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Seroprevalence of SARS-CoV-2 in Slovenia: results of two rounds of a nationwide population study on a probability-based sample, challenges and lessons learned.

Clin Microbiol Infect 2021 Apr 7. Epub 2021 Apr 7.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objectives: Seroprevalence surveys provide crucial information on cumulative SARS-CoV-2 exposure. This Slovenian nationwide population study is the first longitudinal 6-month serosurvey using probability-based sample across all age categories.

Methods: Each participant supplied two blood samples: 1,316 samples in April 2020 (first round) and 1,211 in October/November 2020 (second round). Read More

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The outcome of laparoscopic assisted orchidopexy in very young children: A single hospital experience.

J Pediatr Urol 2021 Mar 17. Epub 2021 Mar 17.

Rotating Doctor, Department of Pediatric Surgery, Salmaniya Medical Complex, P.O. Box 12, Manama, Bahrain. Electronic address:

Introduction: Early orchidopexy has been linked to improved long term outcomes of fertility and reduced malignancy rates. However, the optimal age of intervention has been subject to change over the years.

Objective: This study aims to study males aged 6 months or less who undergo laparoscopic assisted orchidopexy for intraabdominal testes to establish the safety, efficacy, and benefit in the defined age group. Read More

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Digit ratio as an endophenotype in a schizophrenia population.

S Afr J Psychiatr 2021 3;27:1587. Epub 2021 Mar 3.

Biostatistics Unit, South African Medical Research Council, Cape Town, South Africa.

Background: Schizophrenia is a debilitating mental health condition affecting the lives of many South Africans. The origins of the heterogeneity in the presentation of the illness remain uncertain.

Aim: This cross-sectional study performed a retrospective data analysis to determine the usefulness of digit ratio as an endophenotype in a South African schizophrenia population. Read More

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Expanding the Non-Invasive Diagnosis of Acute Rejection in Kidney Transplants Through Detection of Donor-Derived DNA in Urine: Proof-of-Concept Study.

Ann Lab Med 2021 Sep;41(5):469-478

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background: Approximately 10%-20% of kidney transplant (KT) recipients suffer from acute rejection (AR); thus, sensitive and accurate monitoring of allograft status is recommended. We evaluated the clinical utility of donor-derived DNA (dd-DNA) detection in the urine of KT recipients as a non-invasive means for diagnosing AR.

Methods: Urine samples serially collected from 39 KT recipients were tested for 39 single-nucleotide variant loci selected according to technical criteria (i. Read More

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September 2021

Analysis of Physiological Parameters of Strains from Individuals with Colitis.

Open Life Sci 2018 Jan 4;13:481-488. Epub 2019 Jan 4.

Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Intestinal sulfate-reducing bacteria are often isolated from patients with inflammatory bowel disease, including ulcerative colitis, and can be involved in the development of gut inflammation. A comparison of the metabolism of intestinal sulfate-reducing bacteria isolated from individuals with colitis and healthy controls using statistical analysis has never been studied and described before. The aim of our research was to evaluate the parameters of dissimilatory sulfate reduction in species that were isolated from the feces of healthy objects and individuals with colitis. Read More

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January 2018

Assessment and Trends in the Methodological Quality of the Top 50 Most Cited Articles in Shoulder Instability.

Orthop J Sports Med 2020 Dec 15;8(12):2325967120967082. Epub 2020 Dec 15.

Department of Orthopaedic Surgery, Loma Linda University Medical Center, Loma Linda, California, USA.

Background: Citation counts have often been used as a surrogate for the scholarly impact of a particular study, but they do not necessarily correlate with higher-quality investigations. In recent decades, much of the literature regarding shoulder instability is focused on surgical techniques to correct bone loss and prevent recurrence.

Purpose: To determine (1) the top 50 most cited articles in shoulder instability and (2) if there is a correlation between the number of citations and level of evidence or methodological quality. Read More

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December 2020

Beta diversity of aquatic macroinvertebrate assemblages associated with leaf patches in neotropical montane streams.

Ecol Evol 2021 Mar 7;11(6):2551-2560. Epub 2021 Feb 7.

Departamento de Genética, Ecologia e Evolução Centro de Síntese Ecológica e Conservação Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte Brazil.

Over 70% of the total channel length in all river basins is formed by low order streams, many of which originate on mountaintops. Headwater streams play fundamental roles in processing and transporting terrestrial and aquatic organic matter, often harboring high biodiversity in bottom leaf patches deposited from riparian vegetation. The objective of this study was to assess the variation in taxonomic composition (measured by beta diversity of aquatic macroinvertebrates) among stream sites located in the Espinhaço Meridional Mountain Range, part of a UNESCO Biosphere Reserve in eastern Brazil. Read More

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Sound Velocities of Generalized Lennard-Jones ( - 6) Fluids Near Freezing.

Sergey Khrapak

Molecules 2021 Mar 16;26(6). Epub 2021 Mar 16.

Reseash and Edicational Centre for Ion, Bauman Moscow State Technical University, 105005 Moscow, Russia.

In a recent paper [S. Khrapak, Molecules , 3498 (2020)], the longitudinal and transverse sound velocities of a conventional Lennard-Jones system at the liquid-solid coexistence were calculated. It was shown that the sound velocities remain almost invariant along the liquid-solid coexistence boundary lines and that their magnitudes are comparable with those of repulsive soft-sphere and hard-sphere models at the fluid-solid phase transition. Read More

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A New Approach to Obtaining Nano-Sized Graphene Oxide for Biomedical Applications.

Materials (Basel) 2021 Mar 10;14(6). Epub 2021 Mar 10.

Physicochemistry of Carbon Materials Research Group, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.

Graphene oxide (GO) is one of the most exciting and widely used materials. A new method of nanographene oxide (n-GO) formation is presented. The described unique sequence of ultrasonication in dimethyl sulfoxide solution allows us to obtain different sizes of n-GO sheets by controlling the timing of the cutting and re-aggregation processes. Read More

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Medication-related harm in New Zealand general practice: a retrospective records review.

Br J Gen Pract 2021 Apr 1. Epub 2021 Apr 1.

University of Waikato, Hamilton, New Zealand.

Background: The extent of medication-related harm in general practice is unknown.

Aim: To identify and describe all medication-related harm in electronic general practice records.

Design And Setting: Retrospective cohort records review study in 44 randomly selected New Zealand general practices for the three years 2011-2013. Read More

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Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Clin Transl Radiat Oncol 2021 May 11;28:39-47. Epub 2021 Mar 11.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Background And Purpose: Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance.

Materials And Methods: Six pediatric renal cancer cases were transferred to ten radiation oncologists from seven European countries ('participants'). Read More

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Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren's syndrome: An exploratory cross-sectional study.

Saudi Med J 2021 Apr;42(4):405-410

From the Rheumatology Division (Omair), Pulmonary Division (AlHamad, Paramasivam) Department of Medicine, from the Department of Zoology (AlQahtani, Daghestani), College of Medicine, from the Department of Statistics and Operations Research, College of Sciences (Tashkandy), Central Laboratory (Othman), King Saud University; from the Rheumatology Division, Department of Medicine (AlShahrani), Diriyah General Hospital, Ministry of Health; from the Department of Clinical Science, College of Medicine (AlEnzi), Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from the Department of Clinical Sciences, College of Medicine (Halwani), Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.

Objectives: To describe primary Sjögren's syndrome (pSS) cohort in Saudi Arabiain view in of clinical/serological/histopathological phentotype, and, diagnostic delay.

Methods: A cross-sectional study conducted between October 2018 and May 2019. Diagnostic delay was calculated from symptoms onset to clinical diagnosis. Read More

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An update of the Japanese Oslo Sports Trauma Research Center questionnaires on overuse injuries and health problems.

PLoS One 2021 1;16(4):e0249685. Epub 2021 Apr 1.

Department of Sports and Health Science, Japan Women's College of Physical Education, Setagaya, Tokyo, Japan.

Monitoring the health of athletes is important for their protection, and questionnaires such as those produced by the Oslo Sports Trauma Research Center (OSTRC) are a valuable tool in this process. In 2020, several changes were made to the OSTRC questionnaires (OSTRC-O, OSTRC-H), including changes to the wording, structure, and logic of the original questionnaires. In the present study, the Japanese versions of the OSTRC questionnaires (OSTRC-O. Read More

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Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age.

J Psychopharmacol 2021 Mar 28:2698811211003477. Epub 2021 Mar 28.

Center for Mental Health, University Hospital of Würzburg, Würzburg, Germany.

Background: Drug-induced prolongation of cardiac repolarization limits the treatment with many psychotropic drugs. Recently, the contribution of polygenic variation to the individual duration of the QT interval was identified.

Aims: To explore the interaction between antipsychotic drugs and the individual polygenic influence on the QT interval. Read More

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Ride-share Use and Child Passenger Safety Behaviors: An Online Survey of Parents.

Acad Pediatr 2021 Mar 25. Epub 2021 Mar 25.

Northwestern University Feinberg School of Medicine, 420 E. Superior St, Chicago, IL 60611; Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Division of Emergency Medicine, 225 East Chicago Avenue, Chicago, Illinois 60611. Electronic address:

Objective: Ride-share services are increasingly used for transportation, but little is known about ride-share use and passenger safety behaviors among parents of children for whom child restraint systems (CRS) are recommended. Our objectives were to characterize ride-share use with children and examine passenger restraint use in ride-share.

Methods: A cross-sectional survey, distributed to the TurkPrime Parent Panel using Amazon Mechanical Turk (MTurk), was designed to assess ride-share and passenger safety behaviors. Read More

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Diagnostic accuracy and complication rates of percutaneous CT-guided coaxial needle biopsy of pulmonary lesions.

Diagn Interv Radiol 2021 Mar 26. Epub 2021 Mar 26.

Department of Radiology, Hacettepe University, Ankara, Turkey.

Purpose: The aim of this retrospective study was to evaluate and compare diagnostic accuracy and complication rates of percutaneous computed tomography (CT)-guided biopsies of pulmonary lesions 10-35 mm, 35-50 mm, and >50 mm, using the coaxial biopsy technique.

Methods: Over a 4-year period, 235 lung biopsies were performed using the coaxial biopsy technique with 18G semi-automated true-cut needle. There were 163 (69. Read More

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Effects of climate change and anthropogenic pressures in the water quality of a coastal lagoon (Ria Formosa, Portugal).

Sci Total Environ 2021 Mar 16;780:146311. Epub 2021 Mar 16.

Laboratório Nacional de Engenharia Civil, Avenida do Brasil, 101, 1700-066 Lisboa, Portugal.

Understanding how climatic and anthropogenic drivers will influence coastal lagoons is fundamental to guarantee their preservation and sustainability. The Ria Formosa (coastal lagoon, South coast of Portugal) is a very important ecosystem that supports diverse economic activities in the region. The 3D coupled hydrodynamic-biogeochemical model SCHISM was validated and used to assess the influence of climate change and anthropogenic pressures on the water quality of the Ria Formosa. Read More

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Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI.

Int J Cardiol Heart Vasc 2021 Apr 13;33:100750. Epub 2021 Mar 13.

Cardiovascular Research Institute Düsseldorf (CARID), Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Medical Faculty, Duesseldorf, Germany.

Background: Guidelines recommend the PRECISE-DAPT (PD) score to adapt duration of dual antiplatelet therapy due to bleeding risk. However, there is first evidence that PD predicts mortality and ischemic events as well.

Methods: We investigated PD Score in 994 patients after percutaneous coronary intervention (PCI). Read More

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Younger North Americans are exposed to more radon gas due to occupancy biases within the residential built environment.

Sci Rep 2021 Mar 24;11(1):6724. Epub 2021 Mar 24.

Robson DNA Science Centre, Departments of Biochemistry and Molecular Biology and Oncology, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Residential buildings can concentrate radioactive radon gas, exposing occupants to particle radiation that increases lung cancer risk. This has worsened over time in North America, with newer residences containing greater radon. Using data from 18,971 Canadian households, we calculated annual particle radiation dose rates due to long term residential radon exposure, and examined this as a function of occupant demographics. Read More

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Machine learning to identify lymph node metastasis from thyroid cancer in patients undergoing contrast-enhanced CT studies.

Radiography (Lond) 2021 Mar 21. Epub 2021 Mar 21.

Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: We compared the diagnostic performance of morphological methods such as the major axis, the minor axis, the volume and sphericity and of machine learning with texture analysis in the identification of lymph node metastasis in patients with thyroid cancer who had undergone contrast-enhanced CT studies.

Methods: We sampled 772 lymph nodes with histology defined tissue types (84 metastatic and 688 benign lymph nodes) that were visualised on CT images of 117 patients. A support vector machine (SVM), free programming software (Python), and the scikit-learn machine learning library were used to discriminate metastatic-from benign lymph nodes. Read More

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Validation of the Fracture Risk Evaluation Model (FREM) in predicting major osteoporotic fractures and hip fractures using administrative health data.

Bone 2021 Mar 20;147:115934. Epub 2021 Mar 20.

OPEN - Open Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Heden 16, DK-5000 Odense C, Denmark. Electronic address:

Background: Prevention of osteoporotic fractures remains largely insufficient, and effective means to identify patients at high, short-term fracture risk are needed. The FREM tool is available for automated case finding of men and women aged 45 years or older at high imminent (1-year) risk of osteoporotic fractures, based on administrative health data with a 15-year look-back. The aim of this study was to validate the performance of FREM, and the effect of applying a shorter look-back period. Read More

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A robotic chewing simulator supplying six-axis mandibular motion, high occlusal force, and a saliva environment for denture tests.

Proc Inst Mech Eng H 2021 Mar 24:9544119211005601. Epub 2021 Mar 24.

College of Stomatology, Dalian Medical University, Dalian, China.

Six-axis motion is essential for the evaluation of the wear failure modes of dental prostheses with complete teeth morphologies, and a high occlusal force capacity is vital for static clenching and dynamic bruxism. Additionally, the saliva environment influences abrasive particles and crack growth. The present research was aimed at the development of a six-axis masticatory and saliva simulator with these capacities. Read More

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Protamine Binding Site on DNA: Molecular Dynamics Simulations and Free Energy Calculations with Full Atomistic Details.

J Phys Chem B 2021 04 23;125(12):3032-3044. Epub 2021 Mar 23.

GREMAN, CNRS UMR 7347, Université de Tours, 37200 Tours, France.

Protamine, an arginine-rich basic protein, compacts DNAs in sperm nuclei to densities higher than those in somatic cells. The mechanism of this compaction in sperm cells is even less clear than in somatic cells. Even the preferred binding site, if any, of protamine on DNA is not clearly identified. Read More

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Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study.

Indoor Air 2021 Mar 10. Epub 2021 Mar 10.

Department of Health Sciences, Karlstad University, Karlstad, Sweden.

Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. Read More

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A retrospective descriptive analysis of race-day injuries of greyhounds in New Zealand.

Aust Vet J 2021 Mar 21. Epub 2021 Mar 21.

School of Veterinary Science, Massey University, Palmerston North, 4442, New Zealand.

Objectives: To describe the distribution, and determine the incidence, of veterinary reported injuries experienced by greyhounds during racing in New Zealand.

Materials And Methods: This retrospective cohort study utilised data obtained on all greyhound race starts and all racing injuries sustained in New Zealand between 10 September 2014 and 19 June 2019. Greyhound injuries were described by the number and percentage of the type, location, and presumed cause of injuries. Read More

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The radical scavenging activity of abietane diterpenoids: Theoretical insights.

J Mol Graph Model 2021 Mar 4;105:107892. Epub 2021 Mar 4.

Faculty of Chemical Technology- Environment, The University of Danang - University of Technology and Education, Danang 550000, Vietnam. Electronic address:

Salvia species are frequently used in traditional medicine and are a source of diterpenoid antioxidants. In this study, the hydroperoxide radical scavenging activity of seven known abietane diterpenoids (ADs), isolated from Salvia barrelieri, are investigated using a quantum chemical approach. The ADs are 7-oxoroyleanone-12-methyl ether (1), 7a-acetoxyroyleanone-12-methyl ether (2), royleanone (3), horminone (4), 7-acetylhorminone (5), cryptojaponol (6), and inuroyleanol (7). Read More

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Interobserver variability in Lung CT Screening Reporting and Data System categorisation in subsolid nodule-enriched lung cancer screening CTs.

Eur Radiol 2021 Mar 17. Epub 2021 Mar 17.

Department of Radiology, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeongi-do, 13620, Korea.

Objectives: To assess interobserver agreement in Lung CT Screening Reporting and Data System (Lung-RADS) categorisation in subsolid nodule-enriched low-dose screening CTs.

Methods: A retrospective review of low-dose screening CT reports from 2013 to 2017 using keyword searches for subsolid nodules identified 54 baseline CT scans. With an additional 108 negative screening CT scans, a total of 162 CT scans were categorised according to the Lung-RADS by two fellowship-trained thoracic radiologists in consensus. Read More

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Surgical treatment of the neck in patients with salivary gland carcinoma.

Head Neck 2021 Mar 18. Epub 2021 Mar 18.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines.

Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carcinoma were treated with END. Read More

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Reduced-Dose Prasugrel versus Clopidogrel for Patients Undergoing Percutaneous Coronary Intervention.

Int Heart J 2021 Mar 17;62(2):246-255. Epub 2021 Mar 17.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University.

Whether reduced-dose prasugrel has a better efficacy or safety than standard-dose clopidogrel remains unknown in patients undergoing percutaneous coronary intervention (PCI).A systematic search of PubMed, EMBASE, Google Scholar, and Cochrane Library from database inception to May 1, 2020 was performed to compare the clinical outcomes in patients with acute coronary syndrome or stable coronary artery disease undergoing PCI between those treated with reduced-dose prasugrel and clopidogrel. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using the fixed-effect or random-effect model if significant heterogeneity was observed. Read More

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