547 results match your criteria minute qrs

Gestational Age and Neonatal Electrocardiograms.

Pediatrics 2021 Nov 24. Epub 2021 Nov 24.

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Interpretation of the neonatal electrocardiogram (ECG) is challenging due to the profound changes of the cardiovascular system in this period. We aimed to investigate the impact of gestational age (GA) on the neonatal ECG and create GA-specific reference values.

Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of neonates. Read More

View Article and Full-Text PDF
November 2021

Comparison of efficacy and safety of His-Purkinje system pacing versus cardiac resynchronisation therapy in patients with pacing-induced cardiomyopathy: protocol for a randomised controlled trial.

BMJ Open 2021 08 2;11(8):e045302. Epub 2021 Aug 2.

Beijing An Zhen Hospital, Chaoyang-qu, China

Introduction: Recent studies have shown that the His-Purkinje system pacing (HPSP) can achieve electrocardiomechanical synchronisation, and thus improve cardiac function. For patients with pacing-induced cardiomyopathy (PICM) who should be treated with pacemaker upgrade, the HPSP is a viable alternative to cardiac resynchronisation therapy (CRT). However, no randomised controlled trial has been performed to evaluate the efficacy and safety of HPSP in patients with PICM. Read More

View Article and Full-Text PDF

Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6-lead mobile ECG device and a standard 12-lead ECG.

Ann Noninvasive Electrocardiol 2021 11 19;26(6):e12872. Epub 2021 Jul 19.

Windland Smith Rice Comprehensive Sudden Cardiac Death Program, Divisions of Heart Rhythm Services and Pediatric Cardiology, Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

Background: Interval duration measurements (IDMs) were compared between standard 12-lead electrocardiograms (ECGs) and 6-lead ECGs recorded with AliveCor's KardiaMobile 6L, a hand-held mobile device designed for use by patients at home.

Methods: Electrocardiograms were recorded within, on average, 15 min from 705 patients in Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic. Interpretable 12-lead and 6-lead recordings were available for 685 out of 705 (97%) eligible patients. Read More

View Article and Full-Text PDF
November 2021

Flecainide-induced QRS complex widening correlates with negative inotropy.

Heart Rhythm 2021 Aug 10;18(8):1416-1422. Epub 2021 Apr 10.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: The negative inotropic effect of Class IC antiarrhythmic drugs limits their use for acute cardioversion of atrial fibrillation (AF).

Objective: The purpose of this study was to examine, in an intact porcine model, the effects of pulmonary and intravenous (IV) administration of flecainide on left ventricular (LV) contractility and QRS complex width at doses that are effective in converting new-onset AF to sinus rhythm.

Methods: Flecainide (1. Read More

View Article and Full-Text PDF

Spatial distribution of physiologic 12-lead QRS complex.

Sci Rep 2021 02 22;11(1):4289. Epub 2021 Feb 22.

National Heart and Lung Institute, Imperial College, ICTEM, Hammersmith Campus, 72 Du Cane Road, Shepherd's Bush, London, W12 0NN, England.

The normal physiologic range of QRS complex duration spans between 80 and 125 ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. Read More

View Article and Full-Text PDF
February 2021

Relationship between atrial fibrillatory rate based on analysis of a modified base-apex surface electrocardiogram analysis and the results of transvenous electrical cardioversion in horses with spontaneous atrial fibrillation.

J Vet Cardiol 2021 Apr 11;34:73-79. Epub 2021 Jan 11.

Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

Objectives: To compare the atrial fibrillatory rate (AFR) derived from a local right atrial intracardiac recording (RA-FR) and from a single-lead surface electrocardiogram (ECG) during atrial fibrillation (AF) and to evaluate the correlation with transvenous electrical cardioversion (TVEC) threshold (in Joules), number of shocks and cardioversion success rate in horses.

Animals: ECGs and clinical records of horses with AF treated by TVEC. Horses were included if a simultaneous recording of the right atrial intracardiac electrogram and a modified base-apex ECG were available. Read More

View Article and Full-Text PDF

Associations between left bundle branch block with different PR intervals, QRS durations, heart rates and the risk of heart failure: a register-based cohort study using ECG data from the primary care setting.

Open Heart 2021 02;8(1)

Department of Clinical Epidemiology, Aalborg University Hospital, Aalborg, Denmark.

Aim: Left bundle branch block (LBBB) is associated with an increased risk of heart failure (HF). We assessed the impact of common ECG parameters on this association using large-scale data.

Methods And Results: Using ECGs recorded in a large primary care population from 2001 to 2011, we identified HF-naive patients with a first-time LBBB ECG. Read More

View Article and Full-Text PDF
February 2021

Extracorporeal Life Support as a Treatment of Supraventricular Tachycardia in a Newborn.

Pediatr Emerg Care 2021 Feb;37(2):e75-e76

From the Critical Care Medicine, National Center for Child Health and Development, Setagaya, Tokyo, Japan.

Abstract: Supraventricular tachycardia (SVT) is the most common symptomatic tachyarrhythmia in children and requires medical treatment. Thus far, there have been few reports of the use of extracorporeal life support (ECLS) to provide cardiac support in children with low cardiac output resulting from arrhythmia. We present a case of a newborn in whom ECLS was used to provide support for cardiogenic shock secondary to intractable SVT. Read More

View Article and Full-Text PDF
February 2021

Evaluation of Cardiac Repolarization in the Randomized Phase 2 Study of Intermediate- or High-Risk Smoldering Multiple Myeloma Patients Treated with Daratumumab Monotherapy.

Adv Ther 2021 02 20;38(2):1328-1341. Epub 2021 Jan 20.

University Clinic Heidelberg, Internal Medicine V and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Introduction: Daratumumab is a CD38-targeting monoclonal antibody that has demonstrated clinical benefit for multiple myeloma. Daratumumab inhibition of CD38, which is expressed on immune cell populations and cardiomyocytes, could potentially affect cardiac function. This QTc substudy of the phase 2 CENTAURUS study investigated the potential effect of intravenous daratumumab monotherapy on QTc prolongation and other electrocardiogram (ECG) parameters, including concentration-QTc effect modeling. Read More

View Article and Full-Text PDF
February 2021

[Modulation of cardiac contractility in patients with chronic heart failure and atrial fibrillation].

Ter Arkh 2020 Oct 14;92(9):8-14. Epub 2020 Oct 14.

National Medical Research Center for Cardiology.

Aim: to evaluate the effectiveness of cardiac contractility modulation (MSS) in patients with chronic heart failure (CHF) and atrial fibrillation (AF).

Materials And Methods: The following studies were performed in 40 patients with CHF and AF before implantation of the MSS device and after 2 and 6 months of follow-up: 12-channel ECG, transthoracic EchoCG, 6-minute walk test, determination of the level of Pro-natriuretic N-terminal peptide (NT-proBNP), daily ECG monitoring, and a questionnaire based on the Minnesota quality of life questionnaire for patients with CHF (MHFLQ). All patients received long-term optimal drug therapy for CHF before surgery. Read More

View Article and Full-Text PDF
October 2020

Completed atrioventricular block induced by atrial septal defect occluder unfolding: A case report.

World J Clin Cases 2020 Nov;8(22):5715-5721

Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu 610081, Sichuan Province, China.

Background: An atrial septal defect is a common condition and accounts for 25% of adult congenital heart diseases. Transcatheter occlusion is a widely used technique for the treatment of secondary aperture-type atrial septal defects (ASDs).

Case Summary: A 30-year-old female patient was diagnosed with ASD by transthoracic echocardiography (TTE) 1 year ago. Read More

View Article and Full-Text PDF
November 2020

Analysis of the recovery phase after maximal exercise in children with repaired tetralogy of Fallot and the relationship with ventricular function.

PLoS One 2020 18;15(12):e0244312. Epub 2020 Dec 18.

Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium.

Background: Few studies demonstrate delayed recovery after exercise in children and adults with heart disease. We assess the recovery patterns of gas exchange parameters and heart rate (HR) in children with repaired Tetralogy of Fallot (rToF) compared to healthy peers and investigate the correlation with ventricular function and QRS duration.

Methods: 45 children after rToF and 45 controls performed a maximal incremental cardiopulmonary exercise test. Read More

View Article and Full-Text PDF

[Drug-induced ventricular dissynchrony and tachycardiomyopathy in a newborn].

Medicina (B Aires) 2020 ;80(6):726-728

Servicio de Electrofisiología, Sanatorio Finochietto, Buenos Aires, Argentina. E-mail:

Ventricular dysfunction secondary to electrical and mechanical dyssynchrony in chronic right ventricular apical pacing is a well-recognized complication. There are no previous reports of pharmacologically induced dyssynchrony. A 10-day old infant with incessant supraventricular tachycardia was admitted to the neonatal intensive care unit. Read More

View Article and Full-Text PDF
December 2020

Beat-to-beat blood pressure variability in patients with obstructive sleep apnea.

J Clin Sleep Med 2021 03;17(3):381-392

UCLA School of Nursing, Los Angeles, California.

Study Objectives: Cardiovascular comorbidities in obstructive sleep apnea (OSA) are difficult to treat, perhaps due to autonomic dysfunction. We assessed beat-to-beat blood pressure (BP) variability (BPV) in OSA while considering other markers derived from electrocardiogram and continuous BP signals.

Methods: We studied 66 participants (33 participants with OSA: respiratory event index [mean ± SEM]: 21. Read More

View Article and Full-Text PDF

Mexiletine in Myotonic Dystrophy Type 1: A Randomized, Double-Blind, Placebo-Controlled Trial.

Neurology 2021 01 12;96(2):e228-e240. Epub 2020 Oct 12.

From the Department of Neurology (C.H., E.L., S.R., K.E., W.M., J.H., J.D., N.D., C.Z., R.T., G.S., C.A.B., J.F.R., W.Z., C.T., M.P.M., R.M.), University of Rochester, MN; Virginia Commonwealth University (N.J.), Richmond; and Wake Forest Baptist Health (A.P.), Winston-Salem, NC.

Objective: To assess mexiletine's long-term safety and effect on 6-minute walk distance in a well-defined cohort of patients with myotonic dystrophy type 1 (DM1).

Methods: We performed a randomized, double-blind, placebo-controlled trial of mexiletine (150 mg 3 times daily) to evaluate its efficacy and safety in a homogenous cohort of adult ambulatory patients with DM1. The primary outcome was change in 6-minute walk distance at 6 months. Read More

View Article and Full-Text PDF
January 2021

Efficacy and safety of left bundle branch area pacing versus biventricular pacing in heart failure patients with left bundle branch block: study protocol for a randomised controlled trial.

BMJ Open 2020 09 24;10(9):e036972. Epub 2020 Sep 24.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

Introduction: Left bundle branch area pacing (LBBaP) has been accepted as a physiological pacing method that can yield narrow paced QRS waves. For patients with failed biventricular pacing (Bi-V), LBBaP is another feasible option. However, no randomised controlled study has evaluated the efficacy and safety of LBBaP in heart failure patients with left bundle branch block (LBBB). Read More

View Article and Full-Text PDF
September 2020

[Application and efficacy of the adjustment on left ventricular electrical delay and the distance between right and left ventricular pacing polar in optimizing the left ventricular pacing polar].

Zhonghua Xin Xue Guan Bing Za Zhi 2020 Aug;48(8):669-674

Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110016, China.

To investigate the application and efficacy of left ventricular (LV) electrical delay (LVED) and the distance of right ventricular(RV) pacing polar to LV(DRLV) in optimizing LV pacing polar. Heart failure (HF) patients who implanted cardiac resynchronization therapy (CRT) device with a LV quadripolar lead from January 2014 to January 2018 at General Hospital of Northern Theater Command were enrolled in the study. Measurements of LVED and DRLV of each polar of the lead were performed in patients with HF who underwent CRT with LV quadripolar lead. Read More

View Article and Full-Text PDF

Successful treatment of neonatal atrial flutter by synchronized cardioversion: case report and literature review.

BMC Pediatr 2020 08 5;20(1):370. Epub 2020 Aug 5.

Department of Prenatal Cardiology, Department for Fetal Malformations Diagnoses & Prevention, Medical University of Lodz, Rzgowska 281/289, 93-338, Łódź, Poland.

Background: Atrial flutter (AFL) is a supraventricular tachyarrhythmia. In the ECG tracing, it is marked by a fast, irregular atrial activity of 280-500 beats per minute. AFL is known to be a rare and also life-threatening rhythm disorder both at the fetus and neonatal period. Read More

View Article and Full-Text PDF

A Retrospective Analysis of Hospital Electrocardiogram Auto-Populated QT Interval Calculation.

Cureus 2020 Jul 21;12(7):e9317. Epub 2020 Jul 21.

Internal Medicine, Cape Fear Valley Health System, Fayetteville, USA.

Background The current electrocardiogram (ECG) standard for rate correction of the QT interval (QTc) is a power function known as the Bazett formula (QTcB). QTc formulae are either power functions or linear functions. QTcB is known to lack reliability, as heart rate (HR) rises from or falls below 60 beats per minute (bpm). Read More

View Article and Full-Text PDF

Safety assessment of metarrestin in dogs: A clinical candidate targeting a subnuclear structure unique to metastatic cancer cells.

Regul Toxicol Pharmacol 2020 Oct 30;116:104716. Epub 2020 Jun 30.

National Center for Advancing Translational Sciences, NIH, Rockville, Maryland, USA. Electronic address:

Pancreatic cancer is a leading cause of cancer-related deaths in the U.S. Ninety percent of patients with stage IV pancreatic cancer die within one year of diagnosis due to complications of metastasis. Read More

View Article and Full-Text PDF
October 2020

A rare case of narrow QRS tachycardia with "hidden" concealed left-sided accessory pathway.

Herzschrittmacherther Elektrophysiol 2020 Sep 29;31(3):307-310. Epub 2020 Jun 29.

Department of Internal Medicine I, Sophien- and Hufeland-Hospital Weimar, Henry-van-de-Velde-Straße 2, 99425, Weimar, Germany.

A 54-year-old-woman with narrow QRS tachycardia (heart rate, 210 beats per minute) was admitted to the authors' hospital. Tachycardia terminated after administration of adenosine. The 12-lead electrocardiogram after conversion to sinus rhythm was unremarkable. Read More

View Article and Full-Text PDF
September 2020

Transient narrowing of a wide QRS tachycardia. What is the mechanism?

J Arrhythm 2020 Jun 24;36(3):542-543. Epub 2020 Mar 24.

Arrhythmia Unit Department of Cardiology Hospital Clínico Universitario Valencia Valencia Spain.

Electrocardiogram showing a regular wide QRS tachycardia with left branch block (LBBB) like in morphology at 200 beats per minute (bpm). During electrophysiology study, it suddenly gets narrow and faster. What is the mechanism of the switch from a broad complex to a narrow complex tachycardia? Read More

View Article and Full-Text PDF

Successful cryoablation of left ventricular summit premature ventricular contractions via the coronary sinus.

Pacing Clin Electrophysiol 2020 08 15;43(8):894-897. Epub 2020 Jun 15.

Banner-University Medical Center Phoenix and University of Arizona, Phoenix, Arizona.

The left ventricular summit (LVS) is a challenging location for catheter-based percutaneous ablation due to its anatomical location. There have been case reports of cryoablations performed in this region, but the technique may be underutilized when radiofrequency ablation fails. A 45-year-old male was found to have 25 000 premature ventricular contractions (PVCs) a day despite previous ablation and a reduced ejection fraction of 40% despite medical therapy. Read More

View Article and Full-Text PDF

Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish.

PLoS One 2020 13;15(5):e0232457. Epub 2020 May 13.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.

Because of its powerful genetics, the adult zebrafish has been increasingly used for studying cardiovascular diseases. Considering its heart rate of ~100 beats per minute at ambient temperature, which is very close to human, we assessed the use of this vertebrate animal for modeling heart rhythm disorders such as sinus arrest (SA) and sick sinus syndrome (SSS). We firstly optimized a protocol to measure electrocardiogram in adult zebrafish. Read More

View Article and Full-Text PDF

Network meta-analysis of His bundle, biventricular, or right ventricular pacing as a primary strategy for advanced atrioventricular conduction disease with normal or mildly reduced ejection fraction.

J Cardiovasc Electrophysiol 2020 06 20;31(6):1482-1492. Epub 2020 Apr 20.

Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida.

Introduction: Although right ventricular pacing (RVP) may impair ventricular function, it is commonly used for advanced atrioventricular block (AVB) and normal or mildly reduced ejection fraction (EF). We aimed to compare His bundle pacing (HBP), biventricular pacing (BiVP), and RVP for advanced AVB in patients with normal or mildly reduced EF.

Methods And Results: MEDLINE, Embase, Cochrane CENTRAL, ClinicalTrials. Read More

View Article and Full-Text PDF

Refractory Electrical Storm in the Absence of Structural Ischemic Heart Disease.

Cureus 2020 Feb 5;12(2):e6888. Epub 2020 Feb 5.

Cardiology, Corpus Christi Medical Center, Corpus Christi, USA.

Ventricular tachycardia (VT) is characterized as a ventricular rhythm with a QRS >120 milliseconds (ms) and >100 beats-per-minute (BPM) in the absence of an aberrant conduction. It is classified as sustained when lasting >30 seconds. Risk factors associated with the development of VT include increasing age and coronary artery disease with concurrent left ventricular dysfunction, other forms of structural heart disease and acquired or congenital abnormalities in the cardiac sodium, potassium or calcium channels. Read More

View Article and Full-Text PDF
February 2020

Cardiac resynchronization therapy in a case with single ventricle and concommitant noncompaction cardiomyopathy.

Turk Kardiyol Dern Ars 2020 03;48(2):167-170

Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

A 32-year-old male patient was admitted to the hospital with syncope. An electrocardiogram revealed complete atrioventricular (AV) block and a right bundle branch block with a QRS duration of 218 milliseconds. The heart rate was 40 beats/minute. Read More

View Article and Full-Text PDF

Diagnostic computed tomography in acute interscapular pain.

Heart 2020 01;106(2):126-163

Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

Clinical introductionA man in his 60s with no medical history presented with sudden-onset, severe interscapular pain. He was in circulatory shock with a blood pressure of 65/30 mm Hg, heart rate of 115 beats per minute, respiratory rate of 32 breaths per minute and a room air oxygen saturation of 89%. Examination demonstrated weak peripheral pulses, an elevated jugular venous pressure, faint dual heart sounds, no cardiac murmurs and bilateral lung crepitations. Read More

View Article and Full-Text PDF
January 2020