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Development and dosimetric assessment of an automatic dental artifact classification tool to guide artifact management techniques in a fully automated treatment planning workflow.

Comput Med Imaging Graph 2021 Mar 26;90:101907. Epub 2021 Mar 26.

The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX, USA; The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX, USA.

Purpose: We conducted our study to develop a tool capable of automatically detecting dental artifacts in a CT scan on a slice-by-slice basis and to assess the dosimetric impact of implementing the tool into the Radiation Planning Assistant (RPA), a web-based platform designed to fully automate the radiation therapy treatment planning process.

Methods: We developed an automatic dental artifact identification tool and assessed the dosimetric impact of its use in the RPA. Three users manually annotated 83,676 head-and-neck (HN) CT slices (549 patients). Read More

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To ban or not to ban tanning bed use for minors: A cost-effectiveness analysis from multiple US perspectives for invasive melanoma.

Cancer 2021 Apr 12. Epub 2021 Apr 12.

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Tanning bed use is common among US adolescents, but is associated with increased melanoma risk. The decision to ban tanning bed use by adolescents should be made in consideration of the potential health benefits and costs.

Methods: The US population aged 14 to 17 years was modeled by microsimulation, which compared ban versus no ban strategies. Read More

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Robotic-assisted parathyroidectomy via transaxillary approach: feasibility and learning curves.

Gland Surg 2021 Mar;10(3):953-960

Department of Otorhinolaryngology and Head and Neck Surgery, American Hospital of Paris, Paris, France.

Background: There have been few reports of robotic-assisted transaxillary parathyroidectomy in the literature. We aim to report our experience with robotic-assisted transaxillary parathyroidectomy for primary hyperparathyroidism (PHPT) in the Western population.

Methods: A retrospective study was performed from July 2010 through July 2019 at two institutions, one in the United States and one in France. Read More

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Relevance of Major Allergens in Weed Pollen Allergy.

Int Arch Allergy Immunol 2021 Apr 9:1-5. Epub 2021 Apr 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University of Munich, Munich, Germany.

Introduction: Weed pollen allergy is an important and in prevalence increasing cause of pollinosis in Europe and across the world. In this study we focus on the value of common diagnostic tools for detection of a sensitization to mugwort and English plantain, especially with regard to the clinical relevance of the sensitization.

Methods: Eighty weed pollen sensitized patients (41 to mugwort and 39 to English plantain) were assessed retrospectively regarding their clinical anamnesis, in-vivo tests (skin prick test [SPT] and allergen specific provocation) and in-vitro tests (immunoglobulin E [IgE] reactivity to purified natural allergen extract and specific allergen components in serum). Read More

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A case report of a rare nasopharyngeal myoepithelial dominant pleomorphic adenoma.

Int J Surg Case Rep 2021 Apr 1;82:105859. Epub 2021 Apr 1.

Department of Otolaryngology-Head & Neck Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Introduction: Pleomorphic adenoma is the most common benign salivary gland neoplasm. The majority of cases occur in the major salivary glands; however, they can also originate from the minor salivary glands. The nasopharynx is an uncommon site, but it has been reported in the literature. Read More

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Quality of life after hemifacial spasm surgery: French versions of the HFS-8 and HFS-30 questionnaires.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Apr 5. Epub 2021 Apr 5.

Service d'oto-rhino-laryngologie, GHU Pitié-Salpêtrière, Sorbonne Université, AP-HP, DMU ChIR, GRC robotique et innovation chirurgicale, Paris, France.

Objectives: The aim of the present study was to assess quality of life before and after surgery for hemifacial spasm, in order to validate two specific quality of life scales translated in French. Surgical results and complications were reported.

Material And Methods: Twenty-three patients with hemifacial spasm treated by microvascular decompression were retrospectively included. Read More

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Maxillomandibular advancement versus multilevel surgery for treatment of obstructive sleep apnea: A systematic review and meta-analysis.

Sleep Med Rev 2021 Mar 17;57:101471. Epub 2021 Mar 17.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC Location AMC and Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, the Netherlands.

Multilevel surgery (MLS) and maxillomandibular advancement surgery (MMA) are two established options in surgical management of obstructive sleep apnea (OSA), which target different levels of airway obstruction. The objective of this review was to comparatively evaluate the clinical efficacy and safety of MMA and MLS in the treatment of OSA. MEDLINE and Embase databases were searched for studies on MMA and/or MLS in OSA patients. Read More

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Human blood adenosine biomarkers and non-rapid eye movement sleep stage 3 (NREM3) cortical functional connectivity associations during a 30-day head-down-tilt bed rest analogue: Potential effectiveness of a reactive sledge jump as a countermeasure.

J Sleep Res 2021 Apr 7:e13323. Epub 2021 Apr 7.

Laboratory of Medical Physics, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

We investigated the alterations of sleep regulation and promotion biomarkers as adenosine through its enzymes total adenosine deaminase (tADA)/adenosine deaminase (ADA2) in a microgravity analogue environment of head-down-tilt bed rest and their association with brain connectivity networks during non-rapid eye movement sleep stage 3 (NREM3), as well as the effectiveness of the reactive sledge (RSL) jump countermeasure to promote sleep. A total of 23 healthy male volunteers were maintained in 6° head-down-tilt position for 30 days and assigned either to a control or to a RSL group. Blood collection and polysomnographic recordings were performed on data acquisition day 1, 14, 30 and -14, 21, respectively. Read More

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Experimental model for the study of traumatic brain injury.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):729-737

Department of Forensic Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Traumatic brain injury (TBI) represents a public healthcare problem and a major economic burden, all over the world. It is estimated that every year, on the globe, there occur about two million severe TBI and over 42 million mild TBI. The main causes of TBI in civil population are fallings, followed by car accidents. Read More

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Injuries in supercross - Evaluation of trauma during a two-day international indoor motocross event.

J Orthop 2021 Mar-Apr;24:233-238. Epub 2021 Mar 3.

Medical Center of Chemnitz, Department of Orthopaedics, Trauma and Hand Surgery, Flemmingstr. 2, 09116, Chemnitz, Germany.

Introduction: Supercross is characterized by fast and skillful movements, with high concentration being required on an indoor competition circuit, due to the demanding jumps and short distances to the next obstacle. The injuries can turn out to be diverse, including polytraumatization. This paper aims to evaluate the accidents and possible injuries in a single Supercross competition. Read More

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Laryngeal inhalational injuries: A systematic review.

Burns 2021 Feb 27. Epub 2021 Feb 27.

US Army Institute of Surgical Research, Joint Base San Antonio, Fort Sam Houston, TX, USA. Electronic address:

Laryngeal inhalation injury carries a significant increase in mortality rate and often indicates immediate airway evaluation. This may be difficult in the setting of clinical deterioration necessitating immediate intubation, which itself can synergistically cause mucosal damage. Prior studies do not encompass predictive factors or long-term outcomes for the laryngotracheal complex. Read More

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February 2021

The Use of Infrared Thermography to Develop and Assess a Wearable Sock and Monitor Foot Temperature in Diabetic Subjects.

Sensors (Basel) 2021 Mar 5;21(5). Epub 2021 Mar 5.

Department of Nursing, Centro Universitario de Plasencia, University of Extremadura, E10600 Plasencia, Spain.

One important health problem that could affect diabetics is diabetic foot syndrome, as risk of ulceration, neuropathy, ischemia and infection. Unnoticed minor injuries, subsequent infection and ulceration may end in a foot amputation. Preliminary studies have shown a relationship between increased skin temperature and asymmetries between the same regions of both feet. Read More

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Scapular Free Flap Reconstruction of Pharyngoesophageal Defects.

Clin Otolaryngol 2021 Apr 2. Epub 2021 Apr 2.

Medical University of South Carolina, Charleston, SC, USA.

Scapular and parascapular free tissue transfer (SFTT) is a well described reconstructive option for the head and neck. The aim of this study is to describe SFTT for reconstruction of PE (pharyngoesophagyeal) defects. This study was a retrospective review of patients undergoing SFTT for PE defects between 2009 and 2014 at a tertiary center. Read More

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Ambulatory Surgery vs Overnight Observation for Total Thyroidectomy: Cost Analysis and Outcomes.

OTO Open 2021 Jan-Mar;5(1):2473974X21995104. Epub 2021 Mar 10.

Department of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Objective: To compare financial impact between patients undergoing ambulatory (same-day discharge) vs overnight admission after total thyroidectomy while showing associated surgical outcomes.

Study Design: Retrospective review.

Setting: University of Alabama at Birmingham Medical Center from October 2011 and July 2017. Read More

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Motion-compensated noninvasive periodontal health monitoring using handheld and motor-based photoacoustic-ultrasound imaging systems.

Biomed Opt Express 2021 Mar 23;12(3):1543-1558. Epub 2021 Feb 23.

Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Simultaneous visualization of the teeth and periodontium is of significant clinical interest for image-based monitoring of periodontal health. We recently reported the application of a dual-modality photoacoustic-ultrasound (PA-US) imaging system for resolving periodontal anatomy and periodontal pocket depths in humans. This work utilized a linear array transducer attached to a stepper motor to generate 3D images via maximum intensity projection. Read More

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Accuracy of surface-guided patient setup for conventional radiotherapy of brain and nasopharynx cancer.

J Appl Clin Med Phys 2021 Mar 31. Epub 2021 Mar 31.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To evaluate the accuracy of surface-guided radiotherapy (SGRT) in cranial patient setup by direct comparison between optical surface imaging (OSI) and cone-beam computed tomography (CBCT), before applying SGRT-only setup for conventional radiotherapy of brain and nasopharynx cancer.

Methods And Materials: Using CBCT as reference, SGRT setup accuracy was examined based on 269 patients (415 treatments) treated with frameless cranial stereotactic radiosurgery (SRS) during 2018-2019. Patients were immobilized in customized head molds and open-face masks and monitored using OSI during treatment. Read More

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R1352Q Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report.

Case Rep Neurol 2021 Jan-Apr;13(1):123-130. Epub 2021 Feb 16.

Headache and Facial Pain Group, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Mutations in the gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head trauma and culminate in encephalopathy and cerebral oedema. A 37-year-old male without a family history of complex migraine experienced hemiplegic migraine attacks from childhood. Read More

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February 2021

Pediatric Malignant Mandibular Tumors: Personal Experience and Literature Options Discussion.

ORL J Otorhinolaryngol Relat Spec 2021 Mar 31:1-9. Epub 2021 Mar 31.

Maxillo-Facial Surgery Unit, AOU-Careggi, Florence, Italy.

Introduction: Mandibular defects reconstruction could result challenging in childhood, due to facial and mandibular growth patterns. For these reasons, the choice of the most suitable reconstructive option in pediatric patients, affected by mandibular malignancies, still objects of debate.

Objective: The aim of our study was to compare our reconstructive schedules to the existing literature in order to give a personal contribute to the present panorama. Read More

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Optimising Cancer Surgery During COVID-19: Experience of Tertiary Cancer Centre in Eastern India.

Indian J Gynecol Oncol 2021 26;19(2):29. Epub 2021 Mar 26.

Department of Head and Neck Oncology, AHPGIC, Cuttack, Odisha India.

Purpose: The timely management of cancer surgery suffered due to COVID-19 and nationwide lockdown. Continuing cancer surgery was a challenge faced by all. We present our experience on cancer surgery in a cancer centre with high volume of patients and limited resources during early pandemic. Read More

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QSM reconstruction challenge 2.0: Design and report of results.

Magn Reson Med 2021 Mar 30. Epub 2021 Mar 30.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.

Purpose: The aim of the second quantitative susceptibility mapping (QSM) reconstruction challenge (Oct 2019, Seoul, Korea) was to test the accuracy of QSM dipole inversion algorithms in simulated brain data.

Methods: A two-stage design was chosen for this challenge. The participants were provided with datasets of multi-echo gradient echo images synthesized from two realistic in silico head phantoms using an MR simulator. Read More

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Evolving resting head tremor in parkinsonism: Clinicopathological study of a case.

Parkinsonism Relat Disord 2021 Mar 13;86:1-4. Epub 2021 Mar 13.

Saskatchewan Movement Disorders Program, Saskatchewan Health Authority/University of Saskatchewan, Canada. Electronic address:

Introduction: Resting limb tremor (RLT) is a well known feature in parkinsonism. There is very little information on resting head tremor (RHT) in parkinsonism, and none in pathologically confirmed cases. The association between RLT and RHT remains uncertain. Read More

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Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA and MMB-4CN-BUTINACA using a combination of binding and different CB receptor activation assays PART II: Structure activity relationship assessment via a β-arrestin recruitment assay.

Drug Test Anal 2021 Mar 26. Epub 2021 Mar 26.

Laboratory of Toxicology Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Synthetic cannabinoid receptor agonists (SCRAs) are the second largest class of new psychoactive substances (NPS), and are associated with serious adverse effects and even death. Despite this, little pharmacological data are available for many of the most recent SCRAs. This study consists of three different parts, aiming to systematically evaluate a panel of 30 SCRAs using binding and different in vitro human cannabinoid 1 receptor (CB ) activation assays. Read More

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SARS-CoV-2 infection of the oral cavity and saliva.

Nat Med 2021 Mar 25. Epub 2021 Mar 25.

Division of Oral & Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets of the human minor salivary glands and gingiva (9 samples, 13,824 cells), identifying 50 cell clusters. Using integrated cell normalization and annotation, we classified 34 unique cell subpopulations between glands and gingiva. Read More

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Outcome of Adenoid Cystic Carcinoma of Head and Neck After Postoperative Intensity Modulation Radiotherapy: A Single Institution Study.

Cancer Manag Res 2021 15;13:2411-2417. Epub 2021 Mar 15.

Department of Radiation Oncology, Sichuan Cancer Hospital and Research Institute, Chengdu, People's Republic of China.

Objective: This study was retrospectively evaluated the outcome of postoperative intensity modulation radiotherapy (IMRT) for patients with adenoid cystic carcinoma of head and neck (ACCHN), and identified the unfavorable prognostic factors.

Methods: Fifty-five ACCHN patients treated in Sichuan Cancer Hospital between January 2007 and December 2016 were retrospectively evaluated. Median age of patient was 47 years (range, 21-73 years). Read More

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Morphology of immature stages and life cycle of Monotoma testacea Motschulsky (Coleoptera: Monotomidae).

Zootaxa 2021 Mar 5;4941(1):zootaxa.4941.1.3. Epub 2021 Mar 5.

Museum of Natural History, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland..

The egg, all three larval instars, and pupa are described for the cucujoid beetle species Monotoma (s. str.) testacea Motschulsky, which develops in decomposing plant matter. Read More

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Repeat CT after blunt head trauma and Glasgow Coma Scale score 13-15 without neurological deterioration is very low yield for intervention.

Eur J Trauma Emerg Surg 2021 Mar 23. Epub 2021 Mar 23.

Department of Emergency Medicine, Akdeniz University School of Medicine, Antalya, Turkey.

Purpose: Due to the increase in accessibility of computed tomography (CT), repeat head CT scans are routinely ordered for patients with minor head injuries. The aim of this study is to evaluate the necessity and outcomes of routine repeat head CT in patients with GCS score of 13-15 who presented to the emergency department (ED) of Antalya University Hospital in Turkey with blunt head trauma.

Methods: We retrospectively reviewed the charts of patients with minor head trauma that received initial and repeat head CT results from July 1, 2013 to June 30, 2015. Read More

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Czy infrascanner może być przydatny w szpitalnym oddziale ratunkowym do diagnostyki lekkich urazów głowy u dzieci?

J Mother Child 2021 Jan 29;21(1):51-59. Epub 2021 Jan 29.

Oddział Kliniczny Medycyny Ratunkowej dla Dzieci II Katedra Pediatrii UM w Łodzi Ośrodek Pediatryczny im. M. Konopnickiej, Centralny Szpital Kliniczny UM wŁodziPoland.

Cel: Ustalenie, czy badanie przy użyciu Infraskannera ułatwiłoby wykluczenie u dzieci po lekkim urazie głowy, ostrego krwawienia wewnątrzczaszkowego i tym samym pozwoliłoby ograniczyć liczbę wskazań do tomografii komputerowej.

MateriaŁ I Metody: Do badania zakwalifikowano 155 dzieci w wieku 2-18 lat, po lekkim lub średnio ciężkim urazie głowy. Dzieci te były ocenione wg skali Glasgow oraz badane przy użyciu Infrascannera. Read More

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January 2021

Household time activities, food waste, and diet quality: the impact of non-marginal changes due to COVID-19.

Rev Econ Househ 2021 Mar 13:1-30. Epub 2021 Mar 13.

Department of Agricultural Economics, Sociology, and Education, Pennsylvania State University, 208 Armsby, University Park, PA USA.

In early 2020, a novel coronavirus quickly spread across the globe. In response to the rapidly increasing number of confirmed U.S. Read More

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