tympani. In the first set of clinical trials of this technique, heat-induced facial nerve paresis (House-Brackmann II/VI) occurred on a patient on the last day of the initial trial which was scheduled to be halted secondary to a change in the regulatory requirements dictated by the 2012 the Food and Drug Administration Safety and Innovation Act requiring Investigational Device Exemption approval for previously exempted customized medical device testing. To address this adverse event, extensive changes were made to the drilling protocol; additionally, a custom insertion tool was developed. Read More

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Evaluation of quality of life in individuals with chronic stroke who underwent aquatic exercises: A case series.

NeuroRehabilitation 2021 Apr 30. Epub 2021 Apr 30.

Laboratory of Biomechanics and Clinical Epidemiology, PAIFIT Research Group, Universidade Estadual de Londrina, Londrina, PR, Brazil.

Background: Aquatic exercises are among the treatments available to improve the quality of life after stroke.

Objectives: To investigate changes in the quality of life after 8-week of aquatic exercises in post-stroke individuals.

Methods: A case series study was designed, including four male participants. Read More

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Efficacy and Safety of Machine Perfusion for Brain Death Marginal Donor Kidney Transplantation: A Report of 2 Cases.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Department of Surgery, Nephrology Center, Toranomon Hospital Kajigaya, Tokyo, Japan.

Background: After the revised organ transplant law came into effect in Japan, donations of organs under brain death have been increasing; however, because of the expansion of donor indications, donations from expanded criteria donors and cardiac arrest donors (donation after cardiac death) have also increased. In kidney transplantation, ischemia-reperfusion injury results in a high rate of delayed graft function, which adversely affects patients' long-term prognoses. Hypothermic machine perfusion preservation results in superior postoperative function and survival rates compared with cold storage preservation. Read More

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High light-induced photoinhibition is not limiting seedling establishment at abrupt treeline ecotones in New Zealand.

Tree Physiol 2021 May 7. Epub 2021 May 7.

School of Science, Auckland University of Technology, 46 Wakefield St, Auckland, 1010, New Zealand.

•Seedlings of New Zealand's treeline forming Fuscospora cliffortioides (Hook.f.) perform poorly beyond the established canopy, limiting treeline advance. Read More

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The Efficacy of Intraoperative Fluorescent Imaging Using Indocyanine Green for Cholangiography During Cholecystectomy and Hepatectomy.

Clin Exp Gastroenterol 2021 30;14:145-154. Epub 2021 Apr 30.

Division of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa University, Tokyo, Japan.

Purpose: Bile duct injury is one of the most serious complications of laparoscopic cholecystectomy. Intraoperative indocyanine green (ICG) cholangiography is a safe and useful navigation modality for confirming the biliary anatomy. ICG cholangiography is expected to be a routine method for helping avoid bile duct injuries. Read More

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Transradial Neuroendovascular Procedures in Adolescents: Initial Single-Center Experience.

AJNR Am J Neuroradiol 2021 May 6. Epub 2021 May 6.

From the Divisions of Neuroradiology and Image-Guided Therapy (H.A., A.A.D., S.B., V.R., N.S., P.M.), Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Background And Purpose: The feasibility and safety of transradial angiography is not established outside the adult literature. The objective of this study was to assess the feasibility and safety of transradial access for neuroangiography in adolescents.

Materials And Methods: A retrospective case-control study was performed, comparing transradial neuroendovascular procedures in adolescents (age range, 10-18 years) with an age- and procedure-matched cohort of transfemoral neuroendovascular procedures. Read More

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High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Yale School of Medicine, New Haven, Connecticut; Northwestern University Feinberg School of Medicine, Northwestern University, and Northwestern Memorial Hospital, Chicago, Illinois; and the University of California, San Francisco, San Francisco, California.

Objective: To evaluate whether a high-dose oxytocin regimen reduces the risk for primary cesarean birth and other obstetric morbidities when compared with standard dosing.

Methods: In a double-blind randomized clinical trial of nulliparous women at or beyond 36 weeks of gestation who were undergoing augmentation of labor, participants were assigned to high-dose (initial and incremental rates of 6 milliunits/min) or standard-dose (initial and incremental rates of 2 milliunits/min) oxytocin regimens. The primary outcome was cesarean birth. Read More

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Radiation exposure associated with percutaneous fluoroscopically guided lag screw fixation for sacroiliac luxation in dogs.

Vet Surg 2021 May 6. Epub 2021 May 6.

Iowa State University College of Veterinary Medicine, Ames, Iowa, United States.

Objective: To determine radiation exposure to surgical personnel and to evaluate the accuracy of a modified percutaneous lag screw fixation technique for sacroiliac luxation (SIL) under fluoroscopic guidance in dogs.

Study Design: Cadaveric experimental study.

Sample Population: Seventeen beagle cadavers with iatrogenic SIL. Read More

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Prospective Comparison of Moderate Conscious Sedation and Anesthesia Assistance for the Performance of Endoscopic Retrograde Cholangiopancreatography (ERCP).

Can J Gastroenterol Hepatol 2021 13;2021:8892085. Epub 2021 Apr 13.

Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.

Objectives: Recent trends have favored the use of anesthesia personnel more frequently for advanced endoscopic procedures. We hypothesize a selective sedation approach based on patient and procedural factors using either moderate conscious sedation (MCS) or general anesthesia (GA) will result in similar outcomes and safety with significant cost savings.

Methods: A 12-month prospective study of all adult endoscopic retrograde cholangiopancreatography (ERCPs) performed at a tertiary medical center was enrolled. Read More

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An Exploratory Study of a 3-Minute Mindfulness Intervention on Compassion Fatigue in Nurses.

Holist Nurs Pract 2020 Sep-Oct 01;34(5):274-281

Case Western Reserve University, Cleveland, Ohio (Drs Owens, Alfes, and Fitzpatrick); and Weill Cornell Medicine, New York City, New York (Drs Evans and Wyka).

This study shows that breathing mindfully for 3 minutes over a period of 4 weeks, positively affects compassion fatigue in nurses. A nonrandomized, pre/postintervention study was conducted using a 3-minute attentional breathing intervention. Thirty-two nurses participated over 4 weeks. Read More

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Virtual surgical planning and cone beam computed tomography in reconstruction of head and neck tumors - pilot study.

Otolaryngol Pol 2020 Aug;75(2):28-33

Department of Oncologic and Reconstructive Surgery, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.

<b>Introduction:</b> The aim of the study was to prove that a combination of visual surgical planning (VSP) and cone beam computed tomography (CBCT) is an optimal technique in fibular free flap reconstructions after complex tumor resections in the head and neck region and that it leads to better functional and aesthetic outcomes. <br><b>Material and method:</b> Six patients (3 females, 3 males) with head and neck tumors were included in the study. The region concerned midface in 2 cases and mandible in 4 patients. Read More

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Intraoperative neurophysiological monitoring of T9-T10 fracture in a patient with morbid obesity and ankylosing spondylitis: A case report with literature review.

Clin Neurophysiol Pract 2021 26;6:115-122. Epub 2021 Mar 26.

Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Introduction: As the prevalence of obesity continues to rise, there is a growing need to identify practices that protect overweight patients from injury during spine surgery. Intraoperative neurophysiological monitoring (IONM) has been recommended for complex spine surgery, but its use in obese and morbidly obese patients is understudied.

Case Report: This case report describes a patient with morbid obesity and ankylosing spondylitis who was treated for a T9-T10 3-column fracture with a planned, minimally invasive approach. Read More

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Spinal cord infarction. A case report and narrative review.

Acta Biomed 2021 Apr 30;92(S1):e2021080. Epub 2021 Apr 30.

Emergency Department, University Hospital of Parma, Italy.

Spinal cord infarction is a rare but severe disorder, consistently less frequent than ischemic brain injury. It constitutes only 1-2% of all neurological vascular emergencies. Here we describe a case of spinal cord infarction in a 68-year-old Caucasian man without any neurological problem in his clinical history. Read More

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The Largest Uterine Leiomyoma Removed by Robotic-Assisted Laparoscopy in the Late Reproductive Age: A Case Report.

J Menopausal Med 2021 Apr;27(1):37-41

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Uterine leiomyoma is a very common gynecological tumor in the reproductive years. Recent studies have shown that surgical treatment of uterine leiomyoma using robotic-assisted laparoscopic myomectomy (RALM) is associated with significantly fewer complications, lower estimated blood loss, fewer conversions, and less bleeding than conventional laparoscopic myomectomy. This study reports the case of a giant uterine leiomyoma treated using RALM. Read More

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Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation.

J Am Heart Assoc 2021 May 3:e016676. Epub 2021 May 3.

Department of Emergency Medicine and The Heart and Vascular Research Center MetroHealth Campus Case Western Reserve University Cleveland OH.

Background Amiodarone is administered during resuscitation, but its antiarrhythmic effects during targeted temperature management are unknown. The purpose of this study was to determine the effect of both therapeutic hypothermia and amiodarone on arrhythmia substrates during resuscitation from cardiac arrest. Methods and Results We utilized 2 complementary models: (1) In vitro no-flow global ischemia canine left ventricular transmural wedge preparation. Read More

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Methods for Large-Scale Quantitative Analysis of Scribe Impacts on Clinical Documentation.

AMIA Annu Symp Proc 2020 25;2020:573-582. Epub 2021 Jan 25.

Department of Medical Informatics and Clinical Epidemiology.

Many medical providers employ scribes to manage electronic health record (EHR) documentation. Prior studies have shown the benefits of scribes, but no large-scale study has quantitively assessed scribe impact on documentation workflows. We propose methods that leverage EHR data for identifying scribe presence during an office visit, measuring provider documentation time, and determining how notes are edited and composed. Read More

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January 2021

Adhesion barriers and topical hemostatic agents are risk factors for post-cesarean section infections.

Surgery 2021 Apr 28. Epub 2021 Apr 28.

Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Cesarean sections are the most common surgery worldwide, and post-cesarean section infections and hemorrhage are a major cause for morbidity and mortality. In recent years, many surgeons use adhesion barriers as well as hemostatic agents during primary and repeated cesarean section. The data regarding the safety of these agents is relatively limited. Read More

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Acute Cardiac Tamponade: A Case of Life-Threatening Coronavirus Disease 2019 Complication During Air Medical Transportation.

Air Med J 2021 May-Jun;40(3):179-181. Epub 2021 Jan 28.

Aerospace and Sub-Aquatic Medical Faculty, Aja University of Medical Sciences, Tehran, Iran. Electronic address:

A 42-year-old man with coronavirus disease 2019 pneumonia was admitted to a small town hospital that did not have intensive care unit (ICU)-level resources available. Twelve hours later, the patient suddenly became agitated, and an extensive anterolateral ST-elevation myocardial infarction was detected by 12-lead electrocardiography and supported by a rise in serum cardiac enzymes. Low blood oxygen saturation (59%) and cardiac ejection fraction (ejection fraction = 20%) reflected criticality that could potentially require a catheterization laboratory, coronary artery bypass graft surgery, and ICU-level resources. Read More

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January 2021

Dynamics of Selected Serum Immunological Markers During Caesarean Section.


Neuro Endocrinol Lett 2021 Mar 2;42(1). Epub 2021 Mar 2.

Objectives: The presented study aimed to describe the dynamics of the serum levels of the complement components C3, C4, and C1 inhibitor in women immediately before and after giving birth by caesarean section (CS).

Design And Setting: 57 pregnant women undergoing caesarean section were included in this prospective observational study. Blood samples were taken 30 minutes before CS and 30 minutes after the delivery. Read More

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