250,394 results match your criteria minor groove

[Diagnosis and therapy of erysipelas: A position paper of the Society Initiative Chronische Wunde (ICW) e. V.]

Dtsch Med Wochenschr 2021 Jun 15;146(12):822-830. Epub 2021 Jun 15.

Klinik für Dermatologie, Venerologie, Allergologie, Universitätsklinik Essen, Essen.

Erysipelas is a bacterial soft tissue infection caused by β-haemolytic streptococci that spreads proximally along the lymphatic system of the skin. The entry sites of the pathogens can be minor injuries or chronic wounds. The diagnosis of erysipelas is made clinically by the spreading eythema and overheating of the skin, the reduced general condition with fever and chills as well as by means of serological inflammation parameters and must be distinguished from numerous differential diagnoses. Read More

View Article and Full-Text PDF

Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.

Urol Int 2021 Jun 15:1-8. Epub 2021 Jun 15.

Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Obesity is frequently present in patients suffering from end-stage renal disease (ESRD). However, overweight kidney transplant candidates are a challenge for the transplant surgeon. Obese patients tend to develop a large abdominal panniculus after weight loss creating an area predisposed to wound-healing disorders. Read More

View Article and Full-Text PDF

Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring.

J Affect Disord 2021 May 26;292:212-216. Epub 2021 May 26.

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States. Electronic address:

Background: Children of parents with posttraumatic stress (PTS) face heightened risk for developing emotional and behavioral problems, regardless of whether they experience a traumatic event themselves. The current study investigates whether child FKBP5, a stress relevant gene shown to interact with child trauma exposure to increase risk for PTS, also moderates the well-established link between maternal PTS and child symptoms.

Methods: Data are derived from a longitudinal lab-based study for which 205 dyads of trauma-exposed mothers and their preschool-age children from a sample enriched for violence exposure provided DNA samples and completed measures of maternal and child trauma-related symptoms. Read More

View Article and Full-Text PDF

Telehealth Sustainability in a Neurosurgery Department During the COVID-19 Pandemic.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Neurosurgery, University of Kentucky, 800 Rose St., Lexington, KY, 40508 USA; Brain Restoration Center, University of Kentucky, 800 Rose St., Lexington, KY, 40508 USA; Neuroscience, University of Kentucky, 800 Rose St., Lexington, KY, 40508 USA. Electronic address:

Background: The pandemic shifted the dynamics of healthcare and neurosurgical practice. Elective surgeries were suspended for 8 weeks in Kentucky. Our objective was to determine if telehealth (TH) visits could be sustained as an alternative to in-person visits. Read More

View Article and Full-Text PDF

Perioperative findings and complications in Essure® removal surgery.

Eur J Obstet Gynecol Reprod Biol 2021 May 25;263:1-6. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Maastricht University Medical Centre+, P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands. Electronic address:

Objective: To analyze perioperative findings and complications in surgical removal of Essure® microinserts.

Study Design: A prospective cohort study of 274 patients who underwent surgical removal of Essure® microinserts. Outcomes of the surgical procedures and complications were entered into a digital case report form (CRF) by the surgeon and registered in an online database. Read More

View Article and Full-Text PDF

Starting pitchers demonstrate a greater hazard of arm injury compared to relief pitchers.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

University of South Carolina Center for Rehabilitation and Reconstruction Sciences, Greenville, South Carolina, USA.

Context: It is currently unclear how different pitching roles affect arm injury risk in professional pitchers.

Objective: 1) Investigate the differences in arm injury hazard between professional baseball starting and relief pitchers; 2) Separately investigate elbow and shoulder injury hazard between professional baseball starting and relief pitchers.

Study Design: Prospective cohort Setting: Minor League Baseball (MiLB) from 2013-2019 Patients or Other Participants: Pitchers Main Outcome Measures: Pitchers were followed for the entire MiLB season and athletic exposures (AE's) and injuries were recorded. Read More

View Article and Full-Text PDF

Burnout in Mental Health Care Professionals Working with Inpatients in Open or Closed Wards in Psychiatric Hospitals.

Issues Ment Health Nurs 2021 Jun 15:1-8. Epub 2021 Jun 15.

Psychiatry, Aalborg University Hospital, Aalborg, Denmark.

Mental health care professionals are at risk of experiencing burnout. This cross-sectional study aims to investigate burnout in two settings: open and closed psychiatric wards, and two professions: registered nurses and social healthcare assistants in eight psychiatric wards in Denmark. A total of 114 professionals completed the Copenhagen Burnout Inventory and a demographic questionnaire. Read More

View Article and Full-Text PDF

Incidence of Complications from Percutaneous Biopsy in Chronic Liver Disease: A Systematic Review and Meta-Analysis.

Dig Dis Sci 2021 Jun 15. Epub 2021 Jun 15.

Global Liver Institute, Washington, USA.

Background: Approaches to liver biopsy have changed over the past decade in patients with chronic liver disease.

Aims: We conducted a systematic review and meta-analysis on the incidence of all complications and technical failure associated with percutaneous liver biopsy.

Methods: We systematically searched PubMed and the Cochrane Library for cohort studies reporting on complications resulting from liver biopsy published between 2010 and 2020. Read More

View Article and Full-Text PDF

Mapping QTL associated with partial resistance to Aphanomyces root rot in pea (Pisum sativum L.) using a 13.2 K SNP array and SSR markers.

Theor Appl Genet 2021 Jun 15. Epub 2021 Jun 15.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada.

Key Message: A stable and major QTL, which mapped to an approximately 20.0 cM region on pea chromosome 4, was identified as the most consistent region conferring partial resistance to Aphanomyces euteiches. Aphanomyces root rot (ARR), caused by Aphanomyces euteiches Drechs. Read More

View Article and Full-Text PDF

Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations.

Development 2021 Jun 15. Epub 2021 Jun 15.

Department of Human Genetics, McGill University, Montreal, QC, Canada.

5, 10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimutations to be passed to the next generation. Here, we assessed whether the impact of MTHFR deficiency on testis morphology and sperm DNA methylation is exacerbated across generations. Read More

View Article and Full-Text PDF

Clinicopathological analysis and genomic profiling of a rare histiocyte-rich rhabdomyoblastic tumor: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26105

Department of General Surgery, Shenzhen University General Hospital & Carson International Cancer Research Centre, Shenzhen, P.R. China.

Rationale: Skeletal muscle tumors are traditionally classified as rhabdomyomas or rhabdomyosarcomas. However, some soft tissue tumors cannot easily be identified as benign or malignant. We report a case of a histiocyte-rich rhabdomyoblastic tumor, with pathologic characteristics distinct from either rhabdomyoma or rhabdomyosarcoma. Read More

View Article and Full-Text PDF

Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis.

Sci Prog 2021 Apr-Jun;104(2):368504211024569

Department of Neurosurgery, The First Hospital of Lanzhou University, Lanzhou, China.

Benign paroxysmal positional vertigo is characterized by recurrence, which exposes patients to repeated vertigo attacks. Vitamin D deficiency has been found to be a risk factor in benign paroxysmal positional vertigo, although effect of its elimination on recurrence reduction remains unknown. To determine the effect of vitamin D supplementation in preventing recurrence of benign paroxysmal positional vertigo patients with vitamin D deficiency using a meta-analysis study. Read More

View Article and Full-Text PDF

Vapor Condensation and Coating Evaporation Are Both Responsible for Soot Aggregate Restructuring.

Environ Sci Technol 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102, United States.

Fresh soot is made of fractal aggregates, which often appear collapsed in atmospheric samples. A body of work has concluded that the collapse is caused by liquid shells when they form by vapor condensation around soot aggregates. However, some recent studies argue that soot remains fractal even when engulfed by the shells, collapsing only when the shells evaporate. Read More

View Article and Full-Text PDF

Obstetric Lacerations: Prevention and Repair.

Am Fam Physician 2021 Jun;103(12):745-752

Travis Air Force Base Family Medicine Residency, Travis Air Force Base, CA, USA.

Obstetric lacerations are a common complication of vaginal delivery. Lacerations can lead to chronic pain and urinary and fecal incontinence. Perineal lacerations are defined by the depth of musculature involved, with fourth-degree lacerations disrupting the anal sphincter and the underlying rectal mucosa and first-degree lacerations having no perineal muscle involvement. Read More

View Article and Full-Text PDF

Similarities between Cognitive Models of Language Production and Everyday Functioning: Implications for Development of Interventions for Functional Difficulties.

Top Cogn Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Temple University.

The loss of the ability to independently complete activities of daily living, such as meal preparation and household chores, is a defining characteristic of clinical dementia; however, minor difficulties in completing everyday activities emerge in the mild cognitive impairment stage, and even healthy older adults exhibit subtle functional difficulties compared to younger adults. These functional difficulties are associated with an array of negative outcomes, including decreased quality of life, higher costs of care, and increased frustration, depression, caregiver burden, and institutionalization. While cognitive models have been proposed to explain the functional deficits seen in dementia and subtler forms of cognitive decline, in contrast to other cognitive disorders such as aphasia, there are essentially no theoretically motivated interventions to address difficulties in everyday functioning. Read More

View Article and Full-Text PDF

Review: Unaccompanied refugee minors' perception of mental health services and professionals: a systematic review of qualitative studies.

Child Adolesc Ment Health 2021 Jun 15. Epub 2021 Jun 15.

Univ. Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525, Grenoble, France.

Background: Unaccompanied refugee minors (URMs) are a population at risk of mental health problems and a population with whom the therapeutic alliance can be difficult to set up. The therapeutic alliance's quality can impact the result and effectiveness of psychotherapeutic interventions. The aim of the present study was to gather URMs' points of view about mental health services and mental health professionals (MHP) in the host country. Read More

View Article and Full-Text PDF

Diagnostic accuracy of an interdisciplinary tertiary center evaluation in children referred for suspected congenital anomalies of the kidney and urinary tract on fetal ultrasound - a retrospective outcome analysis.

Pediatr Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatric Nephrology, University Children's Hospital Basel, Basel, Switzerland.

Background: Fetal ultrasound organ screening has become a standard of care in most high-income countries. This has resulted in increased detection of congenital abnormalities, which may lead to major uncertainty and anxiety in expectant parents, even though many of them are of minor relevance. In order to optimize prenatal counselling, we introduced an interdisciplinary approach for all pregnant women referred to our center by private obstetricians for a co-assessment of suspected relevant fetal abnormalities of the kidney or urinary tract, involving both experienced prenatal ultrasound specialists and a pediatric nephrologist or urologist. Read More

View Article and Full-Text PDF

Perturbation of resting-state network nodes preferentially propagates to structurally rather than functionally connected regions.

Sci Rep 2021 Jun 14;11(1):12458. Epub 2021 Jun 14.

Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Combining Transcranial Magnetic Stimulation (TMS) with electroencephalography (EEG) offers the opportunity to study signal propagation dynamics at high temporal resolution in the human brain. TMS pulse induces a local effect which propagates across cortical networks engaging distant cortical and subcortical sites. However, the degree of propagation supported by the structural compared to functional connectome remains unclear. Read More

View Article and Full-Text PDF

Treatment effects of Carriere Motion Appliance on patients with class II malocclusion: A systematic review and meta-analysis.

Int Orthod 2021 Jun 11. Epub 2021 Jun 11.

University of Damascus Dental School, Department of Orthodontics, Damascus, Syria.

Objective: To investigate the treatment effects of Carriere Motion Appliance (CMA) on class II patients.

Methods: A comprehensive electronic search was performed in PubMed, Scopus, Web of science, ScienceDirect, ProQuest (dissertation and thesis), Google Scholar and ClinicalTrials.gov. Read More

View Article and Full-Text PDF

Low Risk of Neurological Recurrence while Awaiting Carotid Endarterectomy: Results From a Danish Multicentre Study.

Eur J Vasc Endovasc Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark; Copenhagen Academy for Medical Education and Simulation (CAMES), Capital Region of Denmark, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Objective: The risk of ipsilateral neurological recurrence (NR) was assessed in patients awaiting carotid endarterectomy (CEA) due to symptomatic carotid artery stenosis and whether current national guidelines of performing CEA within 14 days are adequate in present day practice.

Methods: This was a retrospective multicentre observational cohort study. Patients scheduled for CEA due to symptomatic carotid artery stenosis in a five year period, 1 January 2014 to 31 December 2018, from four centres were included. Read More

View Article and Full-Text PDF

Obesity and Postoperative Complications Following Ankle Arthrodesis: A Propensity Score Matched Analysis.

J Foot Ankle Surg 2021 May 17. Epub 2021 May 17.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA. Electronic address:

Obese patients undergoing orthopedic procedure have been reported to have higher rates of postoperative complications, but the published associations have numerous confounders. This study aims to evaluate the independent effect of obesity on postoperative complications and hospital utilization following ankle arthrodesis. A database review of a Medicare database was performed on patients less than 85 years old who underwent ankle arthrodesis between 2005 and 2014. Read More

View Article and Full-Text PDF

NIA-Network: Towards improving lung CT infection detection for COVID-19 diagnosis.

Artif Intell Med 2021 07 2;117:102082. Epub 2021 May 2.

Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, PR China.

During pandemics (e.g., COVID-19) physicians have to focus on diagnosing and treating patients, which often results in that only a limited amount of labeled CT images is available. Read More

View Article and Full-Text PDF

LISTEN UP (Locally Integrated Screening and Testing Ear aNd aUral Programme): a feasibility study protocol for a community pharmacy-based ear health intervention.

Pilot Feasibility Stud 2021 Jun 14;7(1):124. Epub 2021 Jun 14.

College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Background: Ear disease is a major cause of preventable hearing loss and is very common in rural communities, estimated to affect 1.3 million Australians. Rural community pharmacists are well placed to provide improved ear health care to people who are unable to easily access a general practitioner (GP). Read More

View Article and Full-Text PDF

Solving the gap between HCV detection and treatment in prison. HCV-RNA testing and treatment in a cohort of new arriving convicts in Southern Italy.

Rev Recent Clin Trials 2021 Jun 11. Epub 2021 Jun 11.

Internal Medicine and Hepatology Division, Department of Medicine and Surgery "Scuola Medica Salernitana", Salerno, Italy.

Introduction: HCV infection elimination is set to be carried out by 2030. To achieve this goal, the WHO has set minor achievable short-term "mini-goals." One of these is the treatment of "difficult to reach and treat populations," such as prisoners. Read More

View Article and Full-Text PDF

Biodegradation of an essential oil UVCB - Whole substance testing and constituent specific analytics yield biodegradation kinetics of mixture constituents.

Chemosphere 2021 Sep 1;278:130409. Epub 2021 Apr 1.

Technical University of Denmark, Department of Environmental Engineering, Building 115, 2800 Kgs, Lyngby, Denmark. Electronic address:

Testing and assessing the persistency, bioaccumulative and toxic properties of UVCBs (substances of Unknown or Variable composition, Complex reaction products or Biological materials) pose major technical and analytical challenges. The main aim of this study was to combine whole substance biodegradation testing with constituent specific analytics for determining primary biodegradation kinetics of the main UVCB constituents. An additional aim was to link the primary biodegradation kinetics of the main constituents to the bioaccumulation potential and baseline toxicity potential of the UVCB. Read More

View Article and Full-Text PDF
September 2021

Open-circuit-voltage shift of over 0.5 V in organic photovoltaic cells induced by a minor structural difference in alkyl substituents.

Chem Sci 2020 Jan 13;11(7):1825-1831. Epub 2020 Jan 13.

Division of Materials Science, Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma Nara 630-0192 Japan

The recent surge in the efficiency of organic photovoltaic devices (OPVs) largely hinges on the reduction of energy loss () that leads to improvements in open-circuit voltage (). However, there are still many unclarified factors regarding the relationship between the molecular structure and , hampering the establishment of widely applicable, effective principles for the design of active-layer materials. In this contribution, we examine the origin of the large shifts induced by minor structural differences in end-alkyl substituents on a series of anthracene-based p-type compounds. Read More

View Article and Full-Text PDF
January 2020

Diastereoselective synthesis of chiral 3-substituted isoindolinones rhodium(III)-catalyzed oxidative C-H olefination/annulation.

Org Biomol Chem 2021 Jun 14. Epub 2021 Jun 14.

College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. Read More

View Article and Full-Text PDF

Rates and clinical impact of discordant X-ray and CT imaging in transfers to a pediatric emergency department.

Am J Emerg Med 2021 May 29;49:166-171. Epub 2021 May 29.

Children's Hospital of Michigan, Division of Emergency Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, United States; Central Michigan University School of Medicine, 1280 East Campus Dr, Mt Pleasant, MI 48858, United States.

Objectives: Children are often transferred to a Pediatric Emergency Department (PED) for definitive care after completion of diagnostic imaging. There is a paucity of data on the concordance rates of interpretation of imaging studies between referral and PED. Our objective is to describe the rates and clinical impact of discordant interpretation of X-rays and CT in children transferred to a PED. Read More

View Article and Full-Text PDF

Comprehensive characterisation of flexural mechanical properties and a new classification for porosity of 11 contemporary ion-leaching dental restorative materials.

J Mech Behav Biomed Mater 2021 Jun 1;121:104615. Epub 2021 Jun 1.

Melbourne Dental School, The University of Melbourne, Melbourne Victoria Australia 720 Swanston St, Carlton Melbourne, VIC, 3053, Australia. Electronic address:

The objectives of this study were to evaluate 4 aspects of ion-leaching restorative materials (ILMs): 4-point bending flexural strength (4 PB-FS) and relative mechanical properties; biaxial flexural strength (B-FS) in relation to 4 PB-FS; porosity; and surface morphology. Eleven ILMs were used for the 4-point bending test. Bar-shaped (n = 15) samples were fabricated, stored in distilled water for 7 days. Read More

View Article and Full-Text PDF

Evaluation of Long-Term Clinical Outcomes and Patient Satisfaction Rate Following Low Intensity Shock Wave Therapy in Men With Erectile Dysfunction: A Minimum 5-Year Follow-Up on a Prospective Open-Label Single-Arm Clinical Study.

Sex Med 2021 Jun 11;9(4):100384. Epub 2021 Jun 11.

The University of Queensland, Department of Urology, Princess Alexandra Hospital, Brisbane, QLD, Australia.

Introduction: Low intensity extracorporeal shock wave therapy (LIESWT) improves erectile function (EF) in men with vascular erectile dysfunction (ED) but longer-term outcomes remain unknown.

Aim: To evaluate the clinical outcomes of LIESWT at a minimum 5-year follow-up.

Methods: This is an open-label single-arm prospective study involved men with vascular ED who received LIESWT. Read More

View Article and Full-Text PDF